LIVIVO - Search results -

Search results

Result 1 - 10 of total 267

Search options

Article ; Online: Correction to: Extended duration of treatment using reduced‑frequency dosing of anti‑PD‑1 therapy in patients with advanced melanoma and Merkel cell carcinoma.

Tachiki, Lisa May Ling / Hippe, Daniel S / Silva, Karly Williams / Hall, Evan Thomas / McCamy, William / Fritzsche, Dane / Perdue, Andrea / Majovski, Julia / Pulliam, Thomas / Goldstein, Daniel A / Veatch, Joshua / Ho, Joel / Nghiem, Paul T / Thompson, John A / Bhatia, Shailender

Cancer immunology, immunotherapy : CII

2023 Volume 72, Issue 12, Page(s) 4471

Language	English
Publishing date	2023-11-18
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-023-03575-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1237: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma.

Tachiki, Lisa May Ling / Hippe, Daniel S / Williams Silva, Karly / Hall, Evan Thomas / McCamy, William / Fritzsche, Dane / Perdue, Andrea / Majovski, Julia / Pulliam, Thomas / Goldstein, Daniel A / Veatch, Joshua / Ho, Joel / Nghiem, Paul T / Thompson, John A / Bhatia, Shailender

Cancer immunology, immunotherapy : CII

2023 Volume 72, Issue 11, Page(s) 3839–3850

Abstract: Background: Optimal duration of treatment (DoT) with immune checkpoint inhibitors (ICI) in metastatic cancers remains unclear. Many patients, especially those without radiologic complete remission, develop progressive disease after ICI discontinuation. ... ...

Abstract	Background: Optimal duration of treatment (DoT) with immune checkpoint inhibitors (ICI) in metastatic cancers remains unclear. Many patients, especially those without radiologic complete remission, develop progressive disease after ICI discontinuation. Extending DoT with ICI may potentially improve efficacy outcomes but presents major logistical and cost challenges with standard frequency dosing (SFD). Receptor occupancy data supports reduced frequency dosing (RFD) of anti-PD-1 antibodies, which may represent a more practical and economically viable option to extend DoT. Methods: We conducted a retrospective study of patients with metastatic melanoma and Merkel cell carcinoma (MCC), who received ICI at RFD administered every 3 months, after initial disease control at SFD. We evaluated efficacy, safety, and cost-savings of the RFD approach in this cohort. Results: Between 2014 and 2021, 23 patients with advanced melanoma (N = 18) or MCC (N = 5) received anti-PD-1 therapy at RFD. Median DoT was 1.1 years at SFD and 1.2 years at RFD. The 3 year PFS after start of RFD was 73% in melanoma and 100% in MCC patients, which compare favorably to historical control rates. In the subset of 15 patients who received at least 2 years of therapy, total savings amounted to $1.1 million in drug costs and 384 h saved despite the extended DoT (median 3.4 years), as compared to the calculated cost of 2 years at SFD. Conclusions: ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.
MeSH term(s)	Humans ; Carcinoma, Merkel Cell/drug therapy ; Duration of Therapy ; Melanoma/drug therapy ; Prospective Studies ; Retrospective Studies ; Skin Neoplasms/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-09-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-023-03539-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1237: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Impact of Relocating a Trauma Center: Observations on Patient Injury Demographics and Resident Volumes.

Punja, Viren / Capasso, Thomas / Ray, Kelley M / Stokes, Laura / Narveson, Joel / Niu, Fang / Patel, Neil D / Ewing, Kaily / Fernandez, Carlos A / Veatch, Jessica / Kuncir, Eirc

Cureus

2022 Volume 14, Issue 10, Page(s) e30256

Abstract: Introduction Changing the physical zip code location of an academic trauma center may affect the distribution and surgical volume of its trauma patients. General surgical residency case log requirements may also be affected. This study describes the ... ...

