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  1. AU="Verbić, Tatjana"
  2. AU="Abernethy, David"
  3. AU=Bianchi Claudio
  4. AU="Antonelli, Donna"
  5. AU="Patrick, Anna E"
  6. AU="Philippe J. Guerin"
  7. AU="Oygucu, I Hakan"
  8. AU="Salem, Mohammad"
  9. AU="Lotan, Dor"
  10. AU="Mattingly, M C K" AU="Mattingly, M C K"
  11. AU="Rastogi Ajay"
  12. AU="Deniz Kantar"
  13. AU="Stucky, Cheryl L"
  14. AU="Higashino, Kosaku"
  15. AU="Johnston, Sara C"
  16. AU=Fisayo Temitope
  17. AU="Buret, Laetitia"
  18. AU=Guirao Antonio
  19. AU="Tang, Anthony"
  20. AU="Garnelo, Luiza"
  21. AU=Sakanari J A AU=Sakanari J A
  22. AU="Ni, Fuchuan"
  23. AU="Anithachristy S Arumanayagam"
  24. AU="Melman, Dick"

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  1. Artikel ; Online: Applications of biophysical techniques in drug discovery and development.

    Verbić, Tatjana Ž

    ADMET & DMPK

    2019  Band 7, Heft 4, Seite(n) 220–221

    Sprache Englisch
    Erscheinungsdatum 2019-12-11
    Erscheinungsland Croatia
    Dokumenttyp Editorial
    ISSN 1848-7718
    ISSN (online) 1848-7718
    DOI 10.5599/admet.767
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  2. Artikel ; Online: Highly selective water-compatible molecularly imprinted polymers for benzophenone-4

    Pešić Miloš P. / Krstić Jugoslav B. / Verbić Tatjana Ž.

    Journal of the Serbian Chemical Society, Vol 88, Iss 1, Pp 55-

    2023  Band 68

    Abstract: Molecularly imprinting technology was applied for preparing selective sorbents for benzophenone-4 (BP4), an organic UV filter used in sunscreens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. ... ...

    Abstract Molecularly imprinting technology was applied for preparing selective sorbents for benzophenone-4 (BP4), an organic UV filter used in sunscreens and cosmetics. Several imprinted polymers were prepared by bulk polymerization, using BP4 as template. Combination of stability (mechanical and chemical), selectivity and robustness of the imprinted polymers with BP4 properties resulted in a successful imprinting process (imprinting factors in range 1.05–2.60). The prepared polymers were characterised by infrared spectroscopy, elemental analysis, conductometric titrations and nitrogen physisorption at 77 K. Adsorption capacities and selectivity towards 7 other organic UV filters (benzophenone-3, benzophenone-8, homosalate, butyl methoxydibenzoylmethane, ethyl hexyl salicylate, ethyl hexyl p-dimethylamino benzoate and ethyl hexyl p-methoxycinnamate) were determined, proving high adsorption capacity and high selectivity for BP4 binding. The highest adsorption capacity was observed for 4-vinylpyridine/ethylene glycol dimethacrylate co-polymer prepared in dimethyl sulfoxide (1.108 mmol g-1). The imprinted polymer with the highest binding capacity was applied to solid phase extraction of BP4 from aqueous solutions with 98.5 % efficiency.
    Schlagwörter uv filters ; imprinting factor ; binding selectivity ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Serbian Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Clofazimine p

    Verbić, Tatjana Ž / Tam, Kin Y / Veljković, Dušan Ž / Serajuddin, Abu T M / Avdeef, Alex

    Molecular pharmaceutics

    2023  Band 20, Heft 6, Seite(n) 3160–3169

    Abstract: The weakly basic antibiotic and anti-inflammatory drug, clofazimine (CFZ), was first described in 1957. It has been used therapeutically, most notably in the treatment of leprosy. However, the compound is extremely insoluble in aqueous media, and, indeed, ...

    Abstract The weakly basic antibiotic and anti-inflammatory drug, clofazimine (CFZ), was first described in 1957. It has been used therapeutically, most notably in the treatment of leprosy. However, the compound is extremely insoluble in aqueous media, and, indeed, there is poor consensus about what its intrinsic solubility is since the reported values range from 0.04 to 11 ng/mL. To understand the speciation and solubilization of CFZ as a function of pH, it is of paramount importance to know the true aqueous p
    Mesh-Begriff(e) Methanol ; Clofazimine ; Potentiometry/methods ; Hydrogen-Ion Concentration ; Water/chemistry ; Spectrophotometry/methods
    Chemische Substanzen Methanol (Y4S76JWI15) ; Clofazimine (D959AE5USF) ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.3c00172
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  4. Artikel ; Online: Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pH

    Marković, Olivera S / Patel, Nirali G / Serajuddin, Abu T M / Avdeef, Alex / Verbić, Tatjana Ž

    Molecular pharmaceutics

    2022  Band 19, Heft 2, Seite(n) 710–719

    Abstract: The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in phosphate and/or a chloride-containing aqueous suspension using experimental practices recommended in the previously published "white paper" (Avdeef et al., ...

