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  1. AU="Vella, Kevin"
  2. AU="Eisenhaure, Thomas M"
  3. AU="Eggenberger, Caleb"
  4. AU="Choi, Seung-Hye"
  5. AU="Hans, B. T. Hackett S."
  6. AU="Singh, Ronak"
  7. AU=Forcados Gilead Ebiegberi
  8. AU="Kasperbauer, Jan L."
  9. AU="Xiang, Fangfei"
  10. AU=Bhattacharyya Rupam
  11. AU="Stefanski, R J"
  12. AU="Huiyuan Zhang"
  13. AU="Garg, Shivam Kumar"
  14. AU="Bart J. A. Rijnders"
  15. AU="Malaise, D"
  16. AU="Ahammad, Rijwan U"
  17. AU="Wong, Man Yu"
  18. AU="Yilmaz, Adnan"
  19. AU="Turkyilmaz, Ayberk"
  20. AU="Ryan, Sophia C"
  21. AU="Stino, Heiko"
  22. AU=Fischbeck K H
  23. AU="Giadinis, Nektarios D"
  24. AU="Patten, Scott"
  25. AU="Verma, Deepika"
  26. AU="Foo, Anthony Tun Lin"
  27. AU="Georgia Panagiotakos"
  28. AU="Tennankore, Karthik K."
  29. AU=Kubota Kenji
  30. AU="Vieille, Peggy"
  31. AU="Kan, Yin-Shi"
  32. AU="Jasińska-Balwierz, Agata"
  33. AU="Hargitai, Rita"
  34. AU=Ueda Kazumitsu
  35. AU="Andrew N. Jordan"
  36. AU="Millemaggi, Alessia"
  37. AU=Paulsen Paige
  38. AU="Fan, Su-Su"
  39. AU="de Azeredo, Andressa Cardoso"
  40. AU="Miller, Russell"
  41. AU="A Mombet"

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Treffer 1 - 10 von insgesamt 11

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  1. Artikel ; Online: Navigating through the haemostatic paradox in kidney failure: A practical overview.

    Caruana, Jessica / Riva, Nicoletta / Vella, Kevin / Davenport, Andrew / Gatt, Alexander

    British journal of haematology

    2023  Band 202, Heft 2, Seite(n) 230–247

    Abstract: Chronic kidney disease (CKD) affects around 9.1% of humankind globally resulting in a significant health burden. Some of these individuals will also require renal replacement therapy with dialysis due to complete kidney failure. Patients with CKD are ... ...

    Abstract Chronic kidney disease (CKD) affects around 9.1% of humankind globally resulting in a significant health burden. Some of these individuals will also require renal replacement therapy with dialysis due to complete kidney failure. Patients with CKD are known to be at increased risk of both bleeding and thrombosis. Often it is very difficult to manage these yin and yang since both risks tend to co-exist. Clinically, very few studies have looked at the effects of antiplatelet agents and anticoagulants in this highly vulnerable subgroup of medical patients and evidence is very limited. This review attempts to explain the current state-of-the-art regarding the basic science of haemostasis in patients with end-stage kidney disease. We also try to transfer this knowledge into the clinics by looking at some common haemostasis challenges that are encountered in this cohort of patients and what evidence and guidance there is for their optimal management.
    Mesh-Begriff(e) Humans ; Hemostatics/therapeutic use ; Anticoagulants/therapeutic use ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic/complications ; Hemostasis
    Chemische Substanzen Hemostatics ; Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2023-06-04
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18903
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  2. Artikel ; Online: A comparative in vitro study of the anticoagulant effect of branded versus generic rivaroxaban.

    Mangion, Karl / Vella, Kevin / Gatt, Alex / Vella, Amy Marie / Borg, Marica / Borg-Aquilina, Denise / Douxfils, Jonathan / Camilleri, Liberato / Riva, Nicoletta

    Thrombosis research

    2024  Band 235, Seite(n) 41–51

    Abstract: Background: Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of ...

