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Article ; Online: Surgery during covid-19

Venn, ML / Weir, CT / CovidSurg Collaborative

co-producing patient resources

2020

Abstract: This article has been accepted for publication in BMJ: British Medical Journal, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmj ... ...

Abstract	This article has been accepted for publication in BMJ: British Medical Journal, 2020 following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/bmj.m3466
Keywords	covid19
Language	English
Publishing date	2020-09-17
Publisher	BMJ
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Postoperative narcotic use in patients with ovarian cancer on an Enhanced Recovery After Surgery (ERAS) pathway.

Kay, Allison H / Venn, Monica / Urban, Renata / Gray, Heidi J / Goff, Barbara

Gynecologic oncology

2019 Volume 156, Issue 3, Page(s) 624–628

Abstract: Objectives: To determine the impact of an ERAS pathway on post-discharge narcotic use for patients with ovarian cancer undergoing open surgery.: Methods: This was a retrospective cohort study of women who underwent open ovarian cancer surgeries in ... ...

Abstract	Objectives: To determine the impact of an ERAS pathway on post-discharge narcotic use for patients with ovarian cancer undergoing open surgery. Methods: This was a retrospective cohort study of women who underwent open ovarian cancer surgeries in 2014 prior to ERAS ("pre-ERAS") and in 2016/2018 after ERAS was instituted ("ERAS"). Patients taking chronic narcotics were excluded. A statewide prescription monitoring program was used to identify narcotic prescriptions filled in the three months after surgery. Quantity of narcotic medication is referenced in morphine milligram equivalents (MME). Results: 42 pre-ERAS and 94 ERAS patients were included. The groups were similar in age, BMI, diabetes, tobacco use, mean number of prior abdominal/pelvic surgeries, and advanced stage disease. ERAS patients had a shorter hospital stay (6.7 days pre-ERAS vs 4.2 days ERAS, p = 0.003), used less narcotic in the 24 h prior to discharge (74.0 MME pre-ERAS vs 25.8 MME ERAS, p = 0.002), and filled prescriptions at time of discharge for less narcotic (519.9 MME pre-ERAS vs 339.7 MME ERAS, p = 0.011). After hospital discharge, ERAS patients filled fewer additional prescriptions (52.4% pre-ERAS, vs 29.4% ERAS, p = 0.012). In total, ERAS patients filled prescriptions for 55% fewer narcotics in the three months after surgery than the pre-ERAS group (1101.4 MME pre-ERAS vs 492.1 MME ERAS, p < 0.001). Conclusions: Institution of an ERAS protocol appears to decrease the narcotic needs of patients in the three months after ovarian cancer surgery.
MeSH term(s)	Cohort Studies ; Enhanced Recovery After Surgery ; Female ; Humans ; Middle Aged ; Narcotics/administration & dosage ; Ovarian Neoplasms/surgery ; Pain Management/methods ; Pain Management/standards ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Postoperative Care/methods ; Postoperative Care/standards ; Preoperative Care/methods ; Preoperative Care/standards ; Retrospective Studies
Chemical Substances	Narcotics
Language	English
Publishing date	2019-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2019.12.018
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Article ; Online: TAMIS-ESD/EMR excision of a circumferential LST-G polyp in the mid and upper rectum - a video vignette.

El-Beialy, H / Venn, M L / Gangadharan, S / Pitt, J / Driver, I / Malik, A

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2017 Volume 19, Issue 10, Page(s) 947–948

MeSH term(s)	Humans ; Intestinal Mucosa/surgery ; Intestinal Polyps/surgery ; Rectal Diseases/surgery ; Rectum/surgery ; Transanal Endoscopic Surgery/methods
Language	English
Publishing date	2017
Publishing country	England
Document type	Case Reports ; Letter ; Video-Audio Media
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.13845
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Article: A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit.

Venn, M / Newman, J / Grounds, M

Intensive care medicine

2003 Volume 29, Issue 2, Page(s) 201–207

Abstract: Objective: To evaluate dexmedetomidine for sedation of patients in the medical ICU.: Design and setting: Prospective observational study in an intensive care unit of a university hospital. PATIENTS. Twelve ventilated patients with median APACHE II ... ...

