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  1. AU="Venkataraman, Srividhya"
  2. AU="S Asher"
  3. AU="Kaushik, Akanksha"
  4. AU="Crutu, Adrian"
  5. AU=Boardman Dominic A. AU=Boardman Dominic A.
  6. AU="Hao, Zhuang"
  7. AU=Daley Charles L
  8. AU="Arjona-Jimenez, Guadalupe"
  9. AU="d'Epenoux, Louise Ruffier"
  10. AU=Lam Katherine W
  11. AU="Ferrier, I Nicol"
  12. AU="Galanski, Mathea S"
  13. AU="Abdelmalek, Fady"
  14. AU="Junkiert, Ukasz"
  15. AU="Nuss, Rachelle"
  16. AU="Hogenkamp, David G"
  17. AU="Song, Weixiao"
  18. AU="Sharma, Siddhanth"
  19. AU="Maheen, Sara"
  20. AU=Weinhard Laetitia
  21. AU="Sun, Mi"
  22. AU="Pospísil, V"
  23. AU=Driscoll David R AU=Driscoll David R
  24. AU="Wojtalewicz, Nathalie"
  25. AU="Waingrow, Marshall"
  26. AU="Daymé Gonzalez Rodriguez"
  27. AU="Lou, Shuyi"
  28. AU="Figueiredo, Rodrigo S"
  29. AU=Fleet James C
  30. AU="Brohawn, David G"
  31. AU="Cho, Chun-Chieh"
  32. AU="van Raalte, Daniël H"
  33. AU="Zargarian, Loussiné"
  34. AU=Hascalovici Jacob
  35. AU="Spagnolo, Jennifer B"
  36. AU="Anderloni, Giulia"
  37. AU="Ahmad, Shoaib"
  38. AU="Du, Roujia"
  39. AU="Colmenero-Repiso, Ana"
  40. AU="Alvarez-Carbonell, David"
  41. AU="Phelippeau, Michael"
  42. AU="Lunghi, Laura"
  43. AU=Giersiepen Klaus
  44. AU="Drobyshev, Sergey"
  45. AU="Timme, Kathleen H"
  46. AU=Sfriso Paolo
  47. AU="Kim, John S"
  48. AU=Farkash Evan A AU=Farkash Evan A
  49. AU="Xia, Xueqian"

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Treffer 1 - 10 von insgesamt 27

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  1. Buch ; Online ; E-Book: Agricultural biotechnology

    Venkataraman, Srividhya / Hefferon, Kathleen

    genetic engineering for a food cause

    2023  

    Verfasserangabe Srividhya Venkataraman, Kathleen Hefferon
    Schlagwörter Electronic books
    Sprache Englisch
    Umfang 1 Online-Ressource (xiv, 267 Seiten), Illustrationen
    Verlag Elsevier Academic Press
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Anmerkung Description based on publisher supplied metadata and other sources
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030010379
    ISBN 978-0-323-88477-8 ; 9780323884761 ; 0-323-88477-6 ; 0323884768
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Artikel: Plant Molecular Pharming and Plant-Derived Compounds towards Generation of Vaccines and Therapeutics against Coronaviruses.

    Venkataraman, Srividhya

    Vaccines

    2022  Band 10, Heft 11

    Abstract: The current century has witnessed infections of pandemic proportions caused by Coronaviruses (CoV) including severe acute respiratory syndrome-related CoV (SARS-CoV), Middle East respiratory syndrome-related CoV (MERS-CoV) and the recently identified ... ...

    Abstract The current century has witnessed infections of pandemic proportions caused by Coronaviruses (CoV) including severe acute respiratory syndrome-related CoV (SARS-CoV), Middle East respiratory syndrome-related CoV (MERS-CoV) and the recently identified SARS-CoV2. Significantly, the SARS-CoV2 outbreak, declared a pandemic in early 2020, has wreaked devastation and imposed intense pressure on medical establishments world-wide in a short time period by spreading at a rapid pace, resulting in high morbidity and mortality. Therefore, there is a compelling need to combat and contain the CoV infections. The current review addresses the unique features of the molecular virology of major Coronaviruses that may be tractable towards antiviral targeting and design of novel preventative and therapeutic intervention strategies. Plant-derived vaccines, in particular oral vaccines, afford safer, effectual and low-cost avenues to develop antivirals and fast response vaccines, requiring minimal infrastructure and trained personnel for vaccine administration in developing countries. This review article discusses recent developments in the generation of plant-based vaccines, therapeutic/drug molecules, monoclonal antibodies and phytochemicals to preclude and combat infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2 viruses. Efficacious plant-derived antivirals could contribute significantly to combating emerging and re-emerging pathogenic CoV infections and help stem the tide of any future pandemics.
    Sprache Englisch
    Erscheinungsdatum 2022-10-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines10111805
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Application of Plant Viruses in Biotechnology, Medicine, and Human Health.

