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  1. Article ; Online: Soluble urokinase plasminogen activator receptor (suPAR) in the emergency department

    Dimitrios Velissaris / Nicholas Zareifopoulos / Vasileios Karamouzos / Charalampos Pierrakos / Menelaos Karanikolas

    Caspian Journal of Internal Medicine, Vol 13, Iss 4, Pp 650-

    An update

    2022  Volume 665

    Abstract: Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in ... ...

    Abstract Background: The biomarker soluble urokinase plasminogen activator receptor (suPAR) is an indicator of inflammation which is increased in a variety of chronic and acute disease states. Its most promising application in the emergency setting is to aid in the prognostic stratification of patients by identifying those at high risk of deterioration. This is a narrative review of studies evaluating the use of suPAR Methods: We conducted a Medline search for studies on the use of suPAR in patients acutely admitted to the emergency department. Results: 25 original studies were included in the review. suPAR as a marker of inflammation has been used alone or combined to other inflammatory biomarkers in the assessment of patients suffering from various acute and chronic diseases in an emergency setting. As it is non-specific, it may increase in infectious disease, malignancy or acute coronary syndromes among other conditions, but quantitative suPAR levels correlate with disease severity. It may be useful for the identification of high risk patients regardless of underlying pathology. Conclusion: As the ideal biomarker in the emergency setting has not been identified yet, suPAR may be a promising addition to the established biomarkers for the initial assessment of patients in this setting. Additional research is necessary to evaluate the usefulness of suPAR guided management algorithms.
    Keywords supar ; biomarker ; emergency department ; mortaliti ; infection ; sepsis ; Internal medicine ; RC31-1245
    Subject code 610
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Babol University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: High flow nasal cannula oxygen therapy in adults with COVID-19 respiratory failure. A case report

    Vasileios Karamouzos / Fotini Fligou / Charalambos Gogos / Dimitrios Velissaris

    Monaldi Archives for Chest Disease, Vol 90, Iss

    2020  Volume 2

    Abstract: The novel corona virus (SARS-CoV-2) continuous to spread around the globe causing high mortality, tremendous stress on healthcare systems and an unprecedented disruption of everyday life with unpredictable socioeconomic ramifications. The diseaseis ... ...

    Abstract The novel corona virus (SARS-CoV-2) continuous to spread around the globe causing high mortality, tremendous stress on healthcare systems and an unprecedented disruption of everyday life with unpredictable socioeconomic ramifications. The diseaseis typically affecting the respiratory system and some patients will develop refractory hypoxemic respiratory insufficiency requiring mechanical ventilation. The role of non-invasive ventilation (NIV), high flow nasal cannula (HFNC) or continuous positive airway pressure devices (C-PAP) in the treatment of the 2019 corona virus disease (COVID-19) is not yet clear. We hereby report a case of a 44-year-old COVID-19 positive male patient suffering from hypoxic respiratory failure that was successfully treated with high flow nasal cannula oxygen therapy in a negative pressure intensive care room. Although specific criteria for the use of high flow nasal canula devices COVID-19 are not available at this time, clinicians could use this non-invasive modality as analternative method of respiratory support in selected patients presenting with respiratory failure.
    Keywords SARS-CoV-2 ; COVID-19 ; high flow nasal cannula ; Medicine ; R ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The Role of High Flow Nasal Oxygen in the Management of Severe COVID-19

    Themistoklis Paraskevas / Eleousa Oikonomou / Maria Lagadinou / Vasileios Karamouzos / Nikolaos Zareifopoulos / Despoina Spyropoulou / Dimitrios Velissaris

    Acta Médica Portuguesa, Vol 35, Iss 6, Pp 476-

    A Systematic Review

    2022  Volume 483

    Abstract: Introduction: Oxygen therapy remains the cornerstone for managing patients with severe SARS-CoV-2 infection and several modalities of non-invasive ventilation are used worldwide. High-flow oxygen via nasal canula is one therapeutic option which may in ... ...

    Abstract Introduction: Oxygen therapy remains the cornerstone for managing patients with severe SARS-CoV-2 infection and several modalities of non-invasive ventilation are used worldwide. High-flow oxygen via nasal canula is one therapeutic option which may in certain cases prevent the need of mechanical ventilation. The aim of this review is to summarize the current evidence on the use of high-flow nasal oxygen in patients with severe SARS-CoV-2 infection. Material and Methods: We conducted a systematic literature search of the databases PubMed and Cochrane Library until April 2021 using the following search terms: “high flow oxygen and COVID-19” and “high flow nasal and COVID-19’’. Results: Twenty-three articles were included in this review, in four of which prone positioning was used as an adjunctive measure. Most of the articles were cohort studies or case series. High-flow nasal oxygen therapy was associated with a reduced need for invasive ventilation compared to conventional oxygen therapy and led to an improvement in secondary clinical outcomes such as length of stay. The efficacy of high-flow nasal oxygen therapy was comparable to that of other non-invasive ventilation options, but its tolerability is likely higher. Failure of this modality was associated with increased mortality. Conclusion: High flow nasal oxygen is an established option for respiratory support in COVID-19 patients. Further investigation is required to quantify its efficacy and utility in preventing the requirement of invasive ventilation.
    Keywords cannula ; covid-19 ; critical care ; noninvasive ventilation ; oxygen/therapeutic use ; respiration ; artificial ; respiratory distress ; syndrome ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Ordem dos Médicos
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: High-Flow vs. Low-Flow Nasal Cannula in Reducing Hypoxemic Events During Bronchoscopic Procedures

    Fotios Sampsonas / Vasileios Karamouzos / Theodoros Karampitsakos / Ourania Papaioannou / Matthaios Katsaras / Maria Lagadinou / Eirini Zarkadi / Elli Malakounidou / Dimitrios Velissaris / Grigorios Stratakos / Argyrios Tzouvelekis

    Frontiers in Medicine, Vol

    A Systematic Review and Meta-Analysis

    2022  Volume 9

    Abstract: IntroductionHigh-flow nasal cannula (HFNC) oxygenation method has been proven to be successful in oxygenation of patients with respiratory failure and has exhibited clinical superiority compared to low-flow nasal cannula (LFNC).MethodsWe performed a ... ...

