LIVIVO - Search results -

Search results

Result 1 - 10 of total 11

Search options

Article: Pulsed low-dose-rate radiation (PLDR) reduces the tumor-promoting responses induced by conventional chemoradiation in pancreatic cancer-associated fibroblasts.

Franco-Barraza, Janusz / Luong, Tiffany / Wong, Jessica K / Raghavan, Kristopher / Handorf, Elizabeth / Vendramini-Costa, Débora B / Francescone, Ralph / Gardiner, Jaye C / Meyer, Joshua E / Cukierman, Edna

bioRxiv : the preprint server for biology

2024

Abstract: Pancreatic cancer is becoming increasingly deadly, with treatment options limited due to, among others, the complex tumor microenvironment (TME). This short communications study investigates pulsed low-dose-rate radiation (PLDR) as a potential ... ...

Abstract	Pancreatic cancer is becoming increasingly deadly, with treatment options limited due to, among others, the complex tumor microenvironment (TME). This short communications study investigates pulsed low-dose-rate radiation (PLDR) as a potential alternative to conventional radiotherapy for pancreatic cancer neoadjuvant treatment. Our ex vivo research demonstrates that PLDR, in combination with chemotherapy, promotes a shift from tumor-promoting to tumor-suppressing properties in a key component of the pancreatic cancer microenvironment we called CAFu (cancer-associated fibroblasts and selfgenerated extracellular matrix functional units). This beneficial effect translates to reduced desmoplasia (fibrous tumor expansion) and suggests PLDR's potential to improve total neoadjuvant therapy effectiveness. To comprehensively assess this functional shift, we developed the HOST-Factor, a single score integrating multiple biomarkers. This tool provides a more accurate picture of CAFu function compared to individual biomarkers and could be valuable for guiding and monitoring future therapeutic strategies. Our findings support the ongoing NCT04452357 clinical trial testing PLDR safety and TME normalization potential in pancreatic cancer patients. The HOST-Factor will be used in samples collected from this trial to validate its potential as a key tool for personalized medicine in this aggressive disease.
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.13.575510
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Antiproliferative Activity of Two Unusual Dimeric Flavonoids, Brachydin E and Brachydin F, Isolated from

de Lima, Carolina A / Cubero, Mayra C Z / Franco, Yollanda E M / Rodrigues, Carla D P / do Nascimento, Jessyane R / Vendramini-Costa, Débora B / Sciani, Juliana M / da Rocha, Cláudia Q / Longato, Giovanna B

BioMed research international

2022 Volume 2022, Page(s) 3319203

Abstract: Despite the breakthrough in the development of anticancer therapies, plant-derived chemotherapeutics continue to be the basis of treatment for most types of cancers. ...

Abstract	Despite the breakthrough in the development of anticancer therapies, plant-derived chemotherapeutics continue to be the basis of treatment for most types of cancers.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bignoniaceae/chemistry ; Brazil ; Cell Line, Tumor ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Roots/chemistry
Chemical Substances	Antineoplastic Agents ; Flavonoids ; Plant Extracts
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/3319203
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Phenolic composition, antiproliferative and antiulcerogenic activities of a polyphenol‐rich purified extract from açai (Euterpe oleracea) fruits

de Oliveira, Ana Caroline / Miyagawa, Livia Midori / Monteiro, Karin Maia / Dias, Aécio L.S. / Longato, Giovanna B. / Spindola, Humberto / Vendramini‐Costa, Débora B. / Quetin‐Leclercq, Joëlle / Carvalho, João E. / Rogez, Hervé

International journal of food science & technology. 2021 Dec., v. 56, no. 12

2021

Abstract: The bioactivity and phytochemical composition of a partially purified extract of açai (PPEA), concentrated in phenolic compounds (PC) and without the presence of macronutrients, were investigated. The major PC quantified by UHPLC‐DAD‐LTQ‐Orbitrap MS‐MS/ ... ...

