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Article ; Online: Cordycepin: a bioactive metabolite of C

Verma, Akalesh Kumar

Journal of biomolecular structure & dynamics

2020 Volume 40, Issue 8, Page(s) 3745–3752

Abstract: Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are ... ...

Abstract	Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are available to treat SARS-CoV-2. Considering all these challenges, the main objective of the present study was to establish therapeutic potential of cordycepin against COVID-19 as a conventional therapeutic strategy. In the present study; molecular interaction study was performed to assess potential binding affinity of cordycepin with SARS-CoV-2 target proteins using computational approach. Additionally, network pharmacology was used to understand cordycepin-protein interactions and their associated pathways in human body. Cordycepin is under clinical trial (NCT00709215) and possesses structural similarity with adenosine except that, it lacks a 3' hydroxyl group in its ribose moiety and hence it served as a poly(A) polymerase inhibitor and terminate premature protein synthesis. Additionally, it is known that functional RNAs of SARS-CoV-2 genome are highly 3'-plyadenylated and leading to synthesis of all viral proteins and if cordycepin can destabilize SARS-CoV-2 RNAs by inhibiting polyadenylation process then it may step forward in terms of inhibition of viral replication and multiplication in the host. Moreover, cordycepin showed strong binding affinity with SARS-CoV-2 spike protein (-145.3) and main proteases (-180.5) that further corroborate therapeutic potential against COVID-19. Since cordycepin has both pre-clinical and clinical information about antiviral activities, therefore; it is suggested to the world community to undertake repurposing cordycepin to test efficacy and safety for the treatment of COVID-19.
MeSH term(s)	Antiviral Agents/chemistry ; Clinical Trials as Topic ; Cordyceps/metabolism ; Deoxyadenosines ; Humans ; Peptide Hydrolases/metabolism ; Polyadenylation ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; Deoxyadenosines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptide Hydrolases (EC 3.4.-) ; cordycepin (GZ8VF4M2J8)
Language	English
Publishing date	2020-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2020.1850352
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Article ; Online: Cordyceps militaris: A Comprehensive Study on Laboratory Cultivation and Anticancer Potential in Dalton's Ascites Lymphoma Tumor Model.

Dutta, Diksha / Singh, Namram Sushindrajit / Aggarwal, Rohit / Verma, Akalesh Kumar

Anti-cancer agents in medicinal chemistry

2024

Abstract: Background: Cancer, a predominant cause of mortality, poses a formidable challenge in our pursuit of elevating life expectancy. Throughout history, individuals have sought natural remedies with minimal side effects as an appealing substitute for ... ...

Abstract	Background: Cancer, a predominant cause of mortality, poses a formidable challenge in our pursuit of elevating life expectancy. Throughout history, individuals have sought natural remedies with minimal side effects as an appealing substitute for chemotherapeutic drugs. One such remedy is Cordyceps militaris, a renowned medicinal mushroom deeply entrenched in Asian ethnomedicine. Revered for its rejuvenating and curative attributes, it relied upon for ages. Objective: The mushroom's soaring demand outpaced natural availability, necessitating controlled laboratory cultivation as the core focus and exploring the potential of methanolic extracts from harvested Cordyceps militaris fruiting bodies against Dalton's Lymphoma Ascites (DLA) cells in vitro, with a specific emphasis on its anticancer traits. Methods: For cultivation, we employed a diverse range of rice substrates, among which bora rice showed promising growth of C. militaris fruiting bodies. To assess DLA cell cytotoxicity, several assays, including trypan blue exclusion assay, MTT assay, and LDH assay, were employed at different time points (24-96 h), which provided valuable insights on DLA cell viability and proliferation, shedding light on its therapeutic potential against cancer. Results: Our studies unveiled that methanolic extract prompts apoptosis in DLA cells via AO/EB dual staining, manifesting consistent apoptosis indicators such as membrane blebbing, chromatin condensation, nuclei fragmentation, and cellular shrinkage at 48-96 h of treatment. Furthermore, these striking repercussions of apoptosis were comprehended by an in silico approach having molecular docking simulation against antiapoptotic proteins like BCL-2, BCL-XL, MCL-1, BFL-1 HSP100. Conclusion: Methanolic C. militaris extracts exhibited cytotoxicity and apoptotic alterations in DLA cells.
Language	English
Publishing date	2024-02-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/0118715206282174240115082518
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Article ; Online: Anti-inflammatory activity of the phenol rich fraction of Garcinia pedunculata Roxb (ex. Buch Ham): an in vitro and in vivo study.

