LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 37

Search options

  1. Article ; Online: Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy.

    Margarido, Andreia S / Bornes, Laura / Vennin, Claire / van Rheenen, Jacco

    Cold Spring Harbor perspectives in medicine

    2020  Volume 10, Issue 11

    Abstract: Metastasis is a highly dynamic process during which cancer and microenvironmental cells undergo a cascade of events required for efficient dissemination throughout the body. During the metastatic cascade, tumor cells can change their state and behavior, ... ...

    Abstract Metastasis is a highly dynamic process during which cancer and microenvironmental cells undergo a cascade of events required for efficient dissemination throughout the body. During the metastatic cascade, tumor cells can change their state and behavior, a phenomenon commonly defined as cellular plasticity. To monitor cellular plasticity during metastasis, high-resolution intravital microscopy (IVM) techniques have been developed and allow us to visualize individual cells by repeated imaging in animal models. In this review, we summarize the latest technological advancements in the field of IVM and how they have been applied to monitor metastatic events. In particular, we highlight how longitudinal imaging in native tissues can provide new insights into the plastic physiological and developmental processes that are hijacked by cancer cells during metastasis.
    MeSH term(s) Animals ; Cell Plasticity ; Humans ; Intravital Microscopy/methods ; Neoplasm Metastasis/pathology ; Neoplasms/diagnostic imaging ; Tumor Microenvironment
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a037267
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Targeting genetically-tuned CAFs in pancreatic cancer

    Ritchie, Shona / Pereira, Brooke A / Vennin, Claire / Timpson, Paul

    Expert opinion on therapeutic targets

    2020  Volume 24, Issue 3, Page(s) 171–174

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Cancer-Associated Fibroblasts ; Heparan Sulfate Proteoglycans ; Humans ; Pancreatic Neoplasms ; Stromal Cells
    Chemical Substances Heparan Sulfate Proteoglycans ; perlecan (143972-95-6)
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2020.1727887
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5244: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors.

    Morgner, Jessica / Bornes, Laura / Hahn, Kerstin / López-Iglesias, Carmen / Kroese, Lona / Pritchard, Colin E J / Vennin, Claire / Peters, Peter J / Huijbers, Ivo / van Rheenen, Jacco

    Developmental cell

    2023  Volume 58, Issue 7, Page(s) 535–549.e5

    Abstract: The basement membrane (BM) around tumor lobes forms a barrier to prevent cancer cells from invading the surrounding tissue. Although myoepithelial cells are key producers of the healthy mammary epithelium BM, they are nearly absent in mammary tumors. To ... ...

    Abstract The basement membrane (BM) around tumor lobes forms a barrier to prevent cancer cells from invading the surrounding tissue. Although myoepithelial cells are key producers of the healthy mammary epithelium BM, they are nearly absent in mammary tumors. To study the origin and dynamics of the BM, we developed and imaged a laminin beta1-Dendra2 mouse model. We show that the turnover of laminin beta1 is faster in the BMs that surround the tumor lobes than in the BMs that surround the healthy epithelium. Moreover, we find that epithelial cancer cells and tumor-infiltrating endothelial cells synthesize laminin beta1 and that this production is temporarily and locally heterogeneous, leading to local discontinuity of the BM laminin beta1. Collectively, our data draw a new paradigm for tumor BM turnover in which the disassembly happens at a constant rate, and a local misbalance of compensating production leads to reduction or even complete disappearance of the BM.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Basement Membrane ; Breast Neoplasms/pathology ; Endothelial Cells ; Epithelial Cells ; Laminin ; Disease Models, Animal
    Chemical Substances Laminin
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2023.02.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 76: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Transient targeting of the pancreatic cancer stroma as a 'fine-tuned' anti-tumor and anti-metastatic therapy.

    Vennin, Claire / Cox, Thomas R / Pajic, Marina / Timpson, Paul

    Oncotarget

    2017  Volume 8, Issue 49, Page(s) 84635–84636

    Language English
    Publishing date 2017-10-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.21468
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis.

    Uceda-Castro, Rebeca / Margarido, Andreia S / Song, Ji-Ying / de Gooijer, Mark C / Messal, Hendrik A / Chambers, Cecilia R / Nobis, Max / Çitirikkaya, Ceren H / Hahn, Kerstin / Seinstra, Danielle / Herrmann, David / Timpson, Paul / Wesseling, Pieter / van Tellingen, Olaf / Vennin, Claire / van Rheenen, Jacco

    Science advances

    2023  Volume 9, Issue 42, Page(s) eabp9530

    Abstract: Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to chemotherapy. However, ... ...

