Article ; Online: Periparturient blood T-lymphocyte PD-1 and CTLA-4 expression as potential predictors of new intramammary infections in dairy cows during early lactation (short communication).
2024 Volume 20, Issue 1, Page(s) 146
Abstract: Background: The periparturient period in dairy cows is marked by immunosuppression which increases the likelihood of infectious disorders, particularly also mastitis. An in-depth understanding of peripartum leukocyte biology is vital for the ... ...
| Abstract | Background: The periparturient period in dairy cows is marked by immunosuppression which increases the likelihood of infectious disorders, particularly also mastitis. An in-depth understanding of peripartum leukocyte biology is vital for the implementation of highly successful post-partum disease prevention measures. Immune checkpoint molecules, such as programmed death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4), are critical inhibitory receptors expressed on immune cells, particularly T cells, that drive immunosuppressive signaling pathways. However, the potential role of immune checkpoint molecules expression in T-cells on udder health has never been explored. Thus, the association between the occurrence of new postpartum intramammary infections (IMIs) and the expression of programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) on blood T-cells during the peripartum period was investigated. Results: In this study, the incidence of IMIs by any pathogen in early lactation was not associated with a higher expression of PD-1 and CTLA-4 in the periparturient period. However, the incidence of IMIs by major pathogens throughout the first month of lactation was significantly associated with higher expression of PD-1 at 14 days before calving (P = 0.03) and CTLA-4 at parturition (P = 0.03) by blood T-cells. Also, the expression of CTLA-4 at D0 (P = 0.012) by T-cells was associated with the occurrence of persistent IMIs during the first month of lactation. Conclusions: To our knowledge, this is the first report to investigate the expression of PD-1 and CTLA-4 by blood T-lymphocytes during the periparturient period in dairy cows and to explore their relationship with the incidence of new IMIs in the postpartum period. Thus, a comprehensive understanding of leukocyte biology during peripartum would appear to be a prerequisite for the identification of resilient dairy cows or targets innovative (immunological) non-antibiotic approaches in the transition period. |
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| MeSH term(s) | Female ; Cattle ; Animals ; CTLA-4 Antigen ; Immune Checkpoint Proteins ; Programmed Cell Death 1 Receptor ; Lactation/physiology ; T-Lymphocytes ; Milk |
| Chemical Substances | CTLA-4 Antigen ; Immune Checkpoint Proteins ; Programmed Cell Death 1 Receptor |
| Language | English |
| Publishing date | 2024-04-20 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2191675-5 |
| ISSN | 1746-6148 ; 1746-6148 |
| ISSN (online) | 1746-6148 |
| ISSN | 1746-6148 |
| DOI | 10.1186/s12917-024-03977-1 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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