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  1. Article ; Online: Translational regulation and deregulation in erythropoiesis.

    Vatikioti, Alexandra / Karkoulia, Elena / Ioannou, Marina / Strouboulis, John

    Experimental hematology

    2019  Volume 75, Page(s) 11–20

    Abstract: Translational regulation plays a critical role in erythropoiesis, as it reflects the translational needs of enucleated mature erythroid cells in the absence of transcription and the large translational demands of balanced globin chain synthesis during ... ...

    Abstract Translational regulation plays a critical role in erythropoiesis, as it reflects the translational needs of enucleated mature erythroid cells in the absence of transcription and the large translational demands of balanced globin chain synthesis during erythroid maturation. In addition, red blood cells need to respond quickly to changes in their environment and the demands of the organism. Translational regulation occurs at several levels in erythroid cells, including the differential utilization of upstream open reading frames during differentiation and in response to signaling and the employment of RNA-binding proteins in an erythroid cell-specific fashion. Translation initiation is a critical juncture for translational regulation in response to environmental signals such as heme and iron availability, whereas regulatory mechanisms for ribosome recycling are consistent with recent observations highlighting the importance of maintaining adequate ribosome levels in differentiating erythroid cells. Translational deregulation in erythroid cells leads to disease associated with ineffective erythropoiesis, further highlighting the pivotal role translational regulation in erythropoiesis plays in human physiology and homeostasis. Overall, erythropoiesis has served as a unique model that has provided invaluable insight into translational regulation.
    MeSH term(s) Cell Differentiation/physiology ; Erythroid Cells/cytology ; Erythroid Cells/metabolism ; Erythropoiesis/physiology ; Heme/metabolism ; Humans ; Iron/metabolism ; Protein Biosynthesis/physiology ; RNA-Binding Proteins/metabolism ; Ribosomes/metabolism ; Signal Transduction/physiology
    Chemical Substances RNA-Binding Proteins ; Heme (42VZT0U6YR) ; Iron (E1UOL152H7)
    Language English
    Publishing date 2019-05-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2019.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 922: Show issues Location:
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  2. Article ; Online: A triazine di(carboxy)porphyrin dyad versus a triazine di(carboxy)porphyrin triad for sensitizers in DSSCs.

    Zervaki, G E / Tsaka, Vasilitsa / Vatikioti, Alexandra / Georgakaki, Irene / Nikolaou, Vasilis / Sharma, G D / Coutsolelos, A G

    Dalton transactions (Cambridge, England : 2003)

    2015  Volume 44, Issue 30, Page(s) 13550–13564

    Abstract: Two porphyrin-chromophores, i.e. triad PorZn-(PorCOOH)(2)-(piper)2 (GZ-T1) and dyad (PorZn)(2)-NMe2 (GZ-T1), have been synthesized and their photophysical and electrochemical properties have been investigated. The optical properties together with the ... ...

    Abstract Two porphyrin-chromophores, i.e. triad PorZn-(PorCOOH)(2)-(piper)2 (GZ-T1) and dyad (PorZn)(2)-NMe2 (GZ-T1), have been synthesized and their photophysical and electrochemical properties have been investigated. The optical properties together with the appropriate electronic energy levels, i.e. the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels, revealed that both porphyrin assemblies can function as sensitizers for dye sensitized solar cells (DSSCs). The and -based DSSCs have been prepared and studied using 20 mM CDCA as coadsorbent and were found to exhibit an overall power conversion efficiency (PCE) of 5.88% and 4.56%, respectively (under an illumination intensity of 100 mW cm(-2) with TiO(2) films of 12 μm). The higher PCE of the -sensitized DSSC, as revealed from the current-voltage characteristic under illumination and the incident photon to current conversion efficiency (IPCE) spectra of the two DSSCs, is mainly attributed to its enhanced short circuit current (J(sc)), although both the open circuit voltage (V(oc)) and the fill factor are improved too. The electrochemical impedance spectra (EIS) demonstrated a shorter electron transport time, longer electron lifetime and higher charge recombination resistance for the DSSC sensitized with the dye as well as a larger dye loading onto the TiO(2) surface.
    MeSH term(s) Carboxylic Acids/chemistry ; Coloring Agents/chemistry ; Electric Power Supplies ; Electron Transport ; Light ; Models, Molecular ; Porphyrins/chemistry ; Solar Energy ; Triazines/chemistry
    Chemical Substances Carboxylic Acids ; Coloring Agents ; Porphyrins ; Triazines
    Language English
    Publishing date 2015-08-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c5dt01141h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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