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  1. AU="Venegas, M"
  2. AU="Burtnick, Mary N"
  3. AU=Frisoni Giovanni B
  4. AU="Dhiraj Kumar"
  5. AU="Isaac S. Lee"
  6. AU="Bals, Julia"
  7. AU="Rovira-Clavé, Xavier"
  8. AU="Den Boer, Monique L"
  9. AU="Potts, T."
  10. AU="Cifuentes-Diaz, Carmen"
  11. AU="Alvim, Ricardo G"
  12. AU="Barron II, Joseph C"
  13. AU="Godin, Shea-Lee"
  14. AU="Leng, Chengcai"
  15. AU="Hyslop, Brian W"
  16. AU="Suzanne Fischer"
  17. AU="Aboelata, Noha"
  18. AU="Chiang, Sarah N"
  19. AU="Wessel, Kristin M"
  20. AU="Wilson, Jenna M"
  21. AU="Goines, Paula"
  22. AU=Ippolito Mariachiara AU=Ippolito Mariachiara
  23. AU="Jose Chauca"
  24. AU="Asih, Puji B S"
  25. AU="Dsane-Selby, Lydia"
  26. AU="Tolossa, Tadesse"
  27. AU="Erdal Bedir"

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  1. Artikel ; Online: Vaccination coverage among migrants: A systematic review and meta-analysis.

    Rojas-Venegas, M / Cano-Ibáñez, N / Khan, K S

    Semergen

    2022  Band 48, Heft 2, Seite(n) 96–105

    Abstract: Background: Migrants, a population vulnerable to communicable diseases, face multiple barriers in access to immunization programs. Individual studies suggest that they suffer immunization inequity compared to non-migrants, but the gap in vaccination has ...

    Abstract Background: Migrants, a population vulnerable to communicable diseases, face multiple barriers in access to immunization programs. Individual studies suggest that they suffer immunization inequity compared to non-migrants, but the gap in vaccination has not been quantified. This systematic review assessed quantitatively the level of vaccination coverage among migrants, in comparison with non-migrants, collating the published literature.
    Methods: Review protocol was prospectively registered (PROSPERO CRD42021228061). A literature search without language restrictions was conducted in PubMed, Scopus and Web of Science, from database inception to February 2021. This review included observational studies that provided the vaccination rates among migrant and non-migrant groups. Study quality was assessed using Newcastle-Ottawa scale. Data were synthesized pooling data from individual studies to generate summary odds ratio (OR) with 95% confidence interval (CI) using random effects model, assessing heterogeneity with I
    Findings: There were 44 relevant studies (7,937,996 participants). Overall risk of bias was low in 13 (30%), moderate in 22 (50%) and high in 9 (20%) studies. Point estimates of individual ORs showed lower vaccination coverage among migrants in 36 of 39 meta-analyzable studies. Overall, the odds of vaccination coverage among migrants were lower compared to non-migrants (7,375,184 participants; summary OR 0.50; 95% CI 0.37-0.66; I
    Interpretation: Migrants are half as often vaccinated compared to non-migrants. Public health prevention programs need to prioritize vaccination equity, not just to protect migrants but also to protect the host communities.
    Mesh-Begriff(e) Humans ; Immunization Programs ; Transients and Migrants ; Vaccination ; Vaccination Coverage
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland Spain
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ISSN 1578-8865
    ISSN (online) 1578-8865
    DOI 10.1016/j.semerg.2021.10.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch ; Dissertation / Habilitation: Interleukin 6, Cortisol und Schlaf-Wach-Rhythmus bei gesunden Probanden

    Venegas, Marco

    1997  

    Verfasserangabe vorgelegt von Marco Venegas
    Sprache Deutsch
    Umfang 109 Bl. : graph. Darst.
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Freiburg (Breisgau), Univ., Diss., 1997
    HBZ-ID HT008493954
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    98 E 839 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: Indirect estimation of the need for palliative care during the COVID-19 pandemic: A descriptive cross-sectional study using mortality data in the Biobío Region, Chile.

    Barría-Sandoval, Claudia / Espinoza Venegas, Maritza / Ferreira, Guillermo

    PloS one

    2023  Band 18, Heft 7, Seite(n) e0288020

    Abstract: Background: People with chronic diseases in their advanced phase require palliative care. This is essential to ensure their quality of life as it ends. However, a very low percentage of patients receive the necessary palliative care. The COVID-19 ... ...

