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  1. AU="Vee Sin Lee, Peter"
  2. AU="Zhu, Yali"
  3. AU="Jiang-Qi Liu"
  4. AU="Moores, Roxanna"

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  1. Article ; Online: Effects of in vivo fatigue-induced microdamage on local subchondral bone strains.

    Malekipour, Fatemeh / Hitchens, Peta L / Whitton, R Chris / Vee-Sin Lee, Peter

    Journal of the mechanical behavior of biomedical materials

    2022  Volume 136, Page(s) 105491

    Abstract: Biomechanical strain is a major stimulus of subchondral bone (SCB) tissue adaptation in joints but may also lead to initiation and propagation of microcracks, highlighting the importance of quantifying the intratissue strain in subchondral bone. In the ... ...

    Abstract Biomechanical strain is a major stimulus of subchondral bone (SCB) tissue adaptation in joints but may also lead to initiation and propagation of microcracks, highlighting the importance of quantifying the intratissue strain in subchondral bone. In the present study, we used micro computed tomography (μCT) imaging, mechanical testing, and digital image correlation (DIC) techniques to evaluate the biomechanical strains in equine SCB under impact compression applied through the articular surface. We aimed to investigate the effects of in vivo accumulated microdamage in equine SCB on the distribution of mechanical impact strain through the articular cartilage. Under the applied strain of 2.0 ± 0.1% (mean ± standard deviation, n=15) to the articular surface of cartilage-bone plugs, the overall thickness of the SCB developed e
    MeSH term(s) Animals ; Horses ; X-Ray Microtomography ; Muscle Fatigue ; Bone and Bones/diagnostic imaging ; Cartilage, Articular/diagnostic imaging ; Pressure
    Language English
    Publishing date 2022-09-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2022.105491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Low-Profile Electromagnetic Field Sensors in the Measurement and Modelling of Three-Dimensional Jaw Kinematics and Occlusal Loading.

    Woodford, Sarah C / Robinson, Dale L / Edelmann, Cornelia / Mehl, Albert / Röhrle, Oliver / Vee Sin Lee, Peter / Ackland, David C

    Annals of biomedical engineering

    2021  Volume 49, Issue 6, Page(s) 1561–1571

    Abstract: Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a ... ...

    Abstract Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a modelling framework to evaluate subject-specific dynamic occlusal loading during chewing and biting over the entire dental arch. Measurements of jaw motion were performed on one healthy male adult using low-profile electromagnetic field sensors attached to the teeth, and occlusal anatomy quantified using an intra-oral scanner. During testing, the subject chewed and maximally compressed a piece of rubber between both second molars, first molars, premolars and their central incisors. The occlusal anatomy, rubber geometry and experimentally measured rubber material properties were combined in a finite element model. The measured mandibular motion was used to kinematically drive model simulations of chewing and biting of the rubber sample. Three-dimensional dynamic bite forces and contact pressures across the occlusal surfaces were then calculated. Both chewing and biting on the first molars produced the highest bite forces across the dental arch, and a large amount of anterior shear force was produced at the incisors and the second molars. During chewing, the initial tooth-rubber contact evolved from the buccal sides of the molars to the lingual sides at full mouth closure. Low-profile electromagnetic field sensors were shown to provide a clinically relevant measure of jaw kinematics with sufficient accuracy to drive finite element models of occlusal loading during chewing and biting. The modelling framework presented provides a basis for calculation of physiological, dynamic occlusal loading across the dental arch.
    MeSH term(s) Adult ; Biomechanical Phenomena ; Dental Occlusion ; Electromagnetic Fields ; Humans ; Jaw/physiology ; Male ; Mastication/physiology ; Models, Biological ; Patient-Specific Modeling ; Reproducibility of Results
    Language English
    Publishing date 2021-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185984-5
    ISSN 1573-9686 ; 0191-5649 ; 0090-6964
    ISSN (online) 1573-9686
    ISSN 0191-5649 ; 0090-6964
    DOI 10.1007/s10439-020-02688-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1018: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prosthesis loading after temporomandibular joint replacement surgery: a musculoskeletal modeling study.

    Ackland, David C / Moskaljuk, Adrian / Hart, Chris / Vee Sin Lee, Peter / Dimitroulis, George

    Journal of biomechanical engineering

    2015  Volume 137, Issue 4, Page(s) 41001

    Abstract: One of the most widely reported complications associated with temporomandibular joint (TMJ) prosthetic total joint replacement (TJR) surgery is condylar component screw loosening and instability. The objective of this study was to develop a ... ...

    Abstract One of the most widely reported complications associated with temporomandibular joint (TMJ) prosthetic total joint replacement (TJR) surgery is condylar component screw loosening and instability. The objective of this study was to develop a musculoskeletal model of the human jaw to assess the influence of prosthetic condylar component orientation and screw placement on condylar component loading during mastication. A three-dimensional model of the jaw comprising the maxilla, mandible, masticatory muscles, articular cartilage, and articular disks was developed. Simulations of mastication and a maximum force bite were performed for the natural TMJ and the TMJ after prosthetic TJR surgery, including cases for mastication where the condylar component was rotated anteriorly by 0 deg, 5 deg, 10 deg, and 15 deg. Three clinically significant screw configurations were investigated: a complete, posterior, and minimal-posterior screw (MPS) configuration. Increases in condylar anterior rotation led to an increase in prosthetic condylar component contact stresses and substantial increases in condylar component screw stresses. The use of more screws in condylar fixation reduced screw stress magnitudes and maximum condylar component stresses. Screws placed superiorly experienced higher stresses than those of all other condylar fixation screws. The results of the present study have important implication for the way in which prosthetic components are placed during TMJ prosthetic TJR surgery.
    MeSH term(s) Arthroplasty, Replacement ; Bone Screws ; Finite Element Analysis ; Humans ; Joint Prosthesis ; Male ; Mandibular Condyle/anatomy & histology ; Mandibular Condyle/physiology ; Models, Anatomic ; Muscles/anatomy & histology ; Muscles/physiology ; Stress, Mechanical ; Temporomandibular Joint/anatomy & histology ; Temporomandibular Joint/physiology ; Temporomandibular Joint/surgery ; Weight-Bearing
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4029503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2672: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A novel gait platform to measure isolated plantar metatarsal forces during walking.

