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Article ; Online: Electrochemical Cellulase-Linked ELASA for Rapid Liquid Biopsy Testing of Serum HER-2/

Díaz-Fernández, Ana / Ferapontov, Alexey / Vendelbo, Mikkel Holm / Ferapontova, Elena E

ACS measurement science au

2023 Volume 3, Issue 3, Page(s) 226–235

Abstract: Non-invasive liquid biopsy assays for blood-circulating biomarkers of cancer allow both its early diagnosis and treatment monitoring. Here, we assessed serum levels of protein HER-2/ ...

Abstract	Non-invasive liquid biopsy assays for blood-circulating biomarkers of cancer allow both its early diagnosis and treatment monitoring. Here, we assessed serum levels of protein HER-2/
Language	English
Publishing date	2023-04-14
Publishing country	United States
Document type	Journal Article
ISSN	2694-250X
ISSN (online)	2694-250X
DOI	10.1021/acsmeasuresciau.2c00067
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Article: Inclusion of Metabolic Tumor Volume in Prognostic Models of Bone and Soft Tissue Sarcoma Increases the Prognostic Value.

Pedersen, Mette Abildgaard / Baad-Hansen, Thomas / Gormsen, Lars C / Bærentzen, Steen / Sandfeld-Paulsen, Birgitte / Aggerholm-Pedersen, Ninna / Vendelbo, Mikkel Holm

Cancers

2023 Volume 15, Issue 3

Abstract: Sarcomas are rare and have a high mortality rate. Further prognostic classification, with readily available parameters, is warranted, and several studies have examined circulating biomarkers and PET parameters separately. This single-site, retrospective ... ...

Abstract	Sarcomas are rare and have a high mortality rate. Further prognostic classification, with readily available parameters, is warranted, and several studies have examined circulating biomarkers and PET parameters separately. This single-site, retrospective study aimed to examine the prognostic values of several scoring systems in combination with PET parameters. We included 148 patients with sarcoma, who were treated and scanned at Aarhus University Hospital from 1 January 2016 to 31 December 2019. The Akaike information criterion and Harrell's concordance index were used to evaluate whether the PET parameters added prognostic information to existing prognostic models using circulating biomarkers. Of the PET parameters, metabolic tumor volume (MTV) performed best, and when combined with the existing prognostic models, the prognostic value improved in all models. Backward stepwise selection was used to create a new model, SBSpib, which included albumin, lymphocytes, and one PET parameter, MTV. It has scores ranging from zero to three and increasing hazard ratios; HR = 4.83 (1.02-22.75) for group one, HR = 7.40 (1.6-33.42) for group two, and HR = 17.32 (3.45-86.93) for group three. Consequently, implementing PET parameters in prognostic models improved the prognostic value. SBSpib is a new prognostic model that includes both circulating biomarkers and PET parameters; however, validation in another sarcoma cohort is warranted.
Language	English
Publishing date	2023-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030816
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Article ; Online: Pulmonary Opacities and Bronchiectasis Avid on 68Ga-PSMA PET.

Bouchelouche, Kirsten / Vendelbo, Mikkel Holm

Clinical nuclear medicine

2017 Volume 42, Issue 4, Page(s) e216–e217

Abstract: Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and the expression increases with tumor aggressiveness, metastatic disease, and recurrence. Despite its name, PSMA is also expressed in neovasculature of other tumors ... ...

Abstract	Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and the expression increases with tumor aggressiveness, metastatic disease, and recurrence. Despite its name, PSMA is also expressed in neovasculature of other tumors including lung cancer. Here, we demonstrate a case of increased PSMA expression on Ga-PSMA PET/CT in benign lung opacities and bronchiectasis in a prostate cancer patient. Thus, increased PSMA activity in the lungs may be due to both benign and malignant diseases and warrants further evaluation.
MeSH term(s)	Bronchiectasis/complications ; Bronchiectasis/diagnostic imaging ; Edetic Acid/analogs & derivatives ; Humans ; Lung Diseases/complications ; Lung Diseases/diagnostic imaging ; Male ; Middle Aged ; Oligopeptides ; Organometallic Compounds ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
Chemical Substances	Oligopeptides ; Organometallic Compounds ; Radiopharmaceuticals ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2017-01-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000001568
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Article ; Online: Extracardiac findings with increased perfusion during clinical O-15-H

Jochumsen, Mads Ryø / Overgaard, David Lyse / Vendelbo, Mikkel Holm / Madsen, Michael Alle / Tolbod, Lars Poulsen / Gormsen, Lars Christian / Barkholt, Trine Ørhøj

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

2023 Volume 30, Issue 4, Page(s) 1458–1468

Abstract: Background: Coincidental extracardiac findings with increased perfusion were reported during myocardial perfusion imaging (MPI) with various retention radiotracers. Clinical parametric O-15-H: Methods and results: All patients (2963) were scanned ... ...

Abstract	Background: Coincidental extracardiac findings with increased perfusion were reported during myocardial perfusion imaging (MPI) with various retention radiotracers. Clinical parametric O-15-H Methods and results: All patients (2963) were scanned with O-15-H Conclusions: Malignant and benign extracardiac coincidental findings with increased perfusion are readily visible and frequently seen on O-15-H
MeSH term(s)	Male ; Humans ; Positron Emission Tomography Computed Tomography/methods ; COVID-19 ; Myocardial Perfusion Imaging/methods ; Perfusion ; Positron-Emission Tomography/methods
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212505-2
ISSN	1532-6551 ; 1071-3581
ISSN (online)	1532-6551
ISSN	1071-3581
DOI	10.1007/s12350-022-03156-5
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Zs.A 4121: Show issues

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Article ; Online: Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64 Cu PET/CT study in healthy humans.

Kirk, Frederik Teicher / Munk, Ditte Emilie / Swenson, Eugene Scott / Quicquaro, Adam Michael / Vendelbo, Mikkel Holm / Schilsky, Michael L / Ott, Peter / Sandahl, Thomas Damgaard

Hepatology (Baltimore, Md.)

2023 Volume 79, Issue 5, Page(s) 1065–1074

Abstract: Background and aims: Trientine (TRI) and D-penicillamine (PEN) are used to treat copper overload in Wilson disease. Their main mode of action is thought to be through the facilitation of urinary copper excretion. In a recent study, TRI was noninferior ... ...

Abstract	Background and aims: Trientine (TRI) and D-penicillamine (PEN) are used to treat copper overload in Wilson disease. Their main mode of action is thought to be through the facilitation of urinary copper excretion. In a recent study, TRI was noninferior to PEN despite lower 24-hour urinary copper excretion than PEN. We tested whether TRI and/or PEN also inhibit intestinal copper absorption. Approach and results: Sixteen healthy volunteers were examined with positron emission tomography (PET)/CT 1 and 15 hours after an oral Copper-64 ( 64 Cu) dose. They then received 7 days of either PEN or TRI (trientine tetrahydrochloride), after which the 64 Cu PET/CT scans were repeated. Venous blood samples were also collected. Pretreatment to posttreatment changes of the hepatic 64 Cu uptake reflect the effect of drugs on intestinal absorption. 64 Cu activity was normalized to dose and body weight and expressed as the mean standard uptake value. TRI (n=8) reduced hepatic 64 Cu activity 1 hour after 64 Cu dose from 6.17 (4.73) to 1.47 (2.97) standard uptake value, p <0.02, and after 15 hours from 14.24 (3.09) to 6.19 (3.43), p <0.02, indicating strong inhibition of intestinal 64 Cu absorption. PEN (n=8) slightly reduced hepatic standard uptake value at 15 hours, from 16.30 (5.63) to 12.17 (1.44), p <0.04. Conclusions: In this mechanistic study, we show that TRI inhibits intestinal copper absorption, in addition to its cupriuretic effect. In contrast, PEN has modest effects on the intestinal copper absorption. This may explain why TRI and PEN are equally effective although urinary copper excretion is lower with TRI. The study questions whether the same therapeutic targets for 24-hour urinary excretion apply to both drugs.
MeSH term(s)	Humans ; Penicillamine/pharmacology ; Penicillamine/therapeutic use ; Trientine/pharmacology ; Trientine/therapeutic use ; Copper ; Positron Emission Tomography Computed Tomography ; Copper Radioisotopes/therapeutic use ; Hepatolenticular Degeneration/drug therapy ; Positron-Emission Tomography
Chemical Substances	Penicillamine (GNN1DV99GX) ; Trientine (SJ76Y07H5F) ; Copper (789U1901C5) ; Copper-64 ; Copper Radioisotopes
Language	English
Publishing date	2023-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000708
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Zs.A 1660: Show issues

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Article: Increased lesion detectability in patients with locally advanced breast cancer-A pilot study using dynamic whole-body [

Pedersen, Mette Abildgaard / Dias, André H / Hjorthaug, Karin / Gormsen, Lars C / Fledelius, Joan / Johnsson, Anna Lyhne / Borgquist, Signe / Tramm, Trine / Munk, Ole Lajord / Vendelbo, Mikkel Holm

EJNMMI research

2024 Volume 14, Issue 1, Page(s) 31

Abstract: Background: Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph ... ...

Abstract	Background: Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph node biopsy and/or ALN dissection, none of which are without risks and/or long-term complications. It is known that conventional 2-deoxy-2-[ Results: This study prospectively included ten women with locally advanced breast cancer who were referred for an [ Conclusions: D-WB [ Clinical trial registration: The trial is registered in clinicaltrials.gov, NCT05110443, https://www. Clinicaltrials: gov/study/NCT05110443?term=NCT05110443&rank=1 .
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2619892-7
ISSN	2191-219X
ISSN	2191-219X
DOI	10.1186/s13550-024-01096-4
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Article ; Online: Absent 18F-FDG Uptake in the Brain-Unsuspected Brain Death.

Pedersen, Mette Abildgaard / Jensen-Fangel, Søren / Nielsen, Edith / Borghammer, Per / Vendelbo, Mikkel Holm

Clinical nuclear medicine

2021 Volume 45, Issue 10, Page(s) e433–e434

Abstract: Brain death is the complete, irreversible cessation of brain function, including the capacity for brainstem, respiratory, and vegetative activities. It is a clinical diagnosis that can be supplemented with brain perfusion imaging. Absent cerebral blood ... ...

Abstract	Brain death is the complete, irreversible cessation of brain function, including the capacity for brainstem, respiratory, and vegetative activities. It is a clinical diagnosis that can be supplemented with brain perfusion imaging. Absent cerebral blood flow can be visualized with CT angiography or perfusion scintigraphy. F-FDG PET/CT, visualizing glucose uptake, is another approach that has been shown to indicate brain death in small case series. We here present a case with unsuspected absent F-FDG uptake and thus no metabolic activity, in the brain. The patient was declared brain dead later the same day.
MeSH term(s)	Biological Transport ; Brain/diagnostic imaging ; Brain/metabolism ; Brain Death/diagnostic imaging ; Brain Death/metabolism ; Fluorodeoxyglucose F18/metabolism ; Humans ; Positron Emission Tomography Computed Tomography
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-02-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000003237
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Article ; Online: 68Ga-PSMA Uptake in Middle Lobe Syndrome.

Pedersen, Mette Abildgaard / Bouchelouche, Kirsten / Vendelbo, Mikkel Holm

Clinical nuclear medicine

2018 Volume 43, Issue 10, Page(s) e376–e377

Abstract: Prostate cancer cells have abundant expression of the cell surface protein prostate-specific membrane antigen (PSMA). In recent years, PET radioligands detecting this protein has therefore gained substantial interest in prostate cancer staging. It turned ...

Abstract	Prostate cancer cells have abundant expression of the cell surface protein prostate-specific membrane antigen (PSMA). In recent years, PET radioligands detecting this protein has therefore gained substantial interest in prostate cancer staging. It turned out that PSMA expression can be evident in both malignant and benign lesions, and we have previously reported that pulmonary opacities and bronchiectasis can be avid on Ga-PSMA PET/CT. Here, we present a case with Ga-PSMA accumulation in nonobstructive middle lobe syndrome, which further indicate that benign changes in the lungs may be falsely interpreted as malignant disease.
MeSH term(s)	Aged ; Biological Transport ; Edetic Acid/analogs & derivatives ; Edetic Acid/metabolism ; Humans ; Male ; Middle Lobe Syndrome/diagnostic imaging ; Middle Lobe Syndrome/metabolism ; Oligopeptides/metabolism ; Positron Emission Tomography Computed Tomography
Chemical Substances	Oligopeptides ; gallium 68 PSMA-11 ; Edetic Acid (9G34HU7RV0)
Language	English
Publishing date	2018-07-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002213
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Article ; Online: Distribution of non-ceruloplasmin-bound copper after i.v.

Munk, Ditte Emilie / Vendelbo, Mikkel Holm / Kirk, Frederik Teicher / Rewitz, Karina Stubkjær / Bender, Dirk Andreas / Vase, Karina Højrup / Munk, Ole Lajord / Vilstrup, Hendrik / Ott, Peter / Sandahl, Thomas Damgaard

JHEP reports : innovation in hepatology

2023 Volume 5, Issue 11, Page(s) 100916

Abstract: Background & aims: In Wilson disease (WD), copper accumulation and increased non-ceruloplasmin-bound copper in plasma lead to liver and brain pathology. To better understand the fate of non-ceruloplasmin-bound copper, we used PET/CT to examine the whole- ...

Abstract	Background & aims: In Wilson disease (WD), copper accumulation and increased non-ceruloplasmin-bound copper in plasma lead to liver and brain pathology. To better understand the fate of non-ceruloplasmin-bound copper, we used PET/CT to examine the whole-body distribution of intravenously injected 64-copper ( Methods: Eight patients with WD, five heterozygotes, and nine healthy controls were examined by dynamic PET/CT for 90 min and static PET/CT up to 20 h after injection. We measured Results: Initially, a large fraction of injected Conclusion: Non-ceruloplasmin-bound copper is initially distributed into a number of tissues before being redistributed slowly to the eliminating organ, the liver. Cerebral uptake of copper is extremely slow and likely highly regulated. Our findings provide new insights into the mechanisms of copper control. Impact and implications: Maintaining non-ceruloplasmin-bound copper within the normal range is an important treatment goal in WD as this "free" copper is considered toxic to the liver and brain. We found that intravenously injected non-ceruloplasmin-bound copper quickly distributed to a number of tissues, especially skeletal muscle, subcutaneous fat, and the liver, while uptake into the brain was slow. This study offers new insights into the mechanisms of copper control, which may encourage further research into potential new treatment targets. Clinical trial number: 2016-001975-59.
Language	English
Publishing date	2023-09-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-5559
ISSN (online)	2589-5559
DOI	10.1016/j.jhepr.2023.100916
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Article ; Online: Effects of tetrathiomolybdate on copper metabolism in healthy volunteers and in patients with Wilson disease.

Kirk, Frederik Teicher / Munk, Ditte Emilie / Swenson, Eugene Scott / Quicquaro, Adam Michael / Vendelbo, Mikkel Holm / Larsen, Agnete / Schilsky, Michael L / Ott, Peter / Sandahl, Thomas Damgaard

Journal of hepatology

2023 Volume 80, Issue 4, Page(s) 586–595

Abstract: Background & aims: In Wilson disease (WD), copper accumulates in the liver and brain causing disease. Bis-choline tetrathiomolybdate (TTM) is a potent copper chelator that may be associated with a lower risk of inducing paradoxical neurological ... ...

Abstract	Background & aims: In Wilson disease (WD), copper accumulates in the liver and brain causing disease. Bis-choline tetrathiomolybdate (TTM) is a potent copper chelator that may be associated with a lower risk of inducing paradoxical neurological worsening than conventional therapy for neurologic WD. To better understand the mode of action of TTM, we investigated its effects on copper absorption and biliary excretion. Methods: In a double-blind randomized setting, hepatic Results: In healthy volunteers, TTM reduced intestinal Conclusions: While we did not show an increase in biliary excretion of Impact and implications: Bis-choline tetrathiomolybdate (TTM) is an investigational copper chelator being developed for the treatment of Wilson disease. In animal models of Wilson disease, TTM has been shown to facilitate biliary copper excretion. In the present human study, TTM surprisingly did not facilitate biliary copper excretion but instead reduced intestinal copper uptake to a clinically significant degree. Our study builds on our understanding of human copper metabolism and the mechanism of action of TTM.
MeSH term(s)	Animals ; Humans ; Hepatolenticular Degeneration/drug therapy ; Hepatolenticular Degeneration/metabolism ; Copper/metabolism ; Positron Emission Tomography Computed Tomography ; Healthy Volunteers ; Chelating Agents/pharmacology ; Choline ; Molybdenum
Chemical Substances	Copper (789U1901C5) ; tetrathiomolybdate (91U3TGV99T) ; Chelating Agents ; Choline (N91BDP6H0X) ; Molybdenum (81AH48963U)
Language	English
Publishing date	2023-12-10
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2023.11.023
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