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Article: Factors Influencing Running Performance During a Marathon: Breaking the 2-h Barrier.

Venturini, Elio / Giallauria, Francesco

2022 Volume 9, Page(s) 856875

Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.856875
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Article: Exercise Training in Elderly Cancer Patients: A Systematic Review.

Giallauria, Francesco / Testa, Crescenzo / Cuomo, Gianluigi / Di Lorenzo, Anna / Venturini, Elio / Lauretani, Fulvio / Maggio, Marcello Giuseppe / Iannuzzo, Gabriella / Vigorito, Carlo

Cancers

2023 Volume 15, Issue 6

Abstract: Due to the aging of the population, in 70% of cases, a new cancer diagnosis equals a cancer diagnosis in a geriatric patient. In this population, beyond the concept of mortality and morbidity, functional capacity, disability, and quality of life remain ... ...

Abstract	Due to the aging of the population, in 70% of cases, a new cancer diagnosis equals a cancer diagnosis in a geriatric patient. In this population, beyond the concept of mortality and morbidity, functional capacity, disability, and quality of life remain crucial. In fact, when the functional status is preserved, the pathogenetic curve towards disability will stop or even regress. The present systematic review investigated the effectiveness of physical exercise, as part of a holistic assessment of the patient, for preventing disability and improving the patient's quality of life, and partially reducing all-cause mortality. This evidence must point towards decentralization of care by implementing the development of rehabilitation programs for elderly cancer patients either before or after anti-cancer therapy.
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15061671
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Article: Effects of Sacubitril/Valsartan on Exercise Capacity in Patients with Heart Failure with Reduced Ejection Fraction and the Role of Percentage of Delayed Enhancement Measured by Cardiac Magnetic Resonance in Predicting Therapeutic Response: A Multicentre Study.

Nugara, Cinzia / Giallauria, Francesco / Vitale, Giuseppe / Sarullo, Silvia / Gentile, Giovanni / Clemenza, Francesco / Lo Voi, Annamaria / Zarcone, Antonino / Venturini, Elio / Iannuzzo, Gabriella / Coats, Andrew Js / Sarullo, Filippo M

Cardiac failure review

2023 Volume 9, Page(s) e07

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2960293-2
ISSN	2057-7559 ; 2057-7540
ISSN (online)	2057-7559
ISSN	2057-7540
DOI	10.15420/cfr.2022.13
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Article ; Online: Baseline Troponin Level and Cardiac Toxicity in HER2-positive Early Breast Cancer Patients Receiving Trastuzumab.

Canale, Maria Laura / Casolo, Giancarlo / Donati, Sara / Bisceglia, Irma / Puccetti, Cheti / Amoroso, Domenico / Venturini, Elio / Maurea, Nicola / Turazza, Fabio Maria / Camerini, Andrea

In vivo (Athens, Greece)

2023 Volume 37, Issue 5, Page(s) 2139–2146

Abstract: Background/aim: There is controversy around the use of high-sensitive troponin T (hs-TnT) as an early biomarker of cardiac toxicity in patients with breast cancer on trastuzumab (T).: Patients and methods: Patients receiving adjuvant or neo-adjuvant ... ...