    Chen, Wen-Ming / Vee-Sin Lee, Peter / Park, Seung-Bum / Lee, Sung-Jae / Phyau Wui Shim, Victor / Lee, Taeyong

    Journal of biomechanics

    2010  Volume 43, Issue 10, Page(s) 2017–2021

    Abstract: A new gait platform described in this report allows an isolated measurement of the vertical and shear forces under an individual metatarsal head during barefoot walking. The apparatus incorporated a customized tactile force sensor and a high-speed camera ...

    Abstract A new gait platform described in this report allows an isolated measurement of the vertical and shear forces under an individual metatarsal head during barefoot walking. The apparatus incorporated a customized tactile force sensor and a high-speed camera system, which enabled easy identification of a single anatomical landmark at the forefoot's plantar surface that is in contact with the sensor throughout stance. After calibration, the measured peak forces under the 2nd MTH showed variability of 3.7%, 9.2%, and 8.9% in vertical, anterior-posterior, and medial-lateral directions, respectively. The device therefore provides information about the magnitude and timing of such local metatarsal forces, and has been shown to be of significant research and clinical interest. Its ability to achieve this with a high degree of accuracy ensures its potential as a valuable research tool.
    MeSH term(s) Adult ; Biomechanical Phenomena ; Foot/physiology ; Gait/physiology ; Humans ; Male ; Metatarsal Bones/physiology ; Walking/physiology
    Language English
    Publishing date 2010-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218076-5
    ISSN 1873-2380 ; 0021-9290
    ISSN (online) 1873-2380
    ISSN 0021-9290
    DOI 10.1016/j.jbiomech.2010.03.036
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 700: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The influence of GFP-actin expression on the adhesion dynamics of HepG2 cells on a model extracellular matrix.

    Feng, Zhiqin / Ning Chen, Wei / Vee Sin Lee, Peter / Liao, Kin / Chan, Vincent

    Biomaterials

    2005  Volume 26, Issue 26, Page(s) 5348–5358

    Abstract: Integrins belong to a family of important cell surface receptors which mediate the adhesion of most anchorage-dependent cells to nature extracellular matrix (ECM) and biomaterials. It is known that the binding of integrin with ECM proteins triggers ... ...

    Abstract Integrins belong to a family of important cell surface receptors which mediate the adhesion of most anchorage-dependent cells to nature extracellular matrix (ECM) and biomaterials. It is known that the binding of integrin with ECM proteins triggers mechanochemical responses of cytoskeleton. To date, the intricate interplay between integrin-ECM interaction and cytoskeleton dynamics leading to the regulation of cell morphogenesis on biomaterials remains largely unknown. In this study, green fluorescence protein (GFP)-actins were expressed in HepG2 cells for the temporal visualization of cytoskeletal structure of adherent cells on naturally derived materials. By combining confocal reflectance contrast microscopy and fluorescence microscopy, the adhesion contact dynamics, cytoskeleton remodeling and two-dimensional spreading of intact and GFP-actin expressing HepG2 cells on collagen and fibronectin-coated substrates are simultaneously probed during the initial cell seeding. First of all, our results show that the evolution of adhesion contact of HepG2 cells upon integrin-collagen or integrin-fibronectin interaction is impaired by GFP-actin expression. Also, the initial rate of cell deformation is reduced by 70% and 43% on fibronectin and collagen, respectively, upon GFP-actin expression. Interestingly, the steady-state adhesion energy of HepG2 cells remains unchanged and increases on fibronectin- and collagen-coated substrate, respectively, upon GFP-actin expression. Our highly integrated biophysical approach demonstrates that GFP-actins diffusively concentrate in the cytoplasmic cortex during initial cell seeding while adhesion contact evolves and cell spreads. Kinetics analysis on the adhesion contact formation demonstrates the intricate interplay between cytoskeleton property and ECM proteins in cell adhesion.
    MeSH term(s) Actins/metabolism ; Biomimetic Materials/chemistry ; Biomimetic Materials/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Collagen/metabolism ; Cytoskeleton/metabolism ; Extracellular Matrix/chemistry ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/chemistry ; Extracellular Matrix Proteins/metabolism ; Fibronectins/metabolism ; Green Fluorescent Proteins ; Hepatoblastoma/metabolism ; Hepatoblastoma/pathology ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Microscopy, Fluorescence/methods ; Recombinant Fusion Proteins/metabolism
    Chemical Substances Actins ; Extracellular Matrix Proteins ; Fibronectins ; Recombinant Fusion Proteins ; Green Fluorescent Proteins (147336-22-9) ; Collagen (9007-34-5)
    Language English
    Publishing date 2005-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 0142-9612
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2005.01.069
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2371: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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