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Artikel ; Online: Intestinal IFN-γ-producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease.

Alfen, Johanna Sophie / Larghi, Paola / Facciotti, Federica / Gagliani, Nicola / Bosotti, Roberto / Paroni, Moira / Maglie, Stefano / Gruarin, Paola / Vasco, Chiara Maria / Ranzani, Valeria / Frusteri, Cristina / Iseppon, Andrea / Moro, Monica / Crosti, Maria Cristina / Gatti, Stefano / Pagani, Massimiliano / Caprioli, Flavio / Abrignani, Sergio / Flavell, Richard A /
Geginat, Jens

The Journal of allergy and clinical immunology

2018  Band 142, Heft 5, Seite(n) 1537–1547.e8

Abstract: Background: IL-10 is an anti-inflammatory cytokine required for intestinal immune homeostasis. It mediates suppression of T-cell responses by type 1 regulatory T (T: Objective: We aimed to identify and characterize human intestinal T: Methods: CD4! ...

Abstract Background: IL-10 is an anti-inflammatory cytokine required for intestinal immune homeostasis. It mediates suppression of T-cell responses by type 1 regulatory T (T
Objective: We aimed to identify and characterize human intestinal T
Methods: CD4
Results: Intestinal T
Conclusions: We provide the first ex vivo characterization of human intestinal T
Mesh-Begriff(e) Adult ; Aged ; Animals ; Cells, Cultured ; Colonic Neoplasms/immunology ; Cytokines/immunology ; Female ; Humans ; Inflammatory Bowel Diseases/immunology ; Intestinal Mucosa/immunology ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Middle Aged ; Programmed Cell Death 1 Receptor/immunology ; Receptors, CCR5/immunology ; T-Lymphocytes, Regulatory/immunology ; Young Adult
Chemische Substanzen CCR5 protein, human ; Cytokines ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor ; Receptors, CCR5
Sprache Englisch
Erscheinungsdatum 2018-01-31
Erscheinungsland United States
Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID 121011-7
ISSN 1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online) 1097-6825 ; 1085-8725
ISSN 0091-6749
DOI 10.1016/j.jaci.2017.12.984
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