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  1. Book ; Thesis: Bedeutung von Hiv-1 Gag Mutationen für die antiretrovirale Therapie mit Protease-Inhibitoren

    Verheyen, Jens

    = The role of HIV-1 Gag mutations in antiretroviral treatment with protease-inhibitor

    2011  

    Title variant The role of HIV-1 Gag mutations in antiretroviral treatment with protease-inhibitor
    Author's details vorgelegt von Jens Verheyen
    Language German ; English
    Size 79 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Habil.-Schr., 2011
    HBZ-ID HT017063471
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 E 3796 order for loan Magazin

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  2. Article: MALDI-TOF-Massenspektrometrie in der molekularbiologischen Diagnostik

    Alef, Thomas / Verheyen, Jens / Thiele, Bernhard

    Trillium-Diagnostik

    2023  Volume 21, Issue 3, Page(s) 205

    Language German
    Document type Article
    ZDB-ID 2741151-5
    ISSN 2198-1310
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7236: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Bamlanivimab Treatment Leads to Rapid Selection of Immune Escape Variant Carrying the E484K Mutation in a B.1.1.7-Infected and Immunosuppressed Patient.

    Lohr, Benedikt / Niemann, Dirk / Verheyen, Jens

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 11, Page(s) 2144–2145

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Neutralizing ; Humans ; Mutation ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; bamlanivimab (45I6OFJ8QH)
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1505: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  4. Article: Herausforderungen in der Diagnostik und Prävention von Viruserkrankungen. Challenges in diagnosis and prevention of virus infections

    Verheyen, Jens

    Laboratoriumsmedizin

    2014  Volume 38, Issue 2, Page(s) 87

    Language German ; English
    Document type Article
    ZDB-ID 543940-1
    ISSN 0342-3026
    Database Current Contents Medicine

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    Zs.A 1354: Show issues Location:
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  5. Book ; Online ; Thesis: Einfluss der flankierenden Sequenzen von Hepatitis-C-Virus-Epitopen auf die Antigenpräsentation

    Auth, Verna [Verfasser] / Verheyen, Jens [Akademischer Betreuer]

    2020  

    Author's details Verena Auth ; Betreuer: Jens Verheyen
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Liver Failure due to Acute Viral Hepatitis (A-E).

    Manka, Paul / Verheyen, Jens / Gerken, Guido / Canbay, Ali

    Visceral medicine

    2016  Volume 32, Issue 2, Page(s) 80–85

    Abstract: Background: Viral hepatitis is still one of the key causes of acute liver failure (ALF) in the world.: Methods: A selective literature search of the PubMed database was conducted, including current studies, reviews, meta-analyses, and guidelines. We ... ...

    Abstract Background: Viral hepatitis is still one of the key causes of acute liver failure (ALF) in the world.
    Methods: A selective literature search of the PubMed database was conducted, including current studies, reviews, meta-analyses, and guidelines. We obtained an overview of ALF due to viral hepatitis in terms of epidemiology, course, and treatment options.
    Results: Most fulminant viral courses are reported after infection with hepatitis A, B, and B/D, but not with hepatitis C. Hepatitis E is also known to cause ALF but has not gained much attention in recent years. However, more and more autochthonous hepatitis E virus infections have been recently observed in Europe. Reactivation of hepatitis B virus (HBV) under immunosuppressive conditions, such as after intensive chemotherapy, is also an increasing problem. For most viral-induced cases of ALF, liver transplantation represented the only therapeutic option in the past. Today, immediate treatment of HBV-induced ALF with nucleotide or nucleoside analogs is well tolerated and beneficially affects the course of the disease.
    Conclusion: Although numbers in Western European countries are decreasing rapidly, reliable diagnostic screening for hepatitis A-E is necessary to identify the etiology and to determine those most at risk of developing ALF.
    Language English
    Publishing date 2016-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2850733-2
    ISSN 2297-475X ; 2297-4725
    ISSN (online) 2297-475X
    ISSN 2297-4725
    DOI 10.1159/000444915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2103: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Book ; Online ; Thesis: Regulation der Interleukin 2 induzierten Interleukin 5 und Interleukin 13 Produktion durch mononukleäre Zellen gesunder Blutspender

    Verheyen, Jens

    2001  

    Author's details vorgelegt von Jens Verheyen
    Language German
    Size Online-Ressource
    Edition [Elektronische Ressource]
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Düsseldorf, 2001
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: Clinical and Virological Aspects of HBV Reactivation: A Focus on Acute Liver Failure

    Anastasiou, Olympia E / Theissen, Martin / Verheyen, Jens / Bleekmann, Barbara / Wedemeyer, Heiner / Widera, Marek / Ciesek, Sandra

    Viruses. 2019 Sept. 16, v. 11, no. 9

    2019  

    Abstract: Hepatitis B virus (HBV) reactivation in immunosuppressed patients can cause considerable morbidity and mortality. The aim of our study was to evaluate factors associated with acute liver failure (ALF) in HBV reactivation. Clinical, laboratory, and ... ...

