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Article: TIPSS as a bridge to extrahepatic abdominal surgery: a case report.

Kapeleris, Audrey Pamela / Venkatachalapathy, Suresh

2022 Volume 2022, Issue 4, Page(s) omac029

Abstract: Severe portal hypertension in cirrhosis is a relative contraindication to major surgical intervention. Pre-surgical placement of a transjugular intrahepatic portosystemic shunt (TIPSS) can potentially reduce portal hypertension and the risk of ... ...

Abstract	Severe portal hypertension in cirrhosis is a relative contraindication to major surgical intervention. Pre-surgical placement of a transjugular intrahepatic portosystemic shunt (TIPSS) can potentially reduce portal hypertension and the risk of intraoperative bleeding. Two patients in our service, with cirrhosis and portal hypertension, required abdominal surgery and underwent TIPSS placement as a potential bridging therapy. Patient 1, a 56-year-old female, successfully underwent surgery with no intraoperative complications. Patient 2, a 36-year-old male, experienced liver decompensation post-TIPSS and is currently awaiting a liver and bowel transplant. Prophylactic TIPSS placement may allow some patients with decompensated cirrhosis to successfully undergo major extrahepatic abdominal surgery. However, careful patient selection and preoperative counselling for decompensation is necessary.
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Case Reports
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omac029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Copper Nanoparticles on the Flexural Strength of Heat Polymerized Acrylic Resin.

Venkatachalapathy, Sriram / Chander, Gopi N / Reddy, J Ramesh / Muthukumar, Balasubramaniam

Journal of pharmacy & bioallied sciences

2023 Volume 15, Issue Suppl 1, Page(s) S336–S340

Abstract: The aim of this study was to investigate the flexural strength of heat cure acrylic resin reinforced with varying concentration copper nanoparticles. The study followed ISO 20795-1-2013 guidelines for estimating the flexural strength. Hundred samples of ... ...

Abstract	The aim of this study was to investigate the flexural strength of heat cure acrylic resin reinforced with varying concentration copper nanoparticles. The study followed ISO 20795-1-2013 guidelines for estimating the flexural strength. Hundred samples of heat cure acrylic resin of dimension were fabricated. The study had five groups and each group had 20 samples. The samples were grouped as per the concentration of copper (Cu) nanoparticles in acrylic. Three-point bending flexural strength was evaluated with universal testing machine. The load was directed at the midpoint of the sample at a cross-sectional speed of 5 mm/min. The fractured load was recorded and flexural strength was estimated. The data were statistically analyzed with analysis of variance and the post hoc test. The results displayed improved flexural strength in lower Cu concentrations. The increase in flexural strength was observed in 1% (78.38 MPa), 2% (73.08 MPa), and 3% (73.08 MPa) of Cu nanoparticles and it decreased beyond 3% increase in Cu nanoparticles. The tests were statistically insignificant (
Language	English
Publishing date	2023-07-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_523_22
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Article ; Online: Actomyosin contractility as a mechanical checkpoint for cell state transitions.

Venkatachalapathy, Saradha / Sreekumar, Dyuthi / Ratna, Prasuna / Shivashankar, G V

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16063

Abstract: Cell state transitions induced by mechano-chemical cues result in a heterogeneous population of cell states. While much of the work towards understanding the origins of such heterogeneity has focused on the gene regulatory mechanisms, the contribution of ...

Abstract	Cell state transitions induced by mechano-chemical cues result in a heterogeneous population of cell states. While much of the work towards understanding the origins of such heterogeneity has focused on the gene regulatory mechanisms, the contribution of intrinsic mechanical properties of cells remains unknown. In this paper, using a well-defined single cell platform to induce cell-state transitions, we reveal the importance of actomyosin contractile forces in regulating the heterogeneous cell-fate decisions. Temporal analysis of laterally confined growth of fibroblasts revealed sequential changes in the colony morphology which was tightly coupled to the progressive erasure of lineage-specific transcription programs. Pseudo-trajectory constructed using unsupervised diffusion analysis of the colony morphology features revealed a bifurcation event in which some cells undergo successful cell state transitions towards partial reprogramming. Importantly, inhibiting actomyosin contractility before the bifurcation event leads to more efficient dedifferentiation. Taken together, this study highlights the presence of mechanical checkpoints that contribute to the heterogeneity in cell state transitions.
MeSH term(s)	Actin Cytoskeleton/metabolism ; Actomyosin/metabolism ; Cell Differentiation ; Fibroblasts/metabolism ; Gene Expression Regulation
Chemical Substances	Actomyosin (9013-26-7)
Language	English
Publishing date	2022-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20089-8
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Article ; Online: Effect of Mobile Phone with and without Earphones Usage on Nickel Ion Release from Fixed Orthodontic Appliance.