Abstract	Background/aim: There is controversy around the use of high-sensitive troponin T (hs-TnT) as an early biomarker of cardiac toxicity in patients with breast cancer on trastuzumab (T). Patients and methods: Patients receiving adjuvant or neo-adjuvant T for early HER2-positive breast cancer were prospectively included. Transthoracic echocardiograms and matched hs-TnT before T and at 3, 6, and 9 months were performed on all patients. Congestive heart failure, cardiac death, a decline in left ventricular ejection fraction (LVEF) of more than 10% from baseline even if it is still within the normal range, or a drop in LVEF below 55% were all considered signs of cardiac toxicity. Results: In total, 24 patients (median age: 57; range=39-79 years) were enrolled. Anthracyclines were administered to all patients but three as part of neo/adjuvant treatment before T. Cardiovascular toxicity was observed in 3 out of 24 (12.5%) patients: two non-symptomatic LVEF declines (8.3%) and one heart failure episode (4.2%). In the entire population, the mean baseline hs-TnT level was 10.1±8.8 pg/ml, and after 3, 6, and 12 months, no appreciable change was observed. Patients with cardiac toxicity had mean hs-TnT levels higher than those without (18.3±12.3 vs. 8.2±7.2 pg/ml; p=0.049). A definite trend was evident in the chi-square test (chi Conclusion: In anthracycline-exposed patients with early breast cancer, hs-TnT may be able to identify those at risk of developing cardiac toxicity during neo/adjuvant T treatment.
MeSH term(s)	Humans ; Middle Aged ; Female ; Trastuzumab/adverse effects ; Breast Neoplasms/drug therapy ; Cardiotoxicity/etiology ; Cardiotoxicity/diagnosis ; Troponin ; Stroke Volume ; Ventricular Function, Left ; Heart Failure/diagnosis ; Anthracyclines/adverse effects ; Troponin T ; Receptor, ErbB-2
Chemical Substances	Trastuzumab (P188ANX8CK) ; Troponin ; Anthracyclines ; Troponin T ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2023-08-29
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13311
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Article: Potential Role of Global Longitudinal Strain in Cardiac and Oncological Patients Undergoing Cardio-Oncology Rehabilitation (CORE).

Cuomo, Gianluigi / Iannone, Francesca Paola / Di Lorenzo, Anna / Testa, Crescenzo / Ciccarelli, Michele / Venturini, Elio / Cesaro, Arturo / Pacileo, Mario / Tagliamonte, Ercole / D'Andrea, Antonello / Vecchione, Carmine / Vigorito, Carlo / Giallauria, Francesco

Clinics and practice

2023 Volume 13, Issue 2, Page(s) 384–397

Abstract: Although shown to be effective in improving survival and quality of life in patients with cancer, some treatments are well-known causes of cardiotoxicity, such as anthracyclines, monoclonal antibodies against human epidermal growth factor receptor 2 ( ... ...

Abstract	Although shown to be effective in improving survival and quality of life in patients with cancer, some treatments are well-known causes of cardiotoxicity, such as anthracyclines, monoclonal antibodies against human epidermal growth factor receptor 2 (HER2) and radiotherapy. To prevent cardiovascular disease (CVD) in patients living with cancer, cardiologists and oncologists promoted the development of cardio-oncology, an interdisciplinary field which aims to further improving life expectancy in these patients. Cardio-oncology rehabilitation (CORE), through correction of risk factors, prescription of drug therapies and structured exercise programs, tries to improve symptoms, quality of life, cardiorespiratory fitness (CRF) and survival in patients with cancer. Different imaging modalities can be used to evaluate the real effectiveness of exercise training on cardiac function. Among these, the global longitudinal strain (GLS) has recently aroused interest, thanks to its high sensitivity and specificity for cardiac dysfunction detection due to advanced ultrasound programs. This review summarizes the evidence on the usefulness of GLS in patients with cancer undergoing cardiac rehabilitation programs.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2605724-4
ISSN	2039-7283 ; 2039-7275
ISSN (online)	2039-7283
ISSN	2039-7275
DOI	10.3390/clinpract13020035
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Article ; Online: A late presentation of Dandy-Walker malformation and aortic coarctation.

Venturini, Elio / Magni, Lucia / Pucci, Giovanna / Mazzinghi, Fabio

Journal of cardiovascular medicine (Hagerstown, Md.)

2017 Volume 18, Issue 5, Page(s) 381–384

Abstract: The Dandy-Walker malformation is a rare anomaly of the posterior cranial fossa. Concomitant brain or systemic malformations are frequent and can influence the outcome. Associated cardiac congenital defects usually induce a poor prognosis. We report a ... ...

