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Article ; Online: TECHNICAL ASPECTS REGARDING THE IMPROVEMENT OF AEROSPACE AIR DEFENSE VECTORS’ PERFORMANCES

Vasile SANDRU

Journal of Defense Resources Management, Vol 4, Iss 1, Pp 193-

2013 Volume 202

Abstract: Confronted with the spectacular evolution of the aircraft and other aerial vehicles, the systems destined to combat them, especially Surface-to-Air Missile Systems (SAMS), went through an accelerated loss of their performance. The financial crisis has ... ...

Abstract	Confronted with the spectacular evolution of the aircraft and other aerial vehicles, the systems destined to combat them, especially Surface-to-Air Missile Systems (SAMS), went through an accelerated loss of their performance. The financial crisis has forced an extension of the system operation even if the system is outdated. Therefore, a new modernized version has been designed. Many times, it is better to improve an existing system than to buy a new one. This article describes the diversity of SAMS’s challenges, involving a decrease in time regarding their number. The types of challenges can be divided in two categories: technical and institutional ones. The technical challenges can be also divided in two categories: deterioration of material and obsolescence. The classes of material that present interest for us are aerodynamic vector structure, propulsion, and special systems. From an institutional point of view, the main problems are: cost versus performance and cost versus the remaining lifetime (technical resource) of the air defense system. The article finishes with conclusions that support the possibility and necessity of a SAMS upgrade, given the change of the threats characteristics.
Keywords	SAMS (Surface-to-Air Missile Systems) ; Technical and Institutional challenges ; LCC (Life Cycle Cost ; Military Science ; U
Subject code	600
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Regional Department of Defense Resources Management Studies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Esophageal foreign body impaction as a presentation of underlying eosinophilic esophagitis

Ruxandra OPRITA / Madalina ILIE / Vasile SANDRU

Archives of the Balkan Medical Union, Vol 54, Iss 1, Pp 192-

2019 Volume 195

Abstract: Introduction. Eosinophilic esophagitis (EoE) is a rare pathology characterized by chronic inflammation with mucosal eosinophilic infiltrate of the esophagus. The clinical symptoms vary according to the age group, from recurrent abdominal and thoracic ... ...

Abstract	Introduction. Eosinophilic esophagitis (EoE) is a rare pathology characterized by chronic inflammation with mucosal eosinophilic infiltrate of the esophagus. The clinical symptoms vary according to the age group, from recurrent abdominal and thoracic pain, vomiting, dysphagia, food impaction and gastroesophageal reflux symptoms refractory to treatment with proton pump inhibitors. In the recent years, different studies suggest that EoE is now the leading cause of food impaction in the adult population. Case presentation. A 30-year-old female, without a pathological personal history, was admitted with symptoms of esophageal food impaction. Upper endoscopy revealed esophageal rings and the bolus impacted in the lower esophagus. Biopsy samples were obtained from several different locations, including areas away from the site of food impaction. Histopathologic examination revealed esophageal mucosal eosinophilic infiltrate >15 eosinophils per high-power field. Proton pump inhibitor (PPI) therapy, twice-daily dosing for 8 weeks was administered, as the first line treatment. Conclusions. Consensus guidelines for the diagnosis of EoE require symptoms of esophageal dysfunction, 15 or more eosinophils per high-power field on microscopic examination of esophageal biopsy after 8 weeks on a high-dose proton pump inhibitor (PPI), and the absence of alternative causes of eosinophilia.
Keywords	eosinophilic esophagitis ; endoscopy ; food impaction ; dysphagia ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Balkan Medical Union
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Considering Histologic Remission in Ulcerative Colitis as a Long-Term Target

Christopher Pavel / Mircea Mihai Diculescu / Alex-Emilian Stepan / Gabriel Constantinescu / Vasile Sandru / Cristian George Ţieranu / Luiza Tomescu / Alexandru Constantinescu / Cristina Patoni / Oana-Mihaela Plotogea / Madalina Ilie

Journal of Clinical Medicine, Vol 13, Iss 1, p

2024 Volume 289

Abstract: Monitoring disease activity in inflammatory bowel disease (IBD) is challenging since clinical manifestations do not represent reliable surrogates for an accurate reflection of the inflammatory burden. Endoscopic remission had been the most significant ... ...

