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  1. Article: Low-dose, high-pitch, spiral (FLASH) mode versus conventional sequential method for coronary artery calcium scoring: A derivation-validation study.

    Pandey, Niraj Nirmal / Chakraborty, Sayannika / Verma, Mansi / Jagia, Priya

    Journal of cardiovascular and thoracic research

    2024  Volume 16, Issue 1, Page(s) 15–20

    Abstract: Introduction: The present study sought to compare the diagnostic accuracy and radiation dose of ECG-gated, ultra-fast, low-dose, high-pitch, spiral (FLASH) mode versus conventional, ECG-gated, sequential coronary artery calcium (CAC) scoring in patients ...

    Abstract Introduction: The present study sought to compare the diagnostic accuracy and radiation dose of ECG-gated, ultra-fast, low-dose, high-pitch, spiral (FLASH) mode versus conventional, ECG-gated, sequential coronary artery calcium (CAC) scoring in patients with suspected coronary artery disease (CAD).
    Methods: The study included 120 patients who underwent both conventional scanning and FLASH mode scanning and were subdivided into derivation and validation cohorts. In the conventional sequential (step-and-shoot) protocol, prospective ECG-gated, non-contrast acquisition was performed at 70% of R-R interval. The spiral (FLASH) mode utilized a high-pitch and high-speed gantry rotation scanning mode where acquisition of the entire heart was done within a single cardiac cycle with prospective ECG-gating at 70% of R-R interval.
    Results: Correlation between CAC scores derived from conventional (cCAC) and FLASH mode (fCAC) in derivation cohort was excellent (r=0.99;
    Conclusion: CAC scoring using FLASH mode is feasible with high accuracy and shows excellent agreement with conventional CAC scores at significantly reduced radiation doses.
    Language English
    Publishing date 2024-03-13
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2654729-6
    ISSN 2008-6830 ; 2008-5117
    ISSN (online) 2008-6830
    ISSN 2008-5117
    DOI 10.34172/jcvtr.31736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.

    Biernat, Emily / Verma, Mansi / Govind, Chhabi K

    Gene

    2023  Volume 893, Page(s) 147959

    Abstract: RSC (remodels the structure of chromatin) is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. RSC utilizes its ATPase subunit, Sth1, to slide or remove nucleosomes. RSC has been shown to regulate the width of the ... ...

    Abstract RSC (remodels the structure of chromatin) is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. RSC utilizes its ATPase subunit, Sth1, to slide or remove nucleosomes. RSC has been shown to regulate the width of the nucleosome-depleted regions (NDRs) by sliding the flanking nucleosomes away from NDRs. As such, when RSC is depleted, nucleosomes encroach NDRs, leading to transcription initiation defects. In this study, we examined the effects of the catalytic-dead Sth1 on transcription and compared them to those observed during acute and rapid Sth1 depletion by auxin-induced degron strategy. We found that rapid depletion of Sth1 reduces recruitment of TBP and Pol II in highly transcribed genes, as would be expected considering its role in regulating chromatin structure at promoters. In contrast, cells harboring the catalytic-dead Sth1 (sth1-K501R) exhibited a severe reduction in TBP binding, but, surprisingly, also displayed a substantial accumulation in Pol II occupancies within coding regions. The Pol II occupancies further increased upon depleting endogenous Sth1 in the catalytic-dead mutant, suggesting that the inactive Sth1 contributes to Pol II accumulation in coding regions. Notwithstanding the Pol II increase, the ORF occupancies of histone chaperones, FACT and Spt6 were significantly reduced in the mutant. These results suggest a potential role for RSC in recruiting/retaining these chaperones in coding regions. Pol II accumulation despite substantial reductions in TBP, FACT, and Spt6 occupancies in the catalytic-dead mutant could indicate severe transcription elongation and termination defects. Such defects would be consistent with studies showing that RSC is recruited to coding regions in a transcription-dependent manner. Thus, these findings imply a role for RSC in transcription elongation and termination processes, in addition to its established role in transcription initiation.
    MeSH term(s) Chromatin/genetics ; Chromatin/metabolism ; DNA-Binding Proteins/genetics ; High Mobility Group Proteins/genetics ; Nucleosomes/genetics ; Nucleosomes/metabolism ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Transcription Factors/metabolism ; Transcription, Genetic ; Transcriptional Elongation Factors/genetics
    Chemical Substances Chromatin ; DNA-Binding Proteins ; FACT protein, S cerevisiae ; High Mobility Group Proteins ; Nucleosomes ; RNA Polymerase II (EC 2.7.7.-) ; Saccharomyces cerevisiae Proteins ; Transcription Factors ; Transcriptional Elongation Factors ; SPT6 protein, S cerevisiae
    Language English
    Publishing date 2023-11-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2023.147959
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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  3. Article: Unusual large mass on aortic valve in an infant.

    Kadiyani, Lamk / Ramakrishnan, Sivasubramanian / Verma, Mansi / Kumar, Sanjeev / Hote, Milind

    Annals of pediatric cardiology

    2023  Volume 15, Issue 5-6, Page(s) 529–532

    Abstract: Mass on the aortic valve is extremely rare in children, and the differential diagnosis includes vegetation, thrombus, and primary cardiac tumors. A rise in infective endocarditis in infants is seen due to increasing survival of children with congenital ... ...

    Abstract Mass on the aortic valve is extremely rare in children, and the differential diagnosis includes vegetation, thrombus, and primary cardiac tumors. A rise in infective endocarditis in infants is seen due to increasing survival of children with congenital heart diseases and sick newborn infants with prolonged hospitalization. We report a 4-month-old infant born prematurely with early-onset sepsis requiring prolonged antibiotic treatment and valvular aortic stenosis presenting with sudden hemodynamic compromise due to aortic vegetation extending into the ascending aorta eroding through its posterior wall. The report details management of our case and a brief description of available alternative treatment strategies.
    Language English
    Publishing date 2023-03-01
    Publishing country India
    Document type Case Reports
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.apc_240_21
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  4. Article: A large cardiac tuberculoma masquerading a malignant mass in a 15-year-old boy.

    Verma, Mansi / Ojha, Vineeta / Arava, Sudheer / Hote, Milind / Jagia, Priya

    Indian journal of thoracic and cardiovascular surgery

    2023  Volume 39, Issue 3, Page(s) 316–318

    Abstract: We hereby present a case of large cardiac tuberculoma which was thought to be a malignant mass on cardiac magnetic resonance imaging (MRI). The present case highlights that high index of suspicion is necessary to diagnose this rare entity especially in ... ...

    Abstract We hereby present a case of large cardiac tuberculoma which was thought to be a malignant mass on cardiac magnetic resonance imaging (MRI). The present case highlights that high index of suspicion is necessary to diagnose this rare entity especially in tuberculosis-endemic areas, or in those who have relevant past history of this condition.
    Language English
    Publishing date 2023-01-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-022-01459-3
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  5. Article: External iliac artery Endofibrosis in a professional cyclist.

    Verma, Mansi / Pandey, Niraj Nirmal / Kumar, Sanjeev

    Indian journal of thoracic and cardiovascular surgery

    2022  Volume 38, Issue 5, Page(s) 556–558

    Abstract: We present a case of a 30-year-old female professional cyclist who presented with right thigh claudication while performing high-intensity efforts. Based on the typical clinical history and the presence of a smooth long segment diffuse narrowing in the ... ...

    Abstract We present a case of a 30-year-old female professional cyclist who presented with right thigh claudication while performing high-intensity efforts. Based on the typical clinical history and the presence of a smooth long segment diffuse narrowing in the right external iliac artery on non-contrast magnetic resonance angiography, a diagnosis of external iliac artery endofibrosis or "cyclist's iliac syndrome" was made.
    Supplementary information: The online version contains supplementary material available at 10.1007/s12055-022-01349-8.
    Language English
    Publishing date 2022-04-08
    Publishing country India
    Document type Journal Article
    ZDB-ID 2164386-6
    ISSN 0973-7723 ; 0970-9134
    ISSN (online) 0973-7723
    ISSN 0970-9134
    DOI 10.1007/s12055-022-01349-8
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  6. Article ; Online: Context effects on choice under cognitive load.

    Wedell, Douglas H / Hayes, William M / Verma, Mansi

    Psychonomic bulletin & review

    2022  Volume 29, Issue 5, Page(s) 1986–1996

    Abstract: The context-dependent nature of choice is well illustrated by decoy effects, in which adding an alternative to a choice set can change the preference relations among the other alternatives. The current within-subjects study tested whether manipulating ... ...

    Abstract The context-dependent nature of choice is well illustrated by decoy effects, in which adding an alternative to a choice set can change the preference relations among the other alternatives. The current within-subjects study tested whether manipulating cognitive load affects the magnitude of attraction and compromise decoy effects. Participants (n = 96) made simulated online grocery shopping choices from three options described by price and quality for each grocery item they encountered. On half the 96 trials, they had to memorize a telephone number prior to encountering the choice set, after which they recalled the number. The choice task was rated significantly more difficult under load, providing some face validity for the load manipulation. Across decoy types, context effects were large and unaffected by the load manipulation. Bayesian analysis provided substantial evidence in favor of this null effect, with the study powered at better than .95 to detect a moderate effect. Across individuals, the magnitude of decoy effects was positively correlated with perception of the greater difficulty of the task under load, with this relationship fully mediated by increases in response times. These results are consistent with the idea that compromise and attraction decoy effects can operate relatively automatically and require minimal effortful processing.
    MeSH term(s) Bayes Theorem ; Choice Behavior/physiology ; Cognition ; Humans ; Reaction Time ; Reproducibility of Results
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2031311-1
    ISSN 1531-5320 ; 1069-9384
    ISSN (online) 1531-5320
    ISSN 1069-9384
    DOI 10.3758/s13423-022-02113-0
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  7. Article ; Online: Incidentally detected anomalous left atrial fibromuscular band.

    Verma, Mansi / Pandey, Niraj Nirmal / Kumar, Sanjeev / Yadav, Rakesh

    BMJ case reports

    2022  Volume 15, Issue 1

    MeSH term(s) Atrial Appendage ; Atrial Fibrillation ; Cardiac Pacing, Artificial ; Heart Atria/diagnostic imaging ; Humans
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-248402
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  8. Article ; Online: Severe tracheal stenosis secondary to brachiocephalic artery compression syndrome.

    Verma, Mansi / Pandey, Niraj Nirmal / Relan, Jay / Jagia, Priya

    Journal of cardiovascular computed tomography

    2022  Volume 16, Issue 5, Page(s) e38–e39

    MeSH term(s) Brachiocephalic Trunk/diagnostic imaging ; Humans ; Predictive Value of Tests ; Syndrome ; Tracheal Stenosis/diagnostic imaging ; Tracheal Stenosis/etiology
    Language English
    Publishing date 2022-02-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2022.02.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6761: Show issues Location:
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  9. Article ; Online: An unusual paediatric case of mycotic pulmonary artery aneurysm secondary to staphylococcal skin sepsis.

    Verma, Mansi / Malhi, Amarinder Singh / Kumar, Sanjeev / Agarwala, Sandeep

    BMJ case reports

    2022  Volume 15, Issue 2

    MeSH term(s) Aneurysm, Infected/complications ; Aneurysm, Infected/diagnostic imaging ; Bacteremia/complications ; Child ; Humans ; Pulmonary Artery/diagnostic imaging ; Sepsis/complications ; Staphylococcal Infections/complications ; Staphylococcal Infections/diagnosis
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-247711
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  10. Article ; Online: Extremely tortuous vertical vein in supracardiac totally anomalous pulmonary venous connection.

    Verma, Mansi / Pandey, Niraj Nirmal / Arvind, Balaji / Kumar, Sanjeev

    Journal of cardiac surgery

    2022  Volume 37, Issue 3, Page(s) 680–681

    Abstract: We present a case of a 2-month-old boy with supracardiac totally anomalous pulmonary venous connection where computed tomography angiography demonstrated an extremely tortuous course of the vertical vein before its drainage into the left brachiocephalic ... ...

    Abstract We present a case of a 2-month-old boy with supracardiac totally anomalous pulmonary venous connection where computed tomography angiography demonstrated an extremely tortuous course of the vertical vein before its drainage into the left brachiocephalic vein.
    MeSH term(s) Angiography ; Brachiocephalic Veins/diagnostic imaging ; Brachiocephalic Veins/surgery ; Humans ; Infant ; Male ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Scimitar Syndrome/diagnostic imaging ; Scimitar Syndrome/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-01-07
    Publishing country United States
    Document type Case Reports
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.16217
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    Zs.A 2221: Show issues Location:
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