LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Vassilia Théodorou"
  2. AU=Goodwin Lara
  3. AU="Jirina Zapletalova"
  4. AU=Sorbo Grazia
  5. AU="Banerjee, Swarnali"
  6. AU="Deng, Qiyuan"
  7. AU="Raghda H. Gouda"
  8. AU="Copin, Y."
  9. AU="Twomey, Bernadette"
  10. AU="Greendale, Gail A"
  11. AU="Haseli Mashhadi, Nazanin"
  12. AU="Pilecki, Z."
  13. AU="Alegado, Rosanna A"
  14. AU="Lv, Xinpeng"
  15. AU="Mare, Marzia"
  16. AU="Saleem, Nadia"
  17. AU="Garcia, F G"
  18. AU="Choi, Jong-Il"
  19. AU="Jandial, Tanvi"
  20. AU="Sartori, Chiara"
  21. AU="Pugsley, T A"
  22. AU=Passino Claudio
  23. AU="Ji, Ziwei"
  24. AU="Lim, K E"
  25. AU="Foresti, C."
  26. AU="Czimer, Dávid"
  27. AU="Nayak, Naren"
  28. AU="Khan, Jahidur Rahman"
  29. AU="Huber, Tobias B"
  30. AU="Özbek, Süha Süreyya"
  31. AU="Elujoba, Anthony A"
  32. AU="Lucas, Brian P"
  33. AU="Ngabo, Lucien"
  34. AU="M Elizabeth H. Hammond"
  35. AU="Poppe, Katrina"
  36. AU=Du Ping
  37. AU=Adorno E AU=Adorno E
  38. AU="Rehn, Alexandra"
  39. AU="Senff-Ribeiro, Andrea"

Suchergebnis

Treffer 1 - 10 von insgesamt 15

Suchoptionen

  1. Artikel ; Online: Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract

    Valérie Laroute / Catherine Beaufrand / Pedro Gomes / Sébastien Nouaille / Valérie Tondereau / Marie-Line Daveran-Mingot / Vassilia Theodorou / Hélène Eutamene / Muriel Mercier-Bonin / Muriel Cocaign-Bousquet

    eLife, Vol

    2022  Band 11

    Abstract: Gut disorders associated to irritable bowel syndrome (IBS) are combined with anxiety and depression. Evidence suggests that microbially produced neuroactive molecules, like γ-aminobutyric acid (GABA), can modulate the gut-brain axis. Two natural strains ... ...

    Abstract Gut disorders associated to irritable bowel syndrome (IBS) are combined with anxiety and depression. Evidence suggests that microbially produced neuroactive molecules, like γ-aminobutyric acid (GABA), can modulate the gut-brain axis. Two natural strains of Lactococcus lactis and one mutant were characterized in vitro for their GABA production and tested in vivo in rat by oral gavage for their antinociceptive properties. L. lactis NCDO2118 significantly reduced visceral hypersensitivity induced by stress due to its glutamate decarboxylase (GAD) activity. L. lactis NCDO2727 with similar genes for GABA metabolism but no detectable GAD activity had no in vivo effect, as well as the NCDO2118 ΔgadB mutant. The antinociceptive effect observed for the NCDO2118 strain was mediated by the production of GABA in the gastro-intestinal tract and blocked by GABAB receptor antagonist. Only minor changes in the faecal microbiota composition were observed after the L. lactis NCDO2118 treatment. These findings reveal the crucial role of the microbial GAD activity of L. lactis NCDO2118 to deliver GABA into the gastro-intestinal tract for exerting antinociceptive properties in vivo and open avenues for this GRAS (Generally Recognized As safe) bacterium in the management of visceral pain and anxious profile of IBS patients.
    Schlagwörter Lactococcus lactis ; GABA delivery ; GAD activity ; psychological stress ; visceral pain ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-06-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: Mucus

    Kévin Gillois / Mathilde Lévêque / Vassilia Théodorou / Hervé Robert / Muriel Mercier-Bonin

    Microorganisms, Vol 6, Iss 2, p

    An Underestimated Gut Target for Environmental Pollutants and Food Additives

    2018  Band 53

    Abstract: Synthetic chemicals (environmental pollutants, food additives) are widely used for many industrial purposes and consumer-related applications, which implies, through manufactured products, diet, and environment, a repeated exposure of the general ... ...

