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  1. Article ; Online: Mast cells: a novel therapeutic avenue for cardiovascular diseases?

    Poto, Remo / Marone, Gianni / Galli, Stephen J / Varricchi, Gilda

    Cardiovascular research

    2024  

    Abstract: Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a ... ...

    Abstract Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a broad spectrum of vasoactive and proinflammatory mediators, which have potential roles in inflammation, angiogenesis, lymphangiogenesis, tissue remodeling and fibrosis. Mast cells release preformed mediators (e.g., histamine, tryptase, chymase) and de novo synthesized mediators [e.g., cysteinyl leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)], as well as cytokines and chemokines, which can activate different resident immune cells (e.g., macrophages) and structural cells (e.g., fibroblasts, endothelial cells) in the human heart and aorta. The transcriptional profiles of various mast cell populations highlight their potential heterogeneity and distinct gene and proteome expression. Mast cell plasticity and/or heterogeneity enable these cells the potential for performing different, even opposite, functions in response to changing tissue contexts. Human cardiac mast cells display significant differences compared to mast cells isolated from other organs. These characteristics make cardiac mast cells intriguing, given their dichotomous potential roles of inducing or protecting against cardiovascular diseases. Identification of cardiac mast cell subpopulations represents a prerequisite for understanding their potential multifaceted roles in health and disease. Several new drugs specifically targeting human mast cell activation are under development or in clinical trials. Mast cells and/or their subpopulations can potentially represent novel therapeutic targets for cardiovascular disorders.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  2. Article ; Online: Unleashing the power of formyl peptide receptor 2 in cardiovascular disease.

    Prevete, Nella / Poto, Remo / Marone, Gianni / Varricchi, Gilda

    Cytokine

    2023  Volume 169, Page(s) 156298

    Abstract: N-formyl peptide receptors (FPRs) are seven-transmembrane, G protein-coupled receptors with a wide distribution in immune and non-immune cells, recognizing N-formyl peptides from bacterial and mitochondrial origin and several endogenous signals. Three ... ...

    Abstract N-formyl peptide receptors (FPRs) are seven-transmembrane, G protein-coupled receptors with a wide distribution in immune and non-immune cells, recognizing N-formyl peptides from bacterial and mitochondrial origin and several endogenous signals. Three FPRs have been identified in humans: FPR1, FPR2, and FPR3. Most FPR ligands can activate a pro-inflammatory response, while a limited group of FPR agonists can elicit anti-inflammatory and homeostatic responses. Annexin A1 (AnxA1), a glucocorticoid-induced protein, its N-terminal peptide Ac2-26, and lipoxin A4 (LXA
    MeSH term(s) Humans ; Cardiovascular Diseases/drug therapy ; Receptors, Formyl Peptide/agonists ; Receptors, Formyl Peptide/metabolism ; Ligands ; Peptides/chemistry ; Inflammation/metabolism
    Chemical Substances Receptors, Formyl Peptide ; Ligands ; Peptides
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2023.156298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2840: Show issues Location:
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  3. Article ; Online: Imaging of chronic rhinosinusitis with nasal polyps in the era of biological therapies.

    Poto, Remo / Pelaia, Corrado / di Salvatore, Antonio / Saleh, Hesham / Scadding, Guy W / Varricchi, Gilda

    Current opinion in allergy and clinical immunology

    2024  

    Abstract: Purpose of review: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of the sinonasal cavities classified into two major phenotypes: CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). The diagnosis of CRS is based on ... ...

    Abstract Purpose of review: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of the sinonasal cavities classified into two major phenotypes: CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). The diagnosis of CRS is based on clinical symptoms associated with imaging and/or nasal endoscopy findings of mucosal inflammation.
    Recent findings: Recently, novel biological therapies have emerged as therapeutic options for CRSwNP. Imaging is helpful in deciding whether surgery is likely to be beneficial and in guiding surgery. It can also help demonstrate a clinical response to medical therapy. However, specific guidelines concerning the role of imaging in CRwNP are lacking.
    Summary: This article provides a comprehensive and critical multidisciplinary review of the role of conventional radiology, computed tomography (CT), and magnetic resonance imaging (MRI) in the diagnosis and characterization of CRSwNP. Since the complete characterization of nasal polyps on CT or MR images is very challenging, we provide a critical review of the best imaging methods and essential reporting elements used to assess nasal polyps.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5666: Show issues Location:
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  4. Article ; Online: Airway remodelling in asthma and the epithelium: on the edge of a new era.

    Varricchi, Gilda / Brightling, Christopher E / Grainge, Christopher / Lambrecht, Bart N / Chanez, Pascal

    The European respiratory journal

    2024  Volume 63, Issue 4

    Abstract: Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can ... ...

