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Article ; Online: Capsule production promotes Group B

Vaz, Michelle J / Dongas, Sophia / Ratner, Adam J

2023 , Page(s) e0234923

Abstract: Late-onset disease is the most common clinical presentation of Group ... ...

Abstract	Late-onset disease is the most common clinical presentation of Group B
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02349-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and miRNA-126a-5p as Biomarkers of Persistent Pulmonary Hypertension in Neonates with Hypoxic-Ischemic Injury Receiving Therapeutic Hypothermia.

Jano, Eni / Vaz, Michelle J / Mally, Pradeep N / Wachtel, Elena V

American journal of perinatology

2022

Abstract: Objective: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing ... ...

Abstract	Objective: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not. Study design: This was a prospective, observational pilot study including neonates with hypoxic-ischemic injury undergoing therapeutic hypothermia (TH) at two regional perinatal medical centers. PPHN in this population was diagnosed clinically and confirmed by echocardiogram. Serial measurements of biomarkers were performed from 6 to 96 hours post-TH initiation in 40 patients. Results: Of 40 infants in the study, 10 (25%) developed PPHN and 30 (75%) did not. Baseline demographics and hemodynamics were similar between the groups. Patients with PPHN had a significantly higher need for vasopressors compared with patients without PPHN (70 vs. 27%, Conclusion: BNP and troponin are readily available, low-cost biomarkers that showed significant serial elevations in the PPHN group of the study and, thus, may have value in screening for PPHN in the setting of hypoxic-ischemic encephalopathy (HIE). Gal-3 was elevated in all patients with HIE and may be a useful biomarker of hypoxic injury in infants being evaluated for TH. Elevations in miRNA-126a-5p were not consistently seen in this study. Larger studies are required to establish an association between PPHN and these biomarkers in patients with and without HIE. Key points: · Serum biomarkers of persistent pulmonary hypertension of the newborn. · Serum biomarkers of hypoxic-ischemic injury.
Language	English
Publishing date	2022-06-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-1827-7518
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and miRNA-126a-5p as Biomarkers of Persistent Pulmonary Hypertension in Neonates with Hypoxic-Ischemic Injury Receiving Therapeutic Hypothermia

Jano, Eni / Vaz, Michelle J. / Mally, Pradeep N. / Wachtel, Elena V.

American Journal of Perinatology

2022

Abstract	Objective: The objective was to evaluate the utility of brain natriuretic peptide (BNP), troponin, galectin-3 (Gal-3), and microRNA (miRNA)-126a-5p as screening biomarkers for persistent pulmonary hypertension of the newborn (PPHN) by comparing expression in serum of infants with hypoxic-ischemic injury that develop PPHN to those that do not. Study Design: This was a prospective, observational pilot study including neonates with hypoxic-ischemic injury undergoing therapeutic hypothermia (TH) at two regional perinatal medical centers. PPHN in this population was diagnosed clinically and confirmed by echocardiogram. Serial measurements of biomarkers were performed from 6 to 96 hours post-TH initiation in 40 patients. Results: Of 40 infants in the study, 10 (25%) developed PPHN and 30 (75%) did not. Baseline demographics and hemodynamics were similar between the groups. Patients with PPHN had a significantly higher need for vasopressors compared with patients without PPHN (70 vs. 27%, p = 0.007). Mean serum BNP and troponin levels were significantly higher in the PPHN group peaking at 12 to 24 hours and decreasing following PPHN treatment initiation. miRNA-126a-5p expression was increased in patients with PPHN compared with patients without, with statistical significance detected at 12 hours ( p = 0.005) and 96 hours ( p = 0.01). Mean circulating Gal-3 levels were not statistically different between the two groups; however, Gal-3 was elevated in all patients with hypoxic-ischemic injury on TH compared with healthy infants from prior studies. Conclusion: BNP and troponin are readily available, low-cost biomarkers that showed significant serial elevations in the PPHN group of the study and, thus, may have value in screening for PPHN in the setting of hypoxic-ischemic encephalopathy (HIE). Gal-3 was elevated in all patients with HIE and may be a useful biomarker of hypoxic injury in infants being evaluated for TH. Elevations in miRNA-126a-5p were not consistently seen in this study. Larger studies are required to establish an association between PPHN and these biomarkers in patients with and without HIE. Key Points: Serum biomarkers of persistent pulmonary hypertension of the newborn Serum biomarkers of hypoxic-ischemic injury
Keywords	biomarkers ; persistent pulmonary hypertension of the newborn ; hypoxic-ischemic injury
Language	English
Publishing date	2022-04-18
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-1827-7518
Database	Thieme publisher's database

