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Article ; Online: Single metachronous bone metastasis following rectal adenocarcinoma: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2024 Volume 4, Issue 1, Page(s) 6

Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of ... ...

Abstract	Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality in developed countries. While its incidence in early stages has increased due to screening programs, a significant number of patients experience the development of metastases either at the time of diagnosis or during follow-ups. Unlike certain other types of cancer, such as breast, prostate, or lung cancer, where bone tissue is a common site for secondary dissemination, CRC primarily spreads to the lymph nodes, liver and lungs. The occurrence of bone metastases from CRC is rare and usually coincides with tumor involvement in other locations. Risk factors for bone metastases include the location of the primary tumor, the age of the patients, KRAS mutations and the degree of tumor differentiation. Unlike metastases to the liver and lungs, bone metastases tend to be symptomatic, affecting the patient's quality of life and resulting in a poorer prognosis with shorter survival rates. The approach to patient management needs to be personalized. The present study describes the of a patient who underwent surgery for stage IV rectal adenocarcinoma and later developed a metastasis in the costal wall 79 months post-intervention, with no evidence of recurrence at other sites.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2024.130
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Presentation of a large jejunal artery aneurysm: Management and review of the literature.

Minaya-Bravo, Ana María / Vera-Mansilla, Cristina / Ruiz-Grande, Fernando

International journal of surgery case reports

2018 Volume 48, Page(s) 50–53

Abstract: Introduction: Jejunal artery aneurysms (JAAs) constitute less than 1% of all visceral artery aneurysms. They affect mostly men in their fifth decade. In the last years, the widespread of fine cut fine image techniques has increased the number of JAAs ... ...

Abstract	Introduction: Jejunal artery aneurysms (JAAs) constitute less than 1% of all visceral artery aneurysms. They affect mostly men in their fifth decade. In the last years, the widespread of fine cut fine image techniques has increased the number of JAAs diagnosed incidentally. The first case was reported by Levine in 1944. Since then, only a half of hundred cases have been reported. There is a lack of consensus of management of intact JAAs because of the low number of cases published. We present the largest JAA reported in the English literature up to our knowledge. Presentation: We report a 49 year-old woman with a 4 × 5 cm. intact jejunal artery aneurysm found incidentally in a CT. It rose from the first jejunal branch of superior mesenteric artery without signs of rupture. She underwent elective surgery and the aneurysm was completely excised. Discussion: Causes of JAAs include congenital, atherosclerosis or degenerative process. Their rate of rupture depends on location, size and underlying disease and it reaches 10-20% for all visceral artery aneurysms. Risk factors of rupture include pregnancy, hyper-flow situations and connective diseases. Most of cases in the literature presented rupture at the time of diagnosis. JAAs are usually treated following the recommendations for visceral artery aneurysms, so intact JAAs greater than 2 cm. and those causing symptoms should be treated. Treatment includes surgery, embolisation or stent. Surgery is the preferred management for emergency settings. Conclusion: JAAs are extremely rare and constitute only 1% of all visceral aneurysms. They are a life-threatening condition.
Language	English
Publishing date	2018-05-12
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2018.04.042
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Article ; Online: Clostridium perfringens

Sánchez-Gollarte, Ana / Jiménez-Álvarez, Laura / Pérez-González, Marina / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Díez-Alonso, Manuel

Access microbiology

2021 Volume 3, Issue 9, Page(s) 261

Abstract: Pancreatic necrosis infection (PNI) accounts for about 20-40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present, ...

Abstract	Pancreatic necrosis infection (PNI) accounts for about 20-40 % of severe acute pancreatitis. PNI caused by anaerobic bacteria is unusual but when they present,
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Case Reports
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000261
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Article: Surgical Treatment of Gallstone Ileus: Less Is More.

Vera-Mansilla, Cristina / Sanchez-Gollarte, Ana / Matias, Belen / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Garcia-Moreno Nisa, Francisca

Visceral medicine

2021 Volume 38, Issue 1, Page(s) 72–77

Abstract: Introduction: The objective of this study was to evaluate the need for cholecystectomy in patients who underwent surgery for gallstone ileus.: Methods: This was a retrospective review of the clinical history of patients who underwent surgery for ... ...