    Abstract The solubility of a model basic drug, nortriptyline (Nor), was investigated as a function of pH in phosphate and/or a chloride-containing aqueous suspension using experimental practices recommended in the previously published "white paper" (Avdeef et al., 2016). The pH-Ramp Shake-Flask (pH-RSF) method, introduced in our earlier work (Marković et al., 2019), was applied. An improved and more detailed experimental design of the Nor solubility measurement allowed us to exploit the full capacity of the pH-RSF method. Complex equilibria in the aqueous phase (cationic and anionic complex formation between Nor and the phosphate) and solid-phase transformations (Nor free base, 1:1 Nor hydrochloride salt, 1:1 and 1:2 Nor phosphate salts) were characterized by a detailed analysis of the solubility measurements using the computer program
    Mesh-Begriff(e) Calorimetry, Differential Scanning ; Hydrogen-Ion Concentration ; Nortriptyline ; Phosphates ; Sodium Chloride/chemistry ; Solubility
    Chemische Substanzen Phosphates ; Sodium Chloride (451W47IQ8X) ; Nortriptyline (BL03SY4LXB)
    Sprache Englisch
    Erscheinungsdatum 2022-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.1c00919
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  5. Artikel ; Online: Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects.

    Milenković, Mila / Ciasca, Gabriele / Bonasera, Aurelio / Scopelliti, Michelangelo / Marković, Olivera / Verbić, Tatjana / Marković, Biljana Todorović / Jovanović, Svetlana

    Journal of photochemistry and photobiology. B, Biology

    2023  Band 250, Seite(n) 112818

    Abstract: The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents ...

    Abstract The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L-cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp
    Mesh-Begriff(e) Humans ; Quantum Dots/chemistry ; Graphite/pharmacology ; Graphite/chemistry ; Cysteine ; Escherichia coli ; Staphylococcus aureus ; Anti-Bacterial Agents/pharmacology
    Chemische Substanzen Graphite (7782-42-5) ; Cysteine (K848JZ4886) ; Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2023-11-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 623022-2
    ISSN 1873-2682 ; 1011-1344
    ISSN (online) 1873-2682
    ISSN 1011-1344
    DOI 10.1016/j.jphotobiol.2023.112818
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    Zs.A 2347: Hefte anzeigen Standort:
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  6. Artikel ; Online: New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria

    Opsenica Igor / Selaković Milica / Tot Mikloš / Verbić Tatjana / Srbljanović Jelena / Štajner Tijana / Đurković-Đaković Olgica / Šolaja Bogdan

    Journal of the Serbian Chemical Society, Vol 86, Iss 2, Pp 115-

    2021  Band 123

    Abstract: Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) ... ...

    Abstract Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Antimalarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured.
    Schlagwörter quinoline ; bromobenzyl derivatives ; antimalarials ; β-hematin inhibitory activity ; Chemistry ; QD1-999
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Serbian Chemical Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: A novel method of molecular imprinting applied to the template cholesterol.

    Pešić, Miloš P / Todorov, Miljana D / Becskereki, Gergely / Horvai, George / Verbić, Tatjana Ž / Tóth, Blanka

    Talanta

    2020  Band 217, Seite(n) 121075

    Abstract: A novel method is successfully tested for non-covalent imprinting. Conditions are used which practically exclude the formation of prepolymerization complexes. The template is cholesterol, and no so-called functional monomer is used. The polymers contain ... ...

    Abstract A novel method is successfully tested for non-covalent imprinting. Conditions are used which practically exclude the formation of prepolymerization complexes. The template is cholesterol, and no so-called functional monomer is used. The polymers contain only an acrylic diester crosslinker. The porogen isopropanol prevents even hydrogen bonding between the template and the monomer in the prepolymerization solution. Despite of these apparently very disadvantageous conditions, appreciable imprinting factors for cholesterol and imprinted selectivity against some other steroids are observed, similar to other cholesterol MIPs with proven analytical usefulness.
    Mesh-Begriff(e) Cholesterol/analysis ; Molecular Conformation ; Molecular Imprinting/methods ; Polymers/chemical synthesis ; Polymers/chemistry
    Chemische Substanzen Polymers ; Cholesterol (97C5T2UQ7J)
    Sprache Englisch
    Erscheinungsdatum 2020-04-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2020.121075
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  8. Artikel ; Online: Comparison of the single channel and multichannel (multivariate) concepts of selectivity in analytical chemistry.