    Abstract Synthetic chemicals (environmental pollutants, food additives) are widely used for many industrial purposes and consumer-related applications, which implies, through manufactured products, diet, and environment, a repeated exposure of the general population with growing concern regarding health disorders. The gastrointestinal tract is the first physical and biological barrier against these compounds, and thus their first target. Mounting evidence indicates that the gut microbiota represents a major player in the toxicity of environmental pollutants and food additives; however, little is known on the toxicological relevance of the mucus/pollutant interplay, even though mucus is increasingly recognized as essential in gut homeostasis. Here, we aimed at describing how environmental pollutants (heavy metals, pesticides, and other persistent organic pollutants) and food additives (emulsifiers, nanomaterials) might interact with mucus and mucus-related microbial species; that is, “mucophilic” bacteria such as mucus degraders. This review highlights that intestinal mucus, either directly or through its crosstalk with the gut microbiota, is a key, yet underestimated gut player that must be considered for better risk assessment and management of environmental pollution.
    Schlagwörter environmental pollutants ; food additives ; gut barrier ; mucus ; mucophilic bacteria ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2018-06-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: Maternal heme-enriched diet promotes a gut pro-oxidative status associated with microbiota alteration, gut leakiness and glucose intolerance in mice offspring

    Anaïs Mazenc / Loïc Mervant / Claire Maslo / Corinne Lencina / Valérie Bézirard / Mathilde Levêque / Ingrid Ahn / Valérie Alquier-Bacquié / Nathalie Naud / Cécile Héliès-Toussaint / Laurent Debrauwer / Sylvie Chevolleau / Françoise Guéraud / Fabrice H.F. Pierre / Vassilia Théodorou / Maïwenn Olier

    Redox Biology, Vol 53, Iss , Pp 102333- (2022)

    2022  

    Abstract: Maternal environment, including nutrition and microbiota, plays a critical role in determining offspring's risk of chronic diseases such as diabetes later in life. Heme iron requirement is amplified during pregnancy and lactation, while excessive dietary ...

    Abstract Maternal environment, including nutrition and microbiota, plays a critical role in determining offspring's risk of chronic diseases such as diabetes later in life. Heme iron requirement is amplified during pregnancy and lactation, while excessive dietary heme iron intake, compared to non-heme iron, has shown to trigger acute oxidative stress in the gut resulting from reactive aldehyde formation in conjunction with microbiota reshape. Given the immaturity of the antioxidant defense system in early life, we investigated the extent to which a maternal diet enriched with heme iron may have a lasting impact on gut homeostasis and glucose metabolism in 60-day-old C3H/HeN mice offspring.As hypothesized, the form of iron added to the maternal diet differentially governed the offspring's microbiota establishment despite identical fecal iron status in the offspring. Importantly, despite female offspring was unaffected, oxidative stress markers were however higher in the gut of male offspring from heme enriched-fed mothers, and were accompanied by increases in fecal lipocalin-2, intestinal para-cellular permeability and TNF-α expression. In addition, male mice displayed blood glucose intolerance resulting from impaired insulin secretion following oral glucose challenge. Using an integrated approach including an aldehydomic analysis, this male-specific phenotype was further characterized and revealed close covariations between unidentified putative reactive aldehydes and bacterial communities belonging to Bacteroidales and Lachnospirales orders.Our work highlights how the form of dietary iron in the maternal diet can dictate the oxidative status in gut offspring in a sex-dependent manner, and how a gut microbiota-driven oxidative challenge in early life can be associated with gut barrier defects and glucose metabolism disorders that may be predictive of diabetes development.
    Schlagwörter Heme iron ; Early life nutrition ; Lipoperoxidation ; Red meat ; Gut barrier ; Gut microbiota ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 590
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel: Modifications of mesenteric adipose tissue during moderate experimental colitis in mice

    Olivier, Isabelle / Hélène Eutamène / Isabelle Castan-Laurell / Laurent Ferrier / Philippe Valet / Vassilia Theodorou

    Life sciences. 2014 Jan. 14, v. 94, no. 1

    2014  

    Abstract: Adipose tissue secretes various proteins referred to as adipokines, being involved in inflammation. It was recognized that mesenteric adipose tissue (MAT) is altered by inflammation, and pathologies such as inflammatory bowel disease (IBD). The aim of ... ...