    Abstract Background: People with chronic diseases in their advanced phase require palliative care. This is essential to ensure their quality of life as it ends. However, a very low percentage of patients receive the necessary palliative care. The COVID-19 pandemic has adversely affected the planning and provision of palliative care. Despite this, in Chile, palliative care coverage was extended by law to cover nononcological chronic diseases. Implementation of this law is expected to be a significant challenge in terms of material resources, as well as the need for the formation of specialized palliative care teams. Therefore, it is essential to estimate the need for palliative care for all chronic diseases to generate useful input for planning and decision-making in public health.
    Objectives: To indirectly estimate the need for palliative care among people with Chronic Oncological Diseases (COD) and Chronic Non-Oncological Diseases (CNOD) during the prepandemic and pandemic context due to COVID-19 in the Biobío Region in Chile.
    Methods: Cross-sectional study based on mortality data from chronic oncological and nononcological diseases during the prepandemic (2010-2018) and pandemic (2020-2021) contexts due to COVID-19 in a Region of Chile through indirect estimation using minimal estimate, standardized mortality rates and geographically weighted regression.
    Results: It was estimated that 76.25% of deaths from chronic diseases in the Biobío Region would have required palliative care, which represents 77,618 people who should have been included in these health benefits. The pandemic had a significant effect on the average number of deaths from CNOD. People belonging to this group were more likely to die from COVID-19 than from their baseline disease, unlike the deaths of people from COD, where no significant changes were observed.
    Conclusion: These estimates highlight the potential size of the population requiring palliative care and emphasize the importance of recognizing the rights of individuals with COD and CNOD conditions. It is evident that there is a significant demand for palliative care services, as well as a pressing need for adequate resources, effective management, and strategic planning to cater to the needs of this population. This is particularly crucial in the heavily impacted areas and communes of the Biobío Region, Chile.
    Mesh-Begriff(e) Humans ; Palliative Care ; Cross-Sectional Studies ; Pandemics ; COVID-19/epidemiology ; Quality of Life ; Chile/epidemiology ; Chronic Disease
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288020
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  4. Artikel ; Online: Mechanoenzymology: State of the Art and Challenges towards Highly Sustainable Biocatalysis.

    Pérez-Venegas, Mario / Juaristi, Eusebio

    ChemSusChem

    2021  Band 14, Heft 13, Seite(n) 2682–2688

    Abstract: Global awareness of the importance of developing environmentally friendlier and more sustainable methods for the synthesis of valuable chemical compounds has led to the design of novel synthetic strategies, involving bio- and organocatalysis as well as ... ...

    Abstract Global awareness of the importance of developing environmentally friendlier and more sustainable methods for the synthesis of valuable chemical compounds has led to the design of novel synthetic strategies, involving bio- and organocatalysis as well as the application of novel efficient and ground-breaking technologies such as present-day solvent-free mechanochemistry. In this regard, the evaluation of biocatalytic protocols mediated by the combination of mechanical activation and enzymatic catalysis has recently attracted the attention of the chemical community. Such mechanoenzymatic strategy represents an innovative and promising "green" approach in chemical synthesis that poses nevertheless new paradigms regarding the relative resilience of biomolecules to the mechanochemical stress and to the apparent high energy, at least in so-called hot-spots, during the milling process. Herein, relevant comments on the conceptualization of such mechanoenzymatic approach as a sustainable option in chemical synthesis, recent progress in the area, and associated challenges are discussed.
    Sprache Englisch
    Erscheinungsdatum 2021-05-10
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202100624
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Claudins in Cancer: A Current and Future Therapeutic Target.

    Hana, Caroline / Thaw Dar, Nyein Nyein / Galo Venegas, Michael / Vulfovich, Michel

    International journal of molecular sciences

    2024  Band 25, Heft 9

    Abstract: Claudins are a family of 27 proteins that have an important role in the formation of tight junctions. They also have an important function in ion exchange, cell mobility, and the epithelial-to-mesenchymal transition, the latter being very important in ... ...

