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Article ; Online: The brain is the conductor: diet-induced inflammation overlapping physiological control of body mass and metabolism.

Velloso, Licio Augusto

Arquivos brasileiros de endocrinologia e metabologia

2009 Volume 53, Issue 2, Page(s) 151–158

Abstract: Obesity is currently a worldwide pandemic. It affects more than 300 million humans and it will probably increase over the next 20 years. The consumption of calorie-rich foods is responsible for most of the obesity cases, but not all humans exposed to ... ...

Abstract	Obesity is currently a worldwide pandemic. It affects more than 300 million humans and it will probably increase over the next 20 years. The consumption of calorie-rich foods is responsible for most of the obesity cases, but not all humans exposed to high-calorie diets develop the disease. This fact has prompted researchers to investigate the mechanisms linking the consumption of high-calorie diets to the generation of an imbalance between energy intake and expenditure. According to recent studies, the exposure to fat-rich diets induces an inflammatory response in the hypothalamic areas involved in the control of feeding and thermogenesis. The inflammatory process damages the neuronal circuitries that maintain the homeostatic control of the body's energy stores, therefore favoring body mass gain. This review will focus on the main advances obtained in this field.
MeSH term(s)	Animals ; Body Composition ; Body Mass Index ; Diet ; Dietary Fats/adverse effects ; Dietary Fats/metabolism ; Eating/physiology ; Energy Intake/physiology ; Energy Metabolism/physiology ; Humans ; Hypothalamic Diseases/etiology ; Hypothalamic Diseases/physiopathology ; Hypothalamus/physiology ; Leptin/physiology ; Limbic Encephalitis/etiology ; Limbic Encephalitis/physiopathology ; Obesity/etiology ; Obesity/metabolism ; Thermogenesis/physiology
Chemical Substances	Dietary Fats ; Leptin
Language	English
Publishing date	2009-04-15
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/s0004-27302009000200006
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Article ; Online: Novo modelo, velho remédio.

Velloso, Licio Augusto

Arquivos brasileiros de endocrinologia e metabologia

2009 Volume 53, Issue 4, Page(s) 389–390

Title translation	New model, old medicine.
MeSH term(s)	Animals ; Disease Models, Animal ; Metabolic Syndrome/chemically induced ; Metabolic Syndrome/drug therapy ; Rats ; Rats, Inbred SHR
Language	Portuguese
Publishing date	2009-09-01
Publishing country	Brazil
Document type	Editorial ; Comment
ZDB-ID	603919-4
ISSN	1677-9487 ; 0004-2730
ISSN (online)	1677-9487
ISSN	0004-2730
DOI	10.1590/s0004-27302009000400001
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Article ; Online: Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice.

Soares, Gabriela Moreira / Lopes, Luana Emanuelly Sinhori / Balbo, Sandra Lucinei / Marmentini, Carine / Bronczek, Gabriela Alves / Kurauti, Mirian Ayumi / Bonfleur, Maria Lúcia / Velloso, Licio Augusto / Carneiro, Everardo Magalhães / Boschero, Antonio Carlos / Costa-Júnior, José Maria

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Sleeve gastrectomy (SG) successfully recovers metabolic homeostasis in obese humans and rodents while also resulting in the normalization of insulin sensitivity and insulinemia. Reduced insulin levels have been attributed to lower insulin secretion and ... ...

Abstract	Sleeve gastrectomy (SG) successfully recovers metabolic homeostasis in obese humans and rodents while also resulting in the normalization of insulin sensitivity and insulinemia. Reduced insulin levels have been attributed to lower insulin secretion and increased insulin clearance in individuals submitted to SG. Insulin degradation mainly occurs in the liver in a process controlled, at least in part, by the insulin-degrading enzyme (IDE). However, research has yet to explore whether liver IDE expression or activity is altered after SG surgery. In this study, C57BL/6 mice were fed a chow (CTL) or high-fat diet (HFD) for 10 weeks. Afterward, the HFD mice were randomly assigned to two groups: sham-surgical (HFD-SHAM) and SG-surgical (HFD-SG). Here, we confirmed that SG improves glucose-insulin homeostasis in obese mice. Additionally, SG reduced insulinemia by reducing insulin secretion, assessed by the analysis of plasmatic C-peptide content, and increasing insulin clearance, which was evaluated through the calculation of the plasmatic C-peptide:insulin ratio. Although no changes in hepatic IDE activity were observed, IDE expression was higher in the liver of HFD-SG compared with HFD-SHAM mice. These results indicate that SG may be helpful to counteract obesity-induced hyperinsulinemia by increasing insulin clearance, likely through enhanced liver IDE expression.
MeSH term(s)	Humans ; Mice ; Animals ; Insulin/metabolism ; Mice, Obese ; C-Peptide ; Mice, Inbred C57BL ; Weight Loss ; Obesity/etiology ; Obesity/surgery ; Insulin Resistance ; Insulin, Regular, Human ; Hyperinsulinism/etiology ; Gastrectomy/methods ; Diet, High-Fat/adverse effects
Chemical Substances	Insulin ; C-Peptide ; Insulin, Regular, Human
Language	English
Publishing date	2023-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021729
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Article: Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19.

Moraes, Carla Roberta Peachazepi / Borba-Junior, Ivanio Teixeira / De Lima, Franciele / Silva, Jéssica Ribeiro Alves / Bombassaro, Bruna / Palma, André C / Mansour, Eli / Velloso, Lício Augusto / Orsi, Fernanda Andrade / Costa, Fábio Trindade Maranhão / De Paula, Erich Vinicius

Frontiers in physiology

2023 Volume 14, Page(s) 1113968

Abstract: Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of additional ... ...

Abstract	Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of additional mediators of barrier integrity in this process, as well as the potential of serum from COVID-19 patients to induce EB disruption in cell monolayers. In a cohort from a clinical trial consisting of thirty patients with COVID-19 that required hospital admission due to hypoxia we demonstrate that i) levels of soluble Tie2 were increase, and of soluble VE-cadherin were decreased when compared to healthy individuals; ii) sera from these patients induce barrier disruption in monolayers of endothelial cells; and iii) that the magnitude of this effect is proportional to disease severity and to circulating levels of VEGF-A and Ang-2. Our study confirms and extends previous findings on the pathogenesis of acute lung injury in COVID-19, reinforcing the concept that EB is a relevant component of this disease. Our results pave the way for future studies that can refine our understanding of the pathogenesis of acute lung injury in viral respiratory disorders, and contribute to the identification of new biomarkers and therapeutic targets for these conditions.
Language	English
Publishing date	2023-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1113968
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Article: Body mass variability in age-matched outbred male Swiss mice is associated to differential control of food intake by ghrelin

Morari, Joseane / Haddad-Tóvolli, Roberta / Silva Nogueira, Pedro Augusto / Teixeira, Caio Jordão / Maróstica, Rafael / Tobar, Natália / Ramos, Celso Dario / Velloso, Licio Augusto / Dias Bobbo, Vanessa Cristina / Anhê, Gabriel Forato

Molecular and cellular endocrinology. 2022 June 15, v. 550

2022

Abstract: Swiss mice belong to an outbred strain of mice largely used as a model for experimental obesity induced by high fat diet (HFD). We have previously demonstrated that a given cohort of age-matched Swiss mice is hallmarked by heterogeneous changes in body ... ...

Abstract	Swiss mice belong to an outbred strain of mice largely used as a model for experimental obesity induced by high fat diet (HFD). We have previously demonstrated that a given cohort of age-matched Swiss mice is hallmarked by heterogeneous changes in body weight when exposed to HFD. The reasons underlying such variability, however, are not completely understood. Therefore we aimed to clarify the mechanisms underlying the variability in spontaneous weight gain in age-matched male swiss mice. To achieve that, individuals in a cohort of age-matched male Swiss mice were categorized as prone to body mass gain (PBMG) and resistant to body mass gain (RBMG). PBMG animals had higher caloric intake and body mass gain. RBMG and PBMG mice had a similar reduction in food intake when challenged with leptin but only RBMG exhibited a drop in ghrelin concentrations after refeeding. PBMG also showed increased midbrain levels of ghrelin receptor (Ghsr) and Dopamine receptor d2 (Drd2) mRNAs upon refeeding. Pharmacological blockade of GHSR with JMV3002 failed to reduce food intake in PMBG mice as it did in RBMG. On the other hand, the response to JMV3002 seen in PBMG was hallmarked by singular transcriptional response in the midbrain characterized by a simultaneous increase in both tyrosine hydroxylase (Th) and Proopiomelanocortin (Pomc) expressions. In conclusion, our data show that differences in the expression of genes related to the reward system in the midbrain as well as in ghrelin concentrations in serum correlate with spontaneous variability in body mass and food intake seen in age-matched male Swiss mice.
Keywords	blood serum ; brain ; dopamine receptors ; energy intake ; food intake ; ghrelin ; ghrelin receptors ; high fat diet ; leptin ; males ; models ; obesity ; pro-opiomelanocortin ; transcription (genetics) ; tyrosine 3-monooxygenase ; weight gain
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2022.111646
Database	NAL-Catalogue (AGRICOLA)

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Article: Effects of Different Exercise Types on Chrna7 and Chrfam7a Expression in Healthy Normal Weight and Overweight Type 2 Diabetic Adults.

Mateus, Keryma Chaves da Silva / Bonfante, Ivan Luiz Padilha / Sardeli, Amanda Veiga / Duft, Renata Garbellini / Gáspari, Arthur Fernandes / Trombeta, Joice Cristina Dos Santos / Morari, Joseane / Rodrigues, Bruno / Torsoni, Márcio Alberto / Chacon-Mikahil, Mara Patrícia Traina / Velloso, Licio Augusto / Cavaglieri, Cláudia Regina

Biomedicines

2023 Volume 11, Issue 2

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11020565
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Article ; Online: Podoplanin and CLEC-2 levels in patients with COVID-19.

Borba-Junior, Ivanio Teixeira / Lima, Franciele / Vitoria Rodrigues Oliveira, Davi Sidarta / Peachazepi Moraes, Carla Roberta / Annichino-Bizzacchi, Joyce M / Bombassaro, Bruna / Palma, André C / Maranhao Costa, Fabio Trindade / Moretti, Maria Luiza / Mansour, Eli / Velloso, Licio Augusto / Orsi, Fernanda Andrade / De Paula, Erich Vinicius

Research and practice in thrombosis and haemostasis

2023 , Page(s) 100282

Abstract: Introduction: Podoplanin (: Aim: To explore the role of podoplanin and CLEC-2 in COVID-19.: Methods: Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex- ... ...

Abstract	Introduction: Podoplanin ( Aim: To explore the role of podoplanin and CLEC-2 in COVID-19. Methods: Circulating levels of podoplanin and CLEC-2 were measured in 30 consecutive COVID-19 patients admitted due to hypoxia, and in 30 age- and sex-matched healthy individuals. Podoplanin expression in lungs from patients who died of COVID-19 was obtained from two independent public databases of single-cell RNAseq from which data from control lungs were also available. Results: Circulating podoplanin levels were lower in COVID-19, while no difference was observed in CLEC-2 levels. Podoplanin levels were significantly inversely correlated with markers of coagulation, fibrinolysis and innate immunity. scRNAseq data confirmed that Conclusion: Circulating levels of podoplanin are lower in COVID-19, and the magnitude of this reduction is correlated with hemostasis activation. We also demonstrate the downregulation of
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ISSN	2475-0379
ISSN (online)	2475-0379
DOI	10.1016/j.rpth.2023.100282
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New translational and experimental insights into the role of pro-resolving lipid mediators in inflammatory bowel disease.

Pascoal, Lívia Bitencourt / Palma, Bruna Biazon / Chaim, Fabio Henrique Mendonça / de Castro, Marina Moreira / Damázio, Tiago Andrade / Franceschini, Ana Paula Menezes de Freitas / Milanski, Marciane / Velloso, Lício Augusto / Leal, Raquel Franco

World journal of experimental medicine

2022 Volume 12, Issue 1, Page(s) 1–15

Abstract: The resolution of inflammation is an active process, guided by specialized pro-resolution lipid mediators (SPMs). These mediators originate from polyunsaturated fatty acids, such as omega-3. Sufficient evidence suggests that the beneficial effects ... ...

Abstract	The resolution of inflammation is an active process, guided by specialized pro-resolution lipid mediators (SPMs). These mediators originate from polyunsaturated fatty acids, such as omega-3. Sufficient evidence suggests that the beneficial effects attributed to omega-3 are, at least in part, the result of the immunomodulatory action of the SPMs, which act systemically by overcoming inflammation and repairing tissue damage, without suppressing the immune response. Recent studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions, such as inflammatory bowel disease (IBD). Thus, this review highlights the advances made in recent years with regard to the endo-genous synthesis and the biological role of lipoxins, resolvins, protectins, and maresins, as well as their precursors, in the regulation of inflammation; and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.
Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2764849-7
ISSN	2220-315X
ISSN	2220-315X
DOI	10.5493/wjem.v12.i1.1
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Article ; Online: Body mass variability in age-matched outbred male Swiss mice is associated to differential control of food intake by ghrelin.

Molecular and cellular endocrinology

2022 Volume 550, Page(s) 111646

Abstract	Swiss mice belong to an outbred strain of mice largely used as a model for experimental obesity induced by high fat diet (HFD). We have previously demonstrated that a given cohort of age-matched Swiss mice is hallmarked by heterogeneous changes in body weight when exposed to HFD. The reasons underlying such variability, however, are not completely understood. Therefore we aimed to clarify the mechanisms underlying the variability in spontaneous weight gain in age-matched male swiss mice. To achieve that, individuals in a cohort of age-matched male Swiss mice were categorized as prone to body mass gain (PBMG) and resistant to body mass gain (RBMG). PBMG animals had higher caloric intake and body mass gain. RBMG and PBMG mice had a similar reduction in food intake when challenged with leptin but only RBMG exhibited a drop in ghrelin concentrations after refeeding. PBMG also showed increased midbrain levels of ghrelin receptor (Ghsr) and Dopamine receptor d2 (Drd2) mRNAs upon refeeding. Pharmacological blockade of GHSR with JMV3002 failed to reduce food intake in PMBG mice as it did in RBMG. On the other hand, the response to JMV3002 seen in PBMG was hallmarked by singular transcriptional response in the midbrain characterized by a simultaneous increase in both tyrosine hydroxylase (Th) and Proopiomelanocortin (Pomc) expressions. In conclusion, our data show that differences in the expression of genes related to the reward system in the midbrain as well as in ghrelin concentrations in serum correlate with spontaneous variability in body mass and food intake seen in age-matched male Swiss mice.
MeSH term(s)	Animals ; Body Weight ; Diet, High-Fat ; Eating ; Ghrelin/metabolism ; Humans ; Male ; Mice ; Receptors, Ghrelin/genetics ; Receptors, Ghrelin/metabolism
Chemical Substances	Ghrelin ; Receptors, Ghrelin
Language	English
Publishing date	2022-04-10
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2022.111646
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Article ; Conference proceedings: VIAS DE PRÓ-RESOLUÇÃO NA COLITE EXPERIMENTAL – UMA NOVA ABORDAGEM TERAPÊUTICA POSSÍVEL PARA DOENÇAS INFLAMATÓRIAS INTESTINAIS

Chaim, Fabio Henrique Mendonça / Pascoal, Lívia Bitencourt / Palma, Bruna Biazon / Rodrigues, Bruno Lima / de Castro, Marina Moreira / Lopes, Luiz Roberto / Velloso, Lício Augusto / Leal, Raquel Franco

Journal of Coloproctology

2023 Volume 43, Issue S 01

Event/congress	71° Congresso Brasileiro de Coloproctologia, Belo Horizonte, MG, 2023-09-05
Language	English
Publishing date	2023-12-01
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2664477-0
ISSN	2317-6423 ; 2237-9363 ; 2317-6423
ISSN (online)	2317-6423
ISSN	2237-9363 ; 2317-6423
DOI	10.1055/s-0044-1780990
Database	Thieme publisher's database

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