    Abstract Background: Several generic formulations of rivaroxaban were recently marketed to be used interchangeably with their branded equivalent. However, there have been no previously published studies that directly compared the in vitro anticoagulant effect of branded vs. generic rivaroxaban. The aim of this in vitro study was to compare the effects of three raw rivaroxaban materials, obtained from the branded (Xarelto®) and two generic (Rivarolto® and Rivaroxaban Sandoz®) rivaroxaban formulations on an array of coagulation assays.
    Methods: A pool of normal plasma was spiked with several concentrations of the three rivaroxaban (range 50-750 ng/ml). The concentrations were assessed with a rivaroxaban calibrated anti-Xa assay and confirmed by ultra-high-performance liquid chromatography-mass spectrometry coupled with tandem mass spectrometry (UHPLC-MS/MS). The following assays were performed: Prothrombin time (PT), activated Partial Thromboplastin time (aPTT), Diluted Russell's Viper Venom Test (dRVVT), Thrombin time (TT), Clauss Fibrinogen, Factor VII, VIII and IX assays, and thromboelastography.
    Results: The results obtained by the three rivaroxaban at similar concentrations were comparable. Increasing concentrations of the three rivaroxaban showed a strong positive correlation with the PT, aPTT and dRVVT assays (r > 0.95, p < 0.01 for all), and a strong negative correlation with the Factors assays (r < -0.95, p < 0.01 for all). TT and Clauss Fibrinogen were not affected by rivaroxaban. No significant difference was identified in the mean assays' results obtained by the three rivaroxaban.
    Conclusion: This study showed that the branded and generic rivaroxaban exert an identical in vitro anticoagulant effect across a wide range of concentrations.
    Mesh-Begriff(e) Humans ; Rivaroxaban/pharmacology ; Rivaroxaban/therapeutic use ; Tandem Mass Spectrometry ; Research Design ; Fibrinogen ; Hemostatics ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use
    Chemische Substanzen Rivaroxaban (9NDF7JZ4M3) ; Fibrinogen (9001-32-5) ; Hemostatics ; Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2024-01-24
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2024.01.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Teaching an old dog new tricks?

    Gatt, Alex / Vella, Kevin

    British journal of haematology

    2019  Band 187, Heft 4, Seite(n) 416–417

    Mesh-Begriff(e) Fibrin ; Fibrin Clot Lysis Time ; Fibrinolysis ; Hemorrhagic Disorders ; Humans ; Thrombosis
    Chemische Substanzen Fibrin (9001-31-4)
    Sprache Englisch
    Erscheinungsdatum 2019-07-31
    Erscheinungsland England
    Dokumenttyp Editorial ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16110
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  4. Artikel ; Online: Long COVID Syndrome: A Case-Control Study.

    Xuereb, Rachel-Anne / Borg, Marica / Vella, Kevin / Gatt, Alex / Xuereb, Robert G / Barbara, Christopher / Fava, Stephen / Magri, Caroline J

    The American journal of medicine

    2023  

    Abstract: Background: Acute coronavirus disease 2019 (COVID-19) causes various cardiovascular complications. However, it is unknown if there are cardiovascular sequelae in the medium and long-term. The aim of this study was dual. Firstly, we wanted to investigate ...

    Abstract Background: Acute coronavirus disease 2019 (COVID-19) causes various cardiovascular complications. However, it is unknown if there are cardiovascular sequelae in the medium and long-term. The aim of this study was dual. Firstly, we wanted to investigate symptomatology and health-related quality of life (HRQoL) at medium-term follow-up (6 months post-COVID). Secondly, we wanted to assess whether history of COVID-19 and persistent shortness of breath at medium-term follow-up are associated with ongoing inflammation, endothelial dysfunction, and cardiac injury.
    Methods: A case-control study was performed. Virologically proven COVID-19 cases and age- and gender-matched controls were interviewed to assess symptoms and HRQoL. Biochemical tests were also performed.
    Results: The study comprised 174 cases and 75 controls. The mean age of the participants was 46.1±13.8 years. The median follow-up was 173.5 days (interquartile range 129-193.25 days). There was no significant difference in the demographics between cases and controls. At follow-up, cases had a higher frequency of shortness of breath, fatigue, arthralgia, abnormal taste of food (P <.001), and anosmia. Cases also exhibited worse scores in the general health and role physical domains of the Short Form Survey-36. High-sensitivity C-reactive protein (hsCRP) was significantly higher in the cases, and there was a positive correlation of hsCRP with time. Significant determinants of shortness of breath were age, female gender and white cell count, troponin I, and lower hemoglobin levels at follow-up.
    Conclusion: Post-COVID-19 patients have persistent symptomatology at medium-term follow-up. Higher hsCRP in cases and the positive association of hsCRP with time suggest ongoing systemic inflammation in patients persisting for months after COVID-19.
    Sprache Englisch
    Erscheinungsdatum 2023-05-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2023.04.022
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  5. Artikel ; Online: Diagnostic accuracy of D-dimer in patients at high-risk for splanchnic vein thrombosis: A systematic review and meta-analysis.