Dutta, Kasturi / Verma, Akalesh Kumar / Gogoi, Munmi / Devi, Mary / Singh, Maishnam Rustam / Singh, Namram Sushindrajit

Inflammopharmacology

2024

Abstract: Garcinia pedunculata, a tropical plant found abundantly in the north-east region of India, has been used by many traditional healers for various gastrointestinal ailments. Studies are being carried out for the proper pharmacological identification of the ...

Abstract	Garcinia pedunculata, a tropical plant found abundantly in the north-east region of India, has been used by many traditional healers for various gastrointestinal ailments. Studies are being carried out for the proper pharmacological identification of the compounds as well as the mode of action for the treatment of various diseases. In this study, phytochemistry of the fruit was evaluated, followed by a quantitative analysis of the total phenolic and flavonoid content of the methanolic crude extract as well as different fractions (n-hexane, chloroform, ethyl acetate, and n-butanol). The fraction with the most potent flavonoid and phenolic content was evaluated for its anti-inflammatory activity using both in vitro and in vivo assays. The chloroform fraction of G. pedunculata fruit extract was found to have a substantial amount of phenols and flavonoids. This fraction inhibited the denaturation of BSA and significantly stabilized human RBC membrane compared to the standard drug Diclofenac sodium. The fraction also significantly reduced the formaldehyde-induced paw edema in mice and normalized the blood parameters. This study provides evidence that G. pedunculata fruit extract plays a critical role in anti-inflammatory activity, indicating that it can be a potential candidate for further investigation in the treatment of inflammation-related diseases.
Language	English
Publishing date	2024-05-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01484-1
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Article ; Online: Phytochemical analysis and

Verma, Akalesh Kumar / Singh, Sweta

Toxicology reports

2020 Volume 7, Page(s) 443–452

Abstract: ... ...

Abstract	Annonareticulate
Language	English
Publishing date	2020-02-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2805786-7
ISSN	2214-7500 ; 2214-7500
ISSN (online)	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2020.02.016
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Article ; Online: Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm.

Verma, Akalesh Kumar / Aggarwal, Rohit

Chemical biology & drug design

2020 Volume 97, Issue 4, Page(s) 836–853

Abstract: The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molecular ...

Abstract	The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. To evaluate molecular affinities between antiviral drug candidates and SARS-CoV-2 associated target proteins such as spike protein (S) and main protease (M
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Binding Sites ; COVID-19/drug therapy ; COVID-19/pathology ; COVID-19/virology ; Cell Line ; Cell Survival/drug effects ; Deoxyadenosines/chemistry ; Deoxyadenosines/metabolism ; Drug Repositioning ; Humans ; Machine Learning ; Molecular Docking Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/metabolism ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/antagonists & inhibitors ; Spike Glycoprotein, Coronavirus/metabolism ; Structure-Activity Relationship ; Viral Matrix Proteins/antagonists & inhibitors ; Viral Matrix Proteins/metabolism
Chemical Substances	Antiviral Agents ; Deoxyadenosines ; Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; Viral Matrix Proteins ; membrane protein, SARS-CoV-2 ; spike protein, SARS-CoV-2 ; cordycepin (GZ8VF4M2J8)
Language	English
Publishing date	2020-12-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.13812
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Article: Phytochemical analysis and in vitro cytostatic potential of ethnopharmacological important medicinal plants

Verma, Akalesh Kumar / Singh, Sweta

Toxicology reports. 2020, v. 7

2020

Abstract: Annonareticulate (Mart.), Lablab purpureus (L.) Sweet, Murrayakoenigii (L.) Spreng, Moringaoleifera (Lam.), Hibiscussabdariffa (L.) and Euphorbiahirta (L.) are most commonly used medicinal plants by the traditional healers of Karbi Anglong district of ... ...

