LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article ; Online: General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?

    Vellinga, Remco / Eleveld, Douglas J / Struys, Michel M R F / van den Berg, Johannes P

    Current opinion in anaesthesiology

    2023  Volume 36, Issue 5, Page(s) 602–607

    Abstract: Purpose of review: There are various pharmacokinetic-dynamic models available, which describe the time course of drug concentration and effect and which can be incorporated into target-controlled infusion (TCI) systems. For anesthesia and sedation, most ...

    Abstract Purpose of review: There are various pharmacokinetic-dynamic models available, which describe the time course of drug concentration and effect and which can be incorporated into target-controlled infusion (TCI) systems. For anesthesia and sedation, most of these models are derived from narrow patient populations, which restricts applicability for the overall population, including (small) children, elderly, and obese patients. This forces clinicians to select specific models for specific populations.
    Recent findings: Recently, general purpose models have been developed for propofol and remifentanil using data from multiple studies and broad, diverse patient groups. General-purpose models might reduce the risks associated with extrapolation, incorrect usage, and unfamiliarity with a specific TCI-model, as they offer less restrictive boundaries (i.e., the patient "doesn't fit in the selected model") compared with the earlier, simpler models. Extrapolation of a model can lead to delayed recovery or inadequate anesthesia. If multiple models for the same drug are implemented in the pump, it is possible to select the wrong model for that specific case; this can be overcome with one general purpose model implemented in the pump.
    Summary: This article examines the usability of these general-purpose models in relation to the more traditional models.
    MeSH term(s) Child ; Aged ; Humans ; Anesthetics, Intravenous/adverse effects ; Anesthesia, Intravenous/adverse effects ; Anesthesia, General ; Propofol/adverse effects ; Remifentanil/adverse effects
    Chemical Substances Anesthetics, Intravenous ; Propofol (YI7VU623SF) ; Remifentanil (P10582JYYK)
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001300
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2564: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: What's New in Intravenous Anaesthesia? New Hypnotics, New Models and New Applications.

    Vellinga, Remco / Valk, Beatrijs I / Absalom, Anthony R / Struys, Michel M R F / Barends, Clemens R M

    Journal of clinical medicine

    2022  Volume 11, Issue 12

    Abstract: New anaesthetic drugs and new methods to administer anaesthetic drugs are continually becoming available, and the development of new PK-PD models furthers the possibilities of using arget controlled infusion (TCI) for anaesthesia. Additionally, new ... ...

    Abstract New anaesthetic drugs and new methods to administer anaesthetic drugs are continually becoming available, and the development of new PK-PD models furthers the possibilities of using arget controlled infusion (TCI) for anaesthesia. Additionally, new applications of existing anaesthetic drugs are being investigated. This review describes the current situation of anaesthetic drug development and methods of administration, and what can be expected in the near future.
    Language English
    Publishing date 2022-06-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11123493
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Target-controlled Infusion of Remimazolam in Healthy Volunteers Shows Some Acute Tolerance.

    Vellinga, Remco / Koomen, Jeroen V / Eleveld, Douglas J / Stöhr, Thomas / Pesic, Marija / Struys, Michel M R F / Colin, Pieter J

    Anesthesiology

    2023  Volume 140, Issue 2, Page(s) 207–219

    MeSH term(s) Humans ; Anesthesia, General ; Benzodiazepines/pharmacology ; Healthy Volunteers ; Hypnotics and Sedatives/pharmacology ; Infusions, Intravenous
    Chemical Substances Benzodiazepines (12794-10-4) ; Hypnotics and Sedatives ; remimazolam (7V4A8U16MB)
    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004811
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.133: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 199: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Implementation of a Bayesian based advisory tool for target-controlled infusion of propofol using qCON as control variable.

    Vellinga, Remco / Introna, Michele / van Amsterdam, Kai / Zhou, X Y Tommy / De Smet, Tom / Weber Jensen, Erik / Struys, Michel M R F / van den Berg, Johannes P

    Journal of clinical monitoring and computing

    2023  Volume 38, Issue 2, Page(s) 519–529

    Abstract: This single blinded randomized controlled trial aims to assess whether the application of a Bayesian-adjusted ... ...

    Abstract This single blinded randomized controlled trial aims to assess whether the application of a Bayesian-adjusted Ce
    MeSH term(s) Humans ; Propofol/pharmacology ; Anesthetics, Intravenous/pharmacology ; Bayes Theorem ; Anesthesia, Intravenous ; Germany ; Electroencephalography
    Chemical Substances Propofol (YI7VU623SF) ; Anesthetics, Intravenous
    Language English
    Publishing date 2023-12-19
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-023-01106-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2054: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion. Response to Br J Anaesth 2021: 126: e172-4.

    Vellinga, Remco / Hannivoort, Laura N / Koomen, Jeroen V / Colin, Pieter / Absalom, Anthony R / Struys, Michel M R F / Eleveld, Douglas J

    British journal of anaesthesia

    2021  Volume 127, Issue 1, Page(s) e3–e5

    MeSH term(s) Anesthetics, Intravenous ; Humans ; Propofol ; Remifentanil
    Chemical Substances Anesthetics, Intravenous ; Remifentanil (P10582JYYK) ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia.

    Vellinga, Remco / Hannivoort, Laura N / Introna, Michele / Touw, Daan J / Absalom, Anthony R / Eleveld, Douglas J / Struys, Michel M R F

    British journal of anaesthesia

    2020  Volume 126, Issue 2, Page(s) 386–394

    Abstract: Background: Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing models were developed using data from select populations, the use of ... ...

    Abstract Background: Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration. Existing models were developed using data from select populations, the use of which is, strictly speaking, limited to these populations. Recently a propofol PK-PD model was developed for a broad population range. The aim of the study was to prospectively validate this model in children, adults, older subjects, and obese adults undergoing general anaesthesia.
    Methods: The 25 subjects included in each of four groups were stratified by age and weight. Subjects received propofol through TCI with the Eleveld model, titrated to a bispectral index (BIS) of 40-60. Arterial blood samples were collected at 5, 10, 20, 30, 40, and 60 min after the start of propofol infusion, and every 30 min thereafter, to a maximum of 10 samples. BIS was recorded continuously. Predictive performance was assessed using the Varvel criteria.
    Results: For PK, the Eleveld model showed a bias < ±20% in children, adults, and obese adults, but a greater bias (-27%) in older subjects. Precision was <30% in all groups. For PD, the bias and wobble were <5 BIS units and the precision was close to 10 BIS units in all groups. Anaesthetists were able to achieve intraoperative BIS values of 40-60 using effect-site target concentrations about 85-140% of the age-adjusted Ce
    Conclusions: The Eleveld propofol PK-PD model showed predictive precision <30% for arterial plasma concentrations and BIS predictions with a low (population) bias when used in TCI in clinical anaesthesia practice.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Anesthesia, General ; Anesthetics, Intravenous/administration & dosage ; Anesthetics, Intravenous/blood ; Anesthetics, Intravenous/pharmacokinetics ; Body Weight ; Child ; Child, Preschool ; Consciousness/drug effects ; Female ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Models, Biological ; Obesity ; Propofol/administration & dosage ; Propofol/blood ; Propofol/pharmacokinetics ; Prospective Studies ; Reproducibility of Results ; Young Adult
    Chemical Substances Anesthetics, Intravenous ; Propofol (YI7VU623SF)
    Language English
    Publishing date 2020-12-13
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.10.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top