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  1. Article ; Online: ATM and ATR, two central players of the DNA damage response, are involved in the induction of systemic acquired resistance by extracellular DNA, but not the plant wound response.

    Vega-Muñoz, Isaac / Herrera-Estrella, Alfredo / Martínez-de la Vega, Octavio / Heil, Martin

    Frontiers in immunology

    2023  Volume 14, Page(s) 1175786

    Abstract: Background: The plant immune response to DNA is highly self/nonself-specific. Self-DNA triggered stronger responses by early immune signals such as H: Results: We treated : Conclusion: We conclude that both ATM and ATR are required for the ... ...

    Abstract Background: The plant immune response to DNA is highly self/nonself-specific. Self-DNA triggered stronger responses by early immune signals such as H
    Results: We treated
    Conclusion: We conclude that both ATM and ATR are required for the complete activation of the plant immune response to extracellular DNA whereas an as-yet unknown mechanism allows for the self/nonself-differential activation of the JA-dependent wound response.
    MeSH term(s) Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Ataxia Telangiectasia ; Ataxia Telangiectasia Mutated Proteins/genetics ; DNA ; DNA Damage ; Hormones ; Hydrogen Peroxide
    Chemical Substances Arabidopsis Proteins ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, Arabidopsis ; ATR protein, Arabidopsis (EC 2.7.1.-) ; DNA (9007-49-2) ; Hormones ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1175786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nucleic Acid Sensing in Mammals and Plants: Facts and Caveats.

    Heil, Martin / Vega-Muñoz, Isaac

    International review of cell and molecular biology

    2018  Volume 345, Page(s) 225–285

    Abstract: The accumulation of nucleic acids in aberrant compartments is a signal of danger: fragments of cytosolic or extracellular self-DNA indicate cellular dysfunctions or disruption, whereas cytosolic fragments of nonself-DNA or RNA indicate infections. ... ...

    Abstract The accumulation of nucleic acids in aberrant compartments is a signal of danger: fragments of cytosolic or extracellular self-DNA indicate cellular dysfunctions or disruption, whereas cytosolic fragments of nonself-DNA or RNA indicate infections. Therefore, nucleic acids trigger immunity in mammals and plants. In mammals, endosomal Toll-like receptors (TLRs) sense single-stranded (ss) or double-stranded (ds) RNA or CpG-rich DNA, whereas various cytosolic receptors sense dsDNA. Although a self/nonself discrimination could favor targeted immune responses, no sequence-specific sensing of nucleic acids has been reported for mammals. Specific immune responses to extracellular self-DNA versus DNA from related species were recently reported for plants, but the underlying mechanism remains unknown. The subcellular localization of mammalian receptors can favor self/nonself discrimination based on the localization of DNA fragments. However, autoantibodies and diverse damage-associated molecular patterns (DAMPs) shuttle DNA through membranes, and most of the mammalian receptors share downstream signaling elements such as stimulator of interferon genes (STING) and the master transcription regulators, nuclear factor (NF)-κB, and interferon regulatory factor 3 (IRF3). The resulting type I interferon (IFN) response stimulates innate immunity against multiple threats-from infection to physical injury or endogenous DNA damage-all of which lead to the accumulation of eDNA or cytoplasmatic dsDNA. Therefore, no or only low selective pressures might have favored a strict self/nonself discrimination in nucleic acid sensing. We conclude that the discrimination between self- and nonself-DNA is likely to be less strict-and less important-than assumed originally.
    MeSH term(s) Alarmins/metabolism ; Animals ; Biological Evolution ; Humans ; Inflammasomes/metabolism ; Mammals/immunology ; Nucleic Acids/metabolism ; Plants/immunology
    Chemical Substances Alarmins ; Inflammasomes ; Nucleic Acids
    Language English
    Publishing date 2018-11-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/bs.ircmb.2018.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.317: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Breaking Bad News: Dynamic Molecular Mechanisms of Wound Response in Plants.