    Abstract Claudins are a family of 27 proteins that have an important role in the formation of tight junctions. They also have an important function in ion exchange, cell mobility, and the epithelial-to-mesenchymal transition, the latter being very important in cancer invasion and metastasis. Therapeutic targeting of claudins has been investigated to improve cancer outcomes. Recent evidence shows improved outcomes when combining monoclonal antibodies against claudin 18.2 with chemotherapy for patients with gastroesophageal junction cancer. Currently, chimeric antigen receptor T-cells targeting claudin 18 are under investigation. In this review, we will discuss the major functions of claudins, their distribution in the normal as well as cancerous tissues, and their effect in cancer metastasis, with a special focus on the therapeutic targeting of claudins to improve cancer outcomes.
    Mesh-Begriff(e) Humans ; Claudins/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Animals ; Epithelial-Mesenchymal Transition ; Molecular Targeted Therapy/methods ; Tight Junctions/metabolism
    Chemische Substanzen Claudins
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25094634
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  6. Artikel: Influence of Anaerobic Digestion with Pretreatment on the Phytotoxicity of Sewage Sludge

    Venegas, M / A. M. Leiva / Gladys Vidal

    Water, air, and soil pollution. 2018 Dec., v. 229, no. 12

    2018  

    Abstract: The aim of this study is to evaluate the influence of anaerobic digestion with pretreatment on the phytotoxicity of sewage sludge. The phytotoxicity was evaluated on sewage sludge (SS) and biosolids that came from conventional anaerobic digestion (CAD) ... ...

    Abstract The aim of this study is to evaluate the influence of anaerobic digestion with pretreatment on the phytotoxicity of sewage sludge. The phytotoxicity was evaluated on sewage sludge (SS) and biosolids that came from conventional anaerobic digestion (CAD) and anaerobic digestion with a pretreatment by sequential ultrasound and low-thermal hydrolysis, called advance anaerobic digestion (AAD). To compare the phytotoxicity, eight elutriate concentrations (0.5–100% v/v) from SS, CAD, and AAD were studied on three testing plants: Lactuca sativa, Raphanus sativus, and Triticum aestivum. The percentages of seed germination inhibition, root elongation, and germination index (GI) were evaluated. GI is an phytotoxicity indicator that combines seed germination and root growth, therefore reflecting a more complete estimation of toxicity. Phytotoxicity assays showed that SS, CAD, and AAD elutriates have a beneficial effect on R. sativus. Similar results were observed for T. aestivum for CAD and AAD, with GI values up to 80% in both biosolids. Only for SS, moderate toxicity was observed in T. aestivum. Moreover, L. sativa showed GI values below 50% for SS and CAD, which reflected high toxicity. Only for AAD, no presence of phytotoxic substances was observed in L. sativa. This study concluded that biosolids from AAD improved the plants’ development with a GI above 78% with respect to biosolids from SS and CAD and reduced the phytotoxicity of sewage biosolid.
    Schlagwörter Lactuca sativa ; Raphanus sativus ; Triticum aestivum ; anaerobic digestion ; biosolids ; hydrolysis ; phytotoxicity ; root growth ; seed germination ; sewage ; sewage sludge
    Sprache Englisch
    Erscheinungsverlauf 2018-12
    Umfang p. 381.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel
    ZDB-ID 120499-3
    ISSN 1573-2932 ; 0049-6979 ; 0043-1168
    ISSN (online) 1573-2932
    ISSN 0049-6979 ; 0043-1168
    DOI 10.1007/s11270-018-4025-5
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 2719: Hefte anzeigen

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  7. Artikel: A Retrospective Analysis of Admission Trends and Outcomes in a Wildlife Rescue and Rehabilitation Center in Costa Rica.

    Costa, Maria Miguel / Pinto da Cunha, Nazaré / Hagnauer, Isabel / Venegas, Marta

    Animals : an open access journal from MDPI

    2023  Band 14, Heft 1

    Abstract: The evaluation of data regarding rehabilitation practices provides reference values for comparison purposes among different rehabilitation centers to critically review protocols and efficiently improve each center. The aim of the present work was to ... ...

