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Article ; Online: Posterior reversible encephalopathy and Guillain-Barré syndrome: which came first, the chicken or the egg? A review of literature.

Storti, Benedetta / Vedovello, Marcella / Riva, Riccardo / Agazzi, Emanuela / Censori, Bruno / Manara, Ornella / Sessa, Maria / Rottoli, Maria Rosa

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2020 Volume 41, Issue 12, Page(s) 3663–3666

Abstract: Posterior reversible encephalopathy (PRES) is a rare occurrence in patients with Guillain-Barré syndrome (GBS) with only nine adult cases reported to date. We conducted a review of the literature and compared previous cases with a novel case admitted to ... ...

Abstract	Posterior reversible encephalopathy (PRES) is a rare occurrence in patients with Guillain-Barré syndrome (GBS) with only nine adult cases reported to date. We conducted a review of the literature and compared previous cases with a novel case admitted to our clinic. In light of the timing of the symptoms, it is assumable that arterial hypertension can develop acutely during a phase of GBS-related autonomic dysfunction and subsequently precipitates PRES. According to this, dysautonomia caused by GBS could precede motor weakness; thus, PRES in the absence of any strong alternative etiology may suggest an underlying GBS.
MeSH term(s)	Ambulatory Care Facilities ; Brain Diseases ; Guillain-Barre Syndrome/complications ; Guillain-Barre Syndrome/diagnosis ; Humans ; Hypertension ; Posterior Leukoencephalopathy Syndrome
Language	English
Publishing date	2020-06-06
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-020-04496-1
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Article ; Online: Persistent Interictal Musical Hallucination in a Patient With Mesial Temporal Sclerosis-Related Epilepsy: First Case Report and Etiopathological Hypothesis.

Borelli, Paolo / Vedovello, Marcella / Braga, Massimiliano / Pederzoli, Massimo / Beretta, Sandro

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

2016 Volume 29, Issue 4, Page(s) 217–221

Abstract: Musical hallucination is a disorder of complex sound processing of instrumental music, songs, choirs, chants, etc. The underlying pathologies include moderate to severe acquired hearing loss (the auditory equivalent of Charles Bonnet syndrome), ... ...

Abstract	Musical hallucination is a disorder of complex sound processing of instrumental music, songs, choirs, chants, etc. The underlying pathologies include moderate to severe acquired hearing loss (the auditory equivalent of Charles Bonnet syndrome), psychiatric illnesses (depression, schizophrenia), drug intoxication (benzodiazepines, salicylate, pentoxifylline, propranolol), traumatic lesions along the acoustic pathways, and epilepsy. The hallucinations are most likely to begin late in life; 70% of patients are women. Musical hallucination has no known specific therapy. Treating the underlying cause is the most effective approach; neuroleptic and antidepressant medications have only rarely succeeded.Musical hallucination in epilepsy typically presents as simple partial seizures originating in the lateral temporal cortex. To our knowledge, no formal report of musical hallucination in the interictal state has been published before. In contrast, other interictal psychotic features are a relatively common complication, especially in patients with long-standing drug-resistant epilepsy.We describe a 62-year-old woman with a long history of mesial temporal lobe epilepsy whose musical hallucination was solely interictal. We speculate on the possible link between temporal epilepsy and her hallucination. We hypothesize that, as a result of her epileptic activity-induced damage, an imbalance developed between the excitatory and inhibitory projections connecting the mesial temporal cortex to the other auditory structures. These structures may have generated hyperactivity in the lateral temporal cortex through a "release" mechanism that eventually resulted in musical hallucination.
MeSH term(s)	Epilepsy, Temporal Lobe/complications ; Epilepsy, Temporal Lobe/pathology ; Female ; Hallucinations/etiology ; Humans ; Middle Aged ; Music ; Sclerosis ; Temporal Lobe/pathology
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2108112-8
ISSN	1543-3641 ; 1543-3633
ISSN (online)	1543-3641
ISSN	1543-3633
DOI	10.1097/WNN.0000000000000111
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Zs.A 2439: Show issues

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Article ; Online: Diogenes syndrome in patients suffering from dementia.

Cipriani, Gabriele / Lucetti, Claudio / Vedovello, Marcella / Nuti, Angelo

Dialogues in clinical neuroscience

2013 Volume 14, Issue 4, Page(s) 455–460

Abstract: Diogenes syndrome (DS) is a behavioral disorder of the elderly. Symptoms include living in extreme squalor, a neglected physical state, and unhygienic conditions. This is accompanied by a self-imposed isolation, the refusal of external help, and a ... ...