Abstract	Objective: To evaluate dexmedetomidine for sedation of patients in the medical ICU. Design and setting: Prospective observational study in an intensive care unit of a university hospital. PATIENTS. Twelve ventilated patients with median APACHE II score 23 (range 10-26). Interventions: Patients received a loading dexmedetomidine infusion of 1 microg x kg(-1) over 10 min followed by a maintenance infusion rate of 0.2-0.7 microg x kg(-1) x h(-1) for up to 7 days. After experience with the first four patients this maintenance rate of infusion was increased to a maximum of 2.5 microg kg(-1) x h(-1). If required, propofol and morphine provided rescue sedation and analgesia, respectively. Results: The first four patients with dexmedetomidine infusion at 0.7 microg x kg(-1) x h(-1)all required rescue sedation with a propofol infusion. A protocol amendment allowed the next eight patients to receive higher dexmedetomidine infusions (mean 1.0+/- microg x kg(-1) x h(-1)). Five of the next eight patients did not required propofol, and two patients only required minimal propofol infusions (20-40 mg x h(-1)). A further patient, with hepatic encephalopathy, required a propofol at 50-100 mg x h(-1). Only modest falls in arterial pressure, heart rate and cardiac output were seen, and no rebound sequelae occurred on discontinuation of dexmedetomidine. Adverse cardiovascular events were nearly all confined to the initial loading dose period of dexmedetomidine. Conclusions: Sedation with dexmedetomidine is efficacious in critically ill medical patients requiring mechanical ventilation in the intensive care unit. A reduction in loading infusion is advised, but higher maintenance infusions may be required to that seen previously in the postoperative ICU patient.
MeSH term(s)	APACHE ; Adrenergic alpha-Agonists/adverse effects ; Adrenergic alpha-Agonists/therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Non-Narcotic/adverse effects ; Analgesics, Non-Narcotic/therapeutic use ; Blood Pressure/drug effects ; Central Venous Pressure/drug effects ; Conscious Sedation/adverse effects ; Conscious Sedation/methods ; Critical Care/methods ; Dexmedetomidine/adverse effects ; Dexmedetomidine/therapeutic use ; Drug Monitoring ; Female ; Heart Rate/drug effects ; Humans ; Hypnotics and Sedatives/adverse effects ; Hypnotics and Sedatives/therapeutic use ; Infusions, Intravenous ; Male ; Middle Aged ; Pilot Projects ; Respiration, Artificial/adverse effects ; Safety ; Time Factors ; Treatment Outcome
Chemical Substances	Adrenergic alpha-Agonists ; Analgesics, Non-Narcotic ; Hypnotics and Sedatives ; Dexmedetomidine (67VB76HONO)
Language	English
Publishing date	2003-02
Publishing country	United States
Document type	Clinical Trial ; Clinical Trial, Phase II ; Journal Article
ZDB-ID	80387-x
ISSN	1432-1238 ; 0342-4642 ; 0340-0964 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0342-4642 ; 0340-0964 ; 0935-1701
DOI	10.1007/s00134-002-1579-9
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Article: Defining our destiny: trainee working group consensus statement on the future of emergency surgery training in the United Kingdom.

Sharrock, A E / Gokani, V J / Harries, R L / Pearce, L / Smith, S R / Ali, O / Chu, H / Dubois, A / Ferguson, H / Humm, G / Marsden, M / Nepogodiev, D / Venn, M / Singh, S / Swain, C / Kirkby-Bott, J

World journal of emergency surgery : WJES

2015 Volume 10, Page(s) 26

Abstract: The United Kingdom National Health Service treats both elective and emergency patients and seeks to provide high quality care, free at the point of delivery. Equal numbers of emergency and elective general surgical procedures are performed, yet surgical ... ...