Abstract	Introduction Changing the physical zip code location of an academic trauma center may affect the distribution and surgical volume of its trauma patients. General surgical residency case log requirements may also be affected. This study describes the impact of moving a level I trauma center to a different zip code location, on the hospital and resident trauma case volumes. Methods This retrospective analysis included all patients within the local trauma registry across two fiscal years representing the pre- and post-move timeframes. Variables collected included patient basic sociodemographic and injury information, trauma activation level and transfer status, management (operative management [OPM] versus non-operative management [NOPM]), and resident case logs. Results During fiscal years 2016-2017 and 2017-2018, 3,025 patients were included. Pre-move and post-move trauma volumes were 1,208 and 1,817 respectively. Post-move changes demonstrated differences in basic sociodemographics, with differences in age (six years older), a shift toward white and away from black (12.89%), and males being seen more frequently (11.87%). Injury severity score distribution shifted (7.72%) towards less severe trauma scores (<15), the percentage of patients with blunt trauma (4.19%) and falls increased (ground level and greater than 1 meter, 9.78%) while the number of patients considered full activations were decreased (15.67%). Proportions of OPM and NOPM trauma cases remained unchanged with the exception of a reduction in emergent operative trauma (3.1%). Resident case logs requirements were met both pre- and post-move. Conclusion Relocating the trauma center to a different zip code location did not negatively impact our resident case volumes. Total trauma volumes were increased, with a shift in the demographics and severity distribution of injuries.
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.30256
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Associating sleep problems with advanced cancer diagnosis, and immune checkpoint treatment outcomes: a pilot study.

Sillah, Arthur / Peters, Ulrike / Watson, Nathaniel F / Tykodi, Scott S / Hall, Evan T / Silverman, Allison / Malen, Rachel C / Thompson, John A / Lee, Sylvia M / Bhatia, Shailender / Veatch, Joshua / Warner, Jeannie / Thornton, Timothy / Phipps, Amanda I

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2022 Volume 30, Issue 5, Page(s) 3829–3838

Abstract: Background: Sleep problems (SP) are common in cancer patients but have not been previously assessed in patients receiving immune checkpoint inhibitors (ICI).: Methods: We collected questionnaire data on sleep apnea risk, insomnia, and general sleep ... ...

Abstract	Background: Sleep problems (SP) are common in cancer patients but have not been previously assessed in patients receiving immune checkpoint inhibitors (ICI). Methods: We collected questionnaire data on sleep apnea risk, insomnia, and general sleep patterns. We used an adjusted multivariate Poisson regression to calculate prevalence ratios (PRs) and associated 95% confidence intervals (CIs) for associations between these SP and metastatic versus localized cancer stage (M1 vs. M0), and adjusted logistic regression models to calculate ORs for associations between SP with the number of ICI infusions completed (6 + vs. < 6). Results: Among 32 patients who received ICI treatment, the prevalence of low, intermediate, and high-risk OSA risk was 36%, 42%, and 21%, respectively. Overall, 58% of participants reported clinically significant insomnia. We did not find a significant association between intermediate or high risk OSA (vs. low risk) and metastatic cancer status (PR = 1.01 (95% CI: 0.28, 3.67)). Patients in the cohort who reported taking > 15 min to fall asleep were 3.6 times more likely to be diagnosed with metastatic cancer compared to those reporting shorter sleep latency (95% CI (1.74, 7.35)). We did not find a significant association between SP and number of ICI infusions completed. Conclusion: Our data associating sleep apnea risk, insomnia, and sleep patterns with more advanced cancer encourages further exploration in larger-scale observational studies and suggests interventional clinical trials focused on sleep quality improvement that could result in better outcomes for these patients.
MeSH term(s)	Humans ; Neoplasms/complications ; Pilot Projects ; Polysomnography ; Sleep Apnea, Obstructive/epidemiology ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/etiology
Language	English
Publishing date	2022-01-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-022-06825-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3697: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Which Trauma Patients Require Lower Enoxaparin Dosing for Venous Thromboembolism Prophylaxis?

Veatch, Jessica / Hashim, Yassar / Dhillon, Navpreet K / Toscano, Samantha / Mason, Russell / Lin, Ting-Lung / Barmparas, Galinos / Ley, Eric J

The American surgeon

2020 Volume 86, Issue 10, Page(s) 1424–1427

Abstract: Trauma patients have a high risk for venous thromboembolism (VTE) such that an increased enoxaparin dose is necessary to reduce related complications. Given that most trauma patients require an enoxaparin dose of at least 40 mg every 12 hours for VTE ... ...

