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  1. Article ; Online: Reply: Sacubitril/valsartan for Chagas' heart disease heart failure?

    Bocchi, Edimar Alcides / Rassi, Salvador / Veiga Guimarães, Guilherme

    ESC heart failure

    2018  Volume 5, Issue 6, Page(s) 1072–1073

    MeSH term(s) Aminobutyrates ; Chagas Cardiomyopathy ; Drug Combinations ; Heart Failure ; Humans ; Ivabradine ; Tetrazoles ; Valsartan
    Chemical Substances Aminobutyrates ; Drug Combinations ; Tetrazoles ; Ivabradine (3H48L0LPZQ) ; Valsartan (80M03YXJ7I) ; sacubitril and valsartan sodium hydrate drug combination (WB8FT61183)
    Language English
    Publishing date 2018-10-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.12344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Analysis of Cardiovascular Hemodynamic and Autonomic Variables in Individuals with Systemic Arterial Hypertension, Type 2 Diabetes Mellitus, and Parkinson's Disease: A Comparative Study.

    Yuphiwa Ngomane, Awassi / Martins de Abreu, Raphael / Fernandes, Bianca / Roque Marçal, Isabela / Veiga Guimarães, Guilherme / Gomes Ciolac, Emmanuel

    Clinical and experimental hypertension (New York, N.Y. : 1993)

    2021  Volume 44, Issue 2, Page(s) 119–126

    Abstract: Background: Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system.: Aim: The aim of this study was to compare ... ...

    Abstract Background: Systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2DM), and Parkinson's disease (PD) are highly prevalent chronic diseases that can significantly impact the cardiovascular system.
    Aim: The aim of this study was to compare hemodynamic and autonomic variables at rest in individuals with SAH, T2DM, or PD.
    Methods: Fifty sedentary or insufficiently active individuals (22 men) with SAH (age = 66 ± 5.0 yr), T2DM (age = 52 ± 10 yr) or PD (age = 68 ± 8.0 yr) had their resting blood pressure (BP), arterial stiffness, endothelial function, and heart rate variability (HRV) assessed and compared.
    Results: Systolic and diastolic BP were higher in SAH (130 ± 10 / 80 ± 10 mmHg) than T2DM (110 ± 14 / 75 ± 11 mmHg) and PD, and (123 ± 20 / 70 ± 11 mmHg) respectively. T2DM individuals showed lower arterial stiffness (8.4 ± 1.1 m/s), when compared to SAH (10.3 ± 2.3 m/s) and PD (10.6 ± 3.0 m/s). T2DM had greater resting tachycardia showed by the mean RR (759 ± 79 ms), than SAH (962 ± 169 ms) and PD (976 ± 134 ms), which was accompanied by higher sympathetic modulation (low frequency [LF]: 62 ± 19 nu) and lower parasympathetic modulation (high frequency [HF]: 32 ± 16 nu) when compared to SAH (LF: 40 ± 16 nu; HF: 61 ± 33 nu). No differences among groups were found on non-linear HRV markers and endothelial reactivity indexes.
    Conclusions: Individuals with T2DM showed impaired levels of cardiac autonomic markers when compared to individuals with SAH and PD, despite of having lower levels of BP and arterial stiffness.
    MeSH term(s) Adult ; Aged ; Blood Pressure ; Diabetes Mellitus, Type 2/complications ; Heart ; Heart Rate ; Hemodynamics ; Humans ; Hypertension ; Male ; Middle Aged ; Parkinson Disease
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 604757-9
    ISSN 1525-6006 ; 0730-0077
    ISSN (online) 1525-6006
    ISSN 0730-0077
    DOI 10.1080/10641963.2021.2001480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Acute high-intensity interval exercise versus moderate-intensity continuous exercise in heated water-based on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension.

    Roque Marçal, Isabela / Teixeira Do Amaral, Vanessa / Fernandes, Bianca / Martins de Abreu, Raphael / Alvarez, Cristian / Veiga Guimarães, Guilherme / Cornelissen, Véronique A / Gomes Ciolac, Emmanuel

    Clinical and experimental hypertension (New York, N.Y. : 1993)

    2022  Volume 44, Issue 5, Page(s) 427–435

    Abstract: Objectives: This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension.: Methods: Twenty ...

