Article: Petites molécules dans la polyarthrite rhumatoïde.
2020 Volume 16, Issue 685, Page(s) 477–480
Abstract: If treatment target is not reached with a conventional disease-modifying antirheumatic drug (csDMARD) such as methotrexate in rheumatoid arthritis, it is recommended to use a biologic (bDMARD) or a Janus kinase (JAK) inhibitor, small synthetic molecules ... ...
| Title translation | Small molecules treatment in rheumatoid arthritis. |
|---|---|
| Abstract | If treatment target is not reached with a conventional disease-modifying antirheumatic drug (csDMARD) such as methotrexate in rheumatoid arthritis, it is recommended to use a biologic (bDMARD) or a Janus kinase (JAK) inhibitor, small synthetic molecules recently developed. Oral administration and short half-life can favour the choice of JAK inhibitors, as well as the opportunity to use it in monotherapy, even though co-treatment with csDMARD is recommended. As yet long-term studies are lacking, little is known about adverse effects although risk of herpes virus infections is clearly higher with JAK inhibitors than bDMARD treatments. |
| MeSH term(s) | Antirheumatic Agents/administration & dosage ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/chemistry ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Therapy, Combination ; Humans ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/adverse effects ; Janus Kinase Inhibitors/chemistry ; Janus Kinase Inhibitors/therapeutic use ; Methotrexate/therapeutic use ; Treatment Outcome |
| Chemical Substances | Antirheumatic Agents ; Janus Kinase Inhibitors ; Methotrexate (YL5FZ2Y5U1) |
| Language | French |
| Publishing date | 2020-03-17 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2177010-4 |
| ISSN | 1660-9379 |
| ISSN | 1660-9379 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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