Abstract	Trauma patients have a high risk for venous thromboembolism (VTE) such that an increased enoxaparin dose is necessary to reduce related complications. Given that most trauma patients require an enoxaparin dose of at least 40 mg every 12 hours for VTE prophylaxis, we sought to identify which patients require enoxaparin 30 mg every 12 hours and hypothesized that both weight and low creatinine clearance (CrCl) would more likely determine enoxaparin dosing than age, body mass index (BMI), or body surface area (BSA). Single institution data were collected on trauma patients between August 2014 and February 2018 to compare trauma patients who required enoxaparin 30 mg to those who required ≥40 mg every 12 hours. Of the 245 patients included, 86 (35.1%) required enoxaparin at 30 mg to achieve the goal anti-factor Xa trough level. Factors associated with low dose enoxaparin were older age (59.6 vs. 46.2 years,
MeSH term(s)	Anticoagulants/administration & dosage ; Body Weight ; Creatinine/metabolism ; Drug Administration Schedule ; Enoxaparin/administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Venous Thromboembolism/prevention & control ; Wounds and Injuries/complications
Chemical Substances	Anticoagulants ; Enoxaparin ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2020-11-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820964497
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uk I Zs.106: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Predictive lifestyle markers for efficacy of cancer immune checkpoint inhibitors: a commentary.

Sillah, Arthur / Tykodi, Scott S / Hall, Evan T / Thompson, John A / Watson, Nathaniel F / Lee, Sylvia M / Bhatia, Shailender / Veatch, Joshua / Warner, Jeannie / Peters, Ulrike / Malen, Rachel C / Silverman, Allison / Phipps, Amanda I

Future oncology (London, England)

2021 Volume 17, Issue 4, Page(s) 363–369

Abstract: Lifestyle factors could plausibly modulate the host immune system, the tumor microenvironment and, hence, immune checkpoint inhibitor (ICI) response. As such, these factors should be considered in ICI studies. ...

Abstract	Lifestyle factors could plausibly modulate the host immune system, the tumor microenvironment and, hence, immune checkpoint inhibitor (ICI) response. As such, these factors should be considered in ICI studies.
MeSH term(s)	Complementary Therapies ; Exercise ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Life Style ; Neoplasms/drug therapy ; Neoplasms/psychology ; Obesity/complications ; Smoking/adverse effects ; Stress, Psychological/etiology
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-01-05
Publishing country	England
Document type	Editorial ; Review
ZDB-ID	2274956-1
ISSN	1744-8301 ; 1479-6694
ISSN (online)	1744-8301
ISSN	1479-6694
DOI	10.2217/fon-2020-0730
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6478: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Rhodotorula minuta fungemia in a ewe lamb.

Chitko-McKown, C G / Leymaster, K A / Heaton, M P / Griffin, D D / Veatch, J K / Jones, S A / Clawson, M L

Transboundary and emerging diseases

2014 Volume 61, Issue 6, Page(s) e76–8

Abstract: An 8-month-old crossbred ewe, normal upon physical examination, was humanely euthanized for tissue collection. After approximately 3 weeks in tissue culture, fungi began budding out of cells obtained from the choroid plexus. After an additional 3 weeks, ... ...

Abstract	An 8-month-old crossbred ewe, normal upon physical examination, was humanely euthanized for tissue collection. After approximately 3 weeks in tissue culture, fungi began budding out of cells obtained from the choroid plexus. After an additional 3 weeks, budding was observed in kidney cell cultures and eventually in monocyte cultures as well. Serum from the lamb was submitted to the Veterinary Diagnostic Laboratory at Colorado State University for fungal diagnosis and was found negative for Aspergillus, Blastomyces, Coccidioidomycosis and Histoplasmosis. DNA was isolated from fungi collected from tissue culture supernatants and used in a set of pan-fungal PCR assays with DNA from Candida acting as a positive control. PCR products were sequenced and BLAST analysis performed. The unknown fungal sequence aligned with 100% identity to Rhodotorula minuta an emerging opportunistic pathogen. Samples were submitted to The Fungal Testing Laboratory at The University of Texas Health Science Center at San Antonio for additional validation. We believe this to be the first report of Rhodotorula fungemia in a sheep in the United States.
MeSH term(s)	Animals ; Antifungal Agents ; Colorado ; Fungemia/microbiology ; Polymerase Chain Reaction ; Rhodotorula/isolation & purification ; Sheep ; Sheep Diseases/microbiology
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2014-12
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.12062
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Cerebrospinal nematodiasis in a white-handed gibbon (Hylobates lar) due to Baylisascaris sp.

Ball, R L / Dryden, M / Wilson, S / Veatch, J

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

1998 Volume 29, Issue 2, Page(s) 221–224

Abstract: An adult white-handed gibbon (Hylobates lar) at a zoo in eastern Kansas was euthanized after developing a head tremor, generalized motor incoordination, and partial paresis of the right arm that persisted over 2 yr. Magnetic resonance imaging early in ... ...