    Dorkó, Zsanett / Verbić, Tatjana / Horvai, George

    Talanta

    2015  Band 139, Seite(n) 40–49

    Abstract: Different measures of selectivity are in use for single channel and multichannel linear analytical measurements, respectively. It is important to understand that these two measures express related but still distinctly different features of the respective ...

    Abstract Different measures of selectivity are in use for single channel and multichannel linear analytical measurements, respectively. It is important to understand that these two measures express related but still distinctly different features of the respective measurements. These relationships are clarified by introducing new arguments. The most widely used selectivity measure of multichannel linear methods (which is based on the net analyte signal, NAS, concept) expresses the sensitivity to random errors of a determination where all bias from interferents is computationally eliminated using pure component spectra. The conventional selectivity measure of single channel linear measurements, on the other hand, helps to estimate the bias caused by an interferent in a biased measurement. In single channel methods expert knowledge about the samples is used to limit the possible range of interferent concentrations. The same kind of expert knowledge allows improved (lower mean squared error, MSE) analyte determinations also in "classical" multichannel measurements if those are intractable due to perfect collinearity or to high noise inflation. To achieve this goal bias variance tradeoff is employed, hence there remains some bias in the results and therefore the concept of single channel selectivity can be extended in a natural way to multichannel measurements. This extended definition and the resulting selectivity measure can also be applied to the so-called inverse multivariate methods like partial least squares regression (PLSR), principal component regression (PCR) and ridge regression (RR).
    Sprache Englisch
    Erscheinungsdatum 2015-07-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2015.02.030
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  9. Artikel ; Online: Selectivity in analytical chemistry: two interpretations for univariate methods.

    Dorkó, Zsanett / Verbić, Tatjana / Horvai, George

    Talanta

    2015  Band 132, Seite(n) 680–684

    Abstract: Selectivity is extremely important in analytical chemistry but its definition is elusive despite continued efforts by professional organizations and individual scientists. This paper shows that the existing selectivity concepts for univariate analytical ... ...

    Abstract Selectivity is extremely important in analytical chemistry but its definition is elusive despite continued efforts by professional organizations and individual scientists. This paper shows that the existing selectivity concepts for univariate analytical methods broadly fall in two classes: selectivity concepts based on measurement error and concepts based on response surfaces (the response surface being the 3D plot of the univariate signal as a function of analyte and interferent concentration, respectively). The strengths and weaknesses of the different definitions are analyzed and contradictions between them unveiled. The error based selectivity is very general and very safe but its application to a range of samples (as opposed to a single sample) requires the knowledge of some constraint about the possible sample compositions. The selectivity concepts based on the response surface are easily applied to linear response surfaces but may lead to difficulties and counterintuitive results when applied to nonlinear response surfaces. A particular advantage of this class of selectivity is that with linear response surfaces it can provide a concentration independent measure of selectivity. In contrast, the error based selectivity concept allows only yes/no type decision about selectivity.
    Sprache Englisch
    Erscheinungsdatum 2015-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2014.10.018
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  10. Artikel ; Online: Binding capacity of molecularly imprinted polymers and their nonimprinted analogs.

    Dorkó, Zsanett / Szakolczai, Anett / Verbić, Tatjana / Horvai, George

    Journal of separation science

    2015  Band 38, Heft 24, Seite(n) 4240–4247

    Abstract: Molecularly imprinted polymers bind their target compounds at binding sites. The binding sites are typically based on some type of functional group, such as carboxyl group. The total amount of such functional groups and their distribution into available ... ...

    Abstract Molecularly imprinted polymers bind their target compounds at binding sites. The binding sites are typically based on some type of functional group, such as carboxyl group. The total amount of such functional groups and their distribution into available and unavailable groups is not well known. The total binding capacity is usually indirectly determined from adsorption isotherms, which are measured much below the theoretical binding capacity. This work shows that in a variety of differently prepared, methacrylic acid based molecularly imprinted and nonimprinted polymers, all carboxylic groups used for the polymer synthesis are retained in the polymer, 80-90% of them can be accessed by strong bases and essentially the same amount can be used for adsorption of weak bases. This high level of adsorption can only be achieved, however, if the adsorbed weak base is strong enough, if the polymer is sufficiently elastic and if the solvent does not compete too strongly for the binding sites. These results may explain why the maximum binding capacities obtained from isotherm measurements are usually not equal to the total amount of available binding sites. This study confirms the usefulness of nonimprinted polymers at high loadings.
    Sprache Englisch
    Erscheinungsdatum 2015-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201500874
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