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  1. Article ; Online: Appropriate Treatment of Cholangitis Can Prevent Successful Kasai Portoenterostomy Progressing to Liver Transplantation.

    Lal, Bikrant Bihari / Verma, Snigdha / Sood, Vikrant / Khanna, Rajeev / Alam, Seema

    Journal of pediatric gastroenterology and nutrition

    2023  Volume 77, Issue 5, Page(s) e70

    MeSH term(s) Humans ; Infant ; Liver Transplantation ; Biliary Atresia/surgery ; Portoenterostomy, Hepatic ; Cholangitis/etiology ; Cholangitis/surgery ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2023-07-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000003880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1728: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Knowledge, perception and practice towards oxytocin stability and quality: A qualitative study of stakeholders in three resource-limited countries.

    Oliver, Victoria L / Lambert, Peter A / Than, Kyu Kyu / Mohamed, Yasmin / Luchters, Stanley / Verma, Snigdha / Yadav, Ranjana / Kumar, Vishwajeet / Teklu, Alula M / Tolera, Moti / Minaye, Abebaw / McIntosh, Michelle P

    PloS one

    2018  Volume 13, Issue 9, Page(s) e0203810

    Abstract: Background: Oxytocin is the gold standard drug for the prevention of postpartum haemorrhage, but limitations in cold chain systems in resource-constrained settings can severely compromise the quality of oxytocin product available in these environments. ... ...

    Abstract Background: Oxytocin is the gold standard drug for the prevention of postpartum haemorrhage, but limitations in cold chain systems in resource-constrained settings can severely compromise the quality of oxytocin product available in these environments. This study investigated the perspectives and practices of stakeholders in low and lower-middle income countries towards oxytocin, its storage requirements and associated barriers, and the quality of product available.
    Methods: Qualitative inquiries were undertaken in Ethiopia, India and Myanmar, where data was collected through Focus Group Discussions (FGDs) and In-Depth Interviews (IDIs). A total of 12 FGDs and 106 IDIs were conducted with 158 healthcare providers (pharmacists, midwives, nurses, doctors and obstetricians) and 40 key informants (supply chain experts, program managers and policy-makers). Direct observations of oxytocin storage practices and cold chain resources were conducted at 51 healthcare facilities. Verbatim transcripts of FGDs and IDIs were translated to English and analysed according to a thematic content analysis framework.
    Findings: Stakeholder awareness of oxytocin heat sensitivity and the requirement for cold storage of the drug was widespread in Ethiopia but more limited in Myanmar and India. A consistent finding across all study regions was the significant barriers to maintaining a consistent cold chain, with the lack of refrigeration facilities and unreliability of electricity cited as major challenges. Perceptions of compromised oxytocin quality were expressed by some stakeholders in each country.
    Conclusion: Knowledge of the heat sensitivity of oxytocin and the potential impacts of inconsistent cold storage on product quality is not widespread amongst healthcare providers, policy makers and supply chain experts in Myanmar, Ethiopia and India. Targeted training and advocacy messages are warranted to emphasise the importance of cold storage to maintain oxytocin quality.
    MeSH term(s) Cold Temperature ; Developing Countries ; Drug Stability ; Drug Storage/methods ; Drug Storage/standards ; Ethiopia ; Female ; Focus Groups ; Health Knowledge, Attitudes, Practice ; Humans ; India ; Interviews as Topic ; Myanmar ; Oxytocin/chemistry ; Oxytocin/standards ; Oxytocin/therapeutic use ; Postpartum Hemorrhage/prevention & control ; Pregnancy ; Rural Health Services ; Urban Health Services
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2018-09-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0203810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Minimotif Miner: a tool for investigating protein function.

    Balla, Sudha / Thapar, Vishal / Verma, Snigdha / Luong, Thaibinh / Faghri, Tanaz / Huang, Chun-Hsi / Rajasekaran, Sanguthevar / del Campo, Jacob J / Shinn, Jessica H / Mohler, William A / Maciejewski, Mark W / Gryk, Michael R / Piccirillo, Bryan / Schiller, Stanley R / Schiller, Martin R

    Nature methods

    2006  Volume 3, Issue 3, Page(s) 175–177

    Abstract: In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs ... ...

    Abstract In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.
    MeSH term(s) 14-3-3 Proteins/chemistry ; 14-3-3 Proteins/physiology ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Caenorhabditis elegans Proteins/chemistry ; Caenorhabditis elegans Proteins/physiology ; Databases as Topic ; Internet ; Membrane Glycoproteins/chemistry ; Membrane Glycoproteins/physiology ; Molecular Sequence Data ; Proteins/chemistry ; Proteins/physiology ; Sequence Alignment ; Sequence Analysis, Protein/methods ; Software
    Chemical Substances 14-3-3 Proteins ; Caenorhabditis elegans Proteins ; EFF-1 protein, C elegans ; Membrane Glycoproteins ; Proteins
    Language English
    Publishing date 2006-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2169522-2
    ISSN 1548-7105 ; 1548-7091
    ISSN (online) 1548-7105
    ISSN 1548-7091
    DOI 10.1038/nmeth856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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