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  1. Article ; Online: Various vaccine platforms in the field of COVID-19.

    Savina, K / Sreekumar, Rakhy / Soonu, V K / Variyar, E J

    Beni-Suef University journal of basic and applied sciences

    2022  Volume 11, Issue 1, Page(s) 35

    Abstract: Background: With the emergence of Corona virus Disease-2019, a novel worldwide health disaster is threatening the population. The WHO declared COVID-19 as a pandemic in December 2019, when it first surfaced in Hunan seafood market in Wuhan, South China, ...

    Abstract Background: With the emergence of Corona virus Disease-2019, a novel worldwide health disaster is threatening the population. The WHO declared COVID-19 as a pandemic in December 2019, when it first surfaced in Hunan seafood market in Wuhan, South China, and quickly spread far and wide. Different corona virus variants are currently causing concern all across the world.
    Main body: It has become critical for our scientists to develop a viable method to prevent infection or the pandemic from spreading globally. Antiviral medicines, oxygen therapy, and immune system stimulation are all used to treat the condition. SARS-CoV-2 undergoes mutation and due to evolutionary pressures, different mutant strains caused various symptoms in different geographical regions and the epidemic is spreading and becoming more fragile, posing a greater risk of mortality. Vaccines are tools to increase our immunity as a precaution, and increasing the global immunization rate can help improve the situation. Recent developments in the field of vaccine platforms are discussed here.
    Short conclusion: Vaccines are of highest priority to control and eradicate the viral infectious disease COVID-19 more than any other protective solutions. A number of mutations have occurred and some variants such as alpha, beta, gamma, and delta, and it has now progressed to the new version Omicron, which is a variant of concern. Booster doses are anticipated to function as a barrier to the capacity of the most recent known variety, and more research is needed to determine how effective they will be. This page discusses various technologies employed in the field of COVID-19 vaccine, as well as potential barriers and recent developments in this field.
    Language English
    Publishing date 2022-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2768279-1
    ISSN 2314-8543 ; 2314-8535 ; 2314-8543
    ISSN (online) 2314-8543
    ISSN 2314-8535 ; 2314-8543
    DOI 10.1186/s43088-022-00215-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling.

    Remya, Chandran / Variyar, E J / Omkumar, R V / Sadasivan, C / Dileep, K V

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 22418

    Abstract: Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the ...

    Abstract Neurological and psychiatric disorders contribute significantly to the global disease burden, adversely affecting the quality of life for both patients and their families. Impaired glutamatergic signaling is considered to be a major cause for most of the neurological and psychiatric disorders. Glutamate receptors are over activated in excitotoxic conditions, leading to dysregulation of Ca
    MeSH term(s) Humans ; Lobeline ; Molecular Docking Simulation ; Allosteric Regulation ; Quality of Life ; Receptors, N-Methyl-D-Aspartate/metabolism ; Models, Molecular
    Chemical Substances Lobeline (D0P25S3P81) ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2023-12-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-49835-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lipoxygenase inhibitory synthetic derivatives of methyl gallate regulate gene expressions of COX-2 and cytokines to reduce animal model arthritis.

    Sharanya, C S / Abhithaj, J / Arun, K G / Eeda, Koti Reddy / Bhat, Vignesh / Variyar, E J / Sabu, A / Haridas, M

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10644

    Abstract: Mammalian lipoxygenases (LOXs) are involved in the biosynthesis of mediators of anaphylactic reactions and have been implicated in cell maturation, the pathogenesis of bronchial asthma, atherosclerosis, rheumatoid arthritis, cardiovascular diseases, ... ...

    Abstract Mammalian lipoxygenases (LOXs) are involved in the biosynthesis of mediators of anaphylactic reactions and have been implicated in cell maturation, the pathogenesis of bronchial asthma, atherosclerosis, rheumatoid arthritis, cardiovascular diseases, Alzheimer's disease and osteoporosis. Hence LOX inhibition in chronic conditions can lead to reducing the disease progression, which can be a good target for treating these diseases. The present study deals with designing methyl gallate derivatives and their anti-inflammatory effect by in silico, in vitro and in vivo methods. Designed derivatives were docked against LOX enzyme, and molecular dynamic simulations were carried out. Following the synthesis of derivatives, in vitro LOX inhibition assay, enzyme kinetics and fluorescence quenching studies were performed. One of the derivatives of methyl gallate (MGSD 1) was demonstrated as an anti-inflammatory agent for the treatment of rheumatoid arthritis in the animal model. Amelioration of Freund's complete adjuvant (FCA)-induced arthritis by methyl gallate and its derivative with a concentration of 10-40 mg.kg
    MeSH term(s) Animals ; Cytokines ; Lipoxygenase ; Cyclooxygenase 2/genetics ; Tumor Necrosis Factor-alpha ; Diclofenac ; Arthritis, Rheumatoid ; Lipoxygenases ; Gene Expression ; Mammals
    Chemical Substances Cytokines ; Lipoxygenase (EC 1.13.11.12) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Tumor Necrosis Factor-alpha ; methyl gallate (623D3XG80C) ; Diclofenac (144O8QL0L1) ; Lipoxygenases (EC 1.13.11.-)
    Language English
    Publishing date 2023-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37613-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extraction and optimization of Penicillium sclerotiorum strain AK-1 pigment for fabric dyeing.