Abstract	The United Kingdom National Health Service treats both elective and emergency patients and seeks to provide high quality care, free at the point of delivery. Equal numbers of emergency and elective general surgical procedures are performed, yet surgical training prioritisation and organisation of NHS institutions is predicated upon elective care. The increasing ratio of emergency general surgery consultant posts compared to traditional sub-specialities has yet to be addressed. How should the capability gap be bridged to equip motivated, skilled surgeons of the future to deliver a high standard of emergency surgical care? The aim was to address both training requirements for the acquisition of necessary emergency general surgery skills, and the formation of job plans for trainee and consultant posts to meet the current and future requirements of the NHS. Twenty nine trainees and a consultant emergency general surgeon convened as a Working Group at The Association of Surgeons in Training Conference, 2015, to generate a united consensus statement to the training requirement and delivery of emergency general surgery provision by future general surgeons. Unscheduled general surgical care provision, emergency general surgery, trauma competence, training to meet NHS requirements, consultant job planning and future training challenges arose as key themes. Recommendations have been made from these themes in light of published evidence. Careful workforce planning, education, training and fellowship opportunities will provide well-trained enthusiastic individuals to meet public and societal need.
Language	English
Publishing date	2015-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2233734-9
ISSN	1749-7922
ISSN	1749-7922
DOI	10.1186/s13017-015-0019-4
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Article: Localization of mRNA for the apoptosis-linked gene ALG-2 in young and aged rat brain.

Venn, M K / Conway, E L

Neuroreport

1998 Volume 9, Issue 9, Page(s) 1981–1985

Abstract: ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG- ...

Abstract	ALG-2 is a recently described pro-apoptosis gene that codes for a Ca2+-binding protein involved in T-cell receptor-, Fas- and glucocorticoid-induced cell death. We have used in situ hybridization histochemistry to examine the regional distribution of ALG-2 mRNA in the brain of 3- and 24-month old rats. There was widespread, predominantly neuronal distribution of ALG-2 mRNA throughout the brain. Areas expressing high levels included the granule and pyramidal cell layers of the hippocampus, choroid plexus, area postrema, and a number of hindbrain nuclei. ALG-2 mRNA levels in aged rats were not significantly different to young animals. The pattern of expression of ALG-2 mRNA in adult brain is similar to other apoptosis-related genes and suggests it may be involved in neuronal survival.
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Animals ; Apoptosis/physiology ; Brain Chemistry/genetics ; Genes/physiology ; In Situ Hybridization ; Male ; Nerve Degeneration/pathology ; RNA Probes ; RNA, Messenger/biosynthesis ; Rats ; Rats, Wistar
Chemical Substances	RNA Probes ; RNA, Messenger
Language	English
Publishing date	1998-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1049746-8
ISSN	1473-558X ; 0959-4965
ISSN (online)	1473-558X
ISSN	0959-4965
DOI	10.1097/00001756-199806220-00012
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Article: Effect of a barley breakfast cereal on blood glucose and insulin response in normal and diabetic patients.

Rendell, M / Vanderhoof, J / Venn, M / Shehan, M A / Arndt, E / Rao, C S / Gill, G / Newman, R K / Newman, C W

Plant foods for human nutrition (Dordrecht, Netherlands)

2005 Volume 60, Issue 2, Page(s) 63–67

Abstract: Prowashonupana (Prowash) is a shrunken-endosperm, short awn, waxy starch, hulless barley with low starch, high fiber, high protein, and a relatively high concentration of free sugars. The study was designed to compare equivalent breakfast meals (w/w) of ... ...

Abstract	Prowashonupana (Prowash) is a shrunken-endosperm, short awn, waxy starch, hulless barley with low starch, high fiber, high protein, and a relatively high concentration of free sugars. The study was designed to compare equivalent breakfast meals (w/w) of Prowash and oatmeal for glycemic response in diabetic and non-diabetic subjects. A commercial liquid meal replacer (LMR) was included as a reference standard. A substantial reduction of the post-prandial glycemic peak following ingestion of Prowash was observed as compared to LMR or oatmeal. In the non-diabetic subjects, the maximal rise in glucose from baseline was 26.3 +/- 3.9 mg/dL after LMR, 41.3 +/- 3.9 mg/dL after oatmeal and 6.4 +/- 2.7 mg/dL after Prowash (p < 0.01). The maximal increase in glucose in the diabetic patients was 69.9 +/- 4.5 mg/dL after LMR, 80.8 +/- 8.8 mg/dL after oatmeal and 28.4 +/- 3.5 mg/dL after Prowash (p < 0.01). The maximal increase in insulin post-LMR was 33.9 +/- 3.6 mIU/ml in the diabetic patients and 54.0 +/- 9.8 mIU/ml in the non-diabetic controls. Oatmeal elicited a maximal insulin increase of 29.9 +/- 4.2 mIU/ml in the control subjects and 21.4 +/- 2.5 mIU/ml in the diabetic patients. In contrast, the maximal insulin increase after Prowash was 8.6 +/- 1.5 mIU/ml in the non-diabetic controls and 6.8 +/- 1.2 mIU/ml in the diabetic patients (p < 0.01).
MeSH term(s)	Avena ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/diet therapy ; Dietary Fiber/administration & dosage ; Dietary Fiber/metabolism ; Edible Grain ; Female ; Glycemic Index ; Hordeum/chemistry ; Humans ; Insulin/blood ; Male ; Middle Aged ; Postprandial Period ; Treatment Outcome
Chemical Substances	Blood Glucose ; Dietary Fiber ; Insulin
Language	English
Publishing date	2005-03-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	188869-9
ISSN	0921-9668 ; 0377-3205
ISSN	0921-9668 ; 0377-3205
DOI	10.1007/s11130-005-5101-8
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Article: Nurses in service to their community.

