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  1. AU="Vasireddy, Ravikiran"
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  1. Article ; Online: Realistic biomarkers from plasma extracellular vesicles for detection of beryllium exposure.

    Adduri, Raju S R / Vasireddy, Ravikiran / Mroz, Margaret M / Bhakta, Anisha / Li, Yang / Chen, Zhe / Miller, Jeffrey W / Velasco-Alzate, Karen Y / Gopalakrishnan, Vanathi / Maier, Lisa A / Li, Li / Konduru, Nagarjun V

    International archives of occupational and environmental health

    2022  Volume 95, Issue 8, Page(s) 1785–1796

    Abstract: Purpose: Exposures related to beryllium (Be) are an enduring concern among workers in the nuclear weapons and other high-tech industries, calling for regular and rigorous biological monitoring. Conventional biomonitoring of Be in urine is not ... ...

    Abstract Purpose: Exposures related to beryllium (Be) are an enduring concern among workers in the nuclear weapons and other high-tech industries, calling for regular and rigorous biological monitoring. Conventional biomonitoring of Be in urine is not informative of cumulative exposure nor health outcomes. Biomarkers of exposure to Be based on non-invasive biomonitoring could help refine disease risk assessment. In a cohort of workers with Be exposure, we employed blood plasma extracellular vesicles (EVs) to discover novel biomarkers of exposure to Be.
    Methods: EVs were isolated from plasma using size-exclusion chromatography and subjected to mass spectrometry-based proteomics. A protein-based classifier was developed using LASSO regression and validated by ELISA.
    Results: We discovered a dual biomarker signature comprising zymogen granule protein 16B and putative protein FAM10A4 that differentiated between Be-exposed and -unexposed subjects. ELISA-based quantification of the biomarkers in an independent cohort of samples confirmed higher expression of the signature in the Be-exposed group, displaying high predictive accuracy (AUROC = 0.919). Furthermore, the biomarkers efficiently discriminated high- and low-exposure groups (AUROC = 0.749).
    Conclusions: This is the first report of EV biomarkers associated with Be exposure and exposure levels. The biomarkers could be implemented in resource-limited settings for Be exposure assessment.
    MeSH term(s) Beryllium/metabolism ; Biomarkers ; Extracellular Vesicles/chemistry ; Extracellular Vesicles/metabolism ; Humans ; Mass Spectrometry ; Proteomics/methods
    Chemical Substances Biomarkers ; Beryllium (OW5102UV6N)
    Language English
    Publishing date 2022-05-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 129038-1
    ISSN 1432-1246 ; 0340-0131 ; 0367-9977
    ISSN (online) 1432-1246
    ISSN 0340-0131 ; 0367-9977
    DOI 10.1007/s00420-022-01871-7
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  2. Article ; Online: Mycobacterium talmoniae

    Vasireddy, Ravikiran / Vasireddy, Sruthi / Brown-Elliott, Barbara A / Greninger, Alexander L / Davidson, Rebecca M / Ard, Kevin L / Turenne, Christine Y / Wallace, Richard J

    Journal of clinical microbiology

    2019  Volume 57, Issue 2

    Abstract: We characterize three respiratory isolates of the recently described ... ...

    Abstract We characterize three respiratory isolates of the recently described species
    MeSH term(s) Aged ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bronchiectasis/complications ; Chaperonin 60/genetics ; Child ; Cluster Analysis ; Cystic Fibrosis/complications ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; DNA-Directed RNA Polymerases/genetics ; Female ; Humans ; Louisiana ; Lung Diseases, Fungal/diagnosis ; Lung Diseases, Fungal/microbiology ; Male ; Massachusetts ; Microbial Sensitivity Tests ; Mycobacterium/classification ; Mycobacterium/drug effects ; Mycobacterium/genetics ; Mycobacterium/isolation & purification ; Mycobacterium Infections/diagnosis ; Mycobacterium Infections/microbiology ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Texas
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Chaperonin 60 ; DNA, Bacterial ; DNA, Ribosomal ; RNA, Ribosomal, 16S ; heat-shock protein 65, Mycobacterium ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; RNA polymerase beta subunit (EC 2.7.7.6)
    Language English
    Publishing date 2019-01-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00906-18
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  3. Article ; Online: Correction for Vasireddy et al., Mycobacterium arupense, Mycobacterium heraklionense, and a Newly Proposed Species, "Mycobacterium virginiense" sp. nov., but Not Mycobacterium nonchromogenicum, as Species of the Mycobacterium terrae Complex Causing Tenosynovitis and Osteomyelitis.

