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Article ; Online: Impact of the Covid-19 Pandemic on Birth Rates in 2020: The Case of Colombia.

Montaño Mendoza, Vicky Margarita / Velilla, Paula Andrea / Tamayo Hussein, Sergio / Cardona Maya, Walter

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

2021 Volume 43, Issue 6, Page(s) 492–494

MeSH term(s)	Birth Rate/trends ; COVID-19/economics ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/psychology ; Colombia/epidemiology ; Female ; Humans ; Pandemics/economics ; Pandemics/prevention & control
Language	English
Publishing date	2021-07-27
Publishing country	Brazil
Document type	Letter
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0041-1731380
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Crop Modelling Strategy to Improve Cacao Quality and Productivity.

Romero Vergel, Angela Patricia / Camargo Rodriguez, Anyela Valentina / Ramirez, Oscar Dario / Arenas Velilla, Paula Andrea / Gallego, Adriana Maria

Plants (Basel, Switzerland)

2022 Volume 11, Issue 2

Abstract: Cacao production systems in Colombia are of high importance due to their direct impact in the social and economic development of smallholder farmers. Although Colombian cacao has the potential to be in the high value markets for fine flavour, the lack of ...

Abstract	Cacao production systems in Colombia are of high importance due to their direct impact in the social and economic development of smallholder farmers. Although Colombian cacao has the potential to be in the high value markets for fine flavour, the lack of expert support as well as the use of traditional, and often times sub-optimal technologies makes cacao production negligible. Traditionally, cacao harvest takes place at exactly the same time regardless of the geographic and climatic region where it is grown, the problem with this strategy is that cacao beans are often unripe or over matured and a combination of both will negatively affect the quality of the final cacao product. Since cacao fruit development can be considered as the result of a number of physiological and morphological processes that can be described by mathematical relationships even under uncontrolled environments. Environmental parameters that have more association with pod maturation speed should be taken into account to decide the appropriate time to harvest. In this context, crop models are useful tools to simulate and predict crop development over time and under multiple environmental conditions. Since harvesting at the right time can yield high quality cacao, we parameterised a crop model to predict the best time for harvest cacao fruits in Colombia. The cacao model uses weather variables such as temperature and solar radiation to simulate the growth rate of cocoa fruits from flowering to maturity. The model uses thermal time as an indicator of optimal maturity. This model can be used as a practical tool that supports cacao farmers in the production of high quality cacao which is usually paid at a higher price. When comparing simulated and observed data, our results showed an RRMSE of 7.2% for the yield prediction, while the simulated harvest date varied between +/-2 to 20 days depending on the temperature variations of the year between regions. This crop model contributed to understanding and predicting the phenology of cacao fruits for two key cultivars ICS95 y CCN51.
Language	English
Publishing date	2022-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11020157
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Article: A Crop Modelling Strategy to Improve Cacao Quality and Productivity

Romero Vergel, Angela Patricia / Camargo Rodriguez, Anyela Valentina / Ramirez, Oscar Dario / Arenas Velilla, Paula Andrea / Gallego, Adriana Maria