Rajendran, Ramya / Venkatachalapathy, Sudhakar / Thiyagarajan, Balavignesh / Jeevagan, Sruthi / Chinnasamy, Anandadevi / Sivanandham, Muruganandam

The journal of contemporary dental practice

2023 Volume 24, Issue 5, Page(s) 303–307

Abstract: Introduction: This study is an attempt to assess whether the usage of headphones could minimize the nickel ion release from fixed orthodontic appliance compared with hand-held mobile phones. The aim of the study is to validate the hypothesis whether ... ...

Abstract	Introduction: This study is an attempt to assess whether the usage of headphones could minimize the nickel ion release from fixed orthodontic appliance compared with hand-held mobile phones. The aim of the study is to validate the hypothesis whether there is a significant variation in nickel ion release from fixed orthodontic appliance among the patients using hand-held mobile phones and patients using mobile earphones. Materials and methods: This is a cross-sectional study where a total of 60 healthy individuals who were undergoing fixed orthodontic treatment in the Department of Orthodontics and Dentofacial Orthopedics, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Chennai, India, and all these individuals were bonded and banded. All of them are class I malocclusion with bimaxillary protrusion. Salivary samples were collected in their regular checkup after two months and 7th, 14th, and 21st days salivary nickel level was evaluated based on their usage of mobile phones with earphones and without earphones. Results: In this study, paired and independent Conclusion: By our study, we concluded that usage of mobile phones with earphones has a significant reduced effect on metal ion release from fixed orthodontic appliance when compared to usage of mobile phones without earphones.
MeSH term(s)	Humans ; Male ; Female ; Nickel/analysis ; Cross-Sectional Studies ; Saliva/chemistry ; India ; Orthodontic Appliances, Fixed ; Cell Phone ; Orthodontic Appliances
Chemical Substances	Nickel (7OV03QG267)
Language	English
Publishing date	2023-05-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3475
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Article ; Online: Letter to the Editor.

Venkatachalapathy, Sudhakar / Sekar, Aswini Soundharya / Rajendran, Ramya / Rangarajan, Sumanth

The Angle orthodontist

2022 Volume 92, Issue 2, Page(s) 301

Language	English
Publishing date	2022-03-14
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	390289-4
ISSN	1945-7103 ; 0003-3219
ISSN (online)	1945-7103
ISSN	0003-3219
DOI	10.2319/1945-7103-92.2.301
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Article ; Online: Multivariate analysis reveals activation-primed fibroblast geometric states in engineered 3D tumor microenvironments.

Venkatachalapathy, Saradha / Jokhun, Doorgesh Sharma / Shivashankar, G V

Molecular biology of the cell

2020 Volume 31, Issue 8, Page(s) 803–812

Abstract: Fibroblasts are a heterogeneous group of cells comprising subpopulations that have been found to be activated in the stromal microenvironment that regulates tumor initiation and growth. The underlying mechanisms of such selective activation of ... ...

Abstract	Fibroblasts are a heterogeneous group of cells comprising subpopulations that have been found to be activated in the stromal microenvironment that regulates tumor initiation and growth. The underlying mechanisms of such selective activation of fibroblasts are not understood. We propose that the intrinsic geometric heterogeneity of fibroblasts modulates the nuclear mechanotransduction of signals from the microenvironment, resulting in their selective activation. To test this, we developed an engineered 3D fibroblast tumor coculture system and used high resolution images to quantify multiple cell geometry sensitive nuclear morphological and chromatin organizational features. These features were then mapped to activation levels as measured by the nuclear abundance of transcription cofactor, megakaryoblastic leukemia, and protein levels of its target,
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E19-08-0420
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Zs.A 2853: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Single cell imaging-based chromatin biomarkers for tumor progression.