    Abstract Objectives: This crossover study design aimed to assess hemodynamic, cardiac autonomic, and vascular responses to high-intensity interval (HIIE) vs moderate-intensity continuous exercise (MICE) in older individuals with hypertension.
    Methods: Twenty (67 ± 7 y) older individuals with hypertension were randomly assigned to perform HIIE, MICE, or control (CON) sessions in the heated swimming pool (30-32°C). Blood pressure (BP), arterial stiffness, endothelial reactivity, and heart rate variability (HRV) were measured pre, post, and 45 min (recovery) after each intervention followed by 24-h ambulatory BP and HRV.
    Results: One single aerobic exercise session was not effective to provoke post-exercise hypotension and vascular improvements. HIIE was superior to MICE and CON to increasing parasympathetic modulation at post and recovery. Exercise sessions showed to disturb the autonomic system at nighttime compared to CON.
    Conclusions: These results may have important implications in water-based therapy and the elderly with hypertension.
    MeSH term(s) Aged ; Aquatic Therapy/methods ; Autonomic Nervous System/physiopathology ; Blood Pressure/physiology ; Blood Vessels/physiopathology ; Cross-Over Studies ; Exercise/physiology ; Heart/innervation ; Heart/physiopathology ; Heart Rate/physiology ; Heating ; Hemodynamics/physiology ; High-Intensity Interval Training/methods ; Humans ; Hypertension/physiopathology ; Hypertension/therapy ; Middle Aged
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 604757-9
    ISSN 1525-6006 ; 0730-0077
    ISSN (online) 1525-6006
    ISSN 0730-0077
    DOI 10.1080/10641963.2022.2065288
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Assessment of biomarkers and clinical parameters as predictors of survival in patients with chagasic heart failure.

    Bocchi, Edimar Alcides / Veiga Guimarães, Guilherme / Espinoza Romero, Cristhian / Sato, Paula Keiko / de Freitas, Vera Lúcia Teixeira / Yamashiro Kanashiro, Edite Hatsumi / Furuchó, Célia Regina / Das Dores Cruz, Fatima / Shimoda Nakanishi, Érika / Busser, Felipe Delatorre / Bezerra, Rita Cristina / Westphalen, Elizabeth Visone Nunes / Cisotto Rocha, Mussya / Shikanai Yasuda, Maria Aparecida

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 12, Page(s) e0011847

    Abstract: Background: Chagas disease, endemic in Latin America and spreading globally due to emigration, has a significant health burden, particularly in relation to chagasic heart failure (HF). Chagasic cardiomyopathy (CCM) is characterized by chronic ... ...

    Abstract Background: Chagas disease, endemic in Latin America and spreading globally due to emigration, has a significant health burden, particularly in relation to chagasic heart failure (HF). Chagasic cardiomyopathy (CCM) is characterized by chronic inflammatory myocardial disease. This study aimed to identify inflammatory parameters and biomarkers that could aid in the management of patients with chagasic HF.
    Methods and findings: A cohort study was conducted at a tertiary cardiology single-center over a mean follow-up period of 2.4 years. The study included patients with HF secondary to CCM enrolled between October 2013 and July 2017. Various clinical parameters, echocardiography findings, parasitemia status, brain natriuretic peptide (BNP) and troponin T (TnT) levels, and inflammatory biomarkers (IL-6, IL-10, IL-12p70, IL-17A, adiponectin, and IFN-γ) were assessed. The study encompassed a cohort of 103 patients, with a median age of 53 years and 70% being male. The left ventricular ejection fraction (LVEF) was 28%, with 40% of patients classified as NYHA II functional class. The median BNP level was 291 pg/ml. The observed mortality rate during the study period was 38.8%. Predictors of lower survival were identified as elevated levels of BNP, TnT, reduced LVEF, and increased adiponectin (thresholds: BNP > 309 pg/ml, TnT > 27.5 ng/ml, LVEF < 25.5%, adiponectin > 38 μg/mL). Notably, there was no evidence indicating a relationship between parasitemia and the inflammatory parameters with lower survival in these patients, including INF-γ, IL-6, IL-10, IL12-(p70), and IL17a.
    Conclusion: Despite the presence of a chronic inflammatory process, the evaluated inflammatory biomarkers in this cohort were not predictive of survival in patients with chagasic HF with reduced ejection fraction (HFrEF). However, reduced LVEF, elevated BNP, adiponectin levels, and troponin T were identified as predictors of lower survival in these patients.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Heart Failure/epidemiology ; Stroke Volume ; Interleukin-10 ; Ventricular Function, Left ; Cohort Studies ; Troponin T ; Adiponectin ; Interleukin-6 ; Parasitemia ; Biomarkers ; Natriuretic Peptide, Brain ; Chagas Cardiomyopathy ; Prognosis
    Chemical Substances Interleukin-10 (130068-27-8) ; Troponin T ; Adiponectin ; Interleukin-6 ; Biomarkers ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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