    Abstract The evaluation of data regarding rehabilitation practices provides reference values for comparison purposes among different rehabilitation centers to critically review protocols and efficiently improve each center. The aim of the present work was to present the main causes of admission to Rescate Wildlife Rescue Center for each taxonomic group, to determine the admission factors that influenced the release and mortality, and to determine the predictive factors of release and mortality of wildlife. To this end, a retrospective study was carried out based on 5785 admissions registered in the database of Rescate Wildlife Rescue Center in Costa Rica in 2020 and 2021. Statistical analysis consisted of sample characterization via the analysis of several categorical variables: species, order, class, age group, cause of admission, outcome, clinical classification and days in the hospital, and respective association with the mortality or release rate. Most of the rescue animals were birds (59.3%), then mammals (20.7%), reptiles (17.4%), and finally 'others' (2.6%). The main causes of admission were 'captivity' (34.9%), 'found' (23.3%), and 'trauma' (19.3%). Animals rescued due to 'captivity' and the classes 'birds' and 'reptiles' had the highest release rates. The causes of admission 'trauma' and 'orphanhood' and the class 'birds' had the highest mortality rates. In general, a greater number of days spent in the hospital and membership in the classes 'reptiles', 'juveniles', in need of 'basic care', or 'clinically healthy' were predictors of survival. In contrast, the age groups 'infant' and 'nestling' were predictors of mortality. These results demonstrate the value of maintaining, improving, and studying databases from wildlife rehabilitation centers, as they can provide useful information that can be used to enhance the allocation of economic resources, treatment methods, disease surveillance, public education, and regulatory decision-making, leading to a better understanding of threats to wildlife and subsequent implementation of conservation actions.
    Sprache Englisch
    Erscheinungsdatum 2023-12-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14010051
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  8. Artikel ; Online: Comparación entre Xpert® y COBAS®-TaqMan® para la medición de carga viral de virus hepatitis B y C.

    Ramírez, Felipe / Miranda, Julio / Venegas, Mauricio

    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia

    2021  Band 38, Heft 3, Seite(n) 344–348

    Abstract: Background: The measurement of viral load (VL) of hepatitis B (HBV) and C (HCV) viruses is essential in the follow-up of patients with antiviral therapy. The most widely used methodology for this determination is COBAS®-TaqMan®. Recently, the Xpert® ... ...

    Titelübersetzung Comparison between Xpert® and COBAS® TaqMan® for the measuring of viral load of hepatitis B and C viruses.
    Abstract Background: The measurement of viral load (VL) of hepatitis B (HBV) and C (HCV) viruses is essential in the follow-up of patients with antiviral therapy. The most widely used methodology for this determination is COBAS®-TaqMan®. Recently, the Xpert® technology was developed and needs to be evaluated.
    Aim: To compare the measurement of the VL of HBV and HCV by Xpert® methodology with COBAS®-TaqMan® as a reference method.
    Material and methods: 39 serum samples from patients with HBV and 39 with HCV, previously quantified by COBAS®-TaqMan®, were analyzed using Xpert® and the results were compared using Deming regression and Bland-Altman plot.
    Results: There was a high correlation between Xpert® and COBAS®-TaqMan®. For HBV, the Deming equation was XpertHBV = 0.44 + 0.99xCOBASTaqManHBV, with a correlation coefficient of 0.94 and a difference between means of -0.401 log (95% CI: -1.985 to 1.183). For HCV, the Deming equation was XpertHCV = 0.36 + 0.87x COBASTaqManHCV, with a correlation coefficient of 0.98 and a difference between means of0.328 log10 (95% CI: -0.449 to 1.105).
    Conclusion: The new Xpert® system shows a good correlation with COBAS®-TaqMan® for the measurement of the VL of HBV and HCV, being a good alternative for the follow-up of patients under treatment.
    Mesh-Begriff(e) Hepacivirus/genetics ; Hepatitis B/diagnosis ; Hepatitis B virus/genetics ; Humans ; RNA, Viral ; Sensitivity and Specificity ; Viral Load
    Chemische Substanzen RNA, Viral
    Sprache Spanisch
    Erscheinungsdatum 2021-08-31
    Erscheinungsland Chile
    Dokumenttyp Journal Article
    ZDB-ID 2048815-4
    ISSN 0717-6341 ; 0716-1018
    ISSN (online) 0717-6341
    ISSN 0716-1018
    DOI 10.4067/S0716-10182021000300344
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  9. Artikel: Restorative methods as a strategy for the prevention of violence and bullying in primary and secondary schools in Mexico: An exploratory study.

    Pérez-Jorge, David / Alonso-Rodríguez, Isabel / Arriagada-Venegas, Matías / Ariño-Mateo, Eva

    Heliyon

    2023  Band 9, Heft 7, Seite(n) e18267

    Abstract: School coexistence processes are mediated by conflict situations that are often not adequately, immediately and comprehensively resolved by schools, giving rise to violence. School violence has become a matter of global priority not only at the school or ...

