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  1. Article: Cataplexy Mistaken for Seizures in a Patient With Undiagnosed Narcolepsy Type I.

    Rehim, Erafat D / Vendrame, Martina

    Cureus

    2024  Volume 16, Issue 4, Page(s) e57540

    Abstract: Narcolepsy Type 1 is a sleep disorder, with cataplexy as its cardinal feature, characterized by sudden decrease or loss of muscle tone triggered by strong emotions. Cataplexy can be misdiagnosed as epileptic seizures given its clinical similarity to ... ...

    Abstract Narcolepsy Type 1 is a sleep disorder, with cataplexy as its cardinal feature, characterized by sudden decrease or loss of muscle tone triggered by strong emotions. Cataplexy can be misdiagnosed as epileptic seizures given its clinical similarity to atonic seizures. The low prevalence of the disease added another layer of complexity in providing timely and accurate diagnosis. We report a case of a young man with recurrent episodes of falling and an inability to respond, initially misinterpreted as epileptic seizures due to findings in routine electroencephalography (EEG). Anti-seizure medications were ineffective, and subsequent ambulatory EEG revealed no epileptic activity during events. A detailed history uncovered symptoms of cataplexy and daytime sleepiness, leading to the correct diagnosis of narcolepsy type I confirmed by polysomnogram (PSG) and mean sleep latency test (MSLT). Discontinuation of anti-seizure medications and treatment with venlafaxine successfully resolved cataplexy. The case highlights the importance of a thorough clinical history in distinguishing cataplexy from seizures, as well as the caution against relying solely on EEG findings for epilepsy diagnosis. Ambulatory EEG can help exclude epileptic events, and PSG with MSLT are necessary to confirm narcolepsy type I.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Perspective: A resident's role in promoting safe machine-learning tools in sleep medicine.

    Smith, Colin M / Vendrame, Martina

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 19, Issue 11, Page(s) 1985–1987

    Abstract: Residents and fellows can play a helpful role in promoting safe and effective machine-learning tools in sleep medicine. Here we highlight the importance of establishing ground truths, considering key variables, and prioritizing transparency and ... ...

    Abstract Residents and fellows can play a helpful role in promoting safe and effective machine-learning tools in sleep medicine. Here we highlight the importance of establishing ground truths, considering key variables, and prioritizing transparency and accountability in the development of machine-learning tools within the field of artificial intelligence. Through understanding, communication, and collaboration, in-training physicians have a meaningful opportunity to help progress the field toward safe machine-learning tools in sleep medicine.
    Citation: Smith CM, Vendrame M. Perspective: a resident's role in promoting safe machine-learning tools in sleep medicine.
    MeSH term(s) Humans ; Artificial Intelligence ; Machine Learning ; Physicians ; Internship and Residency ; Sleep
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Images: Irregular sleep-wake rhythm disorder in transgender individuals.

    Kokash, Atef / Vendrame, Martina

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 19, Issue 11, Page(s) 1981–1984

    Abstract: Growing evidence suggests that transgender individuals face a significant health disparity and are particularly vulnerable to sleep disorders. We present two patients who developed irregular sleep-wake rhythm disorder after gender reassignment and ... ...

    Abstract Growing evidence suggests that transgender individuals face a significant health disparity and are particularly vulnerable to sleep disorders. We present two patients who developed irregular sleep-wake rhythm disorder after gender reassignment and hormone replacement therapy. The growing interest in transgender health warrants further evaluation of the effects and frequency of all sleep disorders in this population. Efforts to address sleep disorders should consider assessing sleep disturbance in terms of sleep/wake patterns and schedules.
    Citation: Kokash A, Vendrame M. Images: irregular sleep-wake rhythm disorder in transgender individuals.
    MeSH term(s) Humans ; Sleep Disorders, Circadian Rhythm/complications ; Sleep Disorders, Circadian Rhythm/therapy ; Transgender Persons ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/therapy ; Sleep ; Circadian Rhythm
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of REM sleep behavior disorder with trazodone: report of 3 cases.

    Barrow, Jorden / Vendrame, Martina

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2023  Volume 20, Issue 5, Page(s) 821–823

    Abstract: Rapid eye movement sleep behavior disorder is a sleep disturbance characterized by the absence of regular paralysis during rapid eye movement sleep, accompanied by dream enactment behavior. The available pharmacotherapy options for treating rapid eye ... ...

    Abstract Rapid eye movement sleep behavior disorder is a sleep disturbance characterized by the absence of regular paralysis during rapid eye movement sleep, accompanied by dream enactment behavior. The available pharmacotherapy options for treating rapid eye movement sleep behavior disorder are limited, and the utilization of antidepressants has yielded mixed results. We report 3 cases of isolated rapid eye movement sleep behavior disorder improved with trazodone. Doses of 50-100 mg of trazodone at bedtime over 4-6 months resulted in significant clinical improvement. These cases highlight that trazodone could serve as a treatment for isolated rapid eye movement sleep behavior disorder that does not respond to traditional treatments at submaximal dosages.
    Citation: Barrow J, Vendrame M. Treatment of REM sleep behavior disorder with trazodone: report of 3 cases.
    MeSH term(s) Humans ; Trazodone/therapeutic use ; REM Sleep Behavior Disorder/drug therapy ; Male ; Female ; Middle Aged ; Polysomnography/drug effects ; Adult ; Treatment Outcome
    Chemical Substances Trazodone (YBK48BXK30)
    Language English
    Publishing date 2023-12-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.10970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Seizure control with treatment of delayed sleep-wake phase disorder in juvenile myoclonic epilepsy: A case report.

    Rehim, Erafat / Li, Snow Pinxue / Vendrame, Martina

    Epilepsy & behavior reports

    2023  Volume 23, Page(s) 100614

    Abstract: Juvenile Myoclonic Epilepsy (JME) is an idiopathic generalized epilepsy associated with a characteristic sleep/wake rhythm, with the tendency to go to bed later at night, to get up later in the morning. In the pediatric population, we have previously ... ...

    Abstract Juvenile Myoclonic Epilepsy (JME) is an idiopathic generalized epilepsy associated with a characteristic sleep/wake rhythm, with the tendency to go to bed later at night, to get up later in the morning. In the pediatric population, we have previously observed specific circadian and sleep/wake patterns of generalized seizures (6 am-12 pm) and myoclonic seizures (in wakefulness, 6 am to noon). Delayed Sleep-Wake Phase Disorder (DSWPD) is characterized by sleep initiation insomnia when attempting sleep at conventional times and difficulty waking at the required time. Here we present the case of a 20-year-old man with JME, diagnosed DSWPD (sleep schedule 3 am to 11 am), presenting with nocturnal seizures out of sleep, always between 5 and 6am. Improvements in seizure control (seizure frequency from 8 per month to 0 per month) were achieved with timed evening melatonin, combined with behavioral sleep-wake scheduling (sleep schedule 10 pm to 6 am) and morning light therapy. Recognition and characterization of DSWPD in JME, together with assessment of circadian and diurnal seizure patterns, may offer therapeutic consideration for better control of seizures.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Case Reports
    ISSN 2589-9864
    ISSN (online) 2589-9864
    DOI 10.1016/j.ebr.2023.100614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Italy not alone in science system woes.

    Vendrame, Martina

    Science (New York, N.Y.)

    2008  Volume 321, Issue 5888, Page(s) 489

    MeSH term(s) Career Mobility ; Faculty ; Italy ; Research Personnel/economics ; Salaries and Fringe Benefits ; United States
    Language English
    Publishing date 2008-07-25
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.321.5888.489c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Case of Recurrent Hypersomnia With Autonomic Dysfunction.

    Mahmoudi, Mandana / Friedman, Daniel / Vendrame, Martina / Kothare, Sanjeev V

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2017  Volume 13, Issue 7, Page(s) 923–924

    Abstract: Abstract: We report the case of a 50-year-old man with disabling recurrent hypersomnia with autonomic instability due to catatonia in the setting of atypical bipolar disorder. Treatment with valproic acid for bipolar disorder resulted in complete ... ...

    Abstract Abstract: We report the case of a 50-year-old man with disabling recurrent hypersomnia with autonomic instability due to catatonia in the setting of atypical bipolar disorder. Treatment with valproic acid for bipolar disorder resulted in complete resolution of symptoms.
    MeSH term(s) Antimanic Agents/therapeutic use ; Autonomic Nervous System Diseases/complications ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Catatonia/complications ; Disorders of Excessive Somnolence/complications ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Valproic Acid/therapeutic use
    Chemical Substances Antimanic Agents ; Valproic Acid (614OI1Z5WI)
    Language English
    Publishing date 2017-07-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.6668
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Epileptic and nonepileptic paroxysmal events out of sleep in children.

    Vendrame, Martina / Kothare, Sanjeev V

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2011  Volume 28, Issue 2, Page(s) 111–119

    Abstract: The distinction between epileptic and nonepileptic events out of sleep may represent a significant challenge to the pediatrician. It is known that sleep can facilitate epileptic activity and that seizures in sleep tend to occur during specific sleep ... ...

    Abstract The distinction between epileptic and nonepileptic events out of sleep may represent a significant challenge to the pediatrician. It is known that sleep can facilitate epileptic activity and that seizures in sleep tend to occur during specific sleep stages. Certain epilepsy syndromes have a well-documented and strong association with sleep and these can present with a variety of bizarre behaviors and motor activity. Disorders that may present with nocturnal nonepileptic paroxysmal events may include not only sleep-related disorders per se but also psychiatric/behavioral conditions"benign" paroxysmal phenomena with unrelated etiology, and nonneurologic disorders. These phenomena, especially when involving complex motor activity, such as that observed in parasomnias, nocturnal panic attacks, and rapid eye movement behavior disorders may be difficult to differentiate from seizures. Moreover, there is increasing awareness that certain sleep disorders, such as sleep-disordered breathing, may coexist with epilepsy. There are several clinical and electrographical features that allow an accurate diagnosis, and diagnostic tools such as video-EEG polysomnography may be essential.
    MeSH term(s) Brain/physiopathology ; Brain Waves ; Child ; Electroencephalography ; Epilepsy/complications ; Epilepsy/diagnosis ; Epilepsy/physiopathology ; Humans ; Motor Activity ; Neural Pathways/physiopathology ; Periodicity ; Polysomnography ; Predictive Value of Tests ; Sleep ; Sleep Wake Disorders/complications ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/physiopathology ; Video Recording
    Language English
    Publishing date 2011-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0b013e3182120fdc
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Surgical treatment of refractory status epilepticus in children: candidate selection and outcome.

    Vendrame, Martina / Loddenkemper, Tobias

    Seminars in pediatric neurology

    2010  Volume 17, Issue 3, Page(s) 182–189

    Abstract: Surgical treatment emerges as a therapeutic option for refractory status epilepticus (RSE) in children. Surgical approaches for RSE include focal cortical resections, hemispherectomies, multiple subpial transections, and rarely corpus callosotomy and ... ...

    Abstract Surgical treatment emerges as a therapeutic option for refractory status epilepticus (RSE) in children. Surgical approaches for RSE include focal cortical resections, hemispherectomies, multiple subpial transections, and rarely corpus callosotomy and vagal nerve stimulator implantation. Resective surgery has shown immediate- and long-term benefits in cases of definite localization of the epileptogenic focus by elecrographic and imaging data. Evidence of focal electrographic activity may not always be available during prolonged status. Nevertheless, resection may be an option in these cases if extensive, and confined pathology is seen on magnetic resonance imaging. On the contrary, electrographic localization may be complemented by intraoperative electrocorticography during multiple subpial transections in cases of nonlesional pathology. The optimal timing of surgery in eligible patients has been determined by concerns about medical intractability weighed against accumulating risks of RSE and the possible appearance of secondary epileptogenic zones caused by ongoing seizures. Overall, preliminary case series suggest that epilepsy surgery may be an alternative treatment option for selected children with RSE. Additional studies are needed to delineate timing and criteria for intervention as well as prognostic factors.
    MeSH term(s) Brain/surgery ; Child ; Clinical Protocols ; Diagnostic Imaging ; Drug Resistance ; Electroencephalography/methods ; Humans ; Neurosurgical Procedures/adverse effects ; Neurosurgical Procedures/methods ; Patient Selection ; Status Epilepticus/surgery
    Language English
    Publishing date 2010-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1290000-x
    ISSN 1558-0776 ; 1071-9091
    ISSN (online) 1558-0776
    ISSN 1071-9091
    DOI 10.1016/j.spen.2010.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury

    Azizi S Ausim / Vendrame Martina

    BMC Neurology, Vol 7, Iss 1, p

    case report

    2007  Volume 18

    Abstract: Abstract Background The clinical and radiological aspects of hypoxic brain injury without ischemia are not well characterized. A spectrum of clinical manifestations have been observed in patients that recover from hypoxic brain injury, including a subset ...

    Abstract Abstract Background The clinical and radiological aspects of hypoxic brain injury without ischemia are not well characterized. A spectrum of clinical manifestations have been observed in patients that recover from hypoxic brain injury, including a subset that demonstrate persistent motor system disturbances. Early Magnetic Resonance Imaging (MRI) studies have shown abnormalities in basal ganglia, cerebral and cerebellar cortex. Case presentation A 23-year-old man was affected by acute respiratory failure after drug overdose. His clinical condition progressed from coma to partial recovery with persistent lack of control and stiffness in the lower extremities. MRI of the brain showed evolving lesions in the cerebellum, globus pallidus and motor cortex that correlated with neurological signs. Conclusion A careful analysis of this case and a review of the relevant literature indicate that the clinical residua after recovery from hypoxic injury to the brain is predominantly disorders of the motor system, and the MRI manifestations as well as the clinical presentation can evolve over time. Understanding more of the factors that affect hypoxic brain injury can be helpful in determining the clinical outcome and management of these patients.
    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 610
    Language English
    Publishing date 2007-06-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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