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  1. Article ; Online: Correlation of serum uric acid levels with certain anthropometric parameters in prediabetic and drug-naive diabetic subjects.

    Tiwari, Ritu / Verma, Shivam / Verma, Narsingh / Verma, Dileep / Narayan, Jagdish

    Annals of African medicine

    2024  Volume 23, Issue 1, Page(s) 13–18

    Abstract: Introduction: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with ... ...

    Abstract Introduction: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with visceral fat in overweight subjects. The aim of the present study is to find an association of uric acid level with certain anthropometric parameters in subjects having type 2 diabetes.
    Materials and methods: The study included 124 urban drug-naive diabetic Indian subjects above 18 years of age from the general population of the city of North India. Uric acid concentrations were estimated by the uricase method. Fasting plasma glucose (FPG) concentrations were estimated by the glucose oxidase-peroxidase method. Anthropometric measurements and information on lifestyle factors and disease history were collected through in-person meeting.
    Results: All participants of the study subjects had a body mass index (BMI) of more than 23.5. BMI, waist-to-hip ratio (WHR), waist-to-height ratio, waist circumference, neck circumference, weight, age, sagittal abdominal diameter (SAD), skinfold thickness, and body roundness index were positively correlated with the serum uric acid level. The correlation of weight, BMI, SAD, and WHR was statistically significant.
    Conclusion: We found that serum uric acid level increases as body fat content increases. Statistical data show remarkable results for a significant correlation of uric acid level with BMI, WHR, SAD, and FPG. Hypertrophy occurs as a result of inflammatory processes and oxidative stress when the supply of energy starts to exceed the storage capacity of adipocytes, as a result, adipokines such as interleukin (IL)-1, IL-6, and tumor-necrosis factor-alpha are released more frequently which lead to low-grade chronic inflammation. Uric acid levels are much lean toward visceral obesity than overall body fat content.
    MeSH term(s) Humans ; Uric Acid ; Diabetes Mellitus, Type 2/complications ; Prediabetic State/complications ; Anthropometry ; Overweight ; Body Mass Index ; Waist Circumference ; Waist-Hip Ratio
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2024-01-31
    Publishing country India
    Document type Journal Article
    ZDB-ID 2165792-0
    ISSN 0975-5764 ; 0975-5764
    ISSN (online) 0975-5764
    ISSN 0975-5764
    DOI 10.4103/aam.aam_40_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Management of Asymmetric Mandibular Retrognathia with Differential Loading Technique: A Case Report.

    Parihar, Ajit V / Angamuthu, Kavin Prasanth / Sahoo, Rojalin / Verma, Shivam

    International journal of clinical pediatric dentistry

    2022  Volume 14, Issue Suppl 1, Page(s) S107–S113

    Abstract: Class II malocclusion cases possess a constant challenge to orthodontists since time immemorial. Mandibular retrusion is the most common feature of class II malocclusion, rather than maxillary prognathism. Association of class II with asymmetry, a ... ...

    Abstract Class II malocclusion cases possess a constant challenge to orthodontists since time immemorial. Mandibular retrusion is the most common feature of class II malocclusion, rather than maxillary prognathism. Association of class II with asymmetry, a condition called asymmetric mandibular retrognathia (AMR), gives a tougher challenge to orthodontists for management. The following case presents effective management of AMR using differential loading technique. A young boy aged 12 years presented with mandibular retrognathia associated with facial asymmetry. He was treated with a differential force loading technique using a fixed functional appliance.
    Results: Improved facial profile with increased mandibular length achieved. A significant reduction in facial asymmetry was also appreciable.
    Conclusion: Differential force loading technique using fixed functional appliance while being least troublesome for the patient may prove beneficial to harness excellent and satisfactory results with minimal efforts in such cases of mandibular retrusion with facial asymmetries and also decrease the need for surgical correction.
    How to cite this article: Parihar AV, Angamuthu KP, Sahoo R,
    Language English
    Publishing date 2022-01-27
    Publishing country India
    Document type Case Reports
    ISSN 0974-7052
    ISSN 0974-7052
    DOI 10.5005/jp-journals-10005-1969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparative study of different distraction rates in separate retractions of canine: Randomized control trial.