    Venkataraman, Srividhya / Hefferon, Kathleen

    Viruses

    2021  Band 13, Heft 9

    Abstract: Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato ... ...

    Abstract Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato virus X (PVX), by virtue of having high aspect ratios, make ideal platforms for drug delivery. TMV and PVX both possess rod-shaped structures and single-stranded RNA genomes encapsidated by their respective capsid proteins and have shown great promise as drug delivery systems. Cowpea mosaic virus (CPMV) has an icosahedral structure, and thus brings unique benefits as a nanoparticle. The uses of these three plant viruses as either nanostructures or expression vectors for high value pharmaceutical proteins such as vaccines and antibodies are discussed extensively in the following review. In addition, the potential uses of geminiviruses in medical biotechnology are explored. The uses of these expression vectors in plant biotechnology applications are also discussed. Finally, in this review, we project future prospects for plant viruses in the fields of medicine, human health, prophylaxis, and therapy of human diseases.
    Mesh-Begriff(e) Animals ; Biotechnology/methods ; CRISPR-Cas Systems ; Comovirus/physiology ; Global Health ; Humans ; Mice ; Nanoparticles/chemistry ; Nanotechnology/methods ; Pharmaceutical Preparations ; Plant Viruses/classification ; Plant Viruses/genetics ; Plant Viruses/physiology ; Potexvirus/physiology ; Tobacco Mosaic Virus/physiology
    Chemische Substanzen Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2021-08-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091697
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Application of Plant Viruses in Biotechnology, Medicine, and Human Health

    Venkataraman, Srividhya / Hefferon, Kathleen

    Viruses. 2021 Aug. 26, v. 13, no. 9

    2021  

    Abstract: Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato ... ...

    Abstract Plant-based nanotechnology programs using virus-like particles (VLPs) and virus nanoparticles (VNPs) are emerging platforms that are increasingly used for a variety of applications in biotechnology and medicine. Tobacco mosaic virus (TMV) and potato virus X (PVX), by virtue of having high aspect ratios, make ideal platforms for drug delivery. TMV and PVX both possess rod-shaped structures and single-stranded RNA genomes encapsidated by their respective capsid proteins and have shown great promise as drug delivery systems. Cowpea mosaic virus (CPMV) has an icosahedral structure, and thus brings unique benefits as a nanoparticle. The uses of these three plant viruses as either nanostructures or expression vectors for high value pharmaceutical proteins such as vaccines and antibodies are discussed extensively in the following review. In addition, the potential uses of geminiviruses in medical biotechnology are explored. The uses of these expression vectors in plant biotechnology applications are also discussed. Finally, in this review, we project future prospects for plant viruses in the fields of medicine, human health, prophylaxis, and therapy of human diseases.
    Schlagwörter Cowpea mosaic virus ; Geminiviridae ; RNA ; Tobacco mosaic virus ; biotechnology ; capsid ; disease prevention ; genome ; human health ; humans ; medicine ; potatoes ; viruses
    Sprache Englisch
    Erscheinungsverlauf 2021-0826
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13091697
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: Combating Human Viral Diseases: Will Plant-Based Vaccines Be the Answer?

    Venkataraman, Srividhya / Hefferon, Kathleen / Makhzoum, Abdullah / Abouhaidar, Mounir

    Vaccines

    2021  Band 9, Heft 7

    Abstract: Molecular pharming or the technology of application of plants and plant cell culture to manufacture high-value recombinant proteins has progressed a long way over the last three decades. Whether generated in transgenic plants by stable expression or in ... ...

    Abstract Molecular pharming or the technology of application of plants and plant cell culture to manufacture high-value recombinant proteins has progressed a long way over the last three decades. Whether generated in transgenic plants by stable expression or in plant virus-based transient expression systems, biopharmaceuticals have been produced to combat several human viral diseases that have impacted the world in pandemic proportions. Plants have been variously employed in expressing a host of viral antigens as well as monoclonal antibodies. Many of these biopharmaceuticals have shown great promise in animal models and several of them have performed successfully in clinical trials. The current review elaborates the strategies and successes achieved in generating plant-derived vaccines to target several virus-induced health concerns including highly communicable infectious viral diseases. Importantly, plant-made biopharmaceuticals against hepatitis B virus (HBV), hepatitis C virus (HCV), the cancer-causing virus human papillomavirus (HPV), human immunodeficiency virus (HIV), influenza virus, zika virus, and the emerging respiratory virus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have been discussed. The use of plant virus-derived nanoparticles (VNPs) and virus-like particles (VLPs) in generating plant-based vaccines are extensively addressed. The review closes with a critical look at the caveats of plant-based molecular pharming and future prospects towards further advancements in this technology. The use of biopharmed viral vaccines in human medicine and as part of emergency response vaccines and therapeutics in humans looks promising for the near future.
    Sprache Englisch
    Erscheinungsdatum 2021-07-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9070761
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Frontiers in Bioengineering and Biotechnology: Plant Nanoparticles for Anti-Cancer Therapy.