Plants. 2022 Jan. 07, v. 11, no. 2

2022

Abstract	Cacao production systems in Colombia are of high importance due to their direct impact in the social and economic development of smallholder farmers. Although Colombian cacao has the potential to be in the high value markets for fine flavour, the lack of expert support as well as the use of traditional, and often times sub-optimal technologies makes cacao production negligible. Traditionally, cacao harvest takes place at exactly the same time regardless of the geographic and climatic region where it is grown, the problem with this strategy is that cacao beans are often unripe or over matured and a combination of both will negatively affect the quality of the final cacao product. Since cacao fruit development can be considered as the result of a number of physiological and morphological processes that can be described by mathematical relationships even under uncontrolled environments. Environmental parameters that have more association with pod maturation speed should be taken into account to decide the appropriate time to harvest. In this context, crop models are useful tools to simulate and predict crop development over time and under multiple environmental conditions. Since harvesting at the right time can yield high quality cacao, we parameterised a crop model to predict the best time for harvest cacao fruits in Colombia. The cacao model uses weather variables such as temperature and solar radiation to simulate the growth rate of cocoa fruits from flowering to maturity. The model uses thermal time as an indicator of optimal maturity. This model can be used as a practical tool that supports cacao farmers in the production of high quality cacao which is usually paid at a higher price. When comparing simulated and observed data, our results showed an RRMSE of 7.2% for the yield prediction, while the simulated harvest date varied between +/−2 to 20 days depending on the temperature variations of the year between regions. This crop model contributed to understanding and predicting the phenology of cacao fruits for two key cultivars ICS95 y CCN51.
Keywords	climatic zones ; crop models ; cultivars ; economic development ; flavor ; fruiting ; harvest date ; phenology ; prices ; solar radiation ; temperature ; yield forecasting ; Colombia
Language	English
Dates of publication	2022-0107
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11020157
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chikungunya Virus and Zika Virus, Two Different Viruses Examined with a Common Aim: Role of Pattern Recognition Receptors on the Inflammatory Response.

Valdés López, Juan Felipe / Velilla, Paula Andrea / Urcuqui-Inchima, Silvio

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

2019 Volume 39, Issue 9, Page(s) 507–521

Abstract: Chikungunya virus (CHIKV) and Zika virus (ZIKV) are 2 reemerging arboviruses that have been the focus of public health institutions worldwide, since the last decades and following a spate of outbreaks in tropical and subtropical areas. The disease caused ...

Abstract	Chikungunya virus (CHIKV) and Zika virus (ZIKV) are 2 reemerging arboviruses that have been the focus of public health institutions worldwide, since the last decades and following a spate of outbreaks in tropical and subtropical areas. The disease caused by both viruses manifests itself first as an acute stage of severe inflammation into the infected tissues, which later progresses to arthritis and chronic polyarthralgia in the case of CHIKV or congenital microcephaly and neurological disorders such as Guillain-Barré syndrome in the case of ZIKV. This review aims to summarize on current knowledge of the role of different pattern recognition receptors that leads to an elevated production and secretion of antiviral response (interferon) and severe inflammation in response to CHIKV and ZIKV infection.
MeSH term(s)	Chikungunya virus/immunology ; Chikungunya virus/isolation & purification ; Humans ; Inflammation/immunology ; Receptors, Pattern Recognition/immunology ; Zika Virus/immunology ; Zika Virus/isolation & purification
Chemical Substances	Receptors, Pattern Recognition
Language	English
Publishing date	2019-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1226675-9
ISSN	1557-7465 ; 1079-9907
ISSN (online)	1557-7465
ISSN	1079-9907
DOI	10.1089/jir.2019.0058
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Article: Impact of the Covid-19 Pandemic on Birth Rates in 2020: The Case of Colombia

Montaño Mendoza, Vicky Margarita / Velilla, Paula Andrea / Tamayo Hussein, Sergio / Cardona Maya, Walter

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics

2021 Volume 43, Issue 06, Page(s) 492–494

Language	English
Publishing date	2021-06-01
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2105176-8
ISSN	1806-9339 ; 0100-7203
ISSN (online)	1806-9339
ISSN	0100-7203
DOI	10.1055/s-0041-1731380
Database	Thieme publisher's database

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Article ; Online: Dynamics of humoral immune response in SARS-CoV-2 infected individuals with different clinical stages.

Mendez-Cortina, Yorjagis / Rodriguez-Perea, Ana Lucía / Chvatal-Medina, Mateo / Lopera, Tulio Jose / Alvarez-Mesa, Natalia / Rodas-Marín, Jan Karlo / Moncada, Diana Carolina / Rugeles, Maria Teresa / Velilla, Paula Andrea

Frontiers in immunology

2022 Volume 13, Page(s) 1007068

Abstract: Background: The COVID-19 pandemic remains a global health problem. As in other viral infections, the humoral immune response against SARS-CoV-2 is thought to be crucial for controlling the infection. However, the dynamic of B cells in the clinical ... ...