    Abstract Adipose tissue secretes various proteins referred to as adipokines, being involved in inflammation. It was recognized that mesenteric adipose tissue (MAT) is altered by inflammation, and pathologies such as inflammatory bowel disease (IBD). The aim of this study was to investigate the alterations of the mesenteric adipose tissue in two experimental colitis models in mice adapted to obtain moderate colonic inflammation.Colonic inflammation was obtained using two models, either DSS dissolved in drinking water or intra-colonic instillation of DNBS. The expression of adipokines (leptin and adiponectin) and inflammatory markers (IL-6, MCP-1, F4/80) was studied by qRT-PCR in the MAT of treated and control mice.Observations of the colon and IL-6 plasma level determination demonstrated that DNBS treatment led to stronger inflammation. Colitis induced a decrease of mRNA encoding to leptin and adiponectin in MAT. In contrast, colonic inflammation led to an increase of mRNA encoding to IL-6, MCP-1 and F4/80, a specific marker of macrophages.The mesenteric adipose tissue, in two models of moderate colitis, shows a loss of adipose profile and a strong increase of inflammatory pattern, close to the observations made in MAT of IBD patients. These data suggest that these pro-inflammatory modifications of MAT have to be taken into account in the pathophysiology of IBD.
    Schlagwörter adiponectin ; adipose tissue ; colitis ; colon ; drinking water ; inflammation ; interleukin-6 ; leptin ; messenger RNA ; mice ; models ; pathophysiology ; patients ; proteins ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction
    Sprache Englisch
    Erscheinungsverlauf 2014-0114
    Umfang p. 1-7.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2013.09.028
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 73/732: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel ; Online: The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

    Sharon Ann Barretto / Frederic Lasserre / Marine Huillet / Marion Régnier / Arnaud Polizzi / Yannick Lippi / Anne Fougerat / Elodie Person / Sandrine Bruel / Colette Bétoulières / Claire Naylies / Céline Lukowicz / Sarra Smati / Laurence Guzylack / Maïwenn Olier / Vassilia Théodorou / Laila Mselli-Lakhal / Daniel Zalko / Walter Wahli /
    Nicolas Loiseau / Laurence Gamet-Payrastre / Hervé Guillou / Sandrine Ellero-Simatos

    Microbiome, Vol 9, Iss 1, Pp 1-

    2021  Band 16

    Abstract: Abstract Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are not well defined. Results By comparing publicly ... ...

    Abstract Abstract Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are not well defined. Results By comparing publicly available liver transcriptomics data from conventional vs. germ-free mice, we identified pregnane X receptor (PXR, NR1I2) transcriptional activity as strongly affected by the absence of gut microbes. Microbiota depletion using antibiotics in Pxr +/+ vs Pxr -/- C57BL/6J littermate mice followed by hepatic transcriptomics revealed that most microbiota-sensitive genes were PXR-dependent in the liver in males, but not in females. Pathway enrichment analysis suggested that microbiota–PXR interaction controlled fatty acid and xenobiotic metabolism. We confirmed that antibiotic treatment reduced liver triglyceride content and hampered xenobiotic metabolism in the liver from Pxr +/+ but not Pxr -/- male mice. Conclusions These findings identify PXR as a hepatic effector of microbiota-derived signals that regulate the host’s sexually dimorphic lipid and xenobiotic metabolisms in the liver. Thus, our results reveal a potential new mechanism for unexpected drug–drug or food–drug interactions. Video abstract
    Schlagwörter Gut microbiota ; Liver ; Pregnane X receptor ; NR1I2 ; Xenobiotic metabolism ; Fatty acid metabolism ; Microbial ecology ; QR100-130
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: Author Correction

    Céline Lukowicz / Sandrine Ellero-Simatos / Marion Régnier / Fabiana Oliviero / Frédéric Lasserre / Arnaud Polizzi / Alexandra Montagner / Sarra Smati / Frédéric Boudou / Françoise Lenfant / Laurence Guzylack-Pirou / Sandrine Menard / Sharon Barretto / Anne Fougerat / Yannick Lippi / Claire Naylies / Justine Bertrand-Michel / Afifa Ait Belgnaoui / Vassilia Theodorou /
    Nicola Marchi / Pierre Gourdy / Laurence Gamet-Payrastre / Nicolas Loiseau / Hervé Guillou / Laïla Mselli-Lakhal

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

    2020  Band 2

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: Maternal exposure to low levels of corticosterone during lactation protects against experimental inflammatory colitis-induced damage in adult rat offspring.