    Abstract School coexistence processes are mediated by conflict situations that are often not adequately, immediately and comprehensively resolved by schools, giving rise to violence. School violence has become a matter of global priority not only at the school or family level, but also socially due to its magnitude and scope. In the Program for International Student Assessment (PISA), reported in 2018 that 23% of students in Mexico had suffered bullying at least once a month, these data are worrying as they reveal high rate of violence. Considering the increase of violence in Mexican educational institutions, we wonder if students' awareness in the use of communication to resolve disagreements would be achieved after participating in a conflict prevention project applying restorative practices. The objective of this study was to test whether students acquired greater emotional self-regulation, self-determination, and peaceful strategies to resolve conflicts after participating in a project centred on the restorative paradigm. A total of 336 students from an elementary school and a high school located in Mexico participated in this study. An ad hoc questionnaire was administered to the students by a restorative justice specialist in the middle of the school year. Statistical analyses were performed with the Statistical Package for the Social Sciences V. 25. The results obtained showed that, after the implementation of this program for five months, students in both schools showed greater emotional self-regulation and self-determination. In conclusion, providing students with restorative strategies to resolve disputes favoured the use of peaceful conflict resolution strategies.
    Sprache Englisch
    Erscheinungsdatum 2023-07-17
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18267
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  10. Artikel ; Online: The c.415C>T polymorphism in NUDT15 is more frequent than the polymorphisms in TPMT in Chilean patients who use thiopurine drugs.

    von Muhlenbrock, Christian / Estay, Camila / Covarrubias, Natalia / Miranda, Julio / Venegas, Mauricio

    Pharmacogenetics and genomics

    2023  Band 33, Heft 7, Seite(n) 161–163

    Abstract: Azathioprine (AZA) and 6-mercaptopurine (6-MP) are drugs widely used in the treatment of autoimmune diseases. Among the enzymes involved in the metabolism of AZA and 6-MP are thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15). The ... ...

    Abstract Azathioprine (AZA) and 6-mercaptopurine (6-MP) are drugs widely used in the treatment of autoimmune diseases. Among the enzymes involved in the metabolism of AZA and 6-MP are thiopurine methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15). The existence of single nucleotide polymorphisms in the genes that code for these enzymes could decreased enzymatic activity AND lead to severe myelosuppression. The most relevant polymorphism is NUDT15*3 (rs116855232), where the replacement of cytosine for thymine at position 415, which in turn leads to a loss of enzymatic activity. In a previous study, it was identified that together the polymorphisms in the TPMT gene reach an allelic frequency of 3.81%. There is no information regarding the rs116855232 polymorphism in the NUDT15 gene, so this corresponds to the objective of this report. Blood samples from Chilean adult patients with indications for the use of AZA or 6-MP for different pathologies and who had undergone a TPMT gene polymorphism study were retrospectively analyzed. A total of 253 blood samples were analyzed. Of the 253 patients, 47 presented the c.415C>T polymorphism in the NUDT15 gene, 3 being homozygous and 44 heterozygous. Four of the heterozygous patients for NUDT15 also had the *3A variant in the TPMT gene, also heterozygous. The allelic frequency of the minor T allele found (9.88%) was very similar to that found in patients of Asian origin, and much higher than that reported for the European Caucasian or Latin American population.
    Mesh-Begriff(e) Adult ; Humans ; Azathioprine/adverse effects ; Chile ; Mercaptopurine/adverse effects ; Methyltransferases/genetics ; Polymorphism, Single Nucleotide ; Pyrophosphatases/genetics ; Retrospective Studies
    Chemische Substanzen Azathioprine (MRK240IY2L) ; Mercaptopurine (E7WED276I5) ; Methyltransferases (EC 2.1.1.-) ; Pyrophosphatases (EC 3.6.1.-) ; thiopurine methyltransferase (EC 2.1.1.67) ; NUDT15 protein, human (EC 2.6.1.-)
    Sprache Englisch
    Erscheinungsdatum 2023-08-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2175826-8
    ISSN 1744-6880 ; 0960-314X ; 1744-6872
    ISSN (online) 1744-6880
    ISSN 0960-314X ; 1744-6872
    DOI 10.1097/FPC.0000000000000503
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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