Abstract	Background: The COVID-19 pandemic remains a global health problem. As in other viral infections, the humoral immune response against SARS-CoV-2 is thought to be crucial for controlling the infection. However, the dynamic of B cells in the clinical spectrum of this disease is still controversial. This study aimed to characterize B cell subsets and neutralizing responses in COVID-19 patients according to disease severity through a one-month follow-up. Methods: A cohort of 71 individuals with SARS-CoV-2 infection confirmed by RT-PCR were recruited and classified into four groups: i) asymptomatic; ii) symptomatic outpatients; iii) hospitalized in ward, and iv) intensive care unit patients (ICU). Samples were taken at days 0 (inclusion to the study), 7 and 30. B cell subsets and neutralizing antibodies were assessed using multiparametric flow cytometry and plaque reduction neutralization, respectively. Results: Older age, male gender and body mass index over 25 were common factors among hospitalized and ICU patients, compared to those with milder clinical presentations. In addition, those requiring hospitalization had more comorbidities. A significant increase in the frequencies of CD19 Conclusion: The humoral immune response is variable among SARS-CoV-2 infected people depending on the severity and time of clinical evolution. In severe COVID-19 patients, a higher plasmablast frequency and neutralizing antibody response were observed, suggesting that, despite having a robust humoral immunity, this response could be late, having a low impact on disease outcome.
MeSH term(s)	Humans ; Male ; SARS-CoV-2 ; Immunity, Humoral ; COVID-19 ; Pandemics ; Antibodies, Neutralizing
Chemical Substances	Antibodies, Neutralizing
Language	English
Publishing date	2022-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1007068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Functional Profile of CD8

Sánchez-Martínez, Alexandra / Acevedo-Sáenz, Liliana / Alzate-Ángel, Juan Carlos / Álvarez, Cristian M / Guzmán, Fanny / Roman, Tanya / Urcuqui-Inchima, Silvio / Cardona-Maya, Walter D / Velilla, Paula Andrea

Frontiers in immunology

2022 Volume 13, Page(s) 793982

Abstract: ... ...

Abstract	CD8
MeSH term(s)	CD8-Positive T-Lymphocytes ; Colombia ; Epitopes ; Gene Products, gag ; HIV Infections ; HIV Seropositivity ; HIV-1 ; HLA-A Antigens ; Humans ; Immunodominant Epitopes ; Leukocytes, Mononuclear ; Peptides
Chemical Substances	Epitopes ; Gene Products, gag ; HLA-A Antigens ; Immunodominant Epitopes ; Peptides
Language	English
Publishing date	2022-03-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.793982
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Article ; Online: Role of Monocytes in the Pathogenesis of Dengue.

Castillo, Jorge Andrés / Naranjo, Juan Sebastián / Rojas, Mauricio / Castaño, Diana / Velilla, Paula Andrea

Archivum immunologiae et therapiae experimentalis

2018 Volume 67, Issue 1, Page(s) 27–40

Abstract: Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this ... ...

Abstract	Diseases caused by dengue virus (DENV) are a major public health problem worldwide, considered one of the infections with more prevalence in tropical and subtropical zones of the world. Despite the intense research in the pathogenesis of DENV, this feature is not well understood. One of the main target cells for DENV infection is monocytes; these phagocytes can play a dual role, since they are essential to control viremia, but they also participate in the induction of tissue damage during DENV infection. Monocytes produce different pro-inflammatory cytokines and chemokines in response to infection, and also mediate endothelial damage. In peripheral blood, monocytes can be divided into three different subpopulations, namely classical, intermediate and non-classical, which differ in frequency, cytokine production, among others. Studies in the last years suggest that non-classical monocytes have higher affinity for microvasculature endothelium compared to other type of monocytes, which implies that they could be more involved in the increase of endothelial permeability observed during DENV infection. This review provides a general view of the role of monocytes and their subpopulations in DENV pathogenesis and its effect in viral replication. Finally, the potential contribution of these phagocytes in the alterations of endothelial permeability is discussed.
MeSH term(s)	Animals ; Capillary Permeability ; Cytokines/immunology ; Cytokines/metabolism ; Dengue/immunology ; Dengue/metabolism ; Dengue/virology ; Dengue Virus/growth & development ; Dengue Virus/immunology ; Dengue Virus/pathogenicity ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Endothelial Cells/virology ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Microvessels/immunology ; Microvessels/metabolism ; Microvessels/virology ; Monocytes/immunology ; Monocytes/metabolism ; Monocytes/virology ; Phagocytosis ; Signal Transduction ; Virus Replication
Chemical Substances	Cytokines ; Inflammation Mediators
Language	English
Publishing date	2018-09-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	282209-x
ISSN	1661-4917 ; 0004-069X
ISSN (online)	1661-4917
ISSN	0004-069X
DOI	10.1007/s00005-018-0525-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 393: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Chronically HIV-1 Infected Patients Exhibit Low Frequencies of CD25+ Regulatory T Cells.

