Article ; Online: Inception of early-life allergen-induced airway hyperresponsiveness is reliant on IL-13
Science immunology
2018 Volume 3, Issue 27
Abstract: Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) ... ...
| Abstract | Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed. We demonstrate that both recombinant interleukin-33 (rIL-33) and allergen [house dust mite (HDM) or |
|---|---|
| MeSH term(s) | Acinetobacter/immunology ; Allergens/immunology ; Alternaria/immunology ; Animals ; Animals, Newborn ; CD4-Positive T-Lymphocytes/immunology ; Female ; Interleukin-13/immunology ; Interleukin-33/genetics ; Male ; Mice, Inbred BALB C ; Mice, Knockout ; Mice, SCID ; Pyroglyphidae/immunology ; Respiratory Hypersensitivity/immunology |
| Chemical Substances | Allergens ; Il33 protein, mouse ; Interleukin-13 ; Interleukin-33 |
| Language | English |
| Publishing date | 2018-09-05 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2470-9468 |
| ISSN (online) | 2470-9468 |
| DOI | 10.1126/sciimmunol.aan4128 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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