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Zs.A 1929: Show issues

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Article ; Online: Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy.

Kuperwaser, Felicia / Avital, Gal / Vaz, Michelle J / Noble, Kristen N / Dammann, Allison N / Randis, Tara M / Aronoff, David M / Ratner, Adam J / Yanai, Itai

Molecular systems biology

2023 Volume 19, Issue 3, Page(s) e11021

Abstract: Group B Streptococcus (GBS) is a pathobiont that can ascend to the placenta and cause adverse pregnancy outcomes, in part through production of the toxin β-hemolysin/cytolysin (β-h/c). Innate immune cells have been implicated in the response to GBS ... ...

Abstract	Group B Streptococcus (GBS) is a pathobiont that can ascend to the placenta and cause adverse pregnancy outcomes, in part through production of the toxin β-hemolysin/cytolysin (β-h/c). Innate immune cells have been implicated in the response to GBS infection, but the impact of β-h/c on their response is poorly defined. We show that GBS modulates innate immune cell states by subversion of host inflammation through β-h/c, allowing worse outcomes. We used an ascending mouse model of GBS infection to measure placental cell state changes over time following infection with a β-h/c-deficient and isogenic wild type GBS strain. Transcriptomic analysis suggests that β-h/c-producing GBS elicit a worse phenotype through suppression of host inflammatory signaling in placental macrophages and neutrophils, and comparison of human placental macrophages infected with the same strains recapitulates these results. Our findings have implications for identification of new targets in GBS disease to support host defense against pathogenic challenge.
MeSH term(s)	Mice ; Animals ; Female ; Pregnancy ; Humans ; Placenta/metabolism ; Streptococcus agalactiae/genetics ; Streptococcus agalactiae/metabolism ; Inflammation ; Macrophages ; Streptococcal Infections/metabolism
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2193510-5
ISSN	1744-4292 ; 1744-4292
ISSN (online)	1744-4292
ISSN	1744-4292
DOI	10.15252/msb.202211021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn.

Verma, Sourabh / Lumba, Rishi / Kazmi, Sadaf H / Vaz, Michelle J / Prakash, Shrawani Soorneela / Bailey, Sean M / Mally, Pradeep V / Randis, Tara M

American journal of perinatology

2021 Volume 39, Issue 13, Page(s) 1441–1448

Abstract: Objective: The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in neonates with persistent pulmonary hypertension of the newborn (PPHN).: Study design: We conducted a retrospective chart review of 30 patients with PPHN ... ...