Rios, Cesar Mauricio Rueda / Velilla, Paula Andrea / Rugeles, Maria Teresa

The open virology journal

2012 Volume 6, Page(s) 49–58

Abstract: The characterization of regulatory T cells (Treg) during HIV infection has become of particular interest considering their potential role in the pathogenesis of the acquired immunodeficiency syndrome. Different reports on Tregs in HIV-infected patients ... ...

Abstract	The characterization of regulatory T cells (Treg) during HIV infection has become of particular interest considering their potential role in the pathogenesis of the acquired immunodeficiency syndrome. Different reports on Tregs in HIV-infected patients vary greatly, depending on the state of disease progression, anatomical compartment, and the phenotypic markers used to define this cell subpopulation. To determine the frequency of Tregs we included paired samples from peripheral blood and rectal biopsies from controls and chronic HIV patients with or without detectable viral load. Tregs were determined by flow cytometry using three different protocols: CD4(+)Foxp3(+); CD4(+)Foxp3(+)CD127(Low/-), and CD4(+)CD25(+)CD127(Low/-). In addition, and with the purpose to compare the different protocols we also characterized Tregs in peripheral blood of HIV negative individuals with influenza like symptoms. Here, we report that Treg characterization in HIV-infected patients as CD4(+)Foxp3(+) and CD4(+)Foxp3(+)CD127(Low/-) cells was similar, indicating that both protocols represent a suitable method to determine the frequency of Tregs in peripheral blood mononuclear cells (PBMC) and gut associated lymphoid tissue (GALT). In contrast, in HIV but not in flu-like patients, detection of Tregs as CD4(+)CD25(+)CD127(Low/- )cells resulted in a significantly lower percentage of these cells. In both, HIV patients and controls the frequency of Treg was significantly higher in GALT compared to PBMC. The frequency of Tregs in PBMC and GALT using CD4(+)Foxp3(+) and CD4(+)Foxp3(+)CD127(Low/-) was higher in HIV patients than in controls. Similarly, the frequency of Treg using any protocol was higher in flu-like patients compared to controls. The results suggest that relying on the expression of CD25 could be unsuitable to characterize Tregs in PBMC and GALT samples from a chronic infection such as HIV.
Language	English
Publishing date	2012-04-11
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2396020-6
ISSN	1874-3579 ; 1874-3579
ISSN (online)	1874-3579
ISSN	1874-3579
DOI	10.2174/1874357901206010049
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Article: Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma.

Blanquiceth, Yurany / Rodríguez-Perea, Ana Lucia / Tabares Guevara, Jorge H / Correa, Luis Alfonso / Sánchez, María Dulfary / Ramírez-Pineda, José Robinson / Velilla, Paula Andrea

Frontiers in immunology

2016 Volume 7, Page(s) 620

Abstract: Regulatory T cells (Tregs) play an important role by controlling allergic inflammation of airways. Recently, it has been shown that statins have immunomodulatory properties, probably mediated by their effects on Tregs. Therefore, we evaluated ... ...

Abstract	Regulatory T cells (Tregs) play an important role by controlling allergic inflammation of airways. Recently, it has been shown that statins have immunomodulatory properties, probably mediated by their effects on Tregs. Therefore, we evaluated the
Language	English
Publishing date	2016
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2016.00620
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