Article: Presence of Small-Conductance Calcium-Activated Potassium (SK) Channels in the Central and Peripheral Nervous Systems and Their Role in Health and Disease.
Journal of integrative neuroscience
2023 Volume 22, Issue 3, Page(s) 69
Abstract: Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance ... ...
Abstract | Potassium (K+) channels establish and maintain the resting potential of most living cells. Their activity is predominantly regulated by the membrane voltage or the K+ gradient across the cell membrane. However, many cells also express small-conductance calcium-activated potassium (SK) channels, which have the unique ability to translate changes in the level of the intracellular second messenger, Ca2+ to changes in the membrane K+ conductance and, therefore, the resting membrane potential. This article reviews the structure, presence, distribution, and function of SK channels, their pharmacological modulation, and their role in health and disease, emphasizing nociception and pain. |
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MeSH term(s) | Calcium/metabolism ; Small-Conductance Calcium-Activated Potassium Channels/metabolism ; Potassium/metabolism ; Membrane Potentials/physiology ; Peripheral Nervous System/metabolism |
Chemical Substances | Calcium (SY7Q814VUP) ; Small-Conductance Calcium-Activated Potassium Channels ; Potassium (RWP5GA015D) |
Language | English |
Publishing date | 2023-06-01 |
Publishing country | Singapore |
Document type | Journal Article ; Review |
ZDB-ID | 2136427-8 |
ISSN | 0219-6352 |
ISSN | 0219-6352 |
DOI | 10.31083/j.jin2203069 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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