Abstract	Objective: The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in neonates with persistent pulmonary hypertension of the newborn (PPHN). Study design: We conducted a retrospective chart review of 30 patients with PPHN from January 2014 to November 2018, who did not respond to inhaled nitric oxide (iNO) alone and received inhaled iloprost. Twenty-two patients met the inclusion criteria and eight patients were excluded from the study (complex cardiac disease and extreme prematurity). Patients were categorized as responders or nonresponders (patients who required extracorporeal membrane oxygenation or died). Oxygenation index, mean airway pressure (MAP), and arterial partial pressure of oxygen (PaO Results: Among a total of 22 patients who were included in the study, 10 were classified as nonresponders as they required either extracorporeal membrane oxygenation or died. Gestational age and gender did not differ between responders and nonresponders. The median PaO Conclusion: Inhaled iloprost is well tolerated and seems to have beneficial effects in improving oxygenation indices in neonates with PPHN who do not respond to iNO. There is a need of well-designed prospective trials to further ascertain the benefits of using inhaled iloprost as an adjunct treatment in neonates with PPHN who do not respond to iNO alone. Key points: · Inhaled iloprost seems to have beneficial effects in improving oxygenation indices in PPHN.. · Inhaled iloprost is generally well tolerated in newborns with PPHN.. · There is a need for prospective randomized controlled trials to further ascertain the benefits of using inhaled iloprost..
MeSH term(s)	Administration, Inhalation ; Humans ; Hypertension, Pulmonary/drug therapy ; Iloprost/therapeutic use ; Infant, Newborn ; Nitric Oxide ; Oxygen ; Persistent Fetal Circulation Syndrome/drug therapy ; Prospective Studies ; Retrospective Studies ; Vasodilator Agents/therapeutic use
Chemical Substances	Vasodilator Agents ; Nitric Oxide (31C4KY9ESH) ; Iloprost (JED5K35YGL) ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0040-1722653
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1929: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Association of SARS-CoV-2 placental histopathology findings with maternal-fetal comorbidities and severity of COVID-19 hypoxia.

Meyer, Jessica A / Roman, Ashley S / Limaye, Meghana / Grossman, Tracy B / Flaifel, Abdallah / Vaz, Michelle J / Thomas, Kristen M / Penfield, Christina A

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2021 Volume 35, Issue 25, Page(s) 8412–8418

Abstract: Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited ...

Abstract	Objective: SARS-CoV-2 is known to impact multiple organ systems, with growing data to suggest the potential for placental infection and resultant pathology. Understanding how maternal COVID-19 disease can affect placental histopathology has been limited by small study cohorts with mild disease, review by multiple pathologists, and potential confounding by maternal-fetal comorbidities that can also influence placental findings. This study aims to identify pathologic placental findings associated with COVID-19 disease and severity, as well as to distinguish them from changes related to coexisting maternal-fetal comorbidities. Methods: This is an observational study of 61 pregnant women with confirmed SARS-CoV-2 infection who delivered and had a placental histological evaluation at NYU Langone Health between March 19, 2020 and June 30, 2020. Primary outcomes were the prevalence of placental histopathologic features and their association with maternal-fetal comorbidities and severity of COVID-19 related hypoxia. Analysis was performed using Fisher's exact test and Results: Sixty-one placentas were included in the study cohort, 71% from pregnancies complicated by at least one maternal-fetal comorbidity. Twenty-five percent of placentas were small for gestational age and 77% exhibited at least one feature of maternal vascular malperfusion. None of the histopathologic features in the examined placentas were associated with the presence of any specific maternal-fetal comorbidity. Thirteen percent of the cohort required maternal respiratory support for COVID-19 related hypoxia. Villous trophoblast necrosis was associated with maternal supplemental oxygen requirement (67 Conclusion: In pregnancies complicated by COVID-19 disease, there was a high prevalence of placental histopathologic changes identified, particularly features of maternal vascular malperfusion, which could not be attributed solely to the presence of maternal-fetal comorbidities. The significantly increased prevalence of villous trophoblast necrosis in women needing respiratory support suggests a connection to the severity of COVID-19 illness.
MeSH term(s)	Female ; Pregnancy ; Humans ; SARS-CoV-2 ; COVID-19/complications ; Placenta/pathology ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/pathology ; Comorbidity ; Hypoxia/epidemiology ; Necrosis/epidemiology ; Necrosis/pathology
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2021.1977791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3510: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: The Impact of Circulating Antibody on Group B

Vaz, Michelle J / Purrier, Sheryl A / Bonakdar, Maryam / Chamby, Anna B / Ratner, Adam J / Randis, Tara M

Infection and immunity

2020 Volume 89, Issue 1

Abstract: Gastrointestinal (GI) colonization with group ... ...

Abstract	Gastrointestinal (GI) colonization with group B
MeSH term(s)	Age Factors ; Animals ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Disease Models, Animal ; Disease Susceptibility ; Gastroenteritis/immunology ; Gastroenteritis/microbiology ; Gastroenteritis/mortality ; Gastroenteritis/pathology ; Host-Pathogen Interactions/immunology ; Immunization ; Mice ; Streptococcal Infections/immunology ; Streptococcal Infections/microbiology ; Streptococcal Infections/mortality ; Streptococcal Infections/pathology ; Streptococcal Vaccines/immunology ; Streptococcus agalactiae/immunology
Chemical Substances	Antibodies, Bacterial ; Streptococcal Vaccines
Language	English
Publishing date	2020-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00348-20
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Article: Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn

Verma, Sourabh / Lumba, Rishi / Kazmi, Sadaf H. / Vaz, Michelle J. / Prakash, Shrawani Soorneela / Bailey, Sean M. / Mally, Pradeep V. / Randis, Tara M.

American Journal of Perinatology

2021 Volume 39, Issue 13, Page(s) 1441–1448

Abstract: Objective: The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in neonates with persistent pulmonary hypertension of the newborn (PPHN).: Study Design: We conducted a retrospective chart review of 30 patients with PPHN ... ...

Abstract	Objective: The study aimed to evaluate the effects of inhaled iloprost on oxygenation indices in neonates with persistent pulmonary hypertension of the newborn (PPHN). Study Design: We conducted a retrospective chart review of 30 patients with PPHN from January 2014 to November 2018, who did not respond to inhaled nitric oxide (iNO) alone and received inhaled iloprost. Twenty-two patients met the inclusion criteria and eight patients were excluded from the study (complex cardiac disease and extreme prematurity). Patients were categorized as responders or nonresponders (patients who required extracorporeal membrane oxygenation or died). Oxygenation index, mean airway pressure (MAP), and arterial partial pressure of oxygen (PaO 2 ) were recorded. Results: Among a total of 22 patients who were included in the study, 10 were classified as nonresponders as they required either extracorporeal membrane oxygenation or died. Gestational age and gender did not differ between responders and nonresponders. The median PaO 2 was lower (37 vs. 42 mm Hg; p < 0.05) and median MAP was higher (20 vs. 17 cm H 2 O; p < 0.02) in nonresponders compared with responders just prior to initiating iloprost. Iloprost responders had a significant increase in median PaO 2 and decrease in median oxygenation index in the 24 hours after initiating treatment ( p < 0.05), with no significant change in required mean airway pressure over that same period. There was no change in vasopressor use or clinically significant worsening of platelets count, liver, and kidney functions after initiating iloprost. Conclusion: Inhaled iloprost is well tolerated and seems to have beneficial effects in improving oxygenation indices in neonates with PPHN who do not respond to iNO. There is a need of well-designed prospective trials to further ascertain the benefits of using inhaled iloprost as an adjunct treatment in neonates with PPHN who do not respond to iNO alone. Key Points: Inhaled iloprost seems to have beneficial effects in improving oxygenation indices in PPHN. Inhaled iloprost is generally well tolerated in newborns with PPHN. There is a need for prospective randomized controlled trials to further ascertain the benefits of using inhaled iloprost.
Keywords	persistent pulmonary hypertension of the newborn ; iloprost ; nitric oxide ; newborn
Language	English
Publishing date	2021-01-21
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/s-0040-1722653
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 1929: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Capsule production promotes Group B

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Article ; Online: Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and miRNA-126a-5p as Biomarkers of Persistent Pulmonary Hypertension in Neonates with Hypoxic-Ischemic Injury Receiving Therapeutic Hypothermia.

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Article: Pilot Study Investigating Brain Natriuretic Peptide, Troponin, Galectin-3, and miRNA-126a-5p as Biomarkers of Persistent Pulmonary Hypertension in Neonates with Hypoxic-Ischemic Injury Receiving Therapeutic Hypothermia

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Article ; Online: Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy.

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Article ; Online: Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn.

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Article ; Online: Association of SARS-CoV-2 placental histopathology findings with maternal-fetal comorbidities and severity of COVID-19 hypoxia.

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Article ; Online: The Impact of Circulating Antibody on Group B

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Article: Effects of Inhaled Iloprost for the Management of Persistent Pulmonary Hypertension of the Newborn

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