    Shoeb, Erum / Badar, Uzma / Venkataraman, Srividhya / Hefferon, Kathleen

    Vaccines

    2021  Band 9, Heft 8

    Abstract: Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to ... ...

    Abstract Naturally occurring viral nanomaterials have gained popularity owing to their biocompatible and biodegradable nature. Plant virus nanoparticles (VNPs) can be used as nanocarriers for a number of biomedical applications. Plant VNPs are inexpensive to produce, safe to administer and efficacious as treatments. The following review describes how plant virus architecture facilitates the use of VNPs for imaging and a variety of therapeutic applications, with particular emphasis on cancer. Examples of plant viruses which have been engineered to carry drugs and diagnostic agents for specific types of cancer are provided. The drug delivery system in response to the internal conditions is known as stimuli response, recently becoming more applicable using plant viruses based VNPs. The review concludes with a perspective of the future of plant VNPs and plant virus-like particles (VLPs) in cancer research and therapy.
    Sprache Englisch
    Erscheinungsdatum 2021-07-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9080830
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Development of a novel multi‑epitope vaccine against the pathogenic human polyomavirus V6/7 using reverse vaccinology.

    Salahlou, Reza / Farajnia, Safar / Bargahi, Nasrin / Bakhtiyari, Nasim / Elmi, Faranak / Shahgolzari, Mehdi / Fiering, Steven / Venkataraman, Srividhya

    BMC infectious diseases

    2024  Band 24, Heft 1, Seite(n) 177

    Abstract: Background: Human polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure against the malignancies caused by this virus. Therefore, the development of a safe and effective ... ...

    Abstract Background: Human polyomaviruses contribute to human oncogenesis through persistent infections, but currently there is no effective preventive measure against the malignancies caused by this virus. Therefore, the development of a safe and effective vaccine against HPyV is of high priority.
    Methods: First, the proteomes of 2 polyomavirus species (HPyV6 and HPyV7) were downloaded from the NCBI database for the selection of the target proteins. The epitope identification process focused on selecting proteins that were crucial, associated with virulence, present on the surface, antigenic, non-toxic, and non-homologous with the human proteome. Then, the immunoinformatic methods were used to identify cytotoxic T-lymphocyte (CTL), helper T-lymphocyte (HTL), and B-cell epitopes from the target antigens, which could be used to create epitope-based vaccine. The physicochemical features of the designed vaccine were predicted through various online servers. The binding pattern and stability between the vaccine candidate and Toll-like receptors were analyzed through molecular docking and molecular dynamics (MD) simulation, while the immunogenicity of the designed vaccines was assessed using immune simulation.
    Results: Online tools were utilized to forecast the most optimal epitope from the immunogenic targets, including LTAg, VP1, and VP1 antigens of HPyV6 and HPyV7. A multi-epitope vaccine was developed by combining 10 CTL, 7 HTL, and 6 LBL epitopes with suitable linkers and adjuvant. The vaccine displayed 98.35% of the world's population coverage. The 3D model of the vaccine structure revealed that the majority of residues (87.7%) were located in favored regions of the Ramachandran plot. The evaluation of molecular docking and MD simulation revealed that the constructed vaccine exhibits a strong binding (-1414.0 kcal/mol) towards the host's TLR4. Moreover, the vaccine-TLR complexes remained stable throughout the dynamic conditions present in the natural environment. The immune simulation results demonstrated that the vaccine design had the capacity to elicit robust immune responses in the host.
    Conclusion: The multi-parametric analysis revealed that the designed vaccine is capable of inducing sustained immunity against the selected polyomaviruses, although further in-vivo investigations are needed to verify its effectiveness.
    Mesh-Begriff(e) Humans ; Molecular Docking Simulation ; Vaccinology ; Epitopes, T-Lymphocyte ; Vaccines ; Polyomavirus/genetics ; Computational Biology/methods
    Chemische Substanzen Epitopes, T-Lymphocyte ; Vaccines
    Sprache Englisch
    Erscheinungsdatum 2024-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09046-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Recent advances in expression and purification strategies for plant made vaccines.