    Abstract Hepatitis B virus (HBV) reactivation in immunosuppressed patients can cause considerable morbidity and mortality. The aim of our study was to evaluate factors associated with acute liver failure (ALF) in HBV reactivation. Clinical, laboratory, and virological data of 87 patients with HBV reactivation were analyzed retrospectively. Teno torque virus (TTV) plasma loads were measured as a measure of immune competence. HBV genomes isolated from 47 patients were analyzed by next-generation sequencing. A functional analysis of identified HBsAg mutants was performed. In patients with ALF the diagnosis was significantly later confirmed than in the non-ALF group. Patients diagnosed during immunosuppression had a milder clinical course compared to later diagnosed patients (p = 0.018, OR = 4.17). TTV viral loads did not differ significantly between the two groups. The HBV genomes isolated from ALF patients had higher viral complexity. A mutation in C-region of HBsAg (L216*), was associated with reduced HBsAg production and secretion. Patients diagnosed with HBV reactivation during immunosuppression had a milder clinical course compared to patients diagnosed during immune reconstitution. ALF was associated with higher viral complexity. An HBsAg mutation (L216*) was found to be more frequent in ALF patients and was associated with reduced HBsAg production and secretion.
    Keywords Hepatitis B virus ; disease course ; genome ; hepatitis B antigens ; high-throughput nucleotide sequencing ; immunocompetence ; immunosuppression ; liver failure ; morbidity ; mortality ; mutants ; mutation ; patients ; secretion ; viral load ; viruses
    Language English
    Dates of publication 2019-0916
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2516098-9
    ISSN 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v11090863
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: More on shift of HIV tropism in stem-cell transplantation with CCR5 delta32/delta32 mutation.

    Verheyen, Jens / Esser, Stefan / Kordelas, Lambros

    The New England journal of medicine

    2014  Volume 371, Issue 25, Page(s) 2438

    MeSH term(s) HIV-1/physiology ; Humans ; Lymphoma, Large-Cell, Anaplastic/complications ; Receptors, CCR5/genetics ; Stem Cell Transplantation ; Viral Tropism/genetics
    Chemical Substances Receptors, CCR5
    Language English
    Publishing date 2014-12-18
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1412279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  10. Article ; Online: Machine learning on normalized protein sequences

    Hoffmann Daniel / Verheyen Jens / Heider Dominik

    BMC Research Notes, Vol 4, Iss 1, p

    2011  Volume 94

    Abstract: Abstract Background Machine learning techniques have been widely applied to biological sequences, e.g. to predict drug resistance in HIV-1 from sequences of drug target proteins and protein functional classes. As deletions and insertions are frequent in ... ...

    Abstract Abstract Background Machine learning techniques have been widely applied to biological sequences, e.g. to predict drug resistance in HIV-1 from sequences of drug target proteins and protein functional classes. As deletions and insertions are frequent in biological sequences, a major limitation of current methods is the inability to handle varying sequence lengths. Findings We propose to normalize sequences to uniform length. To this end, we tested one linear and four different non-linear interpolation methods for the normalization of sequence lengths of 19 classification datasets. Classification tasks included prediction of HIV-1 drug resistance from drug target sequences and sequence-based prediction of protein function. We applied random forests to the classification of sequences into "positive" and "negative" samples. Statistical tests showed that the linear interpolation outperforms the non-linear interpolation methods in most of the analyzed datasets, while in a few cases non-linear methods had a small but significant advantage. Compared to other published methods, our prediction scheme leads to an improvement in prediction accuracy by up to 14%. Conclusions We found that machine learning on sequences normalized by simple linear interpolation gave better or at least competitive results compared to state-of-the-art procedures, and thus, is a promising alternative to existing methods, especially for protein sequences of variable length.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
    Subject code 006 ; 612
    Language English
    Publishing date 2011-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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