Abstract	Diogenes syndrome (DS) is a behavioral disorder of the elderly. Symptoms include living in extreme squalor, a neglected physical state, and unhygienic conditions. This is accompanied by a self-imposed isolation, the refusal of external help, and a tendency to accumulate unusual objects. To explore the phenomenon of DS in dementia we searched for the terms: "Diogenes syndrome, self-neglect, dementia. " It has long been understood that individuals with dementia often become shut-ins, living in squalor, in the Eastern Baltimore study, dementia was present in 15% of the elderly cases with moderate and severe social breakdown syndrome; twice as many as in the general population of the same age group. Researchers have underlined the frequent presence of DS (36%) in frontotemporal dementia (FTD): different neuropsychological modifications in FTD may contribute to symptoms of DS. The initial treatment should be a behavioral program, but there is not sufficient information regarding pharmacological treatment of the syndrome.
MeSH term(s)	Aged, 80 and over ; Dementia/complications ; Female ; Frail Elderly/psychology ; Homebound Persons/psychology ; Humans ; Male ; Mental Disorders/complications ; Mental Disorders/epidemiology ; Social Isolation
Language	English
Publishing date	2013-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2188781-0
ISSN	1958-5969 ; 1294-8322
ISSN (online)	1958-5969
ISSN	1294-8322
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Zs.A 6188: Show issues

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Article ; Online: Understanding delusion in dementia: a review.

Cipriani, Gabriele / Danti, Sabrina / Vedovello, Marcella / Nuti, Angelo / Lucetti, Claudio

Geriatrics & gerontology international

2014 Volume 14, Issue 1, Page(s) 32–39

Abstract: Alzheimer's disease and other dementia are associated with cognitive and functional impairment, as well as neuropsychiatric sequelae, including psychotic features. Research has largely concentrated on the study of cognitive decline, but the associated ... ...

Abstract	Alzheimer's disease and other dementia are associated with cognitive and functional impairment, as well as neuropsychiatric sequelae, including psychotic features. Research has largely concentrated on the study of cognitive decline, but the associated behavioral and neuropsychiatric symptoms are of equal importance in the clinical profile of the disease. Delusions are common, disabling and persistent in the course of dementia. The purpose of the present review was to examine the phenomenon of delusion in people with dementia. We searched the electronic databases for original research and review articles using the search terms "delusion, dementia, Alzheimer's disease, frontotemporal dementia, vascular dementia and Lewy body disease". Various types of explanations have been proposed regarding the etiology of delusional belief in dementia, and cerebral correlates are considered. Pharmacological and non-pharmacological treatments are analyzed.
MeSH term(s)	Aged ; Cognition/physiology ; Delusions/etiology ; Delusions/psychology ; Dementia/complications ; Dementia/psychology ; Geriatric Assessment ; Humans ; Neuropsychological Tests
Language	English
Publishing date	2014-01
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.12105
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Article ; Online: Repetitive and stereotypic phenomena and dementia.

Cipriani, Gabriele / Vedovello, Marcella / Ulivi, Martina / Nuti, Angelo / Lucetti, Claudio

American journal of Alzheimer's disease and other dementias

2013 Volume 28, Issue 3, Page(s) 223–227

Abstract: Background: Behavioral disturbances of dementia, such as repetitive and stereotypic phenomena, can be distressing to caregivers and may lead to early institutionalization of the patient.: Objective: The purpose of this article is to examine the ... ...

Abstract	Background: Behavioral disturbances of dementia, such as repetitive and stereotypic phenomena, can be distressing to caregivers and may lead to early institutionalization of the patient. Objective: The purpose of this article is to examine the phenomenon of repetitive phenomena in patients with dementia. Methods: We searched the PubMed electronic databases for original research and review articles on repetitive phenomena in patients with dementia using the search terms "repetitive behavior, stereotypic behavior, dementia, Alzheimer's disease, Frontotemporal dementia." Results: Repetitive and stereotypic phenomena are common problems in dementia, which may reflect a disruption of coordinated function within the basal ganglia or corticostriatal structures. Conclusions: There are no systematic studies concerning repetitive phenomena in patients with dementia, and very little is known about the treatment. Further studies are needed to determine the specific phenomena.
MeSH term(s)	Aged ; Alzheimer Disease/physiopathology ; Dementia/physiopathology ; Frontotemporal Dementia/physiopathology ; Humans ; Stereotyped Behavior
Language	English
Publishing date	2013-03-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1283069-0
ISSN	1938-2731 ; 0895-5336 ; 1082-5207 ; 1533-3175
ISSN (online)	1938-2731
ISSN	0895-5336 ; 1082-5207 ; 1533-3175
DOI	10.1177/1533317513481094
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Zs.A 3299: Show issues

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Article ; Online: The impact of the COVID-19 pandemic on people with neurological disorders: an urgent need to enhance the health care system's preparedness.

