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  1. Article: Pseudokinases, Tribbles Proteins and Cancer.

    Velasco, Guillermo / Link, Wolfgang

    Cancers

    2023  Volume 15, Issue 14

    Abstract: The human kinome comprises 518 protein kinases, of which approximately 10% lack one or more of the conserved amino acids necessary for catalytic activity [ ... ]. ...

    Abstract The human kinome comprises 518 protein kinases, of which approximately 10% lack one or more of the conserved amino acids necessary for catalytic activity [...].
    Language English
    Publishing date 2023-07-09
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143547
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  2. Article ; Online: Is immunotherapy safe and effective for older patients with kidney cancer?

    Carneiro, Filipa / de Velasco, Guillermo

    Journal of geriatric oncology

    2023  Volume 14, Issue 5, Page(s) 101527

    MeSH term(s) Humans ; Carcinoma, Renal Cell ; Kidney Neoplasms/therapy ; Immunotherapy/adverse effects ; Neoplasms
    Language English
    Publishing date 2023-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2023.101527
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  3. Article ; Online: Optimising first-line treatment for metastatic renal cell carcinoma.

    de Velasco, Guillermo

    Lancet (London, England)

    2020  Volume 395, Issue 10219, Page(s) e7

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Bevacizumab ; Carcinoma, Renal Cell ; Humans ; Kidney Neoplasms ; Sunitinib
    Chemical Substances Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y) ; Sunitinib (V99T50803M)
    Language English
    Publishing date 2020-01-16
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(19)32495-X
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  4. Article ; Online: The complex relationship of Tribbles pseudokinase 1, PML/RARA and C/EBPα in leukemia: two possible couples but not a trio.

    Velasco, Guillermo

    Haematologica

    2016  Volume 101, Issue 10, Page(s) 1129–1130

    Language English
    Publishing date 2016-10
    Publishing country Italy
    Document type Editorial
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2016.151654
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  5. Article ; Online: Cellular stress responses as modulators of drug cytotoxicity in pharmacotherapy of glioblastoma.

    Kusaczuk, Magdalena / Ambel, Elena Tovar / Naumowicz, Monika / Velasco, Guillermo

    Biochimica et biophysica acta. Reviews on cancer

    2023  Volume 1879, Issue 1, Page(s) 189054

    Abstract: Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM) remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the role of stress responses in GBM therapy has gained a great deal of ... ...

    Abstract Despite the extensive efforts to find effective therapeutic strategies, glioblastoma (GBM) remains a therapeutic challenge with dismal prognosis of survival. Over the last decade the role of stress responses in GBM therapy has gained a great deal of attention, since depending on the duration and intensity of these cellular programs they can be cytoprotective or promote cancer cell death. As such, initiation of the UPR, autophagy or oxidative stress may either impede or facilitate drug-mediated cell killing. In this review, we summarize the mechanisms that regulate ER stress, autophagy, and oxidative stress during GBM development and progression to later discuss the involvement of these stress pathways in the response to different treatments. We also discuss how a precise understanding of the molecular mechanisms regulating stress responses evoked by different pharmacological agents could decisively contribute to the design of novel and more effective combinational treatments against brain malignancies.
    MeSH term(s) Humans ; Glioblastoma/metabolism ; Autophagy ; Oxidative Stress/physiology
    Language English
    Publishing date 2023-12-14
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2023.189054
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  6. Article ; Online: Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies.

    Ambrosini, Giulia / Cordani, Marco / Zarrabi, Ali / Alcon-Rodriguez, Sergio / Sainz, Rosa M / Velasco, Guillermo / Gonzalez-Menendez, Pedro / Dando, Ilaria

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 36

    Abstract: Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis ... ...

    Abstract Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis and progression of this cancer type. Despite growing research demonstrating the pivotal role of oncometabolites in supporting various cancers, including prostate cancer, the root causes of their accumulation, especially in the absence of enzymatic mutations, remain elusive. Consequently, identifying a tangible therapeutic target poses a formidable challenge. In this review, we aim to delve deeper into the implications of oncometabolite accumulation in prostate cancer. We center our focus on the consequential epigenetic alterations and impacts on cancer stem cells, with the ultimate goal of outlining novel therapeutic strategies.
    MeSH term(s) Male ; Humans ; Epigenesis, Genetic ; Tumor Microenvironment ; Prostatic Neoplasms/genetics ; Neoplasms/pathology ; Mutation ; Neoplastic Stem Cells/pathology
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01462-0
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  7. Article ; Online: Immune checkpoints between epithelial-mesenchymal transition and autophagy: A conflicting triangle.

    Cordani, Marco / Strippoli, Raffaele / Trionfetti, Flavia / Barzegar Behrooz, Amir / Rumio, Cristiano / Velasco, Guillermo / Ghavami, Saeid / Marcucci, Fabrizio

    Cancer letters

    2024  Volume 585, Page(s) 216661

    Abstract: Inhibitory immune checkpoint (ICP) molecules are pivotal in inhibiting innate and acquired antitumor immune responses, a mechanism frequently exploited by cancer cells to evade host immunity. These evasion strategies contribute to the complexity of ... ...

    Abstract Inhibitory immune checkpoint (ICP) molecules are pivotal in inhibiting innate and acquired antitumor immune responses, a mechanism frequently exploited by cancer cells to evade host immunity. These evasion strategies contribute to the complexity of cancer progression and therapeutic resistance. For this reason, ICP molecules have become targets for antitumor drugs, particularly monoclonal antibodies, collectively referred to as immune checkpoint inhibitors (ICI), that counteract such cancer-associated immune suppression and restore antitumor immune responses. Over the last decade, however, it has become clear that tumor cell-associated ICPs can also induce tumor cell-intrinsic effects, in particular epithelial-mesenchymal transition (EMT) and macroautophagy (hereafter autophagy). Both of these processes have profound implications for cancer metastasis and drug responsiveness. This article reviews the positive or negative cross-talk that tumor cell-associated ICPs undergo with autophagy and EMT. We discuss that tumor cell-associated ICPs are upregulated in response to the same stimuli that induce EMT. Moreover, ICPs themselves, when overexpressed, become an EMT-inducing stimulus. As regards the cross-talk with autophagy, ICPs have been shown to either stimulate or inhibit autophagy, while autophagy itself can either up- or downregulate the expression of ICPs. This dynamic equilibrium also extends to the autophagy-apoptosis axis, further emphasizing the complexities of cellular responses. Eventually, we delve into the intricate balance between autophagy and apoptosis, elucidating its role in the broader interplay of cellular dynamics influenced by ICPs. In the final part of this article, we speculate about the driving forces underlying the contradictory outcomes of the reciprocal, inhibitory, or stimulatory effects between ICPs, EMT, and autophagy. A conclusive identification of these driving forces may allow to achieve improved antitumor effects when using combinations of ICIs and compounds acting on EMT and/or autophagy. Prospectively, this may translate into increased and/or broadened therapeutic efficacy compared to what is currently achieved with ICI-based clinical protocols.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Autophagy ; Epithelial-Mesenchymal Transition ; Antibodies, Monoclonal/pharmacology
    Chemical Substances Antineoplastic Agents ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-02-02
    Publishing country Ireland
    Document type Review ; Journal Article
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2024.216661
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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Impact of the COVID-19 outbreak on cancer patient flow and management: experience from a large university hospital in Spain.

    Manso, Luis / De Velasco, Guillermo / Paz-Ares, Luis

    ESMO open

    2020  Volume 4, Issue Suppl 2, Page(s) e000828

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Delayed Diagnosis/trends ; Hospitals, University/trends ; Host-Pathogen Interactions ; Humans ; Medical Oncology/trends ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; Pandemics ; Patient Acceptance of Health Care ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Spain/epidemiology ; Time Factors ; Time-to-Treatment/trends ; Workflow
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country England
    Document type Letter
    ISSN 2059-7029
    ISSN (online) 2059-7029
    DOI 10.1136/esmoopen-2020-000828
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  9. Article: Editorial: Molecular Mechanisms of Autophagy in Cancer.

    Humbert, Magali / Vega-Rubin-de-Celis, Silvia / Velasco, Guillermo / Wei, Yongjie

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 918511

    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.918511
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  10. Article ; Online: Immunotherapy maintenance therapy for advanced urothelial carcinoma (aUC): a comprehensive review.

    Carril-Ajuria, Lucia / Martin-Soberón, Maria Cruz / de Velasco, Guillermo / Agarwal, Neeraj / Castellano, Daniel

    Journal of cancer research and clinical oncology

    2022  Volume 148, Issue 5, Page(s) 1097–1105

    Abstract: Immunotherapy has revolutionized the systemic treatment of solid tumors, including advanced urothelial carcinoma (aUC), providing durable responses with a favorable safety profile. Multiple immune checkpoint inhibitor agents have been approved in ... ...

    Abstract Immunotherapy has revolutionized the systemic treatment of solid tumors, including advanced urothelial carcinoma (aUC), providing durable responses with a favorable safety profile. Multiple immune checkpoint inhibitor agents have been approved in monotherapy in second-line setting, and for a selected group of chemo-naïve cisplatin-ineligible patients with high PD-L1 expression. Despite the incorporation of immunotherapy to the systemic treatment landscape of aUC, platinum-based chemotherapy remains the standard of care in frontline setting for vast majority of patients. Urothelial carcinoma is a chemosensitive disease with response rates of up to 50% to frontline chemotherapy. However, the response to chemotherapy is short lasting with vast majority of patients experiencing disease progression and death within months. In this context, maintenance therapy constitutes an attractive therapeutic strategy to maximize the time to treatment failure. Different cytotoxic and targeted agents have been investigated as maintenance therapy for aUC but have not shown an impact on survival. Avelumab has become the first and only drug to improve overall survival as maintenance therapy after frontline platinum-based therapy in aUC patients and the first drug to be approved in this setting. This article will review the rational for maintenance therapy, the different drugs investigated as maintenance therapy for aUC, and the impact of avelumab maintenance therapy as a new standard of care in the management of aUC.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/pathology ; Cisplatin/therapeutic use ; Female ; Humans ; Immunologic Factors ; Immunotherapy ; Male ; Platinum/therapeutic use ; Urinary Bladder Neoplasms/drug therapy ; Urinary Bladder Neoplasms/pathology
    Chemical Substances Antineoplastic Agents ; Immunologic Factors ; Platinum (49DFR088MY) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2022-01-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-021-03882-2
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