    Abstract IntroductionHigh-flow nasal cannula (HFNC) oxygenation method has been proven to be successful in oxygenation of patients with respiratory failure and has exhibited clinical superiority compared to low-flow nasal cannula (LFNC).MethodsWe performed a systematic review and meta-analysis to evaluate the potential favorable impact of HFNC oxygenation during bronchoscopy and related procedures like endobronchial ultrasound-transbronchial needle aspiration. Only randomized control trials (RCTs) were included in the meta-analysis.ResultsSix randomized control trials with 1,170 patients were included in this meta-analysis. Patients who underwent bronchoscopy with the use of high-flow nasal cannula experienced less hypoxemic events/desaturations, less procedural interruptions and pneumothoraxes compared to patients under low-flow nasal cannula treatment. This beneficial effect of HFNC in hypoxemic events was persistent 10 min after the end of procedure.ConclusionThe high-flow nasal cannula (HFNC) oxygenation method could reduce hypoxemic events and related peri- and post-bronchoscopic complications.
    Keywords high-flow nasal cannula ; low-flow nasal cannula ; EBUS TBNA ; hypoxemia ; meta-analysis ; bronchoscopy ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: qSOFA score and LqSOFA score as predictors of outcome in an elderly population with chest infection treated in the Emergency Department. A case series

    Dimitrios Velissaris / Vasileios Karamouzos / Nikolaos Dimitrios Pantzaris / Loukas Kakoullis / Charalampos Pierrakos / Menelaos Karanikolas / Charalampos Gogos

    Emergency Care Journal, Vol 15, Iss

    2019  Volume 3

    Abstract: The objective of this study is to assess the prognostic value regarding 28-day outcome of the quick sequential organ failure assessment (qSOFA) score and the combined score calculated from blood lactate levels + qSOFA (LqSOFA) score in elderly patients ... ...

    Abstract The objective of this study is to assess the prognostic value regarding 28-day outcome of the quick sequential organ failure assessment (qSOFA) score and the combined score calculated from blood lactate levels + qSOFA (LqSOFA) score in elderly patients initially treated in the Emergency Department (ED) for sepsis due to pneumonia or other chest infections. This is a prospective observational study, conducted at the ED in a Greek University Hospital. Forty-one patients with sepsis due to chest infection were enrolled in the study. All patients were treated in the Resuscitation Room of the ED according to the international treatment protocols for sepsis. The qSOFA score was calculated on admission for all patients, and one point was added in the calculation of the LqSOFA score in patients with blood lactate levels >2 mmol/L. Both the qSOFA and the LqSOFA scores had high sensitivity and specificity in predicting unfavorable outcome in elderly patients with chest infection and sepsis. In the ongoing debate of early diagnosis of sepsis and identification of prognostic indexes of the syndrome, qSOFA score alone or in combination with lactate levels could serve as a reliable predictor of outcome. Large prospective studies are needed to further evaluate the role and prognostic validity of these scores in the ED.
    Keywords Sepsis ; Lactate ; qSOFA score ; LqSOFA score ; Emergency Department ; Mortality ; Medicine (General) ; R5-920
    Subject code 616
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Simultaneous Bilateral Spontaneous Pneumothorax in an Adult Patient With Pulmonary Langerhans Cell Histiocytosis

    Vasileios Karamouzos MD / Christos Prokakis MD, PhD / Fotini Kosmopoulou MD / Evangelos Karanikolas / Christina Kalogeropoulou MD, PhD / Diamanto Aretha MD, PhD / Nikolaos Panagiotopoulos MD, PhD / Efstratios Koletsis MD, PhD / Dimitrios Velissaris MD, PhD

    Journal of Investigative Medicine High Impact Case Reports, Vol

    A Case Report

    2018  Volume 6

    Abstract: We report a case of a young female with known history of pulmonary Langerhans cell histiocytosis who was initially presented in the emergency department of a university hospital with respiratory distress. Clinical assessment and diagnostic workup ... ...

    Abstract We report a case of a young female with known history of pulmonary Langerhans cell histiocytosis who was initially presented in the emergency department of a university hospital with respiratory distress. Clinical assessment and diagnostic workup revealed left hemithorax subcutaneous emphysema, bilateral pneumothorax, and atelectasis in both lower lung lobes. The patient was treated with bilateral staged thoracoscopic bullectomy and mechanical abrasion of the parietal pleura combined with chemical pleurodesis with talc. A new occurrence of right-sided pneumothorax was noticed 3 days after surgery, which was treated with chest tube insertion and chemical pleurodesis. The aforementioned surgical approach resulted in complete lung expansion and the patient’s full recovery. A review of pulmonary Langerhans cell histiocytosis and treatment options in cases of pneumothorax due to lung histiocytosis is also presented in this report.
    Keywords Medicine (General) ; R5-920 ; Pathology ; RB1-214
    Subject code 616
    Language English
    Publishing date 2018-08-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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