    Kallingal, Anoop / Ayyolath, Aravind / Thachan Kundil, Varun / Joseph, Tomy M / Chandra D, Naveen / Haponiuk, Józef T / Thomas, Sabu / Variyar E, Jayadevi

    Journal of basic microbiology

    2021  Volume 61, Issue 10, Page(s) 900–909

    Abstract: Recently, the demand for fungal pigments has increased due to their several benefits over synthetic dyes. Many species of fungi are known to produce pigments and a large number of fungal strains for pigment production are yet to be extensively ... ...

    Abstract Recently, the demand for fungal pigments has increased due to their several benefits over synthetic dyes. Many species of fungi are known to produce pigments and a large number of fungal strains for pigment production are yet to be extensively investigated. The natural pigment from sustainable natural sources has good economic and industrial value. Many synthetic colorants used in textile and various industries have many harmful effects on the human population and environment. Pigments and coloring agents may be extracted from a wide range of fungal species. These compounds are among the natural compounds having the most significant promise for medicinal, culinary, cosmetics, and textile applications. This study attempts to isolate and optimize the fermentation conditions of Penicillium sclerotiorum strain AK-1 for pigment production. A dark yellow-colored pigment was isolated from the strain with significant extractive value and antioxidant capacity. This study also identifies that the pigment does not have any cytotoxic effect and is multicomponent. The pigment production was optimized for the parameters such as pH, temperature, carbon and nitrogen source. Fabric dyeing experiments showed significant dyeing capacity of the pigment on cotton fabrics. Accordingly, the natural dye isolated from P. sclerotiorum strain AK-1 has a high potential for industrial-scale dyeing of cotton materials.
    MeSH term(s) Antioxidants ; Biomass ; Carbon ; Coloring Agents ; Fermentation ; Humans ; Hydrogen-Ion Concentration ; Nitrogen ; Penicillium/metabolism ; Pigmentation ; Pigments, Biological/biosynthesis ; Pigments, Biological/isolation & purification ; Temperature ; Textiles
    Chemical Substances Antioxidants ; Coloring Agents ; Pigments, Biological ; Carbon (7440-44-0) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2021-08-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632513-0
    ISSN 1521-4028 ; 0233-111X
    ISSN (online) 1521-4028
    ISSN 0233-111X
    DOI 10.1002/jobm.202100349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 824: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Flavanone glycosides as acetylcholinesterase inhibitors: computational and experimental evidence.

    Remya, C / Dileep, K V / Tintu, I / Variyar, E J / Sadasivan, C

    Indian journal of pharmaceutical sciences

    2014  Volume 76, Issue 6, Page(s) 567–570

    Abstract: Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer's disease is the decrease in the ... ...

    Abstract Acetylcholinesterase hydrolyzes the neurotransmitter called acetylcholine and is crucially involved in the regulation of neurotransmission. One of the observable facts in the neurodegenerative disorders like Alzheimer's disease is the decrease in the level of acetylcholine. Available drugs that are used for the treatment of Alzheimer's disease are primarily acetylcholinesterase inhibitors with multiple activities. They maintain the level of acetylcholine in the brain by inhibiting the acetylcholinesterase function. Hence acetylcholinesterase inhibitors can be used as lead compounds for the development of drugs against AD. In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking. The activity of the top scored compound, naringin was further investigated by enzyme inhibition studies and its inhibitory concentration (IC50) towards acetylcholinesterase was also determined.
    Language English
    Publishing date 2014-11
    Publishing country India
    Document type Journal Article
    ZDB-ID 392332-0
    ISSN 1998-3743 ; 0250-474X
    ISSN (online) 1998-3743
    ISSN 0250-474X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1075: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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