Venn, M R

The Maryland nurse

1980 , Page(s) 23–25

MeSH term(s)	Disasters ; Nursing Care ; Red Cross ; United States
Language	English
Publishing date	1980-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	632635-3
ISSN	0047-6080
ISSN	0047-6080
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Article: Chemical composition of human femoral and head cartilage: influence of topographical position and fibrillation.

Venn, M F

Annals of the rheumatic diseases

1979 Volume 38, Issue 1, Page(s) 57–62

Abstract: Topographical variations in the composition of cartilage have been described in post-mortem femoral head cartilage. Weight bearing cartilage of the superior region was considerably thicker and had a higher glycosaminoglycan content and lower water and ... ...

Abstract	Topographical variations in the composition of cartilage have been described in post-mortem femoral head cartilage. Weight bearing cartilage of the superior region was considerably thicker and had a higher glycosaminoglycan content and lower water and collagen content than cartilage at the periphery and below the fovea. These topographical variations in composition may result both from variations in thickness of the cartilage and from regional areas of degeneration. The composition of cartilage at different depths and with different surface characteristics from different areas of the femoral head was measured. Fibrillated cartilage both from the inferior and superior perifoveal areas had a reduced glycosaminoglycan content and higher water content than intact post-mortem specimens. Cartilage adjacent to fibrillated areas from the superior region did not differ in composition from intact areas of cartilage from the zenith of the femoral head.
MeSH term(s)	Cartilage, Articular/analysis ; Chondroitin Sulfates/analysis ; Collagen/analysis ; Femur Head/analysis ; Humans ; Keratan Sulfate/analysis ; Water/analysis
Chemical Substances	Water (059QF0KO0R) ; Chondroitin Sulfates (9007-28-7) ; Collagen (9007-34-5) ; Keratan Sulfate (9056-36-4)
Language	English
Publishing date	1979-02
Publishing country	England
Document type	Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard.38.1.57
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Article: Variation of chemical composition with age in human femoral head cartilage.

Venn, M F

Annals of the rheumatic diseases

1978 Volume 37, Issue 2, Page(s) 168–174

Abstract: The chemical composition of intact femoral head cartilage was investigated with age. Full-depth cartilage showed a decrease in water content and an increase in keratan sulphate and noncollagenous material with age. When analyzed through the depth of the ... ...

Abstract	The chemical composition of intact femoral head cartilage was investigated with age. Full-depth cartilage showed a decrease in water content and an increase in keratan sulphate and noncollagenous material with age. When analyzed through the depth of the cartilage, keratan sulphate was shown to appear first in the deep zones and later in the surface, while water content was lost mainly in the deep zones. On a dry weight basis collagen content decreased with age. This was not a real loss but was due to a change in the proportions of other materials, mainly in the deep zones.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aging ; Cartilage, Articular/analysis ; Cartilage, Articular/anatomy & histology ; Child ; Child, Preschool ; Collagen/analysis ; Femur Head ; Glycosaminoglycans/analysis ; Humans ; Middle Aged ; Organ Size ; Water/analysis
Chemical Substances	Glycosaminoglycans ; Water (059QF0KO0R) ; Collagen (9007-34-5)
Language	English
Publishing date	1978-04
Publishing country	England
Document type	Journal Article
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/ard.37.2.168
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