Abstract	Annonareticulate (Mart.), Lablab purpureus (L.) Sweet, Murrayakoenigii (L.) Spreng, Moringaoleifera (Lam.), Hibiscussabdariffa (L.) and Euphorbiahirta (L.) are most commonly used medicinal plants by the traditional healers of Karbi Anglong district of Assam, India against different human ailments including cancer suspected cases. The proposed study includes field survey related to ethnomedicinal aspects of medicinal plants, phytochemical analysis, and evaluation of their cytostatic potential with the possible mode of action against Dalton's lymphoma (DL) cell line. The phytochemical analysis of all the plant's extract was studied using standard protocol. The cytotoxicity of the methanol extracts was determined by MTT reduction assay. The effect of the same extract was also tested for development of apoptosis features in DL cells using a fluorescence microscope and flowcytometry. The underlying mechanism closely associated with apoptotic cell death was also studied by measuring reactive oxygen species (ROS), mitochondrial membrane potential, and expression level of apoptosis inducing proteins. Murraya koenigii induced more apoptotic features in DL cells, followed by Annona reticulate. The decrease in mitochondrial membrane potential, release of cytochrome- c, increase in ROS level and higher expression of caspases (3 and 9) after plant extracts treatment may cause involvement of mitochondria in the process of apoptosis. From this study, it can be concluded that the plant species mainly Murraya koenigi and Annona reticulate significantly induced cytotoxicity in DL cells through apoptosis by utilizing mitochondrial pathway.
Keywords	Annona ; Bergera koenigii ; Lablab purpureus ; Murraya ; apoptosis ; caspases ; cell lines ; cytotoxicity ; fluorescence microscopes ; humans ; lymphoma ; mechanism of action ; membrane potential ; methanol ; mitochondria ; mitochondrial membrane ; phytochemicals ; reactive oxygen species ; surveys ; toxicology ; traditional medicine ; India
Language	English
Size	p. 443-452.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2805786-7
ISSN	2214-7500
ISSN	2214-7500
DOI	10.1016/j.toxrep.2020.02.016
Database	NAL-Catalogue (AGRICOLA)

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Article: In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India.

Swargiary, Ananta / Roy, Mritunjoy Kumar / Verma, Akalesh Kumar

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

2021 Volume 45, Issue 4, Page(s) 1123–1134

Abstract: ... Alstonia ... ...

Abstract	Alstonia scholaris
Language	English
Publishing date	2021-06-15
Publishing country	India
Document type	Journal Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-021-01410-0
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Article: In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India

Swargiary, Ananta / Roy, Mritunjoy Kumar / Verma, Akalesh Kumar

Journal of parasitic diseases. 2021 Dec., v. 45, no. 4

2021

Abstract: Alstonia scholaris, Cardiospermum halicacabum, Hydrocotyle sibthorpioides, and Hypericum japonicum are important folk medicinal plants used by tribal communities of Bodoland region of Assam to treat helminth infections. Because of their ethnomedicinal ... ...

Abstract	Alstonia scholaris, Cardiospermum halicacabum, Hydrocotyle sibthorpioides, and Hypericum japonicum are important folk medicinal plants used by tribal communities of Bodoland region of Assam to treat helminth infections. Because of their ethnomedicinal values, the present study was designed to investigate the antioxidant, antiproliferative, and anthelmintic activities of the plants. The antioxidant activity was measured by total antioxidant capacity, total phenolics (TPC), total flavonoid (TFC), FRAP, DPPH, ABTS, and TBARS assay. Antiproliferative and apoptosis-inducing activities of plants were conducted in Dalton’s lymphoma (DL) cells. Cells were treated for 24 h with different doses (25–200 mg/mL) of plant extracts. Anthelmintic study was conducted by treating the Paramphistomum sp. at different doses of plant extracts. Phytochemical and antioxidant studies showed rich TPC, TFC, and free radical scavenging activity in H. japonicum and H. sibthorpioides. Both the antiproliferative and anthelmintic bioassays showed a dose-dependent efficacy in all plants. H. japonicum showed the strongest anthelmintic activity (LC₅₀ 0.21 mg/mL) followed by H. sibthorpioides (5.36 mg/mL), C. halicacabum (13.40 mg/mL), and A. scholaris (18.40 mg/mL). Evidently, H. sibthorpioides showed the strongest antiproliferative and apoptosis-inducing activities among all the plants. The study observed a positive correlation between the antioxidant properties and antiproliferative and anthelmintic activities of the plants. We, therefore, conclude that the phytocompounds present in the crude extracts along with antioxidant molecules may have combined effects contributing to the antiproliferative and anthelmintic activities of the plants.
Keywords	Alstonia scholaris ; Cardiospermum halicacabum ; Hydrocotyle ; Hypericum ; Paramphistomum ; anthelmintics ; antioxidant activity ; dose response ; flavonoids ; free radicals ; helminths ; lymphoma ; India
Language	English
Dates of publication	2021-12
Size	p. 1123-1134.
Publishing place	Springer India
Document type	Article
ZDB-ID	2548456-4
ISSN	0975-0703 ; 0971-7196
ISSN (online)	0975-0703
ISSN	0971-7196
DOI	10.1007/s12639-021-01410-0
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Article ; Online: A pharmacological perspective of banana: implications relating to therapeutic benefits and molecular docking.