Abstract	An adult white-handed gibbon (Hylobates lar) at a zoo in eastern Kansas was euthanized after developing a head tremor, generalized motor incoordination, and partial paresis of the right arm that persisted over 2 yr. Magnetic resonance imaging early in the course of the disease demonstrated a localized left frontal lobe cerebritis. Larvae morphologically consistent with a Baylisascaris species were seen in tissue sections of the cerebrum and cerebellum. Epizootiologic investigation, which included qualitative fecal flotations, evaluation of soil samples for nematode eggs, and necropsy examination of livetrapped raccoons (Procyon lotor), indicated that Baylisascaris procyonis was most likely to have caused the cerebrospinal nematodiasis in this gibbon.
MeSH term(s)	Animals ; Animals, Zoo ; Ascaridida Infections/parasitology ; Ascaridida Infections/pathology ; Ascaridida Infections/veterinary ; Ascaridoidea/isolation & purification ; Brain/parasitology ; Brain/pathology ; Central Nervous System Diseases/parasitology ; Central Nervous System Diseases/pathology ; Central Nervous System Diseases/veterinary ; Cerebellum/parasitology ; Cerebellum/pathology ; Female ; Hylobates/parasitology ; Magnetic Resonance Imaging/veterinary ; Neurologic Examination/veterinary ; Primate Diseases/parasitology ; Primate Diseases/pathology ; Raccoons
Language	English
Publishing date	1998-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2174930-9
ISSN	1937-2825 ; 1042-7260
ISSN (online)	1937-2825
ISSN	1042-7260
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Rhodotorula minuta fungemia in a ewe lamb

Chitko‐McKown, C. G / Leymaster, K. A / Heaton, M. P / Griffin, D. D / Veatch, J. K / Jones, S. A / Clawson, M. L

Transboundary and emerging diseases. 2014 Dec., v. 61, no. 6

2014

Abstract: An 8‐month‐old crossbred ewe, normal upon physical examination, was humanely euthanized for tissue collection. After approximately 3 weeks in tissue culture, fungi began budding out of cells obtained from the choroid plexus. After an additional 3 weeks, ... ...

Abstract	An 8‐month‐old crossbred ewe, normal upon physical examination, was humanely euthanized for tissue collection. After approximately 3 weeks in tissue culture, fungi began budding out of cells obtained from the choroid plexus. After an additional 3 weeks, budding was observed in kidney cell cultures and eventually in monocyte cultures as well. Serum from the lamb was submitted to the Veterinary Diagnostic Laboratory at Colorado State University for fungal diagnosis and was found negative for Aspergillus, Blastomyces, Coccidioidomycosis and Histoplasmosis. DNA was isolated from fungi collected from tissue culture supernatants and used in a set of pan‐fungal PCR assays with DNA from Candida acting as a positive control. PCR products were sequenced and BLAST analysis performed. The unknown fungal sequence aligned with 100% identity to Rhodotorula minuta an emerging opportunistic pathogen. Samples were submitted to The Fungal Testing Laboratory at The University of Texas Health Science Center at San Antonio for additional validation. We believe this to be the first report of Rhodotorula fungemia in a sheep in the United States.
Keywords	Aspergillus ; Blastomyces ; Candida ; DNA ; Rhodotorula ; blood serum ; cell culture ; choroid plexus ; clinical examination ; coccidioidomycosis ; ewes ; fungi ; histoplasmosis ; kidneys ; pathogens ; polymerase chain reaction ; tissue culture ; Texas
Language	English
Dates of publication	2014-12
Size	p. e76-e78.
Publishing place	Blackwell Science
Document type	Article
ZDB-ID	2414822-2
ISSN	1865-1682 ; 1865-1674
ISSN (online)	1865-1682
ISSN	1865-1674
DOI	10.1111/tbed.12062
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Metastatic adenocarcinoma of the mammary gland in a Père David's deer.

Veatch, J K / Carpenter, J W

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

1993 Volume 5, Issue 4, Page(s) 639–640

MeSH term(s)	Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Adenocarcinoma/veterinary ; Animals ; Connective Tissue/pathology ; Deer ; Female ; Mammary Glands, Animal/pathology ; Mammary Neoplasms, Animal/diagnosis ; Mammary Neoplasms, Animal/pathology ; Necrosis ; Neoplasm Metastasis
Language	English
Publishing date	1993-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/104063879300500428
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito