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  1. Article: Upper Airway Characteristics and Morphological Changes by Different MADs in OSA Adult Subjects Assessed by CBCT 3D Imaging.

    Venza, Nicolò / Malara, Arianna / Liguori, Claudio / Cozza, Paola / Laganà, Giuseppina

    Journal of clinical medicine

    2023  Volume 12, Issue 16

    Abstract: This study aimed to analyse the effectiveness of four different designs of the Mandibular Advancement Device (MAD) and the morphological changes on upper airway characteristics of Obstructive Sleep Apnea (OSA) patients inducted by each of them, detected ... ...

    Abstract This study aimed to analyse the effectiveness of four different designs of the Mandibular Advancement Device (MAD) and the morphological changes on upper airway characteristics of Obstructive Sleep Apnea (OSA) patients inducted by each of them, detected by Cone Beam Computer Tomography (CBCT) 3D imaging. Twenty-two patients were recruited after an OSA diagnosis with PSG. Four different customised and titratable MADs were used and an initial CBCT scan was obtained for each patient. Six months after the end of the MAD titration phase, all the subjects performed a second PSG with the MAD in situ; the second PSG showed an Apnoea-Hypopnoea Index (AHI) of <5 or a decrease of 50% in AHI when compared with the initial AHI. Moreover, a second CBCT scan with the MAD in situ was performed. DICOM files were imported into the airway analysis software programme and the pharyngeal area around the oropharynx was highlighted. The area and volume of the oropharynx with and without the device was evaluated. A considerable improvement of the airway was observed (+33.76%), and a significant difference in the enlargement ratio between the posterior soft palate (+32.41%) and the posterior tongue (+36.96%) region was also found. The greatest increase in airway volume was achieved in patients treated with the MAD Forward and TAP (+42.77% and +41.63%, respectively). MAD therapy is effective to treat moderate to severe OSA with an increased upper airway volume. The design of the MAD can influence the effectiveness of the treatment.
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12165315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sleep Bruxism and SDB in Albanian Growing Subjects: A Cross-Sectional Study.

    Laganà, Giuseppina / Osmanagiq, Vesna / Malara, Arianna / Venza, Nicolò / Cozza, Paola

    Dentistry journal

    2021  Volume 9, Issue 3

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj9030025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients.

    Venza, Nicolò / Alloisio, Giulia / Gioia, Magda / Liguori, Claudio / Nappi, Annarita / Danesi, Carlotta / Laganà, Giuseppina

    International journal of environmental research and public health

    2022  Volume 19, Issue 20

    Abstract: Background: Obstructive sleep apnea syndrome (OSAS) may be associated with and activates the stress response system, and variation in the physiological antioxidant capacity of body fluids. Our aim was to evaluate the variation of pH and antioxidant ... ...

    Abstract Background: Obstructive sleep apnea syndrome (OSAS) may be associated with and activates the stress response system, and variation in the physiological antioxidant capacity of body fluids. Our aim was to evaluate the variation of pH and antioxidant capacity on the saliva of obstructive sleep apnea subjects (OG) compared to a control group (CG).
    Method: Fifty subjects with moderate/severe OSAS were recruited in Tor Vergata Hospital and compared with 20 healthy subjects CG. The buffer and the antioxidant capacity of the samples were quantified measuring the pH and the percentage of total salivary antioxidant capacity (%TAC), which refers to the reduced glutathione salivary concentration (GSH). Moreover, the protein concentration and the gelatinolytic activity of metalloproteinases were quantified.
    Results: The data showed that the pH value is slightly more alkaline in OSAS subjects; however, it is not directly related to the severity of OSAS. The %TAC was found to be significantly reduced by 86.2% in the OG. Proteins of saliva from the OG were found 1.5 times more concentrated than in the healthy sample. The gelatinolytic activity of metalloproteinases of healthy and OSA did not show statistically significant changes.
    Conclusions: The salivary samples from OSAS compared to CG show an alteration of the oxidative state, the pH buffering power, and protein concentrations, inducing conditions that can easily evolve chronic gingivitis. Further investigations are necessary to evaluate the feasibility of using salivary fluid for the early diagnosis of oral or systemic problems in OSAS subjects.
    MeSH term(s) Adult ; Humans ; Antioxidants ; Saliva ; Sleep Apnea, Obstructive/diagnosis ; Glutathione ; Hydrogen-Ion Concentration
    Chemical Substances Antioxidants ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192013219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obstructive Sleep Apnea, Palatal Morphology, and Aortic Dilatation in Marfan Syndrome Growing Subjects: A Retrospective Study.

    Laganà, Giuseppina / Venza, Nicolò / Malara, Arianna / Liguori, Claudio / Cozza, Paola / Pisano, Calogera

    International journal of environmental research and public health

    2021  Volume 18, Issue 6

    Abstract: The main cause of mortality in Marfan syndrome (MS) is aortic disease. Obstructive sleep apnea (OSA) is highly prevalent in MS, and it is also associated with cardiovascular risk and maxillary deformities. The aim of this research was to analyze the ... ...

    Abstract The main cause of mortality in Marfan syndrome (MS) is aortic disease. Obstructive sleep apnea (OSA) is highly prevalent in MS, and it is also associated with cardiovascular risk and maxillary deformities. The aim of this research was to analyze the possible relations between OSA, palatal morphology, and aortic root diameters in growing subjects. A group of 15 growing subjects with MS and a control group of healthy peers was selected. All of them underwent nocturnal polygraphic monitoring, digital dental casts, and transthoracic echocardiography. The results showed that OSA indexes and aortic diameters were significantly higher in the study group. Transversal palatal dimension was smaller in MS patients. Moreover, OSA severity was not related with maxillary contraction severity in MS. No correlation between OSA severity and increased aortic diameters occurred. A high prevalence of OSA, increased aortic dimensions, and significant contraction of palatal dimensions were observed in MS compared with the control group. None of these single factors may directly be associated with aortic dilation, but together, they might contribute to the development and progression of aortic aneurysm from a young age.
    MeSH term(s) Aortic Diseases ; Dilatation ; Humans ; Marfan Syndrome ; Retrospective Studies ; Sleep Apnea, Obstructive/epidemiology
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph18063045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Periodontal condition in growing subjects with Marfan Syndrome: a case-control study.

    Venza, Nicolò / Danesi, Carlotta / Contò, Diego / Fabi, Francesco / Mampieri, Gianluca / Sangiuolo, Federica / Laganà, Giuseppina

    PeerJ

    2019  Volume 7, Page(s) e6606

    Abstract: Background: Marfan's syndrome (MFS) is a systemic disorder of connective tissue caused by mutations in the extracellular matrix protein fibrillin-1. Orofacial characteristics may be useful in identification of the syndrome. Severe periodontitis is ... ...

    Abstract Background: Marfan's syndrome (MFS) is a systemic disorder of connective tissue caused by mutations in the extracellular matrix protein fibrillin-1. Orofacial characteristics may be useful in identification of the syndrome. Severe periodontitis is sometimes observed in MFS patients, but no in-depth information has been reported in Italian groups of growing subjects with MFS. The aim of this study was to analyze the periodontal condition on a group of growing subjects affected by MFS, in comparison with a typically developed control group.
    Methods: A group of 16 subjects with diagnosed MFS were recruited from the Centre for Rare Diseases for Marfan Syndrome and Related Disorders of Tor Vergata University Hospital. The Marfan Group (MG) was compared with a Control Group (CG) composed by 20 nonsyndromic subjects. The periodontal clinical parameters like Marginal Gingival Thickness (GT), Plaque Index (PI), Bleeding On Probing (BOP) and Modified Periodontal Screening and Recording (PSR) were assessed.
    Results: The mean value of PI in MG was 59%, instead in CG it reached 21%. Analysis showed a significant difference between MG and CG also for the BOP. In MG the mean value of BOP attained 36% and in CG it reached 16%. A statistical significant difference of distribution of PSR index between the two groups was found for all sextant examined.
    Discussion: Patients with Marfan syndrome reveal a higher presence of plaque and consequently a generalized inflammation in the oral cavity when compared with a control group.
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.6606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Associations between tooth agenesis and displaced maxillary canines: a cross-sectional radiographic study.

    Laganà, Giuseppina / Venza, Nicolò / Lione, Roberta / Chiaramonte, Carlo / Danesi, Carlotta / Cozza, Paola

    Progress in orthodontics

    2018  Volume 19, Issue 1, Page(s) 23

    Abstract: Background: The aim of present study was to test the association between hypodontia and displaced maxillary canine when compared with a control group.: Methods: The study group was composed of 336 subjects with a mean age of 10.7 ± 1.2 years, ... ...

    Abstract Background: The aim of present study was to test the association between hypodontia and displaced maxillary canine when compared with a control group.
    Methods: The study group was composed of 336 subjects with a mean age of 10.7 ± 1.2 years, presenting with at least one missing tooth. Exclusion criteria included syndromes, craniofacial malformations, extractions and trauma history and previous orthodontic treatment. The control group consisted of 336 subjects with a mean age of 10.7 ± 1.2 years, without agenesis. Stepwise multiple logistic regression using the backwards elimination and the Wald test method was performed to identify the best combination of hypodontia and displaced maxillary canine (P < 0.05).
    Results: The most represented category in study group consisted in mild agenesis (86.9%); moderate and severe agenesis groups respectively represented the 11.7 and 1.4% of study group. Agenesis was diagnosed in both arches in 46 subjects. Maxillary hypodontia and mandibular hypodontia was respectively detected in 156 and 134 subjects. The most frequent missing teeth were mandibular second premolars (45.8%), lateral incisors (41.7%) and maxillary second premolars (17.8%). A significant correlation between agenesis and displaced maxillary canine was observed in the study group (P < 0.05). Only the agenesis of maxillary lateral incisors remained in the final model during backward stepwise deletion. Significant association between the severity of dental agenesis and prevalence of displaced maxillary canine was not assessed.
    Conclusions: The outcomes revealed no difference related to the severity of dental agenesis and prevalence of displaced maxillary canine. Only the agenesis of maxillary lateral incisors should be considered directly connected with displaced maxillary canine.
    MeSH term(s) Anodontia/complications ; Anodontia/diagnostic imaging ; Anodontia/pathology ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Maxilla/diagnostic imaging ; Maxilla/pathology ; Radiography, Panoramic ; Tooth Eruption, Ectopic/diagnostic imaging ; Tooth Eruption, Ectopic/etiology ; Tooth Eruption, Ectopic/pathology
    Language English
    Publishing date 2018-07-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2040711-7
    ISSN 2196-1042 ; 1600-9975 ; 1723-7785 ; 1399-7513
    ISSN (online) 2196-1042 ; 1600-9975
    ISSN 1723-7785 ; 1399-7513
    DOI 10.1186/s40510-018-0226-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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