Venkatachalapathy, Saradha / Jokhun, Doorgesh S / Andhari, Madhavi / Shivashankar, G V

Scientific reports

2021 Volume 11, Issue 1, Page(s) 23041

Abstract: Tumour progression within the tissue microenvironment is accompanied by complex biomechanical alterations of the extracellular environment. While histopathology images provide robust biochemical markers for tumor progression in clinical settings, a ... ...

Abstract	Tumour progression within the tissue microenvironment is accompanied by complex biomechanical alterations of the extracellular environment. While histopathology images provide robust biochemical markers for tumor progression in clinical settings, a quantitative single cell score using nuclear morphology and chromatin organization integrated with the long range mechanical coupling within the tumor microenvironment is missing. We propose that the spatial chromatin organization in individual nuclei characterises the cell state and their alterations during tumor progression. In this paper, we first built an image analysis pipeline and implemented it to classify nuclei from patient derived breast tissue biopsies of various cancer stages based on their nuclear and chromatin features. Replacing H&E with DNA binding dyes such as Hoescht stained tissue biopsies, we improved the classification accuracy. Using the nuclear morphology and chromatin organization features, we constructed a pseudo-time model to identify the chromatin state changes that occur during tumour progression. This enabled us to build a single-cell mechano-genomic score that characterises the cell state during tumor progression from a normal to a metastatic state. To gain further insights into the alterations in the local tissue microenvironments, we also used the nuclear orientations to identify spatial neighbourhoods that have been posited to drive tumor progression. Collectively, we demonstrate that image-based single cell chromatin and nuclear features are important single cell biomarkers for phenotypic mapping of tumor progression.
MeSH term(s)	Biomarkers/metabolism ; Biomarkers, Tumor ; Biophysics ; Biopsy ; Breast Neoplasms/metabolism ; Cell Nucleus/metabolism ; Chromatin/chemistry ; Collagen/chemistry ; Computational Biology ; DNA/chemistry ; Disease Progression ; Fibroblasts/metabolism ; Genomics ; Humans ; Image Processing, Computer-Assisted ; In Vitro Techniques ; Machine Learning ; Neoplasm Metastasis ; Neoplasms/metabolism ; Phenotype ; Probability ; Protein Binding ; Tumor Microenvironment
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; Chromatin ; Collagen (9007-34-5) ; DNA (9007-49-2)
Language	English
Publishing date	2021-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-02441-6
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Article ; Online: Efficacy of Fluoride Varnish with Casein Phosphopeptide and Amorphous Calcium Phosphate vs Fluoride Varnish in Prevention of White Spots Lesion in fixed Orthodontic Patients:

Rangarajan, Sumanth / Vikram, N Raj / Dhayananth, Xavier L / Rajakumar, P / Venkatachalapathy, Sudhakar / Karikalan, N

The journal of contemporary dental practice

2022 Volume 23, Issue 11, Page(s) 1100–1105

Abstract: Aim: The aim of the study is to compare the : Materials and methods: A total of 30 patients were selected and divided into two groups I (MI varnish) II (Fluoritop varnish) of 15 patients in each group. All the patients were bonded and then varnish ... ...