Zullo, Silvia / Ingravallo, Francesca / Crespi, Vittorio / Cascioli, Marta / D'Alessandro, Roberto / Gasperini, Marcella / Lalli, Chiara / Lugaresi, Alessandra / Marogna, Maura / Mori, Maurizio / Pesci, Ilaria / Pistoia, Francesca / Porteri, Corinna / Vedovello, Marcella / Veronese, Simone / Pucci, Eugenio / Solari, Alessandra

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 42, Issue 3, Page(s) 799–804

MeSH term(s)	COVID-19 ; Civil Defense ; Communication ; Delivery of Health Care/organization & administration ; Health Education ; Humans ; Italy ; Nervous System Diseases/therapy ; Pandemics
Language	English
Publishing date	2021-01-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-020-04984-4
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Article ; Online: Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients.

Diamanti, Luca / Borrelli, Paola / Dubbioso, Raffaele / Capasso, Margherita / Morelli, Claudia / Lunetta, Christian / Petrucci, Antonio / Mora, Gabriele / Volanti, Paolo / Inghilleri, Maurizio / Tremolizzo, Lucio / Mandrioli, Jessica / Mazzini, Letizia / Vedovello, Marcella / Siciliano, Gabriele / Filosto, Massimiliano / Matà, Sabrina / Montomoli, Cristina

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 43, Issue 5, Page(s) 3195–3200

Abstract: Background: Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for the screening of dysphagia in ALS is validated, and the approach is ... ...

Abstract	Background: Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for the screening of dysphagia in ALS is validated, and the approach is heterogeneous across the Italian centres. Objective: To validate the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire, adapting the DYMUS (dysphagia in multiple sclerosis) questionnaire, for the assessment of dysphagia in ALS patients, in order to uniform the evaluations across the Italian ALS network. Methods: We included 197 patients diagnosed with ALS following the El Escorial criteria, in sixteen Italian ALS centres between 1st December 2019 and 1st July 2020. For each patient, we collected clinical and demographic data and obtained ALSFRS-r score, ALSAQ-5 score, DYMUS score, and EAT-10 score. Results: Across the 197 patients, the ratio M/F was 113/84, and the median age was 64 years (IQR 56-72.5). Bulbar patients were 20%, and spinal patients 80%. The median ALSFRSr total score of patients was 35 (IQR 28-39). DYALS score was statistically higher in bulbar ALS than in spinal ALS (median = 6, IQR 4.5-9 vs median = 1, IQR 0-5, z = 6.253, p < 0.0001). DYALS questionnaire showed a high internal consistency (Cronbach's alpha = 0.88). There was a statistically significant correlation between DYALS and EAT-10 (rho = 0.90, p < 0.0001). Conclusions: DYALS scale is reliable, manageable, and easily usable for the screening of dysphagia in ALS. It can be shared with all the Italian ALS centres in order to collect uniform data for therapeutic strategies and clinical trials.
MeSH term(s)	Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnosis ; Deglutition Disorders/diagnosis ; Deglutition Disorders/etiology ; Humans ; Middle Aged ; Multiple Sclerosis/diagnosis ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-12-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05775-1
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Article ; Online: Dangerous passion: Othello syndrome and dementia.

Cipriani, Gabriele / Vedovello, Marcella / Nuti, Angelo / di Fiorino, Andrea

Psychiatry and clinical neurosciences

2012 Volume 66, Issue 6, Page(s) 467–473

Abstract: Jealousy is a complex emotion that most people have experienced at some time in life; pathological jealousy refers primarily to an irrational state. Othello syndrome is a psychotic disorder characterized by delusion of infidelity or jealousy; it often ... ...