Abstract	Monitoring disease activity in inflammatory bowel disease (IBD) is challenging since clinical manifestations do not represent reliable surrogates for an accurate reflection of the inflammatory burden. Endoscopic remission had been the most significant endpoint target in the last years; nevertheless, a remarkable proportion of patients continue to relapse despite a normal-appearing mucosa, highlighting that endoscopy may underestimate the true extent of the disease. A subtle hint of the importance that histology plays in the long-term course of the disease has been endorsed by the STRIDE-II consensus, which recommends considering histologic healing for ulcerative colitis (UC), even though it is not stated to be a compulsory formal target. It is a continuum-changing paradigm, and it is almost a certainty that in the near future, histologic healing may become the new formal target for ulcerative colitis. It must be emphasized that there is great heterogeneity in defining histological remission, and the main criteria or cut-off values for inflammatory markers are still in an ill-defined area. The complexity of some histologic scores is a source of confusion among clinicians and pathologists, leading to low adherence in clinical practice when it comes to a homogenous histopathological report. Therefore, a standardized and more practical approach is urgently needed.
Keywords	ulcerative colitis ; histologic scores ; remission ; Medicine ; R
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Prevalence and Predictors of Restless Legs Syndrome in Patients with Liver Cirrhosis

Oana-Mihaela Plotogea / Camelia Cristina Diaconu / Gina Gheorghe / Madalina Stan-Ilie / Ruxandra Oprita / Vasile Sandru / Nicolae Bacalbasa / Gabriel Constantinescu

Healthcare, Vol 10, Iss 822, p

2022 Volume 822

Abstract: Introduction and aim. Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of ... ...

Abstract	Introduction and aim. Sleep disorders are highly prevalent in patients with liver cirrhosis. The aim of this study was to investigate the prevalence of restless legs syndrome (RLS), as well as its risk factors and possible predictors, in a cohort of patients with liver cirrhosis. Material and methods. We performed a cross-sectional prospective study over a period of 14 months and enrolled 69 patients with liver cirrhosis, after applying the inclusion and exclusion criteria. The cases of RLS were assessed according to the International Restless Legs Syndrome Study Group (IRLSSG) criteria and severity scale. Results. Out of the total number of patients, 55% fulfilled the criteria for RLS. Age, diabetes, severity of cirrhosis, serum creatinine, glomerular filtration rate (GFR), and mean hemoglobin were associated with the presence of RLS. Moreover, there was a significantly higher prevalence of RLS among patients with decompensated cirrhosis. From all the risk factors introduced into the multivariate analysis, only the GFR could predict the presence of RLS. Conclusions. This research shows that patients with liver cirrhosis have a high risk of RLS. Even though there are multiple risk factors associated with RLS, only the GFR could predict its occurrence in our cohort.
Keywords	cirrhosis ; restless legs syndrome ; risk factors ; predictors ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: INTEGRATION OF ARTILLERY AND MISSILES SYSTEMS IN THE AIR DEFENSE FRAMEWORK

Vasile ŞANDRU / Emilia CALEFARIU

Journal of Defense Resources Management, Vol 5, Iss 2, Pp 159-

2014 Volume 164

Abstract: The topic on integrated systems of weapons represents an actual area of concern for many countries, which are interested in such systems and allocate funding for research programs. From this point of view, Romania is in a development stage, but the ... ...

Abstract	The topic on integrated systems of weapons represents an actual area of concern for many countries, which are interested in such systems and allocate funding for research programs. From this point of view, Romania is in a development stage, but the prospects are encouraging, more and more scientists being interested in the research connected with the development of such platforms. In this paper we present an analysis of the most advanced air defense systems that ensure proper airspace security, emphasizing on the need for their integration on a common weapons systems platform.
Keywords	Integrated Air Defense ; Network Centric Warfare (NCW) ; allocation targets ; flexibility ; redundancy ; Military Science ; U
Language	English
Publishing date	2014-10-01T00:00:00Z
Publisher	Regional Department of Defense Resources Management Studies
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Duodenal Gangliocytic Paragangliomas—Case Series and Literature Review

Madalina Stan-Ilie / Vasile Şandru / Oana-Mihaela Plotogea / Ecaterina Rînja / Christopher Pavel / Gabriel Constantinescu / Lucian Negreanu / Dan Nicolae Paduraru / Alexandra Bolocan / Octavian Andronic / Dragos Davitoiu / Gheorghe G. Bălan / Alexandru Constantinescu

Life, Vol 13, Iss 597, p

2023 Volume 597

Abstract: Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a ... ...