Abstract	Introduction: The objective of this study was to evaluate the need for cholecystectomy in patients who underwent surgery for gallstone ileus. Methods: This was a retrospective review of the clinical history of patients who underwent surgery for gallstone ileus between December 1992 and December 2018 and follow-up until October 2020. Data regarding the surgical intervention, location of the obstruction, and surgical procedure performed were collected, as well as complications in relation to biliary pathology in the postoperative period. Results: Twenty-five patients underwent surgery for gallstone ileus. In all patients, except one, the site of the obstruction was identified. The mean age of the patients was 72 (standard deviation [SD] 13.3) years, with a female predominance (18: 7). The patients presented symptoms, on average, 2.9 (1-7) days before going to the emergency room; the primary symptoms were vomiting associated with abdominal pain and constipation (56%). Fifty-six percent of patients were diagnosed preoperatively by imaging tests. In 72% of patients, an enterolithotomy was performed alone without any other intervention on the gallbladder or bile duct. Eighty-three percent of the patients did not present any cholecystobiliary complications during the entire follow-up period, and urgent or delayed cholecystectomy was not performed after the acute episode. Conclusions: Gallstone ileus is a rare entity, and there are no randomized studies that support a preferred treatment. If surgical intervention is required, enterotomy for stone extraction is a safe and effective technique, and in our experience, urgent or delayed cholecystectomy is not necessary.
Language	English
Publishing date	2021-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2850733-2
ISSN	2297-475X ; 2297-4725
ISSN (online)	2297-475X
ISSN	2297-4725
DOI	10.1159/000518451
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Article ; Online: Spontaneous cervical hematoma caused by giant parathyroid adenoma in an elderly patient: A case report.

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Ovejero-Merino, Enrique / Vera-Mansilla, Cristina / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Jiménez-Martín, Rubén / D'Amico, Rebeca / Lasa-Unzúe, Inmaculada / Gutiérrez-Calvo, Alberto

Medicine international

2023 Volume 4, Issue 1, Page(s) 1

Abstract: Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the ... ...

Abstract	Spontaneous cervical hematoma usually occurs as a consequence of extracapsular bleeding from a parathyroid gland, generally due to the presence of an adenoma (giant adenoma), glandular hyperplasia, cystic component, or, less frequently, due to the existence of a carcinoma. The hematoma can be confined to the cervical compartment or extend to the mediastinum, potentially causing airway compression. Despite this, the recommended management in hemodynamically stable patients consists of surveillance and hospital monitoring with delayed surgery after a few weeks. On the other hand, in those patients with airway compromise and instability, emergency surgery, consisting of cervicotomy and drainage, is mandatory. The present study describes the case of a 78-year-old patient with a medical history of high blood pressure, non-insulin-dependent diabetes mellitus, dyslipidemia, moderate aortic stenosis, chronic kidney disease and sarcoidosis under pharmacological treatment who attended the emergency department due to symptoms of neck pain, an increase in soft tissue, and dyspnea on moderate exertion with an evolution leading to respiratory failure. This was secondary to a diagnosis of spontaneous cervical hematoma that required urgent surgical intervention. The results of histopathological analysis revealed that a giant parathyroid adenoma was responsible for the bleeding. The patient had a complicated post-operative period with a prolonged admission to the intensive care unit.
Language	English
Publishing date	2023-11-30
Publishing country	England
Document type	Case Reports
ISSN	2754-1304
ISSN (online)	2754-1304
DOI	10.3892/mi.2023.125
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Article ; Online: Malignant adipocytic tumours: A 20‑year single‑centre retrospective study.

Mendoza-Moreno, Fernando / Matías-García, Belén / Quiroga-Valcárcel, Ana / García-Moreno Nisa, Francisca / Díez-Corral, Cristina / Blázquez-Martín, Alma / Vera-Mansilla, Cristina / Ovejero-Merino, Enrique / Díez-Alonso, Manuel / Diego-García, Lucía / Alvarez-Mon, Melchor / Ortega, Miguel A / Gutiérrez-Calvo, Alberto

Oncology letters

2023 Volume 25, Issue 6, Page(s) 247

Abstract: Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of ... ...

Abstract	Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non-retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000-2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location.
Language	English
Publishing date	2023-04-21
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2023.13833
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Article: Prognostic Factors of Survival in Patients with Peritoneal Metastasis from Colorectal Cancer.