Abstract	Aim: The aim of the study is to compare the Materials and methods: A total of 30 patients were selected and divided into two groups I (MI varnish) II (Fluoritop varnish) of 15 patients in each group. All the patients were bonded and then varnish was applied around the brackets. Right-side upper and lower first premolar teeth were taken as the control group and left-side upper and lower first premolar teeth as the experimental group. Also, 14, 24 teeth were extracted on day 28 after bonding and 34, 44 teeth after day 56 of bonding. Samples were collected and sent to laboratory for evaluation of surface microhardness (SMH). Results: Based on the statistics results, there was a significant decrease in demineralization and an increase in remineralization of WSLs after the application of varnish. No statistical significance was found between the effectiveness of MI varnish and Fluoritop except in the cervical region. Conclusion: Through our study, we concluded that no statistical significance was found between the effectiveness of MI varnish and Fluoritop except in the cervical region where MI varnish was found to be more effective than Fluoritop in preventing WSLs. Clinical significance: The results from the above study concluded that CPP-ACP varnish can be an effective method in preventing WSLs in patients undergoing fixed orthodontic treatment.
MeSH term(s)	Humans ; Fluorides/therapeutic use ; Fluorides, Topical/therapeutic use ; Caseins/therapeutic use ; Phosphopeptides/therapeutic use ; Tooth Remineralization/methods ; Sodium Fluoride/therapeutic use ; Dental Caries/prevention & control ; Dental Caries/drug therapy
Chemical Substances	Fluorides (Q80VPU408O) ; Fluorides, Topical ; amorphous calcium phosphate ; Caseins ; Phosphopeptides ; Sodium Fluoride (8ZYQ1474W7)
Language	English
Publishing date	2022-11-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3404
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Article ; Online: Detecting radio- and chemoresistant cells in 3D cancer co-cultures using chromatin biomarkers.

Pekeč, Tina / Venkatachalapathy, Saradha / Shim, Anne R / Paysan, Daniel / Grzmil, Michal / Schibli, Roger / Béhé, Martin / Shivashankar, G V

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20662

Abstract: The heterogenous treatment response of tumor cells limits the effectiveness of cancer therapy. While this heterogeneity has been linked to cell-to-cell variability within the complex tumor microenvironment, a quantitative biomarker that identifies and ... ...

Abstract	The heterogenous treatment response of tumor cells limits the effectiveness of cancer therapy. While this heterogeneity has been linked to cell-to-cell variability within the complex tumor microenvironment, a quantitative biomarker that identifies and characterizes treatment-resistant cell populations is still missing. Herein, we use chromatin organization as a cost-efficient readout of the cells' states to identify subpopulations that exhibit distinct responses to radiotherapy. To this end, we developed a 3D co-culture model of cancer spheroids and patient-derived fibroblasts treated with radiotherapy. Using the model we identified treatment-resistant cells that bypassed DNA damage checkpoints and exhibited an aggressive growth phenotype. Importantly, these cells featured more condensed chromatin which primed them for treatment evasion, as inhibiting chromatin condensation and DNA damage repair mechanisms improved the efficacy of not only radio- but also chemotherapy. Collectively, our work shows the potential of using chromatin organization to cost-effectively study the heterogeneous treatment susceptibility of cells and guide therapeutic design.
MeSH term(s)	Humans ; Chromatin ; Coculture Techniques ; Neoplasms/genetics ; Neoplasms/radiotherapy ; DNA Repair ; Biomarkers ; Tumor Microenvironment ; Spheroids, Cellular ; Cell Line, Tumor
Chemical Substances	Chromatin ; Biomarkers
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47287-2
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Article: Therapeutic endoscopic ultrasound.

Venkatachalapathy, Suresh / Nayar, Manu K

Frontline gastroenterology

2017 Volume 8, Issue 2, Page(s) 119–123

Abstract: Endoscopic ultrasound (EUS) is now firmly established as one of the essential tools for diagnosis in most gastrointestinal MDTs across the UK. However, the ability to provide therapy with EUS has resulted in a significant impact on the management of the ... ...

Abstract	Endoscopic ultrasound (EUS) is now firmly established as one of the essential tools for diagnosis in most gastrointestinal MDTs across the UK. However, the ability to provide therapy with EUS has resulted in a significant impact on the management of the patients. These include drainage of peripancreatic collections, EUS-guided endoscopic retrograde cholangiopancreatogram, EUS-guided coeliac plexus blocks, etc. The rapid development of this area in endoscopy is a combination of newer tools and increasing expertise by endosonographers to push the boundaries of intervention with EUS. However, the indications are limited and we are at the start of the learning curve for these high-risk procedures. These therapies should, therefore, be confined to centres with a robust multidisciplinary team, including interventional endoscopists, radiologists and surgeons.
Language	English
Publishing date	2017-02-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2521857-8
ISSN	2041-4137
ISSN	2041-4137
DOI	10.1136/flgastro-2016-100774
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