    Parihar, Ajit Vikram / Verma, Shivam / Subash, P / Singh, Akhilesh Kumar

    National journal of maxillofacial surgery

    2022  Volume 13, Issue 3, Page(s) 390–397

    Abstract: Introduction: Orthodontic treatment typically lasts 18-24 months, but depending on the conditions, it can take a longer duration. In recent years, accelerated orthodontics has been the subject of extensive research to shorten the duration of treatment. ... ...

    Abstract Introduction: Orthodontic treatment typically lasts 18-24 months, but depending on the conditions, it can take a longer duration. In recent years, accelerated orthodontics has been the subject of extensive research to shorten the duration of treatment. In distraction osteogenesis (DO), the surgically created joints are slowly and controllably displaced over time by gradual traction. This results in simultaneous growth of soft tissues and bone volumes at the osteotomy site. The DO field is currently experiencing a modern surge of research and development that has been able to implement numerous innovative and revolutionary distraction systems. In this study, we are comparing two different rates of dentoalveolar distraction.
    Materials and methods: With the use of custom-made distractors, we will compare the different ranges of activation of distractors and their dental effects. Participants are separated into two groups based on 0.4 mm/day activation and 0.5 mm/day activation.
    Results: During the study period, the average tooth movement rate for Group 1 was 0.52 mm and for Group 2 was 0.58 mm. Group 1 completed canine distraction in 11.42 ± 1.81 days and Group 2 in 10.05 ± 1.68 days.
    Conclusions: Retraction days decreased in Group 2, due to increased activation of the distractor. The anchorage loss in Group 2 was higher than that in Group 1, which was 1.39 mm lower. Unlike decreased activation, the mean tooth movement of Group 1 is higher than Group 2.
    Language English
    Publishing date 2022-12-10
    Publishing country India
    Document type Journal Article
    ZDB-ID 2653583-X
    ISSN 2229-3418 ; 0975-5950
    ISSN (online) 2229-3418
    ISSN 0975-5950
    DOI 10.4103/njms.njms_430_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins.

    David, Yael / Vila-Perelló, Miquel / Verma, Shivam / Muir, Tom W

    Nature chemistry

    2015  Volume 7, Issue 5, Page(s) 394–402

    Abstract: Post-translational modification of the histone proteins in chromatin plays a central role in the epigenetic control of DNA-templated processes in eukaryotic cells. Developing methods that enable the structure of histones to be manipulated is, therefore, ... ...

    Abstract Post-translational modification of the histone proteins in chromatin plays a central role in the epigenetic control of DNA-templated processes in eukaryotic cells. Developing methods that enable the structure of histones to be manipulated is, therefore, essential to understand the biochemical mechanisms that underlie genomic regulation. Here we present a synthetic biology method to engineer histones that bear site-specific modifications on cellular chromatin using protein trans-splicing (PTS). We genetically fused the N-terminal fragment of ultrafast split intein to the C terminus of histone H2B, which, on reaction with a complementary synthetic C intein, generated labelled histone. Using this approach, we incorporated various non-native chemical modifications into chromatin in vivo with temporal control. Furthermore, the time and concentration dependence of PTS performed in nucleo enabled us to examine differences in the accessibility of the euchromatin and heterochromatin regions of the epigenome. Finally, we used PTS to semisynthesize a native histone modification, H2BK120 ubiquitination, in isolated nuclei and showed that this can trigger downstream epigenetic crosstalk of H3K79 methylation.
    MeSH term(s) Cell Line ; Chromatin/chemistry ; Chromatin Immunoprecipitation ; Humans ; Inteins ; Polymerase Chain Reaction ; RNA Splicing
    Chemical Substances Chromatin
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/nchem.2224
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Engineered fetal cardiac graft preserves its cardiomyocyte proliferation within postinfarcted myocardium and sustains cardiac function.

    Fujimoto, Kazuro L / Clause, Kelly C / Liu, Li J / Tinney, Joseph P / Verma, Shivam / Wagner, William R / Keller, Bradley B / Tobita, Kimimasa

    Tissue engineering. Part A

    2011  Volume 17, Issue 5-6, Page(s) 585–596

    Abstract: The goal of cellular cardiomyoplasty is to replace damaged myocardium by healthy myocardium achieved by host myocardial regeneration and/or transplantation of donor cardiomyocytes (CMs). In the case of CM transplantation, studies suggest that immature ... ...

    Abstract The goal of cellular cardiomyoplasty is to replace damaged myocardium by healthy myocardium achieved by host myocardial regeneration and/or transplantation of donor cardiomyocytes (CMs). In the case of CM transplantation, studies suggest that immature CMs may be the optimal cell type to survive and functionally integrate into damaged myocardium. In the present study, we tested the hypothesis that active proliferation of immature CMs contributes graft survival and functional recovery of recipient myocardium. We constructed engineered cardiac tissue from gestational day 14 rat fetal cardiac cells (EFCT) or day 3 neonatal cardiac cells (ENCT). Culture day 7 EFCTs or ENCTs were implanted onto the postinfarct adult left ventricle (LV). CM proliferation rate of EFCT was significantly higher than that of ENCT at 3 days and 8 weeks after the graft implantation, whereas CM apoptosis rate remained the same in both groups. Echocardiogram showed that ENCT implantation sustained LV contraction, whereas EFCT implantation significantly increased the LV contraction at 8 weeks versus sham group (p < 0.05, analysis of variance). These results suggest that active CM proliferation may play a critical role in immature donor CM survival and the functional recovery of damaged recipient myocardium.
    MeSH term(s) Animals ; Animals, Newborn ; Apoptosis ; Cell Proliferation ; Female ; Fetal Tissue Transplantation ; Fetus/cytology ; Graft Survival ; Heart/physiopathology ; Heart Function Tests ; Heart Transplantation ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Myocardial Contraction/physiology ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/pathology ; Myocardial Infarction/physiopathology ; Myocardial Infarction/therapy ; Myocytes, Cardiac/cytology ; Neovascularization, Physiologic ; Rats ; Rats, Inbred Lew ; Tissue Culture Techniques ; Tissue Engineering/methods ; Ultrasonography
    Language English
    Publishing date 2011-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2420582-5
    ISSN 1937-335X ; 1937-3341
    ISSN (online) 1937-335X
    ISSN 1937-3341
    DOI 10.1089/ten.TEA.2010.0259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5500/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Evaluation of 3 T pelvic MRI imaging in prostate cancer patients receiving post-prostatectomy IMRT.

    Verma, Vivek / Chen, Ling / Michalski, Jeff M / Hu, Yanle / Zhang, Wenjun / Robinson, Kathryn / Verma, Shivam / Eschen, Laura / Fergus, Sandra / Mullen, Dan / Strope, Seth / Grubb, Robert / Gay, Hiram A

    World journal of urology

    2014  Volume 33, Issue 1, Page(s) 69–75

    Abstract: Purpose: The purpose of the study was to evaluate the utility of a 3 T pelvic magnetic resonance imaging (MRI) in detecting a local recurrence in post-prostatectomy prostate cancer patients prior to receiving adjuvant or salvage intensity-modulated ... ...

    Abstract Purpose: The purpose of the study was to evaluate the utility of a 3 T pelvic magnetic resonance imaging (MRI) in detecting a local recurrence in post-prostatectomy prostate cancer patients prior to receiving adjuvant or salvage intensity-modulated radiation therapy (IMRT).
    Methods: Ninety prostate cancer patients status post-prostatectomy with rising prostate-specific antigen (PSA) had a 3 T pelvic MRI prior to IMRT. The following variables were analyzed for predicting positive findings on MRI: initial presenting and initial post-op PSA, PSA at the time of imaging, PSA velocity, surgical margins, Gleason score, pathological stage, pre-RT digital rectal examination, and type of surgical prostatectomy.
    Results: The only significant variable predictive of a positive MRI was positive margins. Specifically, 15 of 46 (33 %) patients with positive margins had a positive MRI, while 5 of 44 (11 %) patients with negative margins had a positive MRI. In the MRI positive group, the location of the positive findings on MRI corresponded with the pathology report in 9 of 12 (75 %) cases.
    Conclusion: Post-prostatectomy patients with pathologic positive margins are three times more likely to have positive findings on a 3 T MRI.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm, Residual ; Prostate-Specific Antigen ; Prostatectomy ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/surgery ; Radiotherapy, Adjuvant ; Radiotherapy, Intensity-Modulated ; Salvage Therapy ; Sensitivity and Specificity ; Treatment Outcome
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2014-03-20
    Publishing country Germany
    Document type Clinical Study ; Journal Article
    ZDB-ID 380333-8
    ISSN 1433-8726 ; 0724-4983
    ISSN (online) 1433-8726
    ISSN 0724-4983
    DOI 10.1007/s00345-014-1269-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1832: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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