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  1. Book: Calcium signalling

    Raffaello, Anna / Vecellio Reane, Denis

    methods and protocols

    (Methods in molecular biology ; 1925 ; Springer protocols)

    2019  

    Author's details edited by Anna Raffaello (Department of Biomedical Sciences, University of Padua, Padua, Italy), Denis Vecellio Reane (Department of Biomedical Sciences, University of Padua, Padua, Italy)
    Series title Methods in molecular biology ; 1925
    Springer protocols
    Collection
    Language English
    Size xiii, 246 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019982666
    ISBN 978-1-4939-9017-7 ; 9781493990184 ; 1-4939-9017-9 ; 1493990187
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1925- verfügbar in Königswinter Königswinter

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  2. Article: Neither too much nor too little: mitochondrial calcium concentration as a balance between physiological and pathological conditions.

    D'Angelo, Donato / Vecellio Reane, Denis / Raffaello, Anna

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1336416

    Abstract: ... ...

    Abstract Ca
    Language English
    Publishing date 2023-12-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1336416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.

    Vecellio Reane, Denis / Cerqua, Cristina / Sacconi, Sabrina / Salviati, Leonardo / Trevisson, Eva / Raffaello, Anna

    International journal of molecular sciences

    2022  Volume 23, Issue 5

    Abstract: Alternative splicing, the process by which exons within a pre-mRNA transcript are differentially joined or skipped, is crucial in skeletal muscle since it is required both during myogenesis and in post-natal life to reprogram the transcripts of ... ...

    Abstract Alternative splicing, the process by which exons within a pre-mRNA transcript are differentially joined or skipped, is crucial in skeletal muscle since it is required both during myogenesis and in post-natal life to reprogram the transcripts of contractile proteins, metabolic enzymes, and transcription factors in functionally distinct muscle fiber types. The importance of such events is underlined by the numerosity of pathological conditions caused by alternative splicing aberrations. Importantly, many skeletal muscle Ca
    MeSH term(s) Calcium/metabolism ; Calcium Channels/metabolism ; Calcium-Binding Proteins/genetics ; Calcium-Binding Proteins/metabolism ; Cation Transport Proteins/genetics ; Cation Transport Proteins/metabolism ; Humans ; Mitochondrial Membrane Transport Proteins/genetics ; Mitochondrial Membrane Transport Proteins/metabolism ; Muscle Development/genetics ; RNA Splicing Factors/genetics ; RNA Splicing Factors/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism
    Chemical Substances Calcium Channels ; Calcium-Binding Proteins ; Cation Transport Proteins ; MICU1 protein, human ; Mitochondrial Membrane Transport Proteins ; RBFOX2 protein, human ; RNA Splicing Factors ; Repressor Proteins ; mitochondrial calcium uniporter ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23052517
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  4. Article ; Online: The molecular complexity of the Mitochondrial Calcium Uniporter.

    Feno, Simona / Rizzuto, Rosario / Raffaello, Anna / Vecellio Reane, Denis

    Cell calcium

    2020  Volume 93, Page(s) 102322

    Abstract: The role of mitochondria in regulating cellular ... ...

    Abstract The role of mitochondria in regulating cellular Ca
    MeSH term(s) Animals ; Calcium Channels/chemistry ; Calcium Channels/metabolism ; Humans ; Models, Biological ; Organ Specificity ; Protein Subunits/metabolism ; Structure-Activity Relationship
    Chemical Substances Calcium Channels ; Protein Subunits ; mitochondrial calcium uniporter
    Language English
    Publishing date 2020-11-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake.

    Butera, Gaia / Vecellio Reane, Denis / Canato, Marta / Pietrangelo, Laura / Boncompagni, Simona / Protasi, Feliciano / Rizzuto, Rosario / Reggiani, Carlo / Raffaello, Anna

    Cell reports

    2021  Volume 35, Issue 5, Page(s) 109087

    Abstract: Parvalbumin (PV) is a cytosolic ... ...

    Abstract Parvalbumin (PV) is a cytosolic Ca
    MeSH term(s) Animals ; Calcium Channels/metabolism ; Humans ; Mice ; Muscle, Skeletal/metabolism ; Parvalbumins/metabolism ; Transfection
    Chemical Substances Calcium Channels ; Parvalbumins ; mitochondrial calcium uniporter
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109087
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  6. Article ; Online: Crosstalk between Calcium and ROS in Pathophysiological Conditions.

    Feno, Simona / Butera, Gaia / Vecellio Reane, Denis / Rizzuto, Rosario / Raffaello, Anna

    Oxidative medicine and cellular longevity

    2019  Volume 2019, Page(s) 9324018

    Abstract: Calcium ions are highly versatile intracellular signals that regulate many cellular processes. The key to achieving this pleiotropic role is the spatiotemporal control of calcium concentration evoked by an extensive molecular repertoire of signalling ... ...

    Abstract Calcium ions are highly versatile intracellular signals that regulate many cellular processes. The key to achieving this pleiotropic role is the spatiotemporal control of calcium concentration evoked by an extensive molecular repertoire of signalling components. Among these, reactive oxygen species (ROS) signalling, together with calcium signalling, plays a crucial role in controlling several physiopathological events. Although initially considered detrimental by-products of aerobic metabolism, it is now widely accepted that ROS, in subtoxic levels, act as signalling molecules. However, dysfunctions in the mechanisms controlling the physiological ROS concentration affect cellular homeostasis, leading to the pathogenesis of various disorders.
    MeSH term(s) Calcium/metabolism ; Cell Physiological Phenomena/physiology ; Humans ; Reactive Oxygen Species/metabolism
    Chemical Substances Reactive Oxygen Species ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-04-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2019/9324018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Mitochondrial calcium uptake in organ physiology: from molecular mechanism to animal models.