    Riva, Nicoletta / Attard, Laura Maria / Vella, Kevin / Squizzato, Alessandro / Gatt, Alex / Calleja-Agius, Jean

    Thrombosis research

    2021  Band 207, Seite(n) 102–112

    Abstract: Background: D-dimer is included in the diagnostic algorithm for deep vein thrombosis and pulmonary embolism. However, its role in the diagnosis of splanchnic vein thrombosis (SVT) is still controversial. The aim of this study was to evaluate the ... ...

    Abstract Background: D-dimer is included in the diagnostic algorithm for deep vein thrombosis and pulmonary embolism. However, its role in the diagnosis of splanchnic vein thrombosis (SVT) is still controversial. The aim of this study was to evaluate the diagnostic accuracy of D-dimer for SVT.
    Methods: We performed a systematic review of the literature with meta-analysis (PROSPERO protocol registration number: CRD42020184300). The electronic databases MEDLINE, EMBASE, and CENTRAL were searched from inception to March 2021 week 4. Studies which evaluated D-dimer accuracy for SVT in any category of patients were selected. The index test was any D-dimer assay; the reference standard was any radiological imaging. The QUADAS-2 checklist was used for the risk of bias assessment. A bivariate random-effects regression model was used to calculate summary estimates of sensitivity and specificity.
    Results: 12 studies (with a total of 1298 patients) evaluating the accuracy of D-dimer in patients at high risk of SVT (surgical patients, patients with liver cirrhosis or hepatocellular carcinoma) were included. None of the included studies was at low risk of bias. The weighted mean prevalence of SVT was 33.4% (95% CI, 22.5-45.2%, I
    Conclusions: D-dimer seems to have high sensitivity in the diagnosis of patients at high-risk for SVT. However, there is a strong need for more robust evidence on this topic.
    Sprache Englisch
    Erscheinungsdatum 2021-09-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2021.09.016
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The effect of DOAC-Stop

    Riva, Nicoletta / Vella, Kevin / Hickey, Kieron / Gatt, Peter / Grima, Charlie / Zammit, Daniel / Ageno, Walter / Kitchen, Steve / Makris, Michael / Gatt, Alex

    International journal of laboratory hematology

    2021  Band 43, Heft 4, Seite(n) O171–O175

    Mesh-Begriff(e) Administration, Oral ; Adsorption ; Anticoagulants/administration & dosage ; Anticoagulants/blood ; Anticoagulants/chemistry ; Blood Coagulation Tests/methods ; Blood Coagulation Tests/standards ; Charcoal/chemistry ; Humans ; Parenteral Nutrition
    Chemische Substanzen Anticoagulants ; Charcoal (16291-96-6)
    Sprache Englisch
    Erscheinungsdatum 2021-02-17
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.13487
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  7. Artikel ; Online: Anticoagulation control with the point-of-care INR: A retrospective pre-/post-analysis.

    Riva, Nicoletta / Meli, Stephanie / Borg Xuereb, Christian / Vella, Kevin / Ageno, Walter / Makris, Michael / Gatt, Alex

    Thrombosis research

    2020  Band 196, Seite(n) 21–24

    Mesh-Begriff(e) Anticoagulants/therapeutic use ; Humans ; International Normalized Ratio ; Point-of-Care Systems ; Retrospective Studies ; Warfarin
    Chemische Substanzen Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Sprache Englisch
    Erscheinungsdatum 2020-08-01
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.07.050
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  8. Buch ; Online: The marketing firm

    Vella, Kevin J / Foxall, G. R

    economic psychology of corporate behaviour

    2011  

    Abstract: This book provides and expert analysis of theory of the marketing firm by drawing upon operant psychology, economic theory and marketing to argue that all firms exist in order to market. The authors explore the nature of bilateral interdependence and ... ...

