Article ; Online: Increased Oxidative Stress in Gastric Cancer Patients and Their First-Degree Relatives: A Prospective Study from Northeastern Brazil.
Oxidative medicine and cellular longevity
2021 Volume 2021, Page(s) 6657434
Abstract: Background and aims: First-degree relatives of gastric cancer patients are at increased risk of developing gastric cancer. Increased oxidative stress, including lipid peroxidation, has been associated with gastric carcinogenesis. Whether first-degree ... ...
| Abstract | Background and aims: First-degree relatives of gastric cancer patients are at increased risk of developing gastric cancer. Increased oxidative stress, including lipid peroxidation, has been associated with gastric carcinogenesis. Whether first-degree relatives of gastric cancer patients have increased oxidative stress remains unknown. We aimed to compare oxidative stress in patients with gastric cancer, their first-degree relatives, and dyspeptic controls. Methods: A total of 155 patients undergoing upper endoscopy were prospectively enrolled, including 50 with gastric cancer, 49 first-degree relatives of gastric cancer patients, and 56 controls. Serum concentrations of malondialdehyde (MDA) and glutathione) and activities of superoxide dismutase (SOD) and catalase were measured. Multivariate analysis adjusting for sex, age, smoking status, and alcohol consumption was performed. Results: Lipid peroxidation, as measured by concentration of MDA (nmol/mL), was higher ( Conclusions: In this study, similarly to gastric cancer patients, their first-degree relatives were found to have increased oxidative stress compared to controls. Further studies are warranted to validate this observation and to better understand the role of oxidative stress as a possible biomarker in this population. |
|---|---|
| MeSH term(s) | Adult ; Brazil ; Case-Control Studies ; Female ; Humans ; Male ; Medical History Taking/methods ; Oxidative Stress/physiology ; Prospective Studies ; Stomach Neoplasms/physiopathology |
| Language | English |
| Publishing date | 2021-11-27 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2455981-7 |
| ISSN | 1942-0994 ; 1942-0994 |
| ISSN (online) | 1942-0994 |
| ISSN | 1942-0994 |
| DOI | 10.1155/2021/6657434 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.