Sarma, Partha Pratim / Gurumayum, Nonibala / Verma, Akalesh Kumar / Devi, Rajlakshmi

Food & function

2021 Volume 12, Issue 11, Page(s) 4749–4767

Abstract: Banana is one of the most nutritious fruits, as it is rich in carbohydrates, proteins, fatty acids, and minerals. Banana has been used in traditional medicines for managing coughs and colds, ulcers, burns, and diarrhea. Banana contains various bioactive ... ...

Abstract	Banana is one of the most nutritious fruits, as it is rich in carbohydrates, proteins, fatty acids, and minerals. Banana has been used in traditional medicines for managing coughs and colds, ulcers, burns, and diarrhea. Banana contains various bioactive compounds, such as alkaloids, phenols, flavonoids, tannins, and saponins, with reported therapeutic benefits, including antioxidant, anti-diabetic, anti-cancer, anti-inflammatory, and anti-microbial activities. The present review focuses on a comprehensive overview of the nutritional and biological properties and phytochemicals of different species of banana and its different parts. Although detailed characterization of the compounds that are present in many parts of the plant has been carried out, chemical profiling of the seed, pseudostem, and leaves of banana is lacking and requires further exploration. Moreover, the functions of the reported compounds were elucidated using computational tools, supporting their potential role in managing life-threatening diseases and physiological complications.
MeSH term(s)	Alkaloids/analysis ; Animals ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Anti-Ulcer Agents ; Antineoplastic Agents ; Antioxidants/administration & dosage ; Flavonoids/analysis ; Fruit/chemistry ; Humans ; Hypoglycemic Agents ; Medicine, Traditional ; Molecular Docking Simulation ; Musa/chemistry ; Phenols/analysis ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Phytotherapy ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry ; Seeds/chemistry ; Tannins/analysis
Chemical Substances	Alkaloids ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Anti-Ulcer Agents ; Antineoplastic Agents ; Antioxidants ; Flavonoids ; Hypoglycemic Agents ; Phenols ; Phytochemicals ; Plant Extracts ; Tannins
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo00477h
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Article: A pharmacological perspective of banana: implications relating to therapeutic benefits and molecular docking

Sarma, Partha Pratim / Gurumayum, Nonibala / Verma, Akalesh Kumar / Devi, Rajlakshmi

Food & function. 2021 June 8, v. 12, no. 11

2021

Abstract	Banana is one of the most nutritious fruits, as it is rich in carbohydrates, proteins, fatty acids, and minerals. Banana has been used in traditional medicines for managing coughs and colds, ulcers, burns, and diarrhea. Banana contains various bioactive compounds, such as alkaloids, phenols, flavonoids, tannins, and saponins, with reported therapeutic benefits, including antioxidant, anti-diabetic, anti-cancer, anti-inflammatory, and anti-microbial activities. The present review focuses on a comprehensive overview of the nutritional and biological properties and phytochemicals of different species of banana and its different parts. Although detailed characterization of the compounds that are present in many parts of the plant has been carried out, chemical profiling of the seed, pseudostem, and leaves of banana is lacking and requires further exploration. Moreover, the functions of the reported compounds were elucidated using computational tools, supporting their potential role in managing life-threatening diseases and physiological complications.
Keywords	antioxidants ; bananas ; diarrhea ; flavonoids ; saponins ; therapeutics
Language	English
Dates of publication	2021-0608
Size	p. 4749-4767.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d1fo00477h
Database	NAL-Catalogue (AGRICOLA)

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