Abstract	The bioactivity and phytochemical composition of a partially purified extract of açai (PPEA), concentrated in phenolic compounds (PC) and without the presence of macronutrients, were investigated. The major PC quantified by UHPLC‐DAD‐LTQ‐Orbitrap MS‐MS/MS in the PPEA are anthocyanins. In vitro, PPEA showed a cytostatic effect on the K‐562 lymphoid leukaemia at a concentration of 40 μg PC mL⁻¹, with a GI₅₀ equal to 1.08 μg PC mL⁻¹. In vivo, the extract did not promote acute toxicity in mice in any of the doses tested. The extract displayed gastroprotective activity in rats treated orally with 16, 48 and 160 mg PC kg⁻¹, with a significant decrease in the ulcerative lesion index, compared with the negative control. The lack of toxicity and the bioactivity of the PPEA show that this extract is beneficial to health and useful as a commercial food additive containing natural violet colourant, with pharmaceutical and functional potentials.
Keywords	Euterpe oleracea ; acute toxicity ; anthocyanins ; chemical constituents of plants ; food additives ; leukemia ; technology
Language	English
Dates of publication	2021-12
Size	p. 6626-6634.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	883561-5
ISSN	0950-5423
ISSN	0950-5423
DOI	10.1111/ijfs.15332
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2121: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

Ogier, Charline / Solomon, Akino Mercy Charles / Lu, Zhen / Recoules, Ludmila / Klochkova, Alena / Gabitova-Cornell, Linara / Bayarmagnai, Battuya / Restifo, Diana / Surumbayeva, Aizhan / Vendramini-Costa, Débora B / Deneka, Alexander Y / Francescone, Ralph / Lilly, Anna C / Sipman, Alyssa / Gardiner, Jaye C / Luong, Tiffany / Franco-Barraza, Janusz / Ibeme, Nina / Cai, Kathy Q /

Einarson, Margret B / Nicolas, Emmanuelle / Efimov, Andrei / Megill, Emily / Snyder, Nathaniel W / Bousquet, Corinne / Cros, Jerome / Zhou, Yunyun / Golemis, Erica A / Gligorijevic, Bojana / Soboloff, Jonathan / Fuchs, Serge Y / Cukierman, Edna / Astsaturov, Igor

bioRxiv : the preprint server for biology

2023

Abstract: In pancreatic ductal adenocarcinoma (PDAC), the fibroblastic stroma constitutes most of the tumor mass and is remarkably devoid of functional blood vessels. This raises an unresolved question of how PDAC cells obtain essential metabolites and water- ... ...

Abstract	In pancreatic ductal adenocarcinoma (PDAC), the fibroblastic stroma constitutes most of the tumor mass and is remarkably devoid of functional blood vessels. This raises an unresolved question of how PDAC cells obtain essential metabolites and water-insoluble lipids. We have found a critical role for cancer-associated fibroblasts (CAFs) in obtaining and transferring lipids from blood-borne particles to PDAC cells via trogocytosis of CAF plasma membranes. We have also determined that CAF-expressed phospholipid scramblase anoctamin 6 (ANO6) is an essential CAF trogocytosis regulator required to promote PDAC cell survival. During trogocytosis, cancer cells and CAFs form synapse-like plasma membranes contacts that induce cytosolic calcium influx in CAFs via Orai channels. This influx activates ANO6 and results in phosphatidylserine exposure on CAF plasma membrane initiating trogocytosis and transfer of membrane lipids, including cholesterol, to PDAC cells. Importantly, ANO6-dependent trogocytosis also supports the immunosuppressive function of pancreatic CAFs towards cytotoxic T cells by promoting transfer of excessive amounts of cholesterol. Further, blockade of ANO6 antagonizes tumor growth via disruption of delivery of exogenous cholesterol to cancer cells and reverses immune suppression suggesting a potential new strategy for PDAC therapy.
Language	English
Publishing date	2023-09-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.15.557802
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis.