    Vasireddy, Ravikiran / Vasireddy, Sruthi / Brown-Elliott, Barbara A / Wengenack, Nancy L / Eke, Uzoamaka A / Benwill, Jeana L / Turenne, Christine / Wallace, Richard J

    Journal of clinical microbiology

    2017  Volume 55, Issue 3, Page(s) 985

    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02290-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Variation among human, veterinary and environmental Mycobacterium chelonae-abscessus complex isolates observed using core genome phylogenomic analysis, targeted gene comparison, and anti-microbial susceptibility patterns.

    Fogelson, Susan B / Camus, Alvin C / Lorenz, W Walter / Vasireddy, Ravikiran / Vasireddy, Sruthi / Smith, Terry / Brown-Elliott, Barbara A / Wallace, Richard J / Hasan, Nabeeh A / Reischl, Udo / Sanchez, Susan

    PloS one

    2019  Volume 14, Issue 3, Page(s) e0214274

    Abstract: Mycobacterium chelonae is a member of the Mycobacterium chelonae-abscessus complex and a cause of opportunistic disease in fish, reptiles, birds, and mammals including humans. Isolates in the complex are often difficult to identify and have differing ... ...

    Abstract Mycobacterium chelonae is a member of the Mycobacterium chelonae-abscessus complex and a cause of opportunistic disease in fish, reptiles, birds, and mammals including humans. Isolates in the complex are often difficult to identify and have differing antimicrobial susceptibilities. Thirty-one previously identified rapidly-growing, non-tuberculous Mycobacterium sp. isolates cultured from biofilms, fish, reptiles, mammals, including humans, and three ATCC reference strains were evaluated with nine M. chelonae-abscessus complex whole genome sequences from GenBank by phylogenomic analysis, targeted gene comparisons, and in-vitro antimicrobial susceptibility patterns to assess strain variation among isolates from different sources. Results revealed minimal genetic variation among the M. chelonae strains. However, the core genomic alignment and SNP pattern of the complete 16S rRNA sequence clearly separated the turtle type strain ATCC 35752T from the clinical isolates and human reference strain "M. chelonae chemovar niacinogenes" ATCC 19237, providing evidence of two distinct subspecies. Concatenation of the partial rpoB (752 bp) and complete hsp65 (1,626 bp) sequence produced the same species/subspecies delineations as the core phylogeny. Partial rpoB and hsp65 sequences identified all the clinical isolates to the appropriate species level when respective cut-offs of 98% and 98.4% identity to the M. chelonae type strain ATCC 35752T were employed. The human strain, ATCC19237, was the most representative strain for the evaluated human, veterinary, and environmental strains. Additionally, two isolates were identified as Mycobacterium saopaulense, its first identification in a non-fish or non-human host.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Biofilms ; Humans ; Microbial Sensitivity Tests ; Mycobacterium abscessus/classification ; Mycobacterium abscessus/drug effects ; Mycobacterium abscessus/isolation & purification ; Phylogeny ; Polymorphism, Single Nucleotide ; RNA, Ribosomal, 16S/genetics ; Species Specificity ; Whole Genome Sequencing/methods
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2019-03-25
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0214274
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  5. Article ; Online: Comparison of Two Commercial Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Systems for Identification of Nontuberculous Mycobacteria.

    Brown-Elliott, Barbara A / Fritsche, Thomas R / Olson, Brooke J / Vasireddy, Sruthi / Vasireddy, Ravikiran / Iakhiaeva, Elena / Alame, Diana / Wallace, Richard J / Branda, John A

    American journal of clinical pathology

    2019  Volume 152, Issue 4, Page(s) 527–536

    Abstract: Objectives: This multicenter study's aim was to assess the performance of two commercially available matrix-assisted laser desorption/ionization time of flight mass spectrometry systems in identifying a challenge collection of clinically relevant ... ...