Abstract	The Dandy-Walker malformation is a rare anomaly of the posterior cranial fossa. Concomitant brain or systemic malformations are frequent and can influence the outcome. Associated cardiac congenital defects usually induce a poor prognosis. We report a case of a 58-yearold man with hydrocephalus, in whom Dandy-Walker malformation was diagnosed, for the first time, after the demonstration of aortic coarctation. This association is very rare and only a few cases have been described; moreover, to our knowledge, this is the first description of this incidence in a middle-aged patient. The characteristic of diseases and physiopathologic features are discussed, focusing attention on the rare and late clinical manifestations.
MeSH term(s)	Angioplasty, Balloon/instrumentation ; Aortic Coarctation/complications ; Aortic Coarctation/diagnostic imaging ; Aortic Coarctation/therapy ; Dandy-Walker Syndrome/complications ; Dandy-Walker Syndrome/diagnostic imaging ; Dandy-Walker Syndrome/therapy ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Stents ; Treatment Outcome
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0b013e3283356ebe
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Cardiologia riabilitativa e prevenzione secondaria durante la pandemia COVID-19: stato dell'arte e prospettive.

Mureddu, Gian Francesco / Giallauria, Francesco / Venturini, Elio / Fattirolli, Francesco / Ambrosetti, Marco

Giornale italiano di cardiologia (2006)

2020 Volume 21, Issue 7, Page(s) 527–528

Title translation	Cardiac rehabilitation and secondary prevention programs during the COVID-19 pandemic: what's "COVID on"?
MeSH term(s)	Betacoronavirus ; COVID-19 ; Cardiac Rehabilitation/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Female ; Humans ; Italy ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Program Development ; Program Evaluation ; SARS-CoV-2 ; Secondary Prevention/organization & administration
Keywords	covid19
Language	Italian
Publishing date	2020-06-12
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3386.33640
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Zs.A 6738: Show issues

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Article ; Online: La gestione del paziente con diabete di tipo 2 in Cardiologia Preventiva e Riabilitativa. Expert opinion della Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P).

Ambrosetti, Marco / Fattirolli, Francesco / Maranta, Francesco / Ruzzolini, Matteo / Rizzo, Manfredi / Mureddu, Gian Francesco / Griffo, Raffaele / Venturini, Elio / Giallauria, Francesco / Orso, Francesco / Pratesi, Alessandra / Patti, Angelo / Perone, Francesco

Giornale italiano di cardiologia (2006)

2023 Volume 24, Issue 10, Page(s) 834–843

Abstract: Patients with diabetes, regardless of their cardiovascular disease and their index event, are more and more often referred to Cardiac Rehabilitation Units. These patients usually show high or very high cardiovascular risk, marked disability and poor ... ...

Title translation	Management of patients with type 2 diabetes during cardiac prevention and rehabilitation. An expert opinion from the Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P).
Abstract	Patients with diabetes, regardless of their cardiovascular disease and their index event, are more and more often referred to Cardiac Rehabilitation Units. These patients usually show high or very high cardiovascular risk, marked disability and poor quality of life. Furthermore, those with older age, frailty, and female sex have even more rehabilitative needs, thus requiring fine individualized approaches. Consequently, in order to identify their therapeutic goals, the glycemic target should be pursued together with the effective reduction of the global cardiovascular risk. Modern exercise protocols are based on the synergic effect of both aerobic and strength training of moderate and high effort intensities, in order to achieve improvements of cardiorespiratory fitness and glycemic values as well. Exercise training and nutritional intervention are strictly related during the rehabilitation program, thus promoting better lifestyle in the long term too. New antidiabetic drugs (such as sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonists) should be included into a specific "patient journey" along with other core components of the rehabilitation program. Therefore, the active role of all allied professionals (namely nurses, physiotherapists, dietitians and psychologists) is essential to the success of the cardiometabolic team. Diabetes should be routinely included in the outcome evaluation of cardiac rehabilitation programs and in every follow-up plan through a successful crosstalk among cardiologists, diabetologists and patients.
Language	Italian
Publishing date	2023-09-28
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/4100.40985
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Article: Case Series: Recovery of Chemotherapy-Related Acute Heart Failure by the Combined Use of Sacubitril Valsartan and Wearable Cardioverter Defibrillator: A Novel Winning Combination in Cardio-Oncology.