    Abstract Although initially successful, treatments with chemotherapy often fail because of the recurrence of chemoresistant metastases. Since these tumors develop after treatment, resistance is generally thought to occur in response to chemotherapy. However, alternative mechanisms of intrinsic chemoresistance in the chemotherapy-naïve setting may exist but remain poorly understood. Here, we study drug-naïve murine breast cancer brain metastases (BCBMs) to identify how cancer cells growing in a secondary site can acquire intrinsic chemoresistance without cytotoxic agent exposure. We demonstrate that drug-naïve murine breast cancer cells that form cancer lesions in the brain undergo vascular mimicry and concomitantly express the adenosine 5'-triphosphate-binding cassette transporter breast cancer resistance protein (BCRP), a common marker of brain endothelial cells. We reveal that expression of BCRP by the BCBM tumor cells protects them against doxorubicin and topotecan. We conclude that BCRP overexpression can cause intrinsic chemoresistance in cancer cells growing in metastatic sites without prior chemotherapy exposure.
    MeSH term(s) Animals ; Female ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Brain Neoplasms/drug therapy ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Drug Resistance, Neoplasm/genetics ; Endothelial Cells/metabolism ; Neoplasm Proteins/metabolism
    Chemical Substances Antineoplastic Agents ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; ATP-Binding Cassette Transporters ; Neoplasm Proteins ; Abcg2 protein, mouse
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abp9530
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

    Chin, Venessa T / Vennin, Claire / Timpson, Paul / Pajic, Marina

    Molecular & cellular oncology

    2017  Volume 4, Issue 5, Page(s) e1333973

    Abstract: Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly ... ...

    Abstract Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased
    Language English
    Publishing date 2017-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2017.1333973
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence.

    Uceda-Castro, Rebeca / van Asperen, Jessy V / Vennin, Claire / Sluijs, Jacqueline A / van Bodegraven, Emma J / Margarido, Andreia S / Robe, Pierre A J / van Rheenen, Jacco / Hol, Elly M

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 424

    Abstract: Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial fibrillary ... ...

    Abstract Glioma is the most common form of malignant primary brain tumours in adults. Their highly invasive nature makes the disease incurable to date, emphasizing the importance of better understanding the mechanisms driving glioma invasion. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocyte- and neural stem cell-derived gliomas. Glioma malignancy is associated with changes in GFAP alternative splicing, as the canonical isoform GFAPα is downregulated in higher-grade tumours, leading to increased dominance of the GFAPδ isoform in the network. In this study, we used intravital imaging and an ex vivo brain slice invasion model. We show that the GFAPδ and GFAPα isoforms differentially regulate the tumour dynamics of glioma cells. Depletion of either isoform increases the migratory capacity of glioma cells. Remarkably, GFAPδ-depleted cells migrate randomly through the brain tissue, whereas GFAPα-depleted cells show a directionally persistent invasion into the brain parenchyma. This study shows that distinct compositions of the GFAPnetwork lead to specific migratory dynamics and behaviours of gliomas.
    MeSH term(s) Animals ; Brain/pathology ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement ; Female ; Glial Fibrillary Acidic Protein/metabolism ; Glioma/metabolism ; Glioma/pathology ; Intravital Microscopy ; Male ; Mice, Inbred C57BL ; Neoplasm Invasiveness ; Protein Isoforms ; Mice
    Chemical Substances GFAP protein, human ; Glial Fibrillary Acidic Protein ; Protein Isoforms
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-04127-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Imaging fibrosis in pancreatic cancer using second harmonic generation.

    Vennin, Claire / Pajic, Marina / Timpson, Paul

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2015  Volume 15, Issue 2, Page(s) 200–201

    MeSH term(s) Carcinoma, Pancreatic Ductal/pathology ; Collagen Type I/metabolism ; Fibrosis ; Humans ; Pancreas/pathology ; Pancreatic Neoplasms/pathology ; Prognosis ; Treatment Outcome
    Chemical Substances Collagen Type I
    Language English
    Publishing date 2015-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2015.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer.

    Vennin, Claire / Murphy, Kendelle J / Morton, Jennifer P / Cox, Thomas R / Pajic, Marina / Timpson, Paul

    Gastroenterology

    2018  Volume 154, Issue 4, Page(s) 820–838

    Abstract: Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. ... ...

    Abstract Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment-specific therapies.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Biomarkers, Tumor/metabolism ; Cell Communication/drug effects ; Energy Metabolism/drug effects ; Extracellular Matrix/drug effects ; Extracellular Matrix/immunology ; Extracellular Matrix/metabolism ; Extracellular Matrix/pathology ; Humans ; Molecular Targeted Therapy ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Signal Transduction/drug effects ; Stromal Cells/drug effects ; Stromal Cells/immunology ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Tumor Microenvironment
    Chemical Substances Antineoplastic Agents ; Biomarkers, Tumor
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2017.11.280
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 572: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.

    Vennin, Claire / Herrmann, David / Lucas, Morghan C / Timpson, Paul

    F1000Research

    2016  Volume 5

    Abstract: Intravital imaging is providing new insights into the dynamics of tumor progression in native tissues and has started to reveal the layers of complexity found in cancer. Recent advances in intravital imaging have allowed us to look deeper into cancer ... ...

    Abstract Intravital imaging is providing new insights into the dynamics of tumor progression in native tissues and has started to reveal the layers of complexity found in cancer. Recent advances in intravital imaging have allowed us to look deeper into cancer behavior and to dissect the interactions between tumor cells and the ancillary host niche that promote cancer development. In this review, we provide an insight into the latest advances in cancer biology achieved by intravital imaging, focusing on recently discovered mechanisms by which tumor cells manipulate normal tissue to facilitate disease progression.
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.8090.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top