Mendoza-Moreno, Fernando / Diez-Alonso, Manuel / Matías-García, Belén / Ovejero-Merino, Enrique / Gómez-Sanz, Remedios / Blázquez-Martín, Alma / Quiroga-Valcárcel, Ana / Vera-Mansilla, Cristina / Molina, Raquel / San-Juan, Alberto / Barrena-Blázquez, Silvestra / Ortega, Miguel A / Alvarez-Mon, Melchor / Gutiérrez-Calvo, Alberto

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine ... ...

Abstract	Objectives: The aim of this study was to analyze the prognostic factors of survival in patients with peritoneal metastasis (PM) from colorectal cancer (CRC). The type of relationship between survival and the PM time of detection was used to determine whether it was synchronous with the primary tumor or metachronous. Patients and Methods: Retrospective observational study. It included patients treated for colorectal adenocarcinoma diagnosed between January 2005 and December 2019 who presented PM at the time of diagnosis or during follow-up. Variables, such as sex, age, differentiation grade, positive adenopathy (pN+), tumor size (pT), tumor location, mucinous component, peritoneal carcinomatosis index (PCI), and KRAS mutational status, were analyzed. Results: During the study period, 1882 patients were surgically treated for CRC in our hospital. Of these, 240 patients (12.8%) were included in the study after evidence of PM. The mean age was 67 ± 12 years (range: 32−92 years), and 114 patients were female (47.5%). The mean follow-up was 20 ± 13 months (median 12 months). The Kaplan−Meier survival at 36 months was higher in patients with metachronous PM (24% vs. 8%; p = 0.002), WT-KRAS tumors (31% vs. 15%; p < 0.001), N0 stage (30% vs. 19%; p < 0.001), T3 stage tumors (18% vs. 19% in T4A and 3% in T4B; p > 0.001), and tumors with classic adenocarcinoma histology (18% vs. 8%; p = 0.011). Patients with a PCI of 1−10 showed a likelihood of survival at 36 months of 56%, which was longer than that found in patients with a PCI of 11−20 (8%) or a PCI of >20 (0%) (p < 0.001). In the multiple regression analysis, the factors with an independent prognostic value were: poor grade of differentiation (HR 1.995; 95% CI: 1.294−3.077), KRAS mutation (HR 1.751; 95% CI: 1.188−2.581), PCI 11−20 (HR: 9.935; 95% CI: 5.204−18.966) and PCI > 20 (HR: 4.011; 95% CI: 2.291−7.023). Conclusions: PCI should continue as the as the most useful prognostic indicator in order to assess prognostic estimations as well as therapeutic and surgical decisions, but tumor grade and KRAS mutational status may help in the treatment decision process by providing complementary information. The time of PM detection did not achieve statistical significance in the multiple regression analysis.
Language	English
Publishing date	2022-08-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164922
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Article: Unusual Case of Gallbladder Adenocarcinoma Metastasis to the Abdominal Wall 11 Years Later: Synchronous Presentation with Two Malignant Colon Tumors, Coincidence or Not?

Matías-García, Belén / Mendoza-Moreno, Fernando / Díez-Alonso, Manuel / Quiroga-Valcárcel, Ana / Aguirregoicoa-García, Elena / Vera-Mansilla, Cristina / Ovejero-Merino, Enrique / Mínguez-García, Javier / Córdova-García, Diego / Gutiérrez-Calvo, Alberto

Case reports in surgery

2021 Volume 2021, Page(s) 6662275

Abstract: Introduction: Abdominal wall masses are a common finding in clinical practice. A high percentage of these masses are malignant. We present the case of a patient operated for a gallbladder adenocarcinoma, who consulted eleven years later for a malignant ... ...

Abstract	Introduction: Abdominal wall masses are a common finding in clinical practice. A high percentage of these masses are malignant. We present the case of a patient operated for a gallbladder adenocarcinoma, who consulted eleven years later for a malignant mass of the abdominal wall in synchrony with two adenocarcinomas of the left colon and sigmoid. Conclusion: Abdominal wall metastasis from gallbladder carcinoma is rare, and its synchronous presentation with a malignant neoplasm of the colon is exceptional. This is the first report of a patient with abdominal wall metastasis from a gallbladder adenocarcinoma operated eleven years ago that debuted synchronously with two adenocarcinomas of the left colon and sigma.
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2021/6662275
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Article ; Online: Results of the Spanish National Polytrauma Registry. Where are we and where are we heading?

Campos-Serra, Andrea / Pérez-Díaz, Lola / Rey-Valcárcel, Cristina / Montmany-Vioque, Sandra / Artiles-Armas, Manuel / Aparicio-Sánchez, Daniel / Tallón-Aguilar, Luís / Gutiérrez-Andreu, Marta / Bernal-Tirapo, Julia / Garcia-Moreno Nisa, Francisca / Vera-Mansilla, Cristina / González-Conde, Ricardo / Gómez-Viana, Leticia / Titos-García, Alberto / Aranda-Narvaez, Jose

Cirugia espanola

2023 Volume 101, Issue 9, Page(s) 609–616

Abstract: Introduction: In 2017, the Spanish National Polytrauma Registry (SNPR) was initiated in Spain with the goal to improve the quality of severe trauma management and evaluate the use of resources and treatment strategies. The objective of this study is to ... ...

Abstract	Introduction: In 2017, the Spanish National Polytrauma Registry (SNPR) was initiated in Spain with the goal to improve the quality of severe trauma management and evaluate the use of resources and treatment strategies. The objective of this study is to present the data obtained with the SNPR since its inception. Methods: We conducted an observational study with prospective data collection from the SNPR. The trauma patients included were over 14 years of age, with ISS ≥ 15 or penetrating mechanism of injury, from a total of 17 tertiary hospitals in Spain. Results: From 1/1/17 to 1/1/22, 2069 trauma patients were registered. The majority were men (76.4%), with a mean age of 45 years, mean ISS 22.8, and mortality 10.2%. The most common mechanism of injury was blunt trauma (80%), the most frequent being motorcycle accident (23%). Penetrating trauma was presented in 12% of patients, stab wounds being the most common (84%). On hospital arrival, 16% of patients were hemodynamically unstable. The massive transfusion protocol was activated in 14% of patients, and 53% underwent surgery. Median hospital stay was 11 days, while 73.4% of patients required intensive care unit (ICU) admission, with a median ICU stay of 5 days. Conclusions: Trauma patients registered in the SNPR are predominantly middle-aged males who experience blunt trauma with a high incidence of thoracic injuries. Early addressed detection and treatment of these kind of injuries would probably improve the quality of trauma care in our environment.
MeSH term(s)	Middle Aged ; Male ; Humans ; Female ; Multiple Trauma/epidemiology ; Multiple Trauma/therapy ; Hospitalization ; Length of Stay ; Wounds, Nonpenetrating/epidemiology ; Wounds, Nonpenetrating/surgery ; Registries
Language	English
Publishing date	2023-03-20
Publishing country	Spain
Document type	Observational Study ; Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2023.03.007
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Article ; Online: Ileocolic intussusception due to giant ileal lipoma: Review of literature and report of a case.

Minaya Bravo, Ana María / Vera Mansilla, Cristina / Noguerales Fraguas, Fernando / Granell Vicent, Francisco Javier

International journal of surgery case reports

2012 Volume 3, Issue 8, Page(s) 382–384

Abstract: Introduction: Intussusception in adults accounts for less than 5% of all intussusceptions. It occurs when a segment of intestine invaginates into itself.: Presentation of a case: We report a case of ileocolic intussusception in an adult caused by a ... ...

Abstract	Introduction: Intussusception in adults accounts for less than 5% of all intussusceptions. It occurs when a segment of intestine invaginates into itself. Presentation of a case: We report a case of ileocolic intussusception in an adult caused by a giant ileal lipoma. Discussion: Intussusceptions can be classified as ileocolic, ileocecal, colo-colic and ileo-ileal. Most are due to neoplasms (60% malign and 24-40% benign). In the colon, the possibility of malignancy is higher than in small intestine. Lipomas are the most common benign mesenchymal intestinal tumors, accounting for less than 5% of all gastrointestinal tumors. They are more frequent in colon than small intestine. Small lipomas (less than 2cm) are usually asymptomatic. Larger lesions may produce symptoms such as abdominal pain, obstruction or intussusception. Lipomas can be diagnosed with endoscopy, capsule endoscopy, barium enemas, CT and US. Conclusion: Intussusceptions in adults is a rare condition, most of them are caused by a malign neoplasms followed by benign neoplasms. US and CT are useful for diagnosis. Surgery is mandatory.
Language	English
Publishing date	2012-04-17
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN (online)	2210-2612
DOI	10.1016/j.ijscr.2012.03.035
Database	MEDical Literature Analysis and Retrieval System OnLINE

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