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  1. AU="Velutti, Laura"
  2. AU="Tran, Victoria M"
  3. AU=Wechselberger Christian
  4. AU="Weiland, Fabia"
  5. AU=Gaillard Erol A AU=Gaillard Erol A AU=Gaillard Erol A
  6. AU="Costabile, G"
  7. AU="Schäkel, Knut"
  8. AU="Kamoun, Elbadawy A"
  9. AU="Hana M El Sahly"
  10. AU="Tasnim, S."
  11. AU="Crundwell, David J"
  12. AU="Pavan, William J"
  13. AU="Kanie, Keitaro"
  14. AU="Li, Huling"
  15. AU="Joeres, Roman"
  16. AU="Lynce, Ana"
  17. AU="Goksu, Muhammed M"
  18. AU="Škvor, Jiří"
  19. AU=Fomenko Ekaterina Vladimirovna
  20. AU=Abootalebi Shahram AU=Abootalebi Shahram
  21. AU="Salim Kabbani, Mohamed"
  22. AU="Mrówka, Ryszard"
  23. AU="Guzman-Esquivel, José"
  24. AU="Shamloul, Sara"
  25. AU="Fazzari, Carmine"
  26. AU="Tang, K B"
  27. AU="Sansbury, Brian E"
  28. AU="Chapuy-Regaud, Sabine"
  29. AU="Y.Yang, " AU="Y.Yang, "
  30. AU="Banu Bozkurt"
  31. AU="Aguib, Yasmine"

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  1. Artikel ; Online: Well-Being and Professional Efficacy Among Health Care Professionals: The Role of Resilience Through the Mediation of Ethical Vision of Patient Care and the Moderation of Managerial Support.

    Maffoni, Marina / Sommovigo, Valentina / Giardini, Anna / Velutti, Laura / Setti, Ilaria

    Evaluation & the health professions

    2021  Band 45, Heft 4, Seite(n) 381–396

    Abstract: Drawing on the Conservation of Resources theory, this study analyzes whether resilience could be related to healthcare providers' wellbeing and professional self-efficacy, both directly and indirectly, as mediated by ethical vision of patient care and ... ...

    Abstract Drawing on the Conservation of Resources theory, this study analyzes whether resilience could be related to healthcare providers' wellbeing and professional self-efficacy, both directly and indirectly, as mediated by ethical vision of patient care and moderated by managerial support in dealing with ethical issues. Overall, 315 Italian healthcare professionals employed in neuro-rehabilitation medicine or palliative care specialties participated in this multi-centered cross-sectional study. The following variables were investigated: resilience (Connor-Davidson Resilience Scale), wellbeing (Maugeri Stress Index-Reduced), professional self-efficacy (Maslach Burnout Inventory-General Survey), ethical vision of patient care and managerial support in dealing with ethical issues (Italian version of the Hospital Ethical Climate Survey). Overall, resilience was positively associated with healthcare providers' wellbeing and professional self-efficacy, directly and indirectly, as mediated by ethical vision of patient care. Highly resilient healthcare professionals who perceived the presence of a positive ethical vision of patient care in their workplace were more likely to experience greater wellbeing when managerial support in dealing with ethical issues was high (vs. low). Thus, these findings provide suggestions for tailored interventions sustaining healthcare professionals along their daily activity characterized by high-demanding and challenging situations.
    Mesh-Begriff(e) Humans ; Cross-Sectional Studies ; Burnout, Professional ; Health Personnel ; Workplace ; Patient Care
    Sprache Englisch
    Erscheinungsdatum 2021-09-16
    Erscheinungsland United States
    Dokumenttyp Multicenter Study ; Journal Article
    ZDB-ID 603792-6
    ISSN 1552-3918 ; 0163-2787
    ISSN (online) 1552-3918
    ISSN 0163-2787
    DOI 10.1177/01632787211042660
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: SMiLE to Life: Meaning in life in healthcare professionals working in palliative care and rehabilitation medicine.

    Maffoni, Marina / Zanatta, Francesco / Setti, Ilaria / Giorgi, Ines / Velutti, Laura / Giardini, Anna

    La Medicina del lavoro

    2021  Band 112, Heft 5, Seite(n) 387–400

    Abstract: Background: In the healthcare landscape, various protective factors are identified, such as meaning in life (MiL), namely what gives sense to life events. However, little is known about this construct in the healthcare population.: Objectives: To ... ...

    Abstract Background: In the healthcare landscape, various protective factors are identified, such as meaning in life (MiL), namely what gives sense to life events. However, little is known about this construct in the healthcare population.
    Objectives: To describe MiL among healthcare professionals employed in palliative care and neuro-rehabilitation medicine, unveiling possible differences related to medical specialty and socio-demographic characteristics.
    Methods: In this cross-sectional and multicentre study, palliative care and neuro-rehabilitation professionals were recruited. MiL was evaluated with the Schedule for Meaning in Life Evaluation (SMiLE), which provides a list of meaningful areas, as well as related overall indexes of satisfaction (IoS), weighting (IoW), weighted satisfaction (IoWS). Descriptive statistics, t-test, chi-square, linear and binary logistic regressions were performed.
    Results: Overall, 297healthcare professionals (palliative care=89, neuro-rehabilitation medicine=208, 47% of participants ≤ 40 years old) completed the evaluation. The sample was intra- and inter-groups heterogeneous, in particular concerning age and professional role. Conversely, no significant group differences emerged in MiL indexes comparisons, nor in the number of MiL listed areas. As for MiL areas, the category "family" increased the IoWS index, while terms related to "finances" contributed to decrease it. Comparing specialties, palliative care professionals were more likely to report areas like "partnership", "social commitment", and "satisfaction". Nurses (n=116), nurse aides (n=47), and therapists (n=67) were more likely to mention health-related terms (e.g. health, physical wellbeing) than physicians and psychologists (n=65).
    Conclusion: This study highlighted MiL areas among professionals employed in palliative care and neurorehabilitation specialties, providing informative suggestions for tailored health prevention programs which should pay particular attention to social and family relationships, socio-economic status, and health.
    Mesh-Begriff(e) Adult ; Cross-Sectional Studies ; Delivery of Health Care ; Hospice and Palliative Care Nursing ; Humans ; Palliative Care ; Personal Satisfaction
    Sprache Englisch
    Erscheinungsdatum 2021-10-28
    Erscheinungsland Italy
    Dokumenttyp Journal Article ; Multicenter Study
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v112i5.11408
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Favorable incremental cost-effectiveness ratio for lung cancer screening in Italy.

    Veronesi, Giulia / Navone, Niccolò / Novellis, Pierluigi / Dieci, Elisa / Toschi, Luca / Velutti, Laura / Solinas, Michela / Vanni, Elena / Alloisio, Marco / Ghislandi, Simone

    Lung cancer (Amsterdam, Netherlands)

    2020  Band 143, Seite(n) 73–79

    Abstract: Objectives: Lung cancer detection by low-dose computed tomographic screening reduces mortality. However, it is essential to assess cost-effectiveness. We present a cost-effectiveness analysis of screening in Italians at high risk of lung cancer, from ... ...

    Abstract Objectives: Lung cancer detection by low-dose computed tomographic screening reduces mortality. However, it is essential to assess cost-effectiveness. We present a cost-effectiveness analysis of screening in Italians at high risk of lung cancer, from the point of view of the Italian tax-payer.
    Materials and methods: We used a decision model to estimate the cost-effectiveness of annual screening for 5 years in smokers (≥30 pack-years) of 55-79 years. Patients diagnosed in the COSMOS study were the screening arm; patients diagnosed and treated for lung cancer in the Lombardy Region, Italy, constituted the usual care arm. Treatment costs were extracted from our hospital database. Lung cancer survival in screened patients was adjusted for 2-year lead-time bias. Life-years and quality-adjusted life-years were estimated by stage at diagnosis, from which incremental cost-effectiveness ratios per life-year and quality-adjusted life-year gained were estimated.
    Results: Base-case incremental cost-effectiveness ratios were 3297 and 2944 euro per quality-adjusted life-year and life-year gained, respectively. Deterministic sensitivity analysis indicated that these values were particularly sensitive to lung cancer prevalence, screening sensitivity and specificity, screening cost, and treatment costs for stage I and IV disease. From the probabilistic sensitivity analysis incremental cost-effectiveness ratios had a 98 % probability of being <25,000 euro (widely-accepted threshold) and a 55 % probability of being <5000 euro.
    Conclusions: Low-dose computed tomographic screening is associated with an incremental cost of 2944 euro per life-year gained in high risk population, implying that screening can be introduced in Italy at contained cost, saving the lives of many lung cancer patients.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Combined Modality Therapy ; Cost-Benefit Analysis ; Early Detection of Cancer/economics ; Female ; Follow-Up Studies ; Health Care Costs/statistics & numerical data ; Humans ; Italy/epidemiology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/economics ; Lung Neoplasms/epidemiology ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Prognosis ; Quality-Adjusted Life Years ; Survival Rate
    Sprache Englisch
    Erscheinungsdatum 2020-03-19
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2020.03.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Effectiveness of a phone-based nurse monitoring assessment and intervention for chemotherapy-related toxicity: A randomized multicenter trial.

    Antonuzzo, Andrea / Ripamonti, Carla Ida / Roila, Fausto / Sbrana, Andrea / Galli, Luca / Miccinesi, Guido / Sammarco, Enrico / Berruti, Alfredo / Coletta, Deborah / Velutti, Laura / Fabi, Alessandra / Corsi, Domenico Cristiano / Mariani, Gabriella / Di Pede, Patricia / Spinelli, Gian Paolo / Santini, Daniele / Zustovich, Fable / Gunnellini, Marco / Rossi, Maura /
    Giordano, Monica / Di Maio, Massimo / Numico, Gianmauro / Bossi, Paolo

    Frontiers in oncology

    2022  Band 12, Seite(n) 925366

    Abstract: Purpose: Anticancer treatment-related toxicities can impact morbidity and mortality, hamper the administration of treatment, worsen the quality of life and increase the burden on the healthcare system. Therefore, their prompt identification is crucial. ... ...

    Abstract Purpose: Anticancer treatment-related toxicities can impact morbidity and mortality, hamper the administration of treatment, worsen the quality of life and increase the burden on the healthcare system. Therefore, their prompt identification is crucial. NICSO (Italian Network for Supportive Care in Cancer) conducted a nationwide randomized trial to evaluate the role of a planned, weekly phone-based nurse monitoring intervention to prevent and treat chemotherapy, targeted therapy- and immunotherapy-related toxicities. Here, we report the results from the chemotherapy arm.
    Methods: This was a nationwide, randomized, open-label trial conducted among 29 Italian centers (NCT04726020) involving adult patients with breast, colon, or lung cancer and a life expectancy ≥6 months receiving adjuvant chemotherapy. Patients received either a weekly nurse monitoring phone call and an educational leaflet reporting practical advice about prevention and treatment of toxicities (experimental group) or the educational leaflet only (control group).
    Results: The addition of a nurse monitoring intervention may help reduce time spent with severe toxicities (grade ≥3), particularly those less frequently reported in clinical practice, such as fatigue. When considering grade 1-2 AEs, times with mild/moderate diarrhea, mucositis, fatigue and pain were shorter in the experimental arm. Time spent without AEs was significantly longer in the experimental arms for all the toxicities. The requirement for special medical attention was comparable between groups.
    Conclusion: This study suggests the need for implementing a better system of toxicity assessment and management for patients treated with adjuvant chemotherapy to promote effective preventive and/or therapeutic intervention against these events.
    Sprache Englisch
    Erscheinungsdatum 2022-09-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.925366
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Weekly non-pegylated liposomal doxorubicin chemotherapy in heavily pre-treated patients with metastatic breast cancer.

    Masci, Giovanna / Gandini, Chiara / Zuradelli, Monica / Losurdo, Agnese / Torrisi, Rosalba / Rota, Selene / Gullo, Giuseppe / Velutti, Laura / Giordano, Laura / Santoro, Armando

    Anticancer research

    2013  Band 33, Heft 10, Seite(n) 4603–4609

    Abstract: Background: Due to its low cardiac toxicity, non-pegylated liposomal doxorubicin (NPLD) may represent an attractive therapeutic option as salvage therapy for patients with metastatic breast cancer who have already received anthracycline-based ... ...

    Abstract Background: Due to its low cardiac toxicity, non-pegylated liposomal doxorubicin (NPLD) may represent an attractive therapeutic option as salvage therapy for patients with metastatic breast cancer who have already received anthracycline-based chemotherapy.
    Patients and methods: We retrospectively reviewed 47 consecutive patients with metastatic breast cancer treated with NPLD at our Institution between 2008 and 2012. Patients received weekly NPLD at a dose of 20 mg/m(2) i.v. until disease progression or unacceptable toxicity.
    Results: Nine patients (19.1%) achieved a partial response and 11 (23.4%) had stable disease, with a disease control rate of 42.6%; 27 patients (57.4%) had progressive disease. The median progression-free survival and overall survival were 2.7 and 11.5 months, respectively. Grade 3 and 4 adverse events did not occur. No cardiac events were observed.
    Conclusion: Weekly NPLD represents a safe and effective therapy and may be considered a new therapeutic option for heavily pre-treated patients with metastatic breast cancer.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Antibiotics, Antineoplastic/administration & dosage ; Breast Neoplasms/drug therapy ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/drug therapy ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/secondary ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Doxorubicin/analogs & derivatives ; Drug Administration Schedule ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Multivariate Analysis ; Polyethylene Glycols/administration & dosage ; Retrospective Studies ; Salvage Therapy ; Treatment Outcome
    Chemische Substanzen Antibiotics, Antineoplastic ; liposomal doxorubicin ; Polyethylene Glycols (30IQX730WE) ; Doxorubicin (80168379AG)
    Sprache Englisch
    Erscheinungsdatum 2013-10
    Erscheinungsland Greece
    Dokumenttyp Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1642: Hefte anzeigen Standort:
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