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  1. Article: KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer.

    Varlı, Mücahit / Kim, Sung Jin / Noh, Myung-Giun / Kim, Yoon Gyoon / Ha, Hyung-Ho / Kim, Kyung Keun / Kim, Hangun

    Cell & bioscience

    2023  Volume 13, Issue 1, Page(s) 146

    Abstract: Purpose: The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and angiogenesis, resulting in shorter survival times in cancer patients. Here, we aimed to determine the effects of KITENIN on ... ...

    Abstract Purpose: The oncoprotein KAI1 C-terminal interacting tetraspanin (KITENIN; vang-like 1) promotes cell metastasis, invasion, and angiogenesis, resulting in shorter survival times in cancer patients. Here, we aimed to determine the effects of KITENIN on the energy metabolism of human colorectal cancer cells.
    Experimental design: The effects of KITENIN on energy metabolism were evaluated using in vitro assays. The GEPIA web tool was used to extrapolate the clinical relevance of KITENIN in cancer cell metabolism. The bioavailability and effect of the disintegrator of KITENIN complex compounds were evaluated by LC-MS, in vivo animal assay.
    Results: KITENIN markedly upregulated the glycolytic proton efflux rate and aerobic glycolysis by increasing the expression of GLUT1, HK2, PKM2, and LDHA. β-catenin, CD44, CyclinD1 and HIF-1A, including c-Myc, were upregulated by KITENIN expression. In addition, KITENIN promoted nuclear PKM2 and PKM2-induced transactivation, which in turn, increased the expression of downstream mediators. This was found to be mediated through an effect of c-Myc on the transcription of hnRNP isoforms and a switch to the M2 isoform of pyruvate kinase, which increased aerobic glycolysis. The disintegration of KITENIN complex by silencing the KITENIN or MYO1D downregulated aerobic glycolysis. The disintegrator of KITENIN complex compound DKC1125 and its optimized form, DKC-C14S, exhibited the inhibition activity of KITENIN-mediated aerobic glycolysis in vitro and in vivo.
    Conclusions: The oncoprotein KITENIN induces PKM2-mediated aerobic glycolysis by upregulating the c-Myc/hnRNPs axis.
    Language English
    Publishing date 2023-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-023-01089-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Usnic Acid Targets 14-3-3 Proteins and Suppresses Cancer Progression by Blocking Substrate Interaction.

    Varlı, Mücahit / Bhosle, Suresh R / Kim, Eunae / Yang, Yi / Taş, İsa / Zhou, Rui / Pulat, Sultan / Gamage, Chathurika D B / Park, So-Yeon / Ha, Hyung-Ho / Kim, Hangun

    JACS Au

    2024  Volume 4, Issue 4, Page(s) 1521–1537

    Abstract: The anticancer therapeutic effects of usnic acid (UA), a lichen secondary metabolite, have been ... ...

    Abstract The anticancer therapeutic effects of usnic acid (UA), a lichen secondary metabolite, have been demonstrated
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Physical characteristics of black cumin oil emulsions compared to sunflower and corn oils emulsions

    Varlı, Mücahit / Solak, Rukiye / Turan, Semra / Ramadan, Mohamed Fawzy

    Journal of food measurement & characterization. 2021 Aug., v. 15, no. 4

    2021  

    Abstract: This study aimed to investigate the physical properties of black cumin oil (Nigella sativa) emulsions at different oil: water (w/w) ratios. Black cumin oil (BCO) emulsions were prepared as 80:20, 70:30, 60:40 (w/w) water in oil using 0.1%, 0.25%, 0.5%, 1% ...

    Abstract This study aimed to investigate the physical properties of black cumin oil (Nigella sativa) emulsions at different oil: water (w/w) ratios. Black cumin oil (BCO) emulsions were prepared as 80:20, 70:30, 60:40 (w/w) water in oil using 0.1%, 0.25%, 0.5%, 1%, 2% and 3% (w/w) lecithin by high speed homogenizer. The emulsion capacity, emulsion stability, viscosity, droplet size, texture, and color were determined. The physical properties of BCO emulsions were compared to those of sunflower oil (SFO) and corn oil (CO) emulsions. The emulsion capacities of BCO emulsions (13.6–94.7%) were lower than the emulsion capacities of SFO emulsions (19.1–99.3%). Emulsion capacity, emulsion stability, and viscosity of SFO and CO emulsions increased with the increase of lecithin levels. However, in the BCO emulsions, irregular changes in emulsion capacities, emulsion stabilities, and viscosities were observed as the lecithin ratio increased. As the BCO content decreased in emulsions, L* value increased, and a* and b* values decreased. Heterogeneous distribution of droplet size was observed in BCO emulsions according to microscope images, and the particle size analysis results. Due to the health benefits of the BCO and valuable physical properties of BCO emulsions, they can be used in food or the cosmetic industry alone or as a combination with other vegetable oils.
    Keywords Helianthus annuus ; Nigella sativa ; color ; corn ; corn oil ; droplet size ; emulsions ; homogenizers ; industry ; lecithins ; measurement ; particle size ; sunflower oil ; texture ; vegetables ; viscosity
    Language English
    Dates of publication 2021-08
    Size p. 3207-3215.
    Publishing place Springer US
    Document type Article
    ZDB-ID 2754612-3
    ISSN 2193-4134 ; 2193-4126
    ISSN (online) 2193-4134
    ISSN 2193-4126
    DOI 10.1007/s11694-021-00900-2
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived

    Pulat, Sultan / Yang, Inho / Lee, Jihye / Hwang, Sunghoon / Zhou, Rui / Gamage, Chathurika D B / Varlı, Mücahit / Taş, İsa / Yang, Yi / Park, So-Yeon / Hong, Ahreum / Kim, Jeong-Hyeon / Oh, Dong-Chan / Kim, Hangun / Nam, Sang-Jip / Kang, Heonjoong

    Marine drugs

    2024  Volume 22, Issue 2

    Abstract: Anithiactin D ( ...

    Abstract Anithiactin D (
    MeSH term(s) Humans ; Cell Line, Tumor ; Caco-2 Cells ; Streptomyces/metabolism ; A549 Cells ; rho GTP-Binding Proteins/metabolism ; Cell Movement ; Epithelial-Mesenchymal Transition ; Neoplasms
    Chemical Substances rho GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md22020088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells.

    Gamage, Chathurika D B / Kim, Jeong-Hyeon / Yang, Yi / Taş, İsa / Park, So-Yeon / Zhou, Rui / Pulat, Sultan / Varlı, Mücahit / Hur, Jae-Seoun / Nam, Sang-Jip / Kim, Hangun

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Colorectal cancer (CRC) is the third most deadly type of cancer in the world and continuous investigations are required to discover novel therapeutics for CRC. Induction of apoptosis is one of the promising strategies to inhibit cancers. Here, we have ... ...

    Abstract Colorectal cancer (CRC) is the third most deadly type of cancer in the world and continuous investigations are required to discover novel therapeutics for CRC. Induction of apoptosis is one of the promising strategies to inhibit cancers. Here, we have identified a novel compound, Libertellenone T (
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 1'-O-methyl-averantin isolated from the endolichenic fungus Jackrogersella sp. EL001672 suppresses colorectal cancer stemness via sonic Hedgehog and Notch signaling.

    Varlı, Mücahit / Lee, Eun-Young / Yang, Yi / Zhou, Rui / Taş, İsa / Pulat, Sultan / Gamage, Chathurika D B / Park, So-Yeon / Hur, Jae-Seoun / Nam, Sang-Jip / Kim, Hangun

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2811

    Abstract: Endolichenic fungi are host organisms that live on lichens and produce a wide variety of secondary metabolites. Colorectal cancer stem cells are capable of self-renewal and differentiation into cancer cells, which makes cancers difficult to eradicate. ... ...

    Abstract Endolichenic fungi are host organisms that live on lichens and produce a wide variety of secondary metabolites. Colorectal cancer stem cells are capable of self-renewal and differentiation into cancer cells, which makes cancers difficult to eradicate. New alternative therapeutics are needed to inhibit the growth of tumor stem cells. This study examined the ability of an extract of Jackrogersella sp. EL001672 (derived from the lichen Cetraria sp.) and the isolated compound 1'-O-methyl-averantin to inhibit development of cancer stemness. The endolichenic fungus Jackrogersella sp. EL001672 (KACC 83021BP), derived from Cetraria sp., was grown in culture medium. The culture broth was extracted with acetone to obtain a crude extract. Column chromatography and reverse-phase HPLC were used to isolate an active compound. The anticancer activity of the extract and the isolated compound was evaluated by qRT-PCR and western blotting, and in cell viability, spheroid formation, and reporter assays. The acetone extract of EL001672 did not affect cell viability. However, 1'-O-methyl-averantin showed cytotoxic effects against cancer cell lines at 50 μg/mL and 25 μg/mL. Both the crude extract and 1'-O-methyl-averantin suppressed spheroid formation in CRC cell lines, and downregulated expression of stemness markers ALDH1, CD44, CD133, Lgr-5, Msi-1, and EphB1. To further characterize the mechanism underlying anti-stemness activity, we examined sonic Hedgehog and Notch signaling. The results showed that the crude extract and the 1'-O-methyl-averantin inhibited Gli1, Gli2, SMO, Bmi-1, Notch-1, Hes-1, and the CSL complex. Consequently, an acetone extract and 1'-O-methyl-averantin isolated from EL001672 suppresses colorectal cancer stemness by regulating the sonic Hedgehog and Notch signaling pathways.
    MeSH term(s) Humans ; Hedgehog Proteins/metabolism ; Acetone/metabolism ; Lichens/metabolism ; Xylariales/metabolism ; Colorectal Neoplasms/pathology ; Neoplastic Stem Cells/metabolism ; Cell Line, Tumor
    Chemical Substances Hedgehog Proteins ; averantin (6H95D7020N) ; Acetone (1364PS73AF)
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-28773-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phthalides Isolated from the Endolichenic

    Gamage, Chathurika D B / Lee, Kyungha / Park, So-Yeon / Varlı, Mücahit / Lee, Chang Wook / Kim, Seong-Min / Zhou, Rui / Pulat, Sultan / Yang, Yi / Taş, İsa / Hur, Jae-Seoun / Kang, Kyo Bin / Kim, Hangun

    ACS omega

    2023  Volume 8, Issue 13, Page(s) 12548–12557

    Abstract: Endolichenic fungi (ELF) produce specialized metabolites that have various medicinal properties. Inhibition of tumor angiogenesis efficaciously suppresses many types of cancer. This study aimed to discover novel antiangiogenic agents from specialized ... ...

    Abstract Endolichenic fungi (ELF) produce specialized metabolites that have various medicinal properties. Inhibition of tumor angiogenesis efficaciously suppresses many types of cancer. This study aimed to discover novel antiangiogenic agents from specialized metabolite extracts of ELF strains isolated from Korean lichens. The EtOAc extracts of 51 ELF strains were subjected to a screening pipeline consisting of cell viability, scratch wound healing, and Transwell migration assays. The EtOAc extract of
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00876
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: A fatty acid-rich fraction of an endolichenic fungus

    Varlı, Mücahit / Ngo, Men Thi / Kim, Seong-Min / Taş, İsa / Zhou, Rui / Gamage, Chathurika D B / Pulat, Sultan / Park, So-Yeon / Sesal, Nüzhet Cenk / Hur, Jae-Seoun / Kang, Kyo Bin / Kim, Hangun

    Heliyon

    2023  Volume 9, Issue 9, Page(s) e19185

    Abstract: Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new ... ...

    Abstract Lung cancer has the highest mortality rates worldwide. The disease is caused by environmental pollutants, smoking, and many other factors. Recent treatments include immunotherapeutics, which have shown some success; however, the search for new therapeutics is ongoing. Endolichenic fungi produce a whale of a lot of secondary metabolites, the therapeutic effects of which are being evaluated. Here, we used a crude extract and subfractions of the endolichenic fungus,
    Language English
    Publishing date 2023-08-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Marinobazzanan, a Bazzanane-Type Sesquiterpenoid, Suppresses the Cell Motility and Tumorigenesis in Cancer Cells.

    Pulat, Sultan / Hillman, Prima F / Kim, Sojeong / Asolkar, Ratnakar N / Kim, Haerin / Zhou, Rui / Taş, İsa / Gamage, Chathurika D B / Varlı, Mücahit / Park, So-Yeon / Park, Sung Chul / Yang, Inho / Shin, Jongheon / Oh, Dong-Chan / Kim, Hangun / Nam, Sang-Jip / Fenical, William

    Marine drugs

    2023  Volume 21, Issue 3

    Abstract: Marinobazzanan ( ...

    Abstract Marinobazzanan (
    MeSH term(s) Humans ; Animals ; Mice ; Caco-2 Cells ; Cell Transformation, Neoplastic ; Antineoplastic Agents/chemistry ; Cell Movement ; Sesquiterpenes/pharmacology ; Sesquiterpenes/chemistry ; Molecular Structure
    Chemical Substances Antineoplastic Agents ; Sesquiterpenes
    Language English
    Publishing date 2023-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md21030153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: An acetonic extract and secondary metabolites from the endolichenic fungus

    Varlı, Mücahit / Pham, Huong T / Kim, Seong-Min / Taş, İsa / Gamage, Chathurika D B / Zhou, Rui / Pulat, Sultan / Park, So-Yeon / Sesal, Nüzhet Cenk / Hur, Jae-Seoun / Kang, Kyo Bin / Kim, Hangun

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 986946

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.986946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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