Canale, Maria Laura / Coviello, Katia / Solarino, Gianluca / Del Meglio, Jacopo / Simonetti, Federico / Venturini, Elio / Camerini, Andrea / Maurea, Nicola / Bisceglia, Irma / Tessa, Carlo / Casolo, Giancarlo

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 801143

Abstract: Effective anticancer treatments have dramatically improved the outcome of patients with cancer, but cardiac toxicity reduces their clinical efficacy in a non-negligible percentage of patients. Sacubitril/valsartan is a new paradigm in the treatment of ... ...

Abstract	Effective anticancer treatments have dramatically improved the outcome of patients with cancer, but cardiac toxicity reduces their clinical efficacy in a non-negligible percentage of patients. Sacubitril/valsartan is a new paradigm in the treatment of chronic heart failure, with a reduced ejection fraction due to the enhancement of natriuretic peptides' properties when coupled with a blocking effect on the angiotensin II type 1 (AT1) receptors. As with other clinical conditions of heart failure with potentially reversible declines in cardiac function, a wearable cardioverter defibrillator (WCD) is a valid tool for protection against sudden death until recovery occurs. We report a case series of four patients with chemotherapy-related acute cardiac failure with severely reduced cardiac function. They were successfully treated with sacubitril/valsartan while being protected from malignant arrhythmias using a wearable cardioverter defibrillator until the recovery of cardiac function. Sacubitril/valsartan was confirmed to be effective in anthracycline-related cardiac toxicity and the wearable cardioverter defibrillator should be considered as a support tool even in the oncology patient.
Language	English
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.801143
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Article: Short-term treatment of iron deficiency anemia after cardiac surgery.

Venturini, Elio / Iannuzzo, Gabriella / DI Lorenzo, Anna / Cuomo, Gianluigi / D'Angelo, Andrea / Merone, Pasquale / Cudemo, Giuseppe / Pacileo, Mario / D'Andrea, Antonello / Vigorito, Carlo / Giallauria, Francesco

International journal of cardiology. Heart & vasculature

2022 Volume 40, Page(s) 101038

Abstract: Iron deficiency anemia (IDA) is frequent after cardiac surgery and is associated with increased morbidity and mortality. In a retrospective study, we analyzed 106 patients with IDA (hemoglobin [Hb] ≤ 12 g/dl in women and ≤ 13 g/dl in men, transferrin ... ...

Abstract	Iron deficiency anemia (IDA) is frequent after cardiac surgery and is associated with increased morbidity and mortality. In a retrospective study, we analyzed 106 patients with IDA (hemoglobin [Hb] ≤ 12 g/dl in women and ≤ 13 g/dl in men, transferrin saturation [TSAT] ≤ 20%) on admission to a Cardiac Rehabilitation Unit after cardiac surgery. The patients were divided into two groups, one was treated with oral sucrosomial iron (SI) and the other with intravenous ferric carboxymaltose (FCM). Patients received a single 1000 mg dose of FCM from the day after admission to rehabilitation (T1), or a 120 mg/day dose of SI from T1 until discharge (T2); after discharge, SI was reduced to 30 mg/day until the end of follow-up (T3). Hb was evaluated at T1, T2 and T3; the other hematological parameters at T1 and T3; natriuretic peptides at T1, T2 and T3; 6-minute walk test (6MWT) at T1 and T2. Folate, vitamin B12 and reticulocytes were sampled on admission. Folate deficiency was documented in 60.4% of patients. Hb increased in both groups with no significant differences between the two treatments (p = 0.397). The other iron metabolism parameters (sideremia, transferrin, TSAT) displayed similar behavior, showing a significant increase at T3 (p < 0.001) with both therapies, although the increase was faster with FCM. Ferritin - high on admission - decreased at T3 in the SI group and rose significantly in the FCM group (SI 219.5 vs. FCM 689 ng/ml p < 0.0001). The 6MWT increased significantly at T2, with an overlap between SI and FCM. In conclusion, the results of this study show that SI and FCM exhibit the same effectiveness on IDA; the response time to therapy of both treatments is also equally fast. SI and FCM induce a similar increase in functional capacity. The study shows that SI can be a viable alternative to FCM after cardiac surgery in terms of effectiveness and tolerability.
Language	English
Publishing date	2022-05-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2022.101038
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