    Carla Petrella / Chiara Giuli / Simona Agostini / Valérie Bacquie / Manuela Zinni / Vassilia Theodorou / Maria Broccardo / Paola Casolini / Giovanna Improta

    PLoS ONE, Vol 9, Iss 11, p e

    2014  Band 113389

    Abstract: Opposing emotional events (negative/trauma or positive/maternal care) during the postnatal period may differentially influence vulnerability to the effects of stress later in life. The development and course of intestinal disorders such as inflammatory ... ...

    Abstract Opposing emotional events (negative/trauma or positive/maternal care) during the postnatal period may differentially influence vulnerability to the effects of stress later in life. The development and course of intestinal disorders such as inflammatory bowel disease are negatively affected by persistent stress, but to date the role of positive life events on these pathologies has been entirely unknown. In the present study, the effect of early life beneficial experiences in the development of intestinal dysfunctions, where inflammation and stress stimuli play a primary role, was investigated. As a "positive" experimental model we used adult male rat progeny nursed by mothers whose drinking water was supplemented with moderate doses of corticosterone (CORT) (0.2 mg/ml) during the lactation period. Such animals have been generally shown to cope better with different environmental situations during life. The susceptibility to inflammatory experimental colitis induced by intracolonic infusion of TNBS (2,4,6-trinitrobenzenesulphonic acid) was investigated in CORT-nursed rats in comparison with control rats. This mild increase in maternal corticosterone during lactation induced, in CORT-nursed rats, a long lasting protective effect on TNBS-colitis, characterized by improvements in some indices of the disease (increased colonic myeloperoxidase activity, loss of body weight and food intake) and by the involvement of endogenous peripheral pathways known to participate in intestinal disorder development (lower plasma corticosterone levels and colonic mast cell degranulation, alterations in the colonic expression of both corticotrophin releasing factor/CRF and its receptor/CRH-1R). All these findings contribute to suggesting that the reduced vulnerability to TNBS-colitis in CORT-nursed rats is due to recovery from the colonic mucosal barrier dysfunction. Such long lasting changes induced by mild hormonal manipulation during lactation, making the adult also better adapted to colonic inflammatory stress, constitute a useful ...
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis

    Manuela Zinni / Anna Rita Zuena / Veronica Marconi / Carla Petrella / Ilaria Fusco / Chiara Giuli / Nadia Canu / Cinzia Severini / Maria Broccardo / Vassilia Theodorou / Roberta Lattanzi / Paola Casolini

    PLoS ONE, Vol 12, Iss 3, p e

    A study on GR-mediated anti-inflammatory effect and prokineticin system.

    2017  Band 0173484

    Abstract: The early phase of life represents a critical period for the development of an organism. Interestingly, early life experiences are able to influence the development of the gastrointestinal tract and the reactivity to colonic inflammatory stress. We ... ...

    Abstract The early phase of life represents a critical period for the development of an organism. Interestingly, early life experiences are able to influence the development of the gastrointestinal tract and the reactivity to colonic inflammatory stress. We recently demonstrated that adult male rats exposed to low doses of corticosterone during lactation (CORT-nursed rats) are protected against experimental colitis induced by the intracolonic infusion of 2,4,6-trinitrobenzenesulfonic acid (TNBS). Based on these interesting results, we wanted to better investigate which cellular actors could be involved in the protection of CORT-nursed rats from TNBS-induced experimental colitis. Therefore, in the present work, we focused our attention on different factors implicated in GR-mediated anti-inflammatory effect. To address this issue, colonic tissues, collected from control and CORT-nursed healthy animals and from control and CORT-nursed colitic rats, were processed and the following inflammatory factors were evaluated: the expression of (i) glucocorticoid receptors (GR), (ii) glucocorticoid-induced leucine zipper (GILZ), (iii) phospho-p65NF-κB, (iv) the pro-inflammatory cytokines IL-1β and TNF-α, (v) the prokineticins PK2 and PK2L and (vi) their receptors PKR1 and PKR2. We found that adult CORT-nursed rats, in comparison to controls, showed increased expression of colonic GR and reduced expression of pro-inflammatory molecules (IL-1β, TNF-α, PK2 and PK2L) in response to inflammatory colitis. The observed changes were associated with an increase in GILZ colonic expression and with a reduction in phospo-p65NF-κB colonic expression.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel: Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases

    Bessette, Claudine / Bérengère Benoit / Emmanuelle Meugnier / Gwénaële Henry / Jérémie Bruno / Joelle Léonil / Laurent Ferrier / Pascale Plaisancié / Soraya Sekkal / Vassilia Théodorou

    Journal of functional foods. 2016 Dec., v. 27

    2016  

    Abstract: β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its ... ...

    Abstract β-Casofensin is a milk-derived bioactive peptide that interacts with intestinal goblet cells. We aimed to determine whether β-casofensin could prevent intestinal dysfunctions induced by neonatal maternal separation (NMS) and whether it retains its protective effects when administered in a casein matrix. We also evaluated whether a casein matrix enriched in β-casofensin protects against intestinal enteritis induced by indomethacin. β-Casofensin abolished NMS-induced jejunal hyperpermeability and prevented the depletion of goblet and Paneth cells induced by NMS. In addition, β-casofensin maintained its effectiveness against NMS-induced intestinal barrier alterations when administered in a casein matrix. A casein matrix containing β-casofensin also reduced intestinal damages induced by indomethacin. A functional food containing β-casofensin may prevent both the deleterious effects of neonatal stress on the intestinal barrier and indomethacin-induced enteritis. These results suggest a promising application of β-casofensin as a gut barrier protector in the context of bioactive foods and clinical nutrition.
    Schlagwörter absorption barrier ; casein ; clinical nutrition ; enteritis ; functional foods ; goblet cells ; indomethacin ; jejunum ; models ; oral administration ; protective effect
    Sprache Englisch
    Erscheinungsverlauf 2016-12
    Umfang p. 223-235.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2016.09.007
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 7830: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel ; Online: Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

    Céline Lukowicz / Sandrine Ellero-Simatos / Marion Régnier / Fabiana Oliviero / Frédéric Lasserre / Arnaud Polizzi / Alexandra Montagner / Sarra Smati / Frédéric Boudou / Françoise Lenfant / Laurence Guzylack-Pirou / Sandrine Menard / Sharon Barretto / Anne Fougerat / Yannick Lippi / Claire Naylies / Justine Bertrand-Michel / Afifa Ait Belgnaoui / Vassilia Theodorou /
    Nicola Marchi / Pierre Gourdy / Laurence Gamet-Payrastre / Nicolas Loiseau / Hervé Guillou / Laïla Mselli-Lakhal

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 13

    Abstract: Abstract Metabolic diseases such as obesity, type II diabetes and hepatic steatosis are a public health concern in developed countries. The metabolic risk is gender‐dependent. The constitutive androstane receptor (CAR), which is at the crossroads between ...

    Abstract Abstract Metabolic diseases such as obesity, type II diabetes and hepatic steatosis are a public health concern in developed countries. The metabolic risk is gender‐dependent. The constitutive androstane receptor (CAR), which is at the crossroads between energy metabolism and endocrinology, has recently emerged as a promising therapeutic agent for the treatment of obesity and type 2 diabetes. In this study we sought to determine its role in the dimorphic regulation of energy homeostasis. We tracked male and female WT and CAR deficient (CAR−/−) mice for over a year. During aging, CAR−/− male mice developed hypercortisism, obesity, glucose intolerance, insulin insensitivity, dyslipidemia and hepatic steatosis. Remarkably, the latter modifications were absent, or minor, in female CAR−/− mice. When ovariectomized, CAR−/− female mice developed identical patterns of metabolic disorders as observed in male mice. These results highlight the importance of steroid hormones in the regulation of energy metabolism by CAR. They unveil a sexually dimorphic role of CAR in the maintenance of endocrine and metabolic homeostasis underscoring the importance of considering sex in treatment of metabolic diseases.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2019-12-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang