Article ; Online: Pathophysiology of Hepatorenal Syndrome.
Advances in kidney disease and health
2024 Volume 31, Issue 2, Page(s) 87–99
Abstract: Hepatorenal syndrome type 1 (HRS-1) is a unique form of acute kidney injury that affects individuals with decompensated cirrhosis with ascites. The primary mechanism leading to reduction of kidney function in HRS-1 is hemodynamic in nature. Cumulative ... ...
| Abstract | Hepatorenal syndrome type 1 (HRS-1) is a unique form of acute kidney injury that affects individuals with decompensated cirrhosis with ascites. The primary mechanism leading to reduction of kidney function in HRS-1 is hemodynamic in nature. Cumulative evidence points to a cascade of events that led to a profound reduction in kidney perfusion. A state of increased intrahepatic vascular resistance characteristic of advanced cirrhosis and portal hypertension is accompanied by maladaptive peripheral arterial vasodilation and reduction in systemic vascular resistance and mean arterial pressure. As a result of a fall in effective arterial blood volume, there is a compensatory activation of the sympathetic nervous system and the renin-angiotensin system, local renal vasoconstriction, loss of renal autoregulation, decrease in renal blood flow, and ultimately a fall in glomerular filtration rate. Systemic release of nitric oxide stimulated by the fibrotic liver, bacterial translocation, and inflammation constitute key components of the pathogenesis. While angiotensin II and noradrenaline remain the critical mediators of renal arterial and arteriolar vasoconstriction, other novel molecules have been recently implicated. Although the above-described mechanistic pathway remains the backbone of the pathogenesis of HRS-1, other noxious elements may be present in advanced cirrhosis and likely contribute to the renal impairment. Direct liver-kidney crosstalk via the hepatorenal sympathetic reflex can further reduce renal blood flow independently of the systemic derangements. Tense ascites may lead to intraabdominal hypertension and abdominal compartment syndrome. Cardio-hemodynamic processes have also been increasingly recognized. Porto-pulmonary hypertension, cirrhotic cardiomyopathy, and abdominal compartment syndrome may lead to renal congestion and complicate the course of HRS-1. In addition, a degree of ischemic or toxic (cholemic) tubular injury may overlap with the underlying circulatory dysfunction and further exacerbate the course of acute kidney injury. Improving our understanding of the pathogenesis of HRS-1 may lead to improvements in therapeutic options for this seriously ill population. |
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| MeSH term(s) | Humans ; Hepatorenal Syndrome/physiopathology ; Hepatorenal Syndrome/therapy ; Hepatorenal Syndrome/etiology ; Liver Cirrhosis/physiopathology ; Liver Cirrhosis/complications ; Renal Circulation/physiology ; Hemodynamics/physiology ; Renin-Angiotensin System/physiology ; Kidney/physiopathology ; Hypertension, Portal/physiopathology ; Ascites/physiopathology |
| Language | English |
| Publishing date | 2024-04-22 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 3156601-7 |
| ISSN | 2949-8139 |
| ISSN (online) | 2949-8139 |
| DOI | 10.1053/j.akdh.2024.01.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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