    Körperschaft ebrary, Inc
    Verfasserangabe Kevin J. Vella and Gordon R. Foxall
    Abstract This book provides and expert analysis of theory of the marketing firm by drawing upon operant psychology, economic theory and marketing to argue that all firms exist in order to market. The authors explore the nature of bilateral interdependence and suggest a framework to analyse these collaborative and competitive mutually reinforcing relationships within which the firm acts. The Marketing Firm develops a case study methodology for defining the central constructs of the marketing firm that is tested to find support for the core propositions of the theory. Employing the strengths of case stud
    Schlagwörter Marketing
    Sprache Englisch
    Umfang Online-Ressource (vi, 320 p), ill
    Verlag Edward Elgar
    Erscheinungsort Cheltenham, U.K
    Dokumenttyp Buch ; Online
    Anmerkung Includes bibliographical references and index
    ISBN 9781283294058 ; 9781848444157 ; 1283294052 ; 184844415X
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  9. Artikel ; Online: Biomarkers for the diagnosis of venous thromboembolism: D-dimer, thrombin generation, procoagulant phospholipid and soluble P-selectin.

    Riva, Nicoletta / Vella, Kevin / Hickey, Kieron / Bertù, Lorenza / Zammit, Daniel / Spiteri, Silvana / Kitchen, Steve / Makris, Michael / Ageno, Walter / Gatt, Alex

    Journal of clinical pathology

    2018  Band 71, Heft 11, Seite(n) 1015–1022

    Abstract: Background: The diagnostic algorithm for venous thromboembolism (VTE) currently involves a composite of pre-test probability, D-dimer and imaging. Other laboratory tests, however, may assist in the identification of patients with VTE.: Aim: To assess ...

    Abstract Background: The diagnostic algorithm for venous thromboembolism (VTE) currently involves a composite of pre-test probability, D-dimer and imaging. Other laboratory tests, however, may assist in the identification of patients with VTE.
    Aim: To assess the accuracy of different coagulation tests (D-dimer, thrombin generation, phospholipid-dependent (PPL) clotting time, soluble P-selectin (sP-selectin)) as biomarkers of acute VTE.
    Methods: Random samples arriving at the Coagulation Laboratory at Mater Dei Hospital (Msida, Malta) from the Accident and Emergency Department with a request for D-dimer measurement were collected between August 2015 and February 2016. The following tests were performed: Innovance D-dimer (Siemens Healthcare Diagnostics), HemosIL D-dimer HS (Instrumentation Laboratory), thrombin generation (using the calibrated automated thrombogram), STA Procoag PPL (Diagnostica Stago) and sP-selectin (Affymetrix; eBioscience). VTE was objectively confirmed by compression ultrasonography, CT pulmonary angiography or ventilation/perfusion lung scan.
    Results: 100 samples were collected (33 with VTE). A strong positive linear correlation was found between the two D-dimer tests (r=0.97, p<0.001). Patients with VTE showed significantly higher sP-selectin concentrations compared with patients without VTE (75.7 ng/mL vs 53.0 ng/mL, p<0.001). In the random forest plot, the two D-dimer assays showed the highest variable importance, followed by sP-selectin. A sP-selectin cut-off of 74.8 ng/mL was associated with 72.7% sensitivity and 78.2% specificity for acute VTE in our cohort.
    Conclusion: Our results confirmed D-dimer as the main biomarker of VTE and speculated a role for sP-selectin. The impact of thrombin generation was limited and no role emerged for the PPL clotting time. These observations need to be confirmed in large management studies.
    Mesh-Begriff(e) Adult ; Aged ; Biomarkers/blood ; Blood Coagulation ; Blood Coagulation Tests ; Computed Tomography Angiography ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; Male ; Malta ; Middle Aged ; P-Selectin/blood ; Perfusion Imaging ; Phospholipids/blood ; Predictive Value of Tests ; Reproducibility of Results ; Thrombin/metabolism ; Ultrasonography ; Venous Thromboembolism/blood ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/diagnostic imaging
    Chemische Substanzen Biomarkers ; Fibrin Fibrinogen Degradation Products ; P-Selectin ; Phospholipids ; SELP protein, human ; fibrin fragment D ; Thrombin (EC 3.4.21.5)
    Sprache Englisch
    Erscheinungsdatum 2018-08-09
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Evaluation Studies ; Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2018-205293
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Explicating the relationship between identity and culture

    Vella, Kevin James / Melewar, T. C

    Facets of corporate identity, communication, and reputation , p. 3-34

    a multi-perspective conceptual model

    2008  , Seite(n) 3–34

    Verfasserangabe Kevin James Vella; T. C. Melewar
    Schlagwörter Unternehmenskultur
    Sprache Englisch
    Umfang graph. Darst.
    Verlag Routledge
    Erscheinungsort London [u.a.]
    Dokumenttyp Artikel
    ISBN 978-041-540-527-0 ; 041-540-527-0
    Datenquelle ECONomics Information System

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