Abstract	Duodenal gangliocytic paragangliomas are rare neuroendocrine tumors primarily localized in the periampullary area. Though mostly asymptomatic, they can present with various symptoms, most often jaundice, anemia and abdominal pain. The present paper is a case series report, describing our personal experience with patients presenting to the Emergency Unit with different symptoms due to duodenal gangliocytic paraganglioma. Endoscopic resection is safe and indicated in most of the cases, being also associated with lower medical costs. EUS plays a central role in the pre-resection management and in surveillance, and immunostaining is decisive to ascertain the tumor histologic origin. In addition to reporting our experience, we researched the literature regarding these rare tumors and performed a comprehensive review.
Keywords	duodenal gangliocytic paraganglioma ; jaundice ; gastrointestinal bleeding ; endoscopy ; surgery ; immunohistochemistry ; Science ; Q
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predicting Hospitalization, Organ Dysfunction, and Mortality in Post-Endoscopic Retrograde Cholangiopancreatography Acute Pancreatitis

Gheorghe Gh. Balan / Oana Timofte / Georgiana-Emmanuela Gilca-Blanariu / Catalin Sfarti / Smaranda Diaconescu / Nicoleta Gimiga / Simona Petronela Antighin / Ion Sandu / Vasile Sandru / Anca Trifan / Mihaela Moscalu / Gabriela Stefanescu

Applied Sciences, Vol 13, Iss 6650, p

Are SIRS and qSOFA Reliable Tools?

2023 Volume 6650

Abstract: Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has shown constant incidence throughout time, despite advances in endoscopic technology, devices, or personal skills of the operating endoscopists, with prevention ... ...

Abstract	Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) has shown constant incidence throughout time, despite advances in endoscopic technology, devices, or personal skills of the operating endoscopists, with prevention and prediction of severity in PEP being constant concerns. Several prospective studies have investigated the role of systemic inflammatory response syndrome (SIRS) criteria or the quick Sequential Organ Failure Assessment (qSOFA) score in the PEP severity assessment. However, there are no clearly defined tools for the prediction of PEP severity. Methods: A total of 403 patients were prospectively monitored 60 days after ERCP for the detection of PEP development. Consequently, we evaluated the lengths of stay, incidence of organic dysfunction, and mortality rates of these patients. The predictive power of the univariate model was evaluated by using the receiver operating characteristic curve and analyzing the area under the curve (AUC). Results: Incidence of PEP was similar to that reported in the majority of trials. The 60-day survival rate of PEP patients reached 82.8%. A qSOFA score ≥ 1 is a very good predictor for organ dysfunction (AUC 0.993, p < 0.0001). SIRS can also be considered a significant predictor for organic dysfunctions in PEP patients (AUC 0.926, p < 0.0001). However, only qSOFA was found to significantly predict mortality in PEP patients (AUC 0.885, p = 0.003), with SIRS criteria showing a much lower predictive power. Neither SIRS nor qSOFA showed any predictive value for the length of stay of PEP patients. Conclusion: Our study offers novel information about severity prediction in PEP patients. Both SIRS criteria and qSOFA showed good predictive value for organic dysfunction, mortality, and hospitalization.
Keywords	endoscopic retrograde cholangiopancreatography ; systemic inflammatory response syndrome ; SIRS ; quick Sequential Organ Failure Assessment ; qSOFA ; hospitalization ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gastrointestinal bleeding in patients admitted to the intensive care unit

Ruxandra OPRITA / Madalina ILIE / Vasile SANDRU / Daniel BERCEANU / Gabriel CONSTANTINESCU

Archives of the Balkan Medical Union, Vol 53, Iss 4, Pp 544-

2018 Volume 550

Abstract: Introduction. Gastrointestinal bleeding is a life-threatening condition, with a mortality depending on the cause and severity. The objective of this study was to retrospectively evaluate the epidemiological, clinical and evolutionary aspects of a series ... ...

Abstract	Introduction. Gastrointestinal bleeding is a life-threatening condition, with a mortality depending on the cause and severity. The objective of this study was to retrospectively evaluate the epidemiological, clinical and evolutionary aspects of a series of patients diagnosed with gastrointestinal bleeding, admitted to the Intensive Care Unit of the Clinical Emergency Hospital of Bucharest, Romania. Material and methods. A retrospective, descriptive study was carried out, of patients diagnosed with upper and lower gastrointestinal bleeding, admitted to the Intensive Care Unit of the Clinical Emergency Hospital of Bucharest, Romania, between January 1st, 2013 – December 30th, 2018. The clinical variables were collected in a database designed exclusively for the study. Results. We observed that most of the cases were bleedings situated above the Treitz’s angle; the most frequent causes were peptic ulcer disease, followed by variceal hemorrhage and erosive gastroduodenitis. The three most frequent causes of upper gastrointestinal bleeding in our series were peptic ulcer disease, variceal hemorrhage and erosive gastroduodenitis. The global mortality due to gastrointestinal bleeding was 9.8%, with all cases occurring in the group of patients with upper gastrointestinal bleeding. Conclusions. It should be noted that in the group of patients who died, all had hemorrhagic shock at the time of admission, a fact that occurred only in 23% of the cases who survived. This highlights the prognostic value of the hemorrhagic shock on admission.
Keywords	gastrointestinal bleeding ; hemorrhage ; intensive care unit ; epidemiology ; mortality ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Balkan Medical Union
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiovascular and Metabolic Consequences of Liver Transplantation