    Vega-Muñoz, Isaac / Duran-Flores, Dalia / Fernández-Fernández, Álvaro Daniel / Heyman, Jefri / Ritter, Andrés / Stael, Simon

    Frontiers in plant science

    2020  Volume 11, Page(s) 610445

    Abstract: Recognition and repair of damaged tissue are an integral part of life. The failure of cells and tissues to appropriately respond to damage can lead to severe dysfunction and disease. Therefore, it is essential that we understand the molecular pathways of ...

    Abstract Recognition and repair of damaged tissue are an integral part of life. The failure of cells and tissues to appropriately respond to damage can lead to severe dysfunction and disease. Therefore, it is essential that we understand the molecular pathways of wound recognition and response. In this review, we aim to provide a broad overview of the molecular mechanisms underlying the fate of damaged cells and damage recognition in plants. Damaged cells release the so-called damage associated molecular patterns to warn the surrounding tissue. Local signaling through calcium (Ca
    Language English
    Publishing date 2020-12-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2020.610445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Arabidopsis thaliana Response to Extracellular DNA: Self Versus Nonself Exposure

    Chiusano, Maria Luisa / Incerti, Guido / Colantuono, Chiara / Termolino, Pasquale / Palomba, Emanuela / Monticolo, Francesco / Benvenuto, Giovanna / Foscari, Alessandro / Esposito, Alfonso / Marti, Lucia / de Lorenzo, Giulia / Vega-Muñoz, Isaac / Heil, Martin / Carteni, Fabrizio / Bonanomi, Giuliano / Mazzoleni, Stefano

    Plants. 2021 Aug. 23, v. 10, no. 8

    2021  

    Abstract: The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, the inhibition has been observed on root growth and seed germination, demonstrating its role in plant–soil ... ...

    Abstract The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, the inhibition has been observed on root growth and seed germination, demonstrating its role in plant–soil negative feedback. Several hypotheses have been proposed to explain the early response to exDNA and the inhibitory effect of conspecific exDNA. We here contribute with a whole-plant transcriptome profiling in the model species Arabidopsis thaliana exposed to extracellular self- (conspecific) and nonself- (heterologous) DNA. The results highlight that cells distinguish self- from nonself-DNA. Moreover, confocal microscopy analyses reveal that nonself-DNA enters root tissues and cells, while self-DNA remains outside. Specifically, exposure to self-DNA limits cell permeability, affecting chloroplast functioning and reactive oxygen species (ROS) production, eventually causing cell cycle arrest, consistently with macroscopic observations of root apex necrosis, increased root hair density and leaf chlorosis. In contrast, nonself-DNA enters the cells triggering the activation of a hypersensitive response and evolving into systemic acquired resistance. Complex and different cascades of events emerge from exposure to extracellular self- or nonself-DNA and are discussed in the context of Damage- and Pathogen-Associated Molecular Patterns (DAMP and PAMP, respectively) responses.
    Keywords Arabidopsis thaliana ; DNA ; cell cycle checkpoints ; chloroplasts ; chlorosis ; confocal microscopy ; conspecificity ; hypersensitive response ; leaves ; necrosis ; permeability ; reactive oxygen species ; root growth ; root hairs ; seed germination ; systemic acquired resistance ; transcriptome
    Language English
    Dates of publication 2021-0823
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10081744
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Arabidopsis thaliana

    Chiusano, Maria Luisa / Incerti, Guido / Colantuono, Chiara / Termolino, Pasquale / Palomba, Emanuela / Monticolo, Francesco / Benvenuto, Giovanna / Foscari, Alessandro / Esposito, Alfonso / Marti, Lucia / de Lorenzo, Giulia / Vega-Muñoz, Isaac / Heil, Martin / Carteni, Fabrizio / Bonanomi, Giuliano / Mazzoleni, Stefano

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, the inhibition has been observed on root growth and seed germination, demonstrating its role in plant-soil ... ...

    Abstract The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, the inhibition has been observed on root growth and seed germination, demonstrating its role in plant-soil negative feedback. Several hypotheses have been proposed to explain the early response to exDNA and the inhibitory effect of conspecific exDNA. We here contribute with a whole-plant transcriptome profiling in the model species
    Language English
    Publishing date 2021-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10081744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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