    Venkataraman, Srividhya / Khan, Imran / Habibi, Peyman / Le, Maria / Lippert, Rory / Hefferon, Kathleen

    Frontiers in plant science

    2023  Band 14, Seite(n) 1273958

    Abstract: Plants have been explored as a platform to produce pharmaceutical proteins for over 20 years. Important features such as the cost-effectiveness of production, the ease of scaling up to manufacturing capacity, the lack of cold chain requirements and the ... ...

    Abstract Plants have been explored as a platform to produce pharmaceutical proteins for over 20 years. Important features such as the cost-effectiveness of production, the ease of scaling up to manufacturing capacity, the lack of cold chain requirements and the ability to produce complex therapeutic proteins which are biologically and functionally identical to their mammalian counterparts, make plants a strong alternative for vaccine production. This review article focuses on both the expression as well as the downstream purification processes for plant made vaccines. Expression strategies including transgenic, transient and cell suspension cultures are outlined, and various plant tissues targeted such as leaves and seeds are described. The principal components used for downstream processing of plant made vaccines are examined. The review concludes with a reflection of the future benefits of plant production platforms for vaccine production.
    Sprache Englisch
    Erscheinungsdatum 2023-11-23
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1273958
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Plant Virus Nanoparticles Combat Cancer.

    Shahgolzari, Mehdi / Venkataraman, Srividhya / Osano, Anne / Akpa, Paul Achile / Hefferon, Kathleen

    Vaccines

    2023  Band 11, Heft 8

    Abstract: Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both ... ...

    Abstract Plant virus nanoparticles (PVNPs) have garnered considerable interest as a promising nanotechnology approach to combat cancer. Owing to their biocompatibility, stability, and adjustable surface functionality, PVNPs hold tremendous potential for both therapeutic and imaging applications. The versatility of PVNPs is evident from their ability to be tailored to transport a range of therapeutic agents, including chemotherapy drugs, siRNA, and immunomodulators, thereby facilitating targeted delivery to the tumor microenvironment (TME). Furthermore, PVNPs may be customized with targeting ligands to selectively bind to cancer cell receptors, reducing off-target effects. Additionally, PVNPs possess immunogenic properties and can be engineered to exhibit tumor-associated antigens, thereby stimulating anti-tumor immune responses. In conclusion, the potential of PVNPs as a versatile platform for fighting cancer is immense, and further research is required to fully explore their potential and translate them into clinical applications.
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11081278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Plant Virus Nanoparticles for Anti-cancer Therapy.

    Venkataraman, Srividhya / Apka, Paul / Shoeb, Erum / Badar, Uzma / Hefferon, Kathleen

    Frontiers in bioengineering and biotechnology

    2021  Band 9, Seite(n) 642794

    Abstract: Plant virus nanoparticles (VNPs) are inexpensive to produce, safe, biodegradable and efficacious as treatments. The applications of r plant virus nanoparticles range from epitope carriers for vaccines to agents in cancer immunotherapy. Both VNPs and ... ...

    Abstract Plant virus nanoparticles (VNPs) are inexpensive to produce, safe, biodegradable and efficacious as treatments. The applications of r plant virus nanoparticles range from epitope carriers for vaccines to agents in cancer immunotherapy. Both VNPs and virus-like particles (VLPs) are highly immunogenic and are readily phagocytosed by antigen presenting cells (APCs), which in turn elicit antigen processing and display of pathogenic epitopes on their surfaces. Since the VLPs are composed of multiple copies of their respective capsid proteins, they present repetitive multivalent scaffolds which aid in antigen presentation. Therefore, the VLPs prove to be highly suitable platforms for delivery and presentation of antigenic epitopes, resulting in induction of more robust immune response compared to those of their soluble counterparts. Since the tumor microenvironment poses the challenge of self-antigen tolerance, VLPs are preferrable platforms for delivery and display of self-antigens as well as otherwise weakly immunogenic antigens. These properties, in addition to their diminutive size, enable the VLPs to deliver vaccines to the draining lymph nodes in addition to promoting APC interactions. Furthermore, many plant viral VLPs possess inherent adjuvant properties dispensing with the requirement of additional adjuvants to stimulate immune activity. Some of the highly immunogenic VLPs elicit innate immune activity, which in turn instigate adaptive immunity in tumor micro-environments. Plant viral VLPs are nontoxic, inherently stable, and capable of being mass-produced as well as being modified with antigens and drugs, therefore providing an attractive option for eliciting anti-tumor immunity. The following review explores the use of plant viruses as epitope carrying nanoparticles and as a novel tools in cancer immunotherapy.
    Sprache Englisch
    Erscheinungsdatum 2021-12-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2021.642794
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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