Banzato, Thais P / Gubiani, Juliana R / Bernardi, Darlon I / Nogueira, Cláudio R / Monteiro, Afif F / Juliano, Fernanda F / de Alencar, Severino M / Pilli, Ronaldo A / Lima, Carolina A de / Longato, Giovanna B / Ferreira, Antonio G / Foglio, Mary Ann / Carvalho, João E de / Vendramini-Costa, Débora B / Berlinck, Roberto G S

Journal of natural products

2020 Volume 83, Issue 6, Page(s) 1784–1793

Abstract: Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D ( ...

Abstract	Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (
MeSH term(s)	Antibiotics, Antineoplastic/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Brazil ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Ovarian Neoplasms/drug therapy ; Propolis/chemistry
Chemical Substances	Antibiotics, Antineoplastic ; Antineoplastic Agents ; Doxorubicin (80168379AG) ; Propolis (9009-62-5)
Language	English
Publishing date	2020-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b01136
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1144: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Diastereoselective Synthesis of Biologically Active Cyclopenta[b]indoles.

Santos, Marilia S / Fernandes, Daniara C / Rodrigues, Manoel T / Regiani, Thais / Andricopulo, Adriano D / Ruiz, Ana Lúcia T G / Vendramini-Costa, Débora B / de Carvalho, João E / Eberlin, Marcos N / Coelho, Fernando

The Journal of organic chemistry

2016 Volume 81, Issue 15, Page(s) 6626–6639

Abstract: The cyclopenta[b]indole motif is present in several natural and synthetic biologically active compounds, being directly responsible for the biological effects some of them present. We described herein a three step sequence for the synthesis of cyclopenta[ ...

Abstract	The cyclopenta[b]indole motif is present in several natural and synthetic biologically active compounds, being directly responsible for the biological effects some of them present. We described herein a three step sequence for the synthesis of cyclopenta[b]indoles with a great structural diversity. The method is based on an oxidative Michael addition of suitable indoles on the double bond of Morita-Baylis-Hillman adducts mediated by a hypervalent iodine reagent (IBX) to form β-ketoesters, which were chemoselectively reduced with NaBH4 in THF to give the corresponding β-hydroxy-esters. The diastereoisomeric mixture was then treated with a catalytic amount of triflic acid (20 mol %) to give cyclopenta[b]indoles with overall yields ranging from 8 to 73% (for 2 steps). The acid-catalyzed cyclization step gave the required heterocycles, via an intramolecular Friedel-Crafts reaction, with high diastereoselectivity, where only the trans product was observed. A mechanistic study monitored by ESI-(+)-MS was also conducted to collect evidence about the mechanism of this reaction. The new molecules herein synthesized were also evaluated against a panel of human cancer cells demonstrating a promising antitumoral profile.
MeSH term(s)	Amino Acid Motifs ; Catalysis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cyclization ; Dimerization ; Drug Screening Assays, Antitumor ; Esters/chemistry ; HT29 Cells ; Humans ; Indoles/chemical synthesis ; Iodine/chemistry ; K562 Cells ; Metals/chemistry ; Molecular Structure ; Neoplasms/metabolism ; Oxidation-Reduction ; Oxygen/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Stereoisomerism
Chemical Substances	Esters ; Indoles ; Metals ; Iodine (9679TC07X4) ; Oxygen (S88TT14065)
Language	English
Publishing date	2016--05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.6b01270
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4473: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The antinociceptive activity of harmicine on chemical-induced neurogenic and inflammatory pain models in mice.

Spindola, Humberto M / Vendramini-Costa, Débora B / Rodrigues, Manoel T / Foglio, Mary A / Pilli, Ronaldo A / Carvalho, João E

Pharmacology, biochemistry, and behavior

2012 Volume 102, Issue 1, Page(s) 133–138

Abstract: Harmicine is a β-carboline alkaloid isolated and identified as a major active compound present in many plant species and marine invertebrates. This alkaloid exhibits a wide spectrum of pharmacological activities, including antispasmodic, antipyretic, and ...

