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  1. Article ; Online: Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization.

    Ruigrok, Ynte M / Veldink, Jan H / Bakker, Mark K

    European stroke journal

    2024  , Page(s) 23969873241234134

    Abstract: Introduction: There is no non-invasive treatment to prevent aneurysmal subarachnoid hemorrhage (ASAH) caused by intracranial aneurysm (IA) rupture. We aimed to identify drug classes that may affect liability to IA using a genetic approach.: Patients ... ...

    Abstract Introduction: There is no non-invasive treatment to prevent aneurysmal subarachnoid hemorrhage (ASAH) caused by intracranial aneurysm (IA) rupture. We aimed to identify drug classes that may affect liability to IA using a genetic approach.
    Patients and methods: Using genome-wide association summary statistics we calculated genetic correlation between unruptured IA (
    Results: Correlations with IA were found for antidepressants, paracetamol, acetylsalicylic acid, opioids, beta-blockers, and peptic ulcer and gastro-esophageal reflux disease drugs. MR showed no evidence that genetically predicted usage of these drug classes caused IA. Genetically predicted high responders to antidepressant drugs were at higher risk of IA (odds ratio [OR] = 1.61, 95% confidence interval (CI) = 1.09-2.39,
    Conclusions: We did not find drugs decreasing liability to IA and ASAH but found that antidepressant drugs may increase liability. We observed pleiotropic relationships between IA and other drug classes and indications. Our results improve understanding of pathogenic mechanisms underlying IA.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2851287-X
    ISSN 2396-9881 ; 2396-9873
    ISSN (online) 2396-9881
    ISSN 2396-9873
    DOI 10.1177/23969873241234134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ALS genetic epidemiology 'How simplex is the genetic epidemiology of ALS?'

    Veldink, Jan H

    Journal of neurology, neurosurgery, and psychiatry

    2017  Volume 88, Issue 7, Page(s) 537

    MeSH term(s) Amyotrophic Lateral Sclerosis ; Humans ; Molecular Epidemiology ; Risk Factors
    Language English
    Publishing date 2017-02-16
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2016-315469
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  3. Article ; Online: Comment: the environmental and genetic impact of spatial cluster analysis in ALS.

    Veldink, Jan H

    Neurology

    2015  Volume 84, Issue 15, Page(s) 1543

    MeSH term(s) Amyotrophic Lateral Sclerosis/epidemiology ; Cluster Analysis ; Female ; Humans ; Male ; Registries/statistics & numerical data ; Spatial Analysis
    Language English
    Publishing date 2015-04-14
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000001481
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  4. Book ; Online: Chapter Genetics of Amyotrophic Lateral Sclerosis

    Koppers, Max / Es, Michael van / Berg, Leonard H. van den / Veldink, Jan H. / Pasterkamp, R. Jeroen

    2012  

    Keywords Astronautics ; Technology, engineering, agriculture
    Size 1 Online-Ressource
    Publisher InTechOpen
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021047423
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Analysis of aneurysmal subarachnoid hemorrhage as a multistep process.

    Ruigrok, Ynte M / Rinkel, Gabriel J E / Chang, Han-Sol / Hackenberg, Katharina A M / Etminan, Nima / Veldink, Jan H

    European journal of neurology

    2023  Volume 31, Issue 2, Page(s) e16118

    Abstract: Background and purpose: Aneurysmal subarachnoid hemorrhage (ASAH) is a complex disease with higher incidence in women compared to men and in Japan compared to other countries. It was hypothesized that ASAH is consistent with a multistep model of disease. ...

    Abstract Background and purpose: Aneurysmal subarachnoid hemorrhage (ASAH) is a complex disease with higher incidence in women compared to men and in Japan compared to other countries. It was hypothesized that ASAH is consistent with a multistep model of disease. The following assessments were made: (1) the number of steps needed for the disease to occur and (2) whether this number may be different in female versus male and in Japanese versus non-Japanese patients.
    Methods: Incidence data were generated from a meta-analysis on ASAH incidence until 2017, which was supplemented with a literature search from 2017 to April 2023. Age- and sex-adjusted incidences per 10-year age groups were calculated and the logarithm of age-specific incidence against the logarithm of age was regressed with least-squares regression.
    Results: In 2317 ASAH patients a linear relationship between logarithm of incidence and logarithm of age was found with a slope estimate of 3.13 (95% confidence interval 2.60-3.65), consistent with a four-step process. Similar estimates were found for female, male, Japanese and non-Japanese patients.
    Conclusions: Our results suggest that ASAH is a four-step process, also in subgroups with higher ASAH incidence. Elucidation of the exact nature of these steps can provide important clues for identification of disease mechanisms underlying ASAH.
    MeSH term(s) Humans ; Male ; Female ; Subarachnoid Hemorrhage/epidemiology ; Intracranial Aneurysm ; Incidence ; Japan/epidemiology
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16118
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    Zs.MO 592: Show issues

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  6. Article ; Online: Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in

    Van Wijk, Iris F / Van Eijk, Ruben P A / Van Boxmeer, Loes / Westeneng, Henk-Jan / Van Es, Michael A / Van Rheenen, Wouter / Van Den Berg, Leonard H / Eijkemans, Marinus J C / Veldink, Jan H

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2024  Volume 25, Issue 1-2, Page(s) 188–196

    Abstract: Objectives: We aimed to estimate the age-related risk of ALS in first-degree relatives of patients with ALS carrying the : Methods: We included all patients with ALS carrying a : Results: In total, 214 of the 2,486 (9.2%) patients with ALS carried ...

    Abstract Objectives: We aimed to estimate the age-related risk of ALS in first-degree relatives of patients with ALS carrying the
    Methods: We included all patients with ALS carrying a
    Results: In total, 214 of the 2,486 (9.2%) patients with ALS carried the
    Conclusions: On average, our estimated risk of ALS in the
    MeSH term(s) Humans ; Aged, 80 and over ; Frontotemporal Dementia/genetics ; Amyotrophic Lateral Sclerosis/epidemiology ; Amyotrophic Lateral Sclerosis/genetics ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Proteins/genetics
    Chemical Substances C9orf72 Protein ; Proteins ; C9orf72 protein, human
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2272187
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  7. Article ; Online: Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility.

    Schijven, Dick / Veldink, Jan H / Luykx, Jurjen J

    The British journal of psychiatry : the journal of mental science

    2019  Volume 216, Issue 5, Page(s) 246–249

    Abstract: Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most widespread methods and their ... ...

    Abstract Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most widespread methods and their clinical utility with regard to diagnosis, prediction, disease aetiology and treatment in psychiatry.
    MeSH term(s) Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/genetics ; Mental Disorders/therapy ; Psychiatry
    Language English
    Publishing date 2019-03-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2019.72
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  8. Article ; Online: A stroke of insight from genetics.

    Visscher, Peter M / Veldink, Jan H

    The Lancet. Neurology

    2016  Volume 15, Issue 7, Page(s) 653–654

    MeSH term(s) Humans ; Stroke
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2079704-7
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(16)30028-X
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  9. Article ; Online: Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms.

    Bakker, Mark K / Cobyte, Suze / Hennekam, Frederic A M / Rinkel, Gabriel J E / Veldink, Jan H / Ruigrok, Ynte M

    European journal of human genetics : EJHG

    2022  Volume 30, Issue 7, Page(s) 833–840

    Abstract: Rupture of an intracranial aneurysm (IA) leads to aneurysmal subarachnoid haemorrhage (ASAH), a severe type of stroke. Some rare variants that cause IA in families have been identified, but still, the majority of genetic causes, as well as the biological ...

    Abstract Rupture of an intracranial aneurysm (IA) leads to aneurysmal subarachnoid haemorrhage (ASAH), a severe type of stroke. Some rare variants that cause IA in families have been identified, but still, the majority of genetic causes, as well as the biological mechanisms of IA development and rupture, remain unknown. We aimed to identify rare, damaging variants for IA in three large Dutch families with multiple affected members with IA (N = 9, 11, and 6). By combining linkage analysis and genome sequencing (GS), we identified six rare and damaging variants for which all cases within one of the families were heterozygous. These variants were p.Tyr87Cys in SYCP1, p.Phe1077Leu in FMNL2, p.Thr754Lys in TBC1D2, p.Arg321His in ZNF782, p.Arg979Trp in CCDC180, and p.Val125Met in NCBP1. None of the variants showed association with IA status in a large cohort of 937 patients from the general IA patient population and 1046 controls. Gene expression in IA and cerebral artery tissue further prioritized FMNL2 and TBC1D2 as potential important players in IA pathophysiology. Further studies are needed to characterize the functional consequences of the identified variants and their role in the biological mechanisms of IA.
    MeSH term(s) Chromosome Mapping ; Formins ; Genetic Linkage ; Genetic Predisposition to Disease ; Humans ; Intracranial Aneurysm/epidemiology ; Intracranial Aneurysm/genetics ; Subarachnoid Hemorrhage/epidemiology ; Subarachnoid Hemorrhage/genetics
    Chemical Substances FMNL2 protein, human ; Formins
    Language English
    Publishing date 2022-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-022-01059-0
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    Zs.A 3589: Show issues Location:
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  10. Article ; Online: Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response.

    Dekkers, Koen F / Slieker, Roderick C / Ioan-Facsinay, Andreea / van Iterson, Maarten / Ikram, M Arfan / van Greevenbroek, Marleen M J / Veldink, Jan H / Franke, Lude / Boomsma, Dorret I / Slagboom, P Eline / Jukema, J Wouter / Heijmans, Bastiaan T

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 544

    Abstract: Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the molecular changes involved, we here ... ...

    Abstract Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the molecular changes involved, we here perform a transcriptome-wide association analysis of blood triglycerides, HDL cholesterol, and LDL cholesterol in 3229 individuals, followed by a systematic bidirectional Mendelian randomization analysis to assess the direction of effects and control for pleiotropy. Triglycerides are found to induce transcriptional changes in 55 genes and HDL cholesterol in 5 genes. The function and cell-specific expression pattern of these genes implies that triglycerides downregulate both cellular lipid metabolism and, unexpectedly, allergic response. Indeed, a Mendelian randomization approach based on GWAS summary statistics indicates that several of these genes, including interleukin-4 (IL4) and IgE receptors (FCER1A, MS4A2), affect the incidence of allergic diseases. Our findings highlight the interplay between triglycerides and immune cells in allergic disease.
    MeSH term(s) Humans ; Cholesterol, HDL ; Transcriptome ; Lipid Metabolism/genetics ; Triglycerides ; Cholesterol, LDL ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Risk Factors
    Chemical Substances Cholesterol, HDL ; Triglycerides ; Cholesterol, LDL
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-35663-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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