    Mammucari, Cristina / Raffaello, Anna / Vecellio Reane, Denis / Gherardi, Gaia / De Mario, Agnese / Rizzuto, Rosario

    Pflugers Archiv : European journal of physiology

    2018  Volume 470, Issue 8, Page(s) 1165–1179

    Abstract: Mitochondrial ... ...

    Abstract Mitochondrial Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels/metabolism ; Calcium Signaling/physiology ; Humans ; Mitochondria/metabolism ; Mitochondria/physiology ; Models, Animal ; Sodium-Calcium Exchanger/metabolism
    Chemical Substances Calcium Channels ; Sodium-Calcium Exchanger ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-03-15
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-018-2123-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.35: Show issues Location:
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  8. Article: Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter.

    Mammucari, Cristina / Raffaello, Anna / Vecellio Reane, Denis / Rizzuto, Rosario

    Biochimica et biophysica acta

    2016  Volume 1863, Issue 10, Page(s) 2457–2464

    Abstract: Mitochondrial Ca(2+) uptake regulates a wide array of cell functions, from stimulation of aerobic metabolism and ATP production in physiological settings, to induction of cell death in pathological conditions. The molecular identity of the Mitochondrial ... ...

    Abstract Mitochondrial Ca(2+) uptake regulates a wide array of cell functions, from stimulation of aerobic metabolism and ATP production in physiological settings, to induction of cell death in pathological conditions. The molecular identity of the Mitochondrial Calcium Uniporter (MCU), the highly selective channel responsible for Ca(2+) entry through the IMM, has been described less than five years ago. Since then, research has been conducted to clarify the modulation of its activity, which relies on the dynamic interaction with regulatory proteins, and its contribution to the pathophysiology of organs and tissues. Particular attention has been placed on characterizing the role of MCU in cardiac and skeletal muscles. In this review we summarize the molecular structure and regulation of the MCU complex in addition to its pathophysiological role, with particular attention to striated muscle tissues. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou.
    MeSH term(s) Animals ; Calcium/metabolism ; Calcium Channels/chemistry ; Calcium Channels/deficiency ; Calcium Channels/physiology ; Calcium Signaling ; Calcium-Binding Proteins/deficiency ; Disease Models, Animal ; Humans ; Ion Transport/physiology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Mitochondria, Heart/metabolism ; Mitochondria, Muscle/metabolism ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/physiopathology ; Mitochondrial Membrane Transport Proteins/chemistry ; Mitochondrial Membrane Transport Proteins/deficiency ; Mitochondrial Membrane Transport Proteins/physiology ; Mitochondrial Membranes/metabolism ; Muscle Proteins/chemistry ; Muscle Proteins/physiology ; Organ Specificity ; Protein Conformation
    Chemical Substances Calcium Channels ; Calcium-Binding Proteins ; MICU1 protein, mouse ; Mitochondrial Membrane Transport Proteins ; Muscle Proteins ; mitochondrial calcium uniporter ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2016
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbamcr.2016.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  9. Article ; Online: Publisher Correction: Parkin-dependent regulation of the MCU complex component MICU1.

    Matteucci, Alessandra / Patron, Maria / Vecellio Reane, Denis / Gastaldello, Stefano / Amoroso, Salvatore / Rizzuto, Rosario / Brini, Marisa / Raffaello, Anna / Calì, Tito

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 4665

    Abstract: A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    Abstract A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
    Language English
    Publishing date 2019-03-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-37929-1
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  10. Article ; Online: Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.

    De Mario, Agnese / Tosatto, Anna / Hill, Julia Marie / Kriston-Vizi, Janos / Ketteler, Robin / Vecellio Reane, Denis / Cortopassi, Gino / Szabadkai, Gyorgy / Rizzuto, Rosario / Mammucari, Cristina

    Cell reports

    2021  Volume 35, Issue 12, Page(s) 109275

    Abstract: The mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial ... ...

    Abstract The mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca
    MeSH term(s) Animals ; Apoptosis/drug effects ; Benzethonium/pharmacology ; Breast Neoplasms/pathology ; Calcium/metabolism ; Calcium Channels/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cytoprotection/drug effects ; Duloxetine Hydrochloride/pharmacology ; Energy Metabolism/drug effects ; Female ; High-Throughput Screening Assays ; Homeostasis/drug effects ; Humans ; Hypertrophy ; Mice ; Mitochondria/drug effects ; Mitochondria/metabolism ; Morpholines/pharmacology ; Muscle Fibers, Skeletal/drug effects ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/pathology ; Oxygen Consumption/drug effects ; Reactive Oxygen Species/metabolism ; Reproducibility of Results ; United States ; United States Food and Drug Administration
    Chemical Substances Calcium Channels ; Morpholines ; Reactive Oxygen Species ; mitochondrial calcium uniporter ; Benzethonium (1VU15B70BP) ; Duloxetine Hydrochloride (9044SC542W) ; amorolfine (AB0BHP2FH0) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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