Abstract	Harmicine is a β-carboline alkaloid isolated and identified as a major active compound present in many plant species and marine invertebrates. This alkaloid exhibits a wide spectrum of pharmacological activities, including antispasmodic, antipyretic, and anticancer properties. This report described the antinociceptive properties of harmicine by means of chemical experimental models in order to evaluate the use for pain relief. The results demonstrating the potential analgesic properties of harmicine administered intraperitoneally were shown with the writhing test, reducing writhes around 60% (1 mg/kg), and in the formalin test, where harmicine was more effective toward neurogenic (reducing reaction time around 60%, 1 mg/kg) than inflammatory (68% reduction, 10 mg/kg) pain responses. Furthermore, these effects may operate via vanilloid receptors as revealed by the capsaicin test (41% reduction, with 3 mg/kg), as well as via peripheral glutamate receptors as shown by the glutamate test (50% reduction, with 1 mg/kg). Moreover, the opioid antagonist naloxone hydrochloride did not interfere in the antinociceptive properties of harmicine in the writhing test, revealing that this effect may not have a relationship with the opioid systems. Concluding, this report highlights harmicine as a new candidate to be used as analgesic in the future. Therefore, further studies are being undertaken in order to understand the exact mechanisms involved with the antinociceptive properties of harmicine.
MeSH term(s)	Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Capsaicin/toxicity ; Disease Models, Animal ; Indole Alkaloids/pharmacology ; Indole Alkaloids/therapeutic use ; Male ; Mice ; Neurogenic Inflammation/chemically induced ; Neurogenic Inflammation/drug therapy ; Neurogenic Inflammation/pathology ; Pain/chemically induced ; Pain/drug therapy ; Pain/pathology ; Pain Measurement/drug effects ; Pain Measurement/methods ; Reaction Time/drug effects ; Reaction Time/physiology
Chemical Substances	Analgesics ; Indole Alkaloids ; harmicine ; Capsaicin (S07O44R1ZM)
Language	English
Publishing date	2012-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191042-5
ISSN	1873-5177 ; 0091-3057
ISSN (online)	1873-5177
ISSN	0091-3057
DOI	10.1016/j.pbb.2012.03.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1060: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity.

Petreanu, Marcel / Ferreira, Emili Kamila / Sagaz, Ana Paula M / Vendramini-Costa, Débora B / Ruiz, Ana Lúcia T G / De Carvalho, João Ernesto / Campos, Adriana / Cechinel Filho, Valdir / Delle Monache, Franco / Niero, Rivaldo

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 341216

Abstract: This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R. rosaefolius leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H(1) and C(13) and ... ...

Abstract	This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R. rosaefolius leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H(1) and C(13) and identified as 5,7-dihydroxy-6,8,4'-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (2), and tormentic acid (3). Both hexane and dichloromethane fractions showed selectivity for multidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 μg/ml, respectively. Compound 1 also showed selective activity against the same cell line (18.8 μg/ml); however, it was especially effective against glioma cells (2.8 μg/ml), suggesting that this compound may be involved with the in vitro antiproliferative action.
Language	English
Publishing date	2015-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/341216
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5995: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Two new hydronaphthoquinones from Sinningia aggregata (Gesneriaceae) and cytotoxic activity of aggregatin D.

Verdan, Maria Helena / Mera de Souza, Lauro / Ernesto de Carvalho, João / Vendramini Costa, Débora B / Salvador, Marcos José / Barison, Andersson / Alves Stefanello, Maria Élida

Chemistry & biodiversity

2015 Volume 12, Issue 1, Page(s) 148–152

Abstract: Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (Ker-Gawl.) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2- ... ...

