Article ; Online: Two Permeases Associated with the Multifunctional CtaP Cysteine Transport System in Listeria monocytogenes Play Distinct Roles in Pathogenesis.
2023 Volume 11, Issue 3, Page(s) e0331722
Abstract: The soil-dwelling bacterium Listeria monocytogenes survives a multitude of conditions when residing in the outside environment and as a pathogen within host cells. Key to survival within the infected mammalian host is the expression of bacterial gene ... ...
| Abstract | The soil-dwelling bacterium Listeria monocytogenes survives a multitude of conditions when residing in the outside environment and as a pathogen within host cells. Key to survival within the infected mammalian host is the expression of bacterial gene products necessary for nutrient acquisition. Similar to many bacteria, L. monocytogenes uses peptide import to acquire amino acids. Peptide transport systems play an important role in nutrient uptake as well as in additional functions that include bacterial quorum sensing and signal transduction, recycling of peptidoglycan fragments, adherence to eukaryotic cells, and alterations in antibiotic susceptibility. It has been previously described that CtaP, encoded by |
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| MeSH term(s) | Animals ; Mice ; Listeria monocytogenes/genetics ; Cysteine/metabolism ; Virulence ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Virulence Factors/genetics ; Bacterial Proteins/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Bacterial ; Mammals |
| Chemical Substances | Cysteine (K848JZ4886) ; Membrane Transport Proteins ; Virulence Factors ; Bacterial Proteins |
| Language | English |
| Publishing date | 2023-05-18 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2807133-5 |
| ISSN | 2165-0497 ; 2165-0497 |
| ISSN (online) | 2165-0497 |
| ISSN | 2165-0497 |
| DOI | 10.1128/spectrum.03317-22 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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