    Abstract Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can initiate remodelling
    MeSH term(s) Humans ; Airway Remodeling ; Asthma ; Cytokines ; Thymic Stromal Lymphopoietin ; Epithelium
    Chemical Substances Cytokines ; Thymic Stromal Lymphopoietin (GT0IL38SP4)
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01619-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  5. Article ; Online: Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery.

    Varricchi, Gilda / Marone, Gianni

    International journal of molecular sciences

    2020  Volume 21, Issue 2

    Abstract: Some of the basic characteristics of tissue mast cells were described over 140 years ago by Paul Ehrlich, the founder of modern immunology [ ... ]. ...

    Abstract Some of the basic characteristics of tissue mast cells were described over 140 years ago by Paul Ehrlich, the founder of modern immunology [...].
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Cardiovascular Diseases/immunology ; Humans ; Mast Cells/immunology ; Neoplasms/immunology
    Language English
    Publishing date 2020-01-11
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21020464
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Smoldering Inflammation in Cardio-Immune-Metabolic Disorders.

    Varricchi, Gilda / Paolocci, Nazareno / Rivellese, Felice / Rengo, Giuseppe

    Frontiers in physiology

    2021  Volume 12, Page(s) 651946

    Language English
    Publishing date 2021-03-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.651946
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  7. Article ; Online: Letter by Varricchi et al Regarding Article, "Role of IgE-FcεR1 in Pathological Cardiac Remodeling and Dysfunction".

    Varricchi, Gilda / Rengo, Giuseppe / Galli, Stephen J

    Circulation

    2021  Volume 144, Issue 13, Page(s) e214–e215

    MeSH term(s) Heart ; Humans ; Immunoglobulin E ; Ventricular Remodeling
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2021-09-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.121.055167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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  8. Article ; Online: Novel actors on the stage of cardiac dysfunction induced by anti-PD1 oncological treatments.

    Varricchi, Gilda / Galdiero, Maria Rosaria / Tocchetti, Carlo G

    European heart journal

    2021  Volume 43, Issue 4, Page(s) 330–332

    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; Heart Diseases ; Humans ; Medical Oncology
    Chemical Substances Antineoplastic Agents, Immunological
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehab584
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  9. Article ; Online: Advancing precision medicine in asthma: Evolution of treatment outcomes.

    Canonica, Giorgio Walter / Varricchi, Gilda / Paoletti, Giovanni / Heffler, Enrico / Virchow, Johann Christian

    The Journal of allergy and clinical immunology

    2023  Volume 152, Issue 4, Page(s) 835–840

    Abstract: The article discusses the historical evolution of asthma treatment and highlights recent advancements in personalized medicine, specifically the use of biologics in severe asthma therapy and its potential combination with allergen immunotherapy (AIT). ... ...

    Abstract The article discusses the historical evolution of asthma treatment and highlights recent advancements in personalized medicine, specifically the use of biologics in severe asthma therapy and its potential combination with allergen immunotherapy (AIT). One of the major breakthroughs of biologics is their potential effect on airway remodeling, a crucial aspect of asthma chronicity. The article introduces the concept of disease-modifying antiasthmatic drugs, which aim to modify the course of asthma and possibly modulate or prevent airway remodeling. Furthermore, the critical importance of patient-centered outcome measures to evaluate the efficacy and effectiveness of asthma treatments is emphasized, with the innovative concept of asthma remission introduced as a potential outcome. Recent studies suggest that AIT can be used as an additional therapy to biologic agents for the treatment of allergic asthma. The combination of these treatments has been shown to induce improved clinical outcomes. However, AIT is actually not recommended for use in patients with severe asthma, but encouraging results from studies investigating the combined use of AIT and biologics indicate a novel approach to exploring these treatment modalities. In conclusion, the introduction of biologics and AIT has changed the scenario of respiratory allergy treatment, from a "one size fits all" approach to embracing "individual treatments."
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition.

    Bencivenga, Leonardo / Rengo, Giuseppe / Varricchi, Gilda

    GeroScience

    2020  Volume 42, Issue 4, Page(s) 1089–1092

    Abstract: The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers and statistics, which probably underestimate ...

    Abstract The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers and statistics, which probably underestimate the ongoing tragedy. In the present opinion paper, we have focused our attention on the evidence of the relationship among malnutrition, immunosenescence, and the higher morbidity and mortality in elderly patients. In particular, we propose the intriguing hypothesis that correction of nutritional deficits may attenuate the age-dependent alterations of the innate and adaptive immune system which participate in the increased susceptibility and worse outcome observed in the elderly COVID-19 patients.
    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Humans ; Immunosenescence/physiology ; Malnutrition/complications ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-020-00218-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1502: Show issues Location:
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