Abstract	Two new hydronaphthoquinones, aggregatins E and F (1 and 2, resp.) were isolated from the tubers of Sinningia aggregata (Ker-Gawl.) Wiehler (Gesneriaceae), along with twelve known compounds aggregatin D (3), tectoquinone (4), 1-hydroxy-2-methylanthraquinone (5), icosyl ferulate (6), pustuline (7), 1,6-dihydroxy-2-methylanthranquinone (8), 6-hydroxy-2-methylanthraquinone (9), 7-hydroxy-2-methylanthraquinone (10), tyrosol (11), halleridone (12), calceolarioside B (13), and cornoside (14). All compounds were identified by analysis of spectroscopic and spectrometric data. Compounds 3, 4, and 10 had already been reported in this species. Compounds 2 and 3 were evaluated against several tumor cell lines, but only 3 exhibited activities against UACC-62, 786-0 and OVCAR-3 cell lines, with IC50 values of 12.3, 12.8 and 0.3 μg/ml, respectively, without toxic effects on non-cancer cell line HaCat (human keratinocyte).
MeSH term(s)	Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Magnoliopsida/chemistry ; Naphthoquinones/isolation & purification ; Naphthoquinones/pharmacology
Chemical Substances	Antineoplastic Agents ; Naphthoquinones ; aggregatin D
Language	English
Publishing date	2015-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.201400281
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article ; Online: Pharmacological characterization of Solanum cernuum Vell.: 31-norcycloartanones with analgesic and anti-inflammatory properties.

Lopes, Luciane C / de Carvalho, João Ernesto / Kakimore, Marise / Vendramini-Costa, Débora B / Medeiros, Maria A / Spindola, Humberto M / Ávila-Román, Javier / Lourenço, Ana M / Motilva, Virginia

Inflammopharmacology

2013 Volume 22, Issue 3, Page(s) 179–185

Abstract: Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses ... ...

Abstract	Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed that (2) has selective activity against lung tumor cell line (NCIH460) which expresses high levels of COX-2, suggesting its role in inflammatory process, and also a link between chronic inflammation and cancer-associated process. Dichloromethane crude extract (DCE) significantly reduced writhing and stretching induced by 0.8 % acetic acid at a dose of 100, 300, and 600 mg/kg, po; oral administration of different doses of (1) and (2) also displayed significant analgesic and anti-inflammatory effects in the writhing acetic acid test (p < 0.0001). Selected oral doses of both compounds (100 and 50 mg/kg) were assayed in the carrageenan-induced paw edema model. Compound (2) showed significant activity during the early phase (1.5-6 h) and also in the late phase (48 h) (p < 0.01). The anti-nociceptive activity observed for the compounds (1) and (2) and DCE was found to be related to the inhibition of different mediators involved in inflammation and nociceptive process. Both compounds decrease COX-2 protein expression, although only compound (2) reached a significant response (p < 0.05 vs control). However, in vitro Sirtuin 1 activity and TNF-α production in THP-1 macrophages were not affected.
MeSH term(s)	Analgesics/isolation & purification ; Analgesics/therapeutic use ; Animals ; Anti-Inflammatory Agents/isolation & purification ; Anti-Inflammatory Agents/therapeutic use ; Edema/drug therapy ; Edema/pathology ; Mice ; Mice, Inbred BALB C ; Pain/drug therapy ; Pain/pathology ; Phytosterols/chemistry ; Phytosterols/isolation & purification ; Phytosterols/therapeutic use ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Solanum ; Triterpenes/chemistry ; Triterpenes/isolation & purification ; Triterpenes/therapeutic use
Chemical Substances	Analgesics ; Anti-Inflammatory Agents ; Phytosterols ; Plant Extracts ; Triterpenes ; cycloartenol (YU32VE82N3)
Language	English
Publishing date	2013-08-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-013-0182-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3274: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito