Article ; Online: Determining sequencing depth in a single-cell RNA-seq experiment
Nature Communications, Vol 11, Iss 1, Pp 1-
2020 Volume 11
Abstract: For single-cell RNA-seq experiments the sequencing budget is limited, and how it should be optimally allocated to maximize information is not clear. Here the authors develop a mathematical framework to show that, for estimating many gene properties, the ... ...
Abstract | For single-cell RNA-seq experiments the sequencing budget is limited, and how it should be optimally allocated to maximize information is not clear. Here the authors develop a mathematical framework to show that, for estimating many gene properties, the optimal allocation is to sequence at the depth of one read per cell per gene. |
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Keywords | Science ; Q |
Language | English |
Publishing date | 2020-02-01T00:00:00Z |
Publisher | Nature Portfolio |
Document type | Article ; Online |
Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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