Oana Plotogea / Madalina Ilie / Vasile Sandru / Alexandru Chiotoroiu / Ovidiu Bratu / Camelia Diaconu

Medicina, Vol 55, Iss 8, p

A Review

2019 Volume 489

Abstract: Liver transplantation (LT) is considered the curative treatment option for selected patients who suffer from end-stage or acute liver disease or hepatic malignancy (primary). After LT, patients should be carefully monitored for complications that may ... ...

Abstract	Liver transplantation (LT) is considered the curative treatment option for selected patients who suffer from end-stage or acute liver disease or hepatic malignancy (primary). After LT, patients should be carefully monitored for complications that may appear, partially due to immunosuppressive therapy, but not entirely. Cardiovascular diseases are frequently encountered in patients with LT, being responsible for high morbidity and mortality. Patients with underlying cardiovascular and metabolic pathologies are prone to complications after the transplant, but these complications can also appear de novo, mostly associated with immunosuppressants. Metabolic syndrome, defined by obesity, hypertension, dyslipidemia, and hyperglycemia, is diagnosed among LT recipients and is aggravated after LT, influencing the long-term survival. In this review, our purpose was to summarize the current knowledge regarding cardiovascular (CV) diseases and the metabolic syndrome associated with LT and to assess their impact on short and long-term morbidity and mortality.
Keywords	liver transplantation ; cardiovascular complications ; metabolic consequences ; hypertension ; dyslipidemia ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Endoscopic Management of Biliary Strictures after Orthotopic Liver Transplantation

Vasile Sandru / Madalina Stan-Ilie / Oana-Mihaela Plotogea / Catalina Vladut / Bogdan Silviu Ungureanu / Gheorghe G. Balan / Dan Ionut Gheonea / Gabriel Constantinescu

Diagnostics, Vol 12, Iss 1221, p

A Single Center Experience Study

2022 Volume 1221

Abstract: Background and Aim. Endoscopic therapy is the method of choice in the management of biliary strictures after orthotopic liver transplantation (OLT). Even though the mainstay approach for OLT stricture complications is represented by consecutive ... ...

Abstract	Background and Aim. Endoscopic therapy is the method of choice in the management of biliary strictures after orthotopic liver transplantation (OLT). Even though the mainstay approach for OLT stricture complications is represented by consecutive procedures of multiple plastic stents (MPS) insertion, a valuable alternative is the use of fully covered self-expandable metal stents (FCSEMS). The aim of the study was to compare MPS with FCSEMS used in the management of OLT biliary strictures, in terms of clinical outcomes and complications. Material and Methods. This is a retrospective, single-center study conducted between February 2014 and November 2019 in the Clinical Emergency Hospital of Bucharest, Romania. We enrolled all consecutive patients who developed biliary strictures after OLT and were treated by endoscopic retrograde cholangiopancreatography (ERCP) either with MPS or FCSEMS. Results. Thirty-six patients were included in the study, 27 patients had MPS and nine patients had FCSEMS. 106 ERCP procedures were performed and 159 stents were inserted. The mean number of ERCP procedures required per patient was significantly higher for MPS than for FCSEMS (3.34 ± 1.46 vs. 2.11 ± 0.33, p < 0.001). In the FCSEMS group only one patient had three procedures, due to stent migration. Difficult cannulation was encountered in 22 patients, 18 patients from MPS group and four patients from FCSEMS group. Dilation was performed in 20 (77%) MPS patients and in four FCSEMS patients (44%). Overall, we used 159 stents for stricture resolution, 149 plastic stents and 10 FCSEMS. Mean number of stents inserted was significantly lower in the FCSEMS group compared to MPS group (1.16 ± 0.40 vs. 5.73 ± 2.64, p < 0.001). Conclusions. Stricture resolution using FCSEMS is comparable to MPS and even has some advantages. In line with prior studies, FCSEMS are effective, with fewer complications and similar outcome compared to plastic stents. Other particular aspects should be further assessed, especially long-term follow up of FCSEMS ...
Keywords	orthotopic liver transplantation (OLT) ; biliary strictures ; fully covered self-expandable metal stents (FCSEMS) ; multiple plastic stents (MPS) ; therapeutic endoscopy ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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