Abstract	Jealousy is a complex emotion that most people have experienced at some time in life; pathological jealousy refers primarily to an irrational state. Othello syndrome is a psychotic disorder characterized by delusion of infidelity or jealousy; it often occurs in the context of medical, psychiatric or neurological disorders. At least 30% of cases in the literature show a neurological basis for their delusion of infidelity, although its biological basis is not fully understood. The purpose of this paper is to examine the phenomenon of pathological jealousy in people with dementia. We searched the electronic databases for original research and review articles on Othello syndrome in demented patients using the search terms 'Othello syndrome, morbid jealousy, pathological jealousy, delusional disorders, dementia'. Convictions about the partner's infidelities may form the content of psychopathological phenomena, such as delusions. Delusional jealousy is a frequent problem in dementia. Coexistent delusions and hallucinations are frequent. The violence in demented patients suffering from this syndrome is well documented and forensic aspects are highlighted. There are no systematic researches about the clinical characteristics of Othello syndrome in persons suffering from dementia, but only case reports and it is not possible to differentiate or compare differences of delusional jealousy across the various type of dementia or distinguish the syndrome in demented patients from the syndrome in other psychiatric disorders. Frontal lobe dysfunction may be called into question in delineating the cause of the delusional jealousy seen in Othello syndrome.
MeSH term(s)	Delusions/psychology ; Dementia/psychology ; Forensic Psychiatry ; Humans ; Inpatients ; Jealousy ; Psychotic Disorders/psychology
Language	English
Publishing date	2012-10
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	1292906-2
ISSN	1440-1819 ; 1323-1316
ISSN (online)	1440-1819
ISSN	1323-1316
DOI	10.1111/j.1440-1819.2012.02386.x
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Article ; Online: Localized calcific hematoma of the scalp presenting as a nummular-like headache: a case report.

Ulivi, Martina / Baldacci, Filippo / Vedovello, Marcella / Vergallo, Andrea / Borelli, Paolo / Nuti, Angelo / Bonuccelli, Ubaldo

Headache

2014 Volume 54, Issue 2, Page(s) 370–372

MeSH term(s)	Calcinosis/complications ; Calcinosis/diagnosis ; Female ; Headache/diagnosis ; Headache/etiology ; Hematoma/complications ; Hematoma/diagnosis ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Remission, Spontaneous ; Scalp ; Skin Diseases/complications ; Skin Diseases/diagnosis ; Tomography, X-Ray Computed
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.12131
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Article ; Online: The Italian multicenter experience with edaravone in amyotrophic lateral sclerosis.

Lunetta, Christian / Moglia, Cristina / Lizio, Andrea / Caponnetto, Claudia / Dubbioso, Raffaele / Giannini, Fabio / Matà, Sabrina / Mazzini, Letizia / Sabatelli, Mario / Siciliano, Gabriele / Simone, Isabella Laura / Sorarù, Gianni / Toriello, Antonella / Trojsi, Francesca / Vedovello, Marcella / D'Ovidio, Fabrizio / Filippi, Massimo / Calvo, Andrea

Journal of neurology

2020 Volume 267, Issue 11, Page(s) 3258–3267

Abstract: Objectives: The aim of the study is to analyze the ALS disease progression and respiratory function of Italian patients treated with edaravone (EVN), as well as the adherence to, and the effects of, the therapy.: Methods: We performed an ... ...

Abstract	Objectives: The aim of the study is to analyze the ALS disease progression and respiratory function of Italian patients treated with edaravone (EVN), as well as the adherence to, and the effects of, the therapy. Methods: We performed an observational study of patients treated with EVN from May 2017 to May 2019, in 39 Italian ALS Centers. Taking into account ALS patients with at least 12 months of EVN treatment, we compared the decline of ALSFRS-R and FVC with a group of matched historical controls from the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database, using both descriptive and survival analysis approaches. Results: A total of 331 ALS Italian patients treated with EVN and 290 matched historical controls were recruited in this study. No significant differences on disease progression or respiratory function were found comparing the two cohorts in both descriptive and survival analyses. The EVN treatment was overall well tolerated. Conclusions: The study showed that EVN treatment was well tolerated. No significant differences were reported in ALS patients treated and not treated with EVN, in terms of both disease progression and respiratory function. These findings prove that further studies are required to better clarify whether EVN could be considered an effective treatment for ALS disease.
MeSH term(s)	Amyotrophic Lateral Sclerosis/drug therapy ; Disease Progression ; Edaravone ; Humans ; Italy ; Treatment Outcome
Chemical Substances	Edaravone (S798V6YJRP)
Language	English
Publishing date	2020-06-17
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-020-09993-z
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