    Abstract Objectives: This multicenter study's aim was to assess the performance of two commercially available matrix-assisted laser desorption/ionization time of flight mass spectrometry systems in identifying a challenge collection of clinically relevant nontuberculous mycobacteria (NTM).
    Methods: NTM clinical isolates (n = 244) belonging to 23 species/subspecies were identified by gene sequencing and analyzed using Bruker Biotyper with Mycobacterial Library v5.0.0 and bioMérieux VITEK MS with v3.0 database.
    Results: Using the Bruker or bioMérieux systems, 92% and 95% of NTM strains, respectively, were identified at least to the complex/group level; 62% and 57%, respectively, were identified to the highest taxonomic level. Differentiation between members of Mycobacterium abscessus, M fortuitum, M mucogenicum, M avium, and M terrae complexes/groups was problematic for both systems, as was identification of M chelonae for the Bruker system.
    Conclusions: Both systems identified most NTM isolates to the group/complex level, and many to the highest taxonomic level. Performance was comparable.
    MeSH term(s) Diagnostic Tests, Routine ; Humans ; Nontuberculous Mycobacteria/isolation & purification ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
    Language English
    Publishing date 2019-07-16
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqz073
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  6. Article ; Online: Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012.

    Lande, Leah / Alexander, David C / Wallace, Richard J / Kwait, Rebecca / Iakhiaeva, Elena / Williams, Myra / Cameron, Andrew D S / Olshefsky, Stephen / Devon, Ronit / Vasireddy, Ravikiran / Peterson, Donald D / Falkinham, Joseph O

    Emerging infectious diseases

    2019  Volume 25, Issue 3, Page(s) 473–481

    Abstract: Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable- ...

    Abstract Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Environmental Microbiology ; Female ; Genotype ; History, 21st Century ; Humans ; Male ; Middle Aged ; Minisatellite Repeats ; Multilocus Sequence Typing ; Mycobacterium avium/classification ; Mycobacterium avium/genetics ; Mycobacterium avium/isolation & purification ; Mycobacterium avium Complex/classification ; Mycobacterium avium Complex/genetics ; Mycobacterium avium Complex/isolation & purification ; Mycobacterium avium-intracellulare Infection/epidemiology ; Mycobacterium avium-intracellulare Infection/history ; Mycobacterium avium-intracellulare Infection/microbiology ; Philadelphia/epidemiology ; Phylogeny ; Public Health Surveillance ; Water Microbiology ; Whole Genome Sequencing
    Language English
    Publishing date 2019-02-13
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2503.180336
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  7. Article ; Online: Mycobacterium arupense, Mycobacterium heraklionense, and a Newly Proposed Species, "Mycobacterium virginiense" sp. nov., but Not Mycobacterium nonchromogenicum, as Species of the Mycobacterium terrae Complex Causing Tenosynovitis and Osteomyelitis.

    Vasireddy, Ravikiran / Vasireddy, Sruthi / Brown-Elliott, Barbara A / Wengenack, Nancy L / Eke, Uzoamaka A / Benwill, Jeana L / Turenne, Christine / Wallace, Richard J

    Journal of clinical microbiology

    2016  Volume 54, Issue 5, Page(s) 1340–1351

    Abstract: Mycobacterium terrae complex has been recognized as a cause of tenosynovitis, with M. terrae and Mycobacterium nonchromogenicum reported as the primary etiologic pathogens. The molecular taxonomy of the M. terrae complex causing tenosynovitis has not ... ...

    Abstract Mycobacterium terrae complex has been recognized as a cause of tenosynovitis, with M. terrae and Mycobacterium nonchromogenicum reported as the primary etiologic pathogens. The molecular taxonomy of the M. terrae complex causing tenosynovitis has not been established despite approximately 50 previously reported cases. We evaluated 26 isolates of the M. terrae complex associated with tenosynovitis or osteomyelitis recovered between 1984 and 2014 from 13 states, including 5 isolates reported in 1991 as M. nonchromogenicum by nonmolecular methods. The isolates belonged to three validated species, one new proposed species, and two novel related strains. The majority of isolates (20/26, or 77%) belonged to two recently described species: Mycobacterium arupense (10 isolates, or 38%) and Mycobacterium heraklionense (10 isolates, or 38%). Three isolates (12%) had 100% sequence identity to each other by 16S rRNA and 99.3 to 100% identity by rpoB gene region V sequencing and represent a previously undescribed species within the M. terrae complex. There were no isolates of M. terrae or M. nonchromogenicum, including among the five isolates reported in 1991. The 26 isolates were susceptible to clarithromycin (100%), rifabutin (100%), ethambutol (92%), and sulfamethoxazole or trimethoprim-sulfamethoxazole (70%). The current study suggests that M. arupense, M. heraklionense, and a newly proposed species ("M. virginiense" sp. nov.; proposed type strain MO-233 [DSM 100883, CIP 110918]) within the M. terrae complex are the major causes of tenosynovitis and osteomyelitis in the United States, with little change over 20 years. Species identification within this complex requires sequencing methods.
    MeSH term(s) Adult ; Aged ; Antitubercular Agents/pharmacology ; DNA, Ribosomal/chemistry ; DNA, Ribosomal/genetics ; DNA-Directed RNA Polymerases ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mycobacterium/classification ; Mycobacterium/drug effects ; Mycobacterium/genetics ; Mycobacterium/isolation & purification ; Mycobacterium Infections, Nontuberculous/microbiology ; Osteomyelitis/microbiology ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Tenosynovitis/microbiology ; United States ; Young Adult
    Chemical Substances Antitubercular Agents ; DNA, Ribosomal ; RNA, Ribosomal, 16S ; DNA-Directed RNA Polymerases (EC 2.7.7.6) ; RNA polymerase beta subunit (EC 2.7.7.6)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00198-16
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  8. Article ; Online: Mycobacterium avium pseudo-outbreak associated with an outpatient bronchoscopy clinic: Lessons for reprocessing.

    Seidelman, Jessica L / Wallace, Richard J / Iakhiaeva, Elena / Vasireddy, Ravikiran / Brown-Elliott, Barbara A / McKnight, Celeste / Chen, Luke F / Smith, Terry / Lewis, Sarah S

    Infection control and hospital epidemiology

    2018  Volume 40, Issue 1, Page(s) 106–108

    Abstract: We identified a pseudo-outbreak of Mycobacterium avium in an outpatient bronchoscopy clinic following an increase in clinic procedure volume. We terminated the pseudo-outbreak by increasing the frequency of automated endoscope reprocessors (AER) filter ... ...

    Abstract We identified a pseudo-outbreak of Mycobacterium avium in an outpatient bronchoscopy clinic following an increase in clinic procedure volume. We terminated the pseudo-outbreak by increasing the frequency of automated endoscope reprocessors (AER) filter changes from quarterly to monthly. Filter changing schedules should depend on use rather than fixed time intervals.
    MeSH term(s) Bronchoalveolar Lavage Fluid/microbiology ; Bronchoscopes/microbiology ; Bronchoscopy/instrumentation ; Cross Infection/diagnosis ; Cross Infection/epidemiology ; Disease Outbreaks ; Disinfection/methods ; Equipment Contamination ; Equipment Reuse ; Humans ; Mycobacterium avium Complex/isolation & purification ; Mycobacterium avium-intracellulare Infection/diagnosis ; Mycobacterium avium-intracellulare Infection/epidemiology ; North Carolina/epidemiology ; Outpatients ; Tertiary Care Centers
    Language English
    Publishing date 2018-11-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2018.298
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  9. Article ; Online: Nocardia thailandica Pulmonary Nocardiosis in a Post-Solid Organ Transplant Patient.

    Canterino, Joseph / Paniz-Mondolfi, Alberto / Brown-Elliott, Barbara A / Vientos, Wilson / Vasireddy, Ravikiran / Wallace, Richard J / Campbell, Sheldon

    Journal of clinical microbiology

    2015  Volume 53, Issue 11, Page(s) 3686–3690

    Abstract: Nocardia thailandica is a rare pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis that, since its original description in 2004, has only been reported to cause wound and ocular infections in humans. We report a ...

    Abstract Nocardia thailandica is a rare pathogen related to Nocardia asteroides, Nocardia neocaledoniensis, and Nocardia caishijiensis that, since its original description in 2004, has only been reported to cause wound and ocular infections in humans. We report a case of pulmonary nocardiosis caused by Nocardia thailandica in a 66-year-old solid organ transplant patient from Connecticut, which was identified at the molecular taxonomic level by secA1 analysis, 16S rRNA gene sequencing, and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). To our knowledge, this is the first reported case of N. thailandica in the United States and the first report of pulmonary infection by this pathogen in the literature.
    MeSH term(s) Adenosine Triphosphatases/genetics ; Aged ; Bacterial Proteins/genetics ; Base Sequence ; Connecticut ; DNA, Bacterial/genetics ; DNA, Ribosomal/genetics ; Heart Transplantation/adverse effects ; Humans ; Immunocompromised Host/immunology ; Immunosuppression/adverse effects ; Lung Diseases/diagnosis ; Lung Diseases/immunology ; Lung Diseases/microbiology ; Male ; Membrane Transport Proteins/genetics ; Molecular Sequence Data ; Nocardia/isolation & purification ; Nocardia Infections/diagnosis ; Nocardia Infections/immunology ; Nocardia Infections/microbiology ; RNA, Ribosomal, 16S/genetics ; SEC Translocation Channels ; Sequence Analysis, DNA ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Chemical Substances Bacterial Proteins ; DNA, Bacterial ; DNA, Ribosomal ; Membrane Transport Proteins ; RNA, Ribosomal, 16S ; SEC Translocation Channels ; SecA protein, Bacteria (119129-39-4) ; Adenosine Triphosphatases (EC 3.6.1.-)
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00959-15
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  10. Article ; Online: Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease.

    Alexander, David C / Vasireddy, Ravikiran / Vasireddy, Sruthi / Philley, Julie V / Brown-Elliott, Barbara A / Perry, Benjamin J / Griffith, David E / Benwill, Jeana L / Cameron, Andrew D S / Wallace, Richard J

    Journal of clinical microbiology

    2017  Volume 55, Issue 2, Page(s) 574–584

    Abstract: Bedaquiline (BDQ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections that no longer respond to conventional drugs. While investigating the off-label use of BDQ as salvage ... ...

    Abstract Bedaquiline (BDQ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections that no longer respond to conventional drugs. While investigating the off-label use of BDQ as salvage therapy, seven of 13 patients with Mycobacterium intracellulare lung disease had an initial microbiological response and then relapsed. Whole-genome comparison of pretreatment and relapse isolates of M. intracellulare uncovered mutations in a previously uncharacterized locus, mmpT5 Preliminary analysis suggested similarities between mmpT5 and the mmpR5 locus, which is associated with low-level BDQ resistance in M. tuberculosis Both genes encode transcriptional regulators and are adjacent to orthologs of the mmpS5-mmpL5 drug efflux operon. However, MmpT5 belongs to the TetR superfamily, whereas MmpR5 is a MarR family protein. Targeted sequencing uncovered nonsynonymous mmpT5 mutations in isolates from all seven relapse cases, including two pretreatment isolates. In contrast, only two relapse patient isolates had nonsynonymous changes in ATP synthase subunit c (atpE), the primary target of BDQ. Susceptibility testing indicated that mmpT5 mutations are associated with modest 2- to 8-fold increases in MICs for BDQ and clofazimine, whereas one atpE mutant exhibited a 50-fold increase in MIC for BDQ. Bedaquiline shows potential for the treatment of M. intracellulare lung disease, but optimization of treatment regimens is required to prevent the emergence of mmpT5 variants and microbiological relapse.
    MeSH term(s) Aged ; Antitubercular Agents/therapeutic use ; Diarylquinolines/therapeutic use ; Drug Resistance, Bacterial ; Female ; Genome, Bacterial ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mutation, Missense ; Mycobacterium avium Complex/genetics ; Mycobacterium avium Complex/isolation & purification ; Recurrence ; Sequence Analysis, DNA ; Transcription Factors/genetics ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/microbiology
    Chemical Substances Antitubercular Agents ; Diarylquinolines ; Transcription Factors ; bedaquiline (78846I289Y)
    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02087-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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