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Book ; Thesis: Supramolecular coordination polymers in water

Vermonden, Tina

rings, chains and networks

2005

Author's details	Tina Vermonden
Language	English
Size	128 S. : Ill., graph. Darst.
Publishing country	Netherlands
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Wageningen, Univ., Diss., 2005
Note	Zsfassung in niederländ. Sprache
HBZ-ID	HT014537757
ISBN	90-8504-148-1 ; 978-90-8504-148-1
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Shelf mark	Loan status	Location
058/2493	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: Injectable hydrogels for sustained delivery of extracellular vesicles in cartilage regeneration.

van de Looij, Sanne M / de Jong, Olivier G / Vermonden, Tina / Lorenowicz, Magdalena J

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 355, Page(s) 685–708

Abstract: Extracellular vesicles (EVs) are a population of small vesicles secreted by essentially all cell types, containing a wide variety of biological macromolecules. Due to their intrinsic capabilities for efficient intercellular communication, they are ... ...

Abstract	Extracellular vesicles (EVs) are a population of small vesicles secreted by essentially all cell types, containing a wide variety of biological macromolecules. Due to their intrinsic capabilities for efficient intercellular communication, they are involved in various aspects of cellular functioning. In the past decade, EVs derived from stem cells attracted interest in the field of regenerative medicine. Owing to their regenerative properties, they have great potential for use in tissue repair, in particular for tissues with limited regenerative capabilities such as cartilage. The maintenance of articular cartilage is dependent on a precarious balance of many different components that can be disrupted by the onset of prevalent rheumatic diseases. However, while cartilage is a tissue with strong mechanical properties that can withstand movement and heavy loads for years, it is virtually incapable of repairing itself after damage has occurred. Stem cell-derived EVs (SC-EVs) transport regenerative components such as proteins and nucleic acids from their parental cells to recipient cells, thereby promoting cartilage healing. Many possible pathways through which SC-EVs execute their regenerative function have been reported, but likely there are still numerous other pathways that are still unknown. This review discusses various preclinical studies investigating intra-articular injections of free SC-EVs, which, while often promoting chondrogenesis and cartilage repair in vivo, showed a recurring limitation of the need for multiple administrations to achieve sufficient tissue regeneration. Potentially, this drawback can be overcome by making use of an EV delivery platform that is capable of sustainably releasing EVs over time. With their remarkable versatility and favourable chemical, biological and mechanical properties, hydrogels can facilitate this release profile by encapsulating EVs in their porous structure. Ideally, the optimal delivery platform can be formed in-situ, by means of an injectable hydrogel that can be administered directly into the affected joint. Relevant research fulfilling these criteria is discussed in detail, including the steps that still need to be taken before injectable hydrogels for sustained delivery of EVs can be applied in the context of cartilage regeneration in the clinic.
MeSH term(s)	Hydrogels/chemistry ; Cartilage, Articular ; Stem Cells ; Cell Communication ; Extracellular Vesicles/metabolism
Chemical Substances	Hydrogels
Language	English
Publishing date	2023-02-18
Publishing country	Netherlands
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.01.060
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Injectable hydrogels for sustained delivery of extracellular vesicles in cartilage regeneration

van de Looij, Sanne M. / de Jong, Olivier G. / Vermonden, Tina / Lorenowicz, Magdalena J.

Journal of Controlled Release.

2023

Abstract	Extracellular vesicles (EVs) are a population of small vesicles secreted by essentially all cell types, containing a wide variety of biological macromolecules. Due to their intrinsic capabilities for efficient intercellular communication, they are involved in various aspects of cellular functioning. In the past decade, EVs derived from stem cells attracted interest in the field of regenerative medicine. Owing to their regenerative properties, they have great potential for use in tissue repair, in particular for tissues with limited regenerative capabilities such as cartilage. The maintenance of articular cartilage is dependent on a precarious balance of many different components that can be disrupted by the onset of prevalent rheumatic diseases. However, while cartilage is a tissue with strong mechanical properties that can withstand movement and heavy loads for years, it is virtually incapable of repairing itself after damage has occurred. Stem cell-derived EVs (SC-EVs) transport regenerative components such as proteins and nucleic acids from their parental cells to recipient cells, thereby promoting cartilage healing. Many possible pathways through which SC-EVs execute their regenerative function have been reported, but likely there are still numerous other pathways that are still unknown. This review discusses various preclinical studies investigating intra-articular injections of free SC-EVs, which, while often promoting chondrogenesis and cartilage repair in vivo, showed a recurring limitation of the need for multiple administrations to achieve sufficient tissue regeneration. Potentially, this drawback can be overcome by making use of an EV delivery platform that is capable of sustainably releasing EVs over time. With their remarkable versatility and favourable chemical, biological and mechanical properties, hydrogels can facilitate this release profile by encapsulating EVs in their porous structure. Ideally, the optimal delivery platform can be formed in-situ, by means of an injectable hydrogel that can be administered directly into the affected joint. Relevant research fulfilling these criteria is discussed in detail, including the steps that still need to be taken before injectable hydrogels for sustained delivery of EVs can be applied in the context of cartilage regeneration in the clinic.
Keywords	cartilage ; cell communication ; chondrogenesis ; hydrogels ; medicine ; tissue repair ; Extracellular vesicles ; Osteoarthritis, Hydrogels ; Sustained delivery ; Regeneration ; Abbreviation ; 2D ; 3D ; AD ; AdMSC ; AFSC ; BMSC ; cc-siRNA ; CD ; cGMP ; circRNA ; COS ; CRISPR ; CRY2 ; CPC ; CS ; DAF ; DIM ; dKO ; ECM ; EDC/NHS ; EGCG ; ESC ; EV ; FGF ; GelMa ; HA ; HE staining ; HRP ; HUVEC ; ICRS ; IA ; IGF ; IL-6 ; iPSC ; ISEV ; ITG ; IV ; lnc-malat-1 ; lncRNA ; miRNA ; MMP ; mRNA ; MSC ; OA ; OARSI score ; PBS ; PCNA ; PDGF ; PEG ; PLEL ; PRP ; PTEC ; RA ; RNAi ; RSF ; SC-EV ; SEC ; sgRNA ; siRNA ; SMD ; SMSC ; TFF ; TGF ; UCSC ; UPy ; UTR
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.01.060
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Local changes in microtubule network mobility instruct neuronal polarization and axon specification.

Burute, Mithila / Jansen, Klara I / Mihajlovic, Marko / Vermonden, Tina / Kapitein, Lukas C

Science advances

2022 Volume 8, Issue 44, Page(s) eabo2343

Abstract: The polarization of neurons into axons and dendrites depends on extracellular cues, intracellular signaling, cytoskeletal rearrangements, and polarized transport, but the interplay between these processes during polarization remains unresolved. Here, we ... ...

Abstract	The polarization of neurons into axons and dendrites depends on extracellular cues, intracellular signaling, cytoskeletal rearrangements, and polarized transport, but the interplay between these processes during polarization remains unresolved. Here, we show that axon specification is determined by differences in microtubule network mobility between neurites, regulated by Rho guanosine triphosphatases (GTPases) and extracellular cues. In developing neurons, retrograde microtubule flow prevents the entry of the axon-selective motor protein Kinesin-1 into most neurites. Using inducible assays to control microtubule network flow, we demonstrate that local inhibition of microtubule mobility is sufficient to guide Kinesin-1 into a specific neurite, whereas long-term global inhibition induces the formation of multiple axons. We furthermore show that extracellular mechanical cues and intracellular Rho GTPase signaling control the local differences in microtubule network flow. These results reveal a novel cytoskeletal mechanism for neuronal polarization.
MeSH term(s)	Kinesins ; Hippocampus/metabolism ; Cell Polarity/physiology ; Cells, Cultured ; Axons/metabolism ; Neurons/physiology ; Microtubules/metabolism
Chemical Substances	Kinesins (EC 3.6.4.4)
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abo2343
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Creating a Functional Biomimetic Cartilage Implant Using Hydrogels Based on Methacrylated Chondroitin Sulfate and Hyaluronic Acid.

Schuiringa, Gerke H / Mihajlovic, Marko / van Donkelaar, Corrinus C / Vermonden, Tina / Ito, Keita

Gels (Basel, Switzerland)

2022 Volume 8, Issue 7

Abstract: The load-bearing function of articular cartilage tissue contrasts with the poor load-bearing capacity of most soft hydrogels used for its regeneration. The present study explores whether a hydrogel based on the methacrylated natural polymers chondroitin ... ...

Abstract	The load-bearing function of articular cartilage tissue contrasts with the poor load-bearing capacity of most soft hydrogels used for its regeneration. The present study explores whether a hydrogel based on the methacrylated natural polymers chondroitin sulfate (CSMA) and hyaluronic acid (HAMA), injected into warp-knitted spacer fabrics, could be used to create a biomimetic construct with cartilage-like mechanical properties. The swelling ratio of the combined CSMA/HAMA hydrogels in the first 20 days was higher for hydrogels with a higher CSMA concentration, and these hydrogels also degraded quicker, whereas those with a 1.33 wt% of HAMA were stable for more than 120 days. When confined by a polyamide 6 (PA6) spacer fabric, the volumetric swelling of the combined CSMA/HAMA gels (10 wt%, 6.5 × CSMA:HAMA ratio) was reduced by ~53%. Both the apparent peak and the equilibrium modulus significantly increased in the PA6-restricted constructs compared to the free-swelling hydrogels after 28 days of swelling, and no significant differences in the moduli and time constant compared to native bovine cartilage were observed. Moreover, the cell viability in the CSMA/HAMA PA6 constructs was comparable to that in gelatin-methacrylamide (GelMA) PA6 constructs at one day after polymerization. These results suggest that using a HydroSpacer construct with an extracellular matrix (ECM)-like biopolymer-based hydrogel is a promising approach for mimicking the load-bearing properties of native cartilage.
Language	English
Publishing date	2022-07-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels8070457
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Self-Healing Thermosensitive Hydrogel for Sustained Release of Dexamethasone for Ocular Therapy.

Annala, Ada / Ilochonwu, Blessing C / Wilbie, Danny / Sadeghi, Amir / Hennink, Wim E / Vermonden, Tina

ACS polymers Au

2022 Volume 3, Issue 1, Page(s) 118–131

Abstract: The aim of this study was to develop an injectable hydrogel delivery system for sustained ocular delivery of dexamethasone. To this end, a self-healing hydrogel consisting of a thermosensitive ABA triblock copolymer was designed. The drug was covalently ... ...

Abstract	The aim of this study was to develop an injectable hydrogel delivery system for sustained ocular delivery of dexamethasone. To this end, a self-healing hydrogel consisting of a thermosensitive ABA triblock copolymer was designed. The drug was covalently linked to the polymer by copolymerization of methacrylated dexamethasone with
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article
ISSN	2694-2453
ISSN (online)	2694-2453
DOI	10.1021/acspolymersau.2c00038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Stimuli-Responsive Hydrogels: The Dynamic Smart Biomaterials of Tomorrow.

Neumann, Myriam / di Marco, Greta / Iudin, Dmitrii / Viola, Martina / van Nostrum, Cornelus F / van Ravensteijn, Bas G P / Vermonden, Tina

Macromolecules

2023 Volume 56, Issue 21, Page(s) 8377–8392

Abstract: In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but ... ...

Abstract	In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart hydrogels can not only replicate the physicochemical properties of the extracellular matrix but also mimic dynamic processes that are crucial for the regulation of cell behavior. Dynamic changes can be influenced by the hydrogel itself (isotropic vs anisotropic) or guided by applying localized triggers. The resulting swelling-shrinking, shape-morphing, as well as patterns have been shown to influence cell function in a spatiotemporally controlled manner. Furthermore, the use of stimuli-responsive hydrogels as bioinks in 4D bioprinting is very promising as they allow the biofabrication of complex microstructures. This perspective discusses recent cutting-edge advances as well as current challenges in the field of smart biomaterials for tissue engineering. Additionally, emerging trends and potential future directions are addressed.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3436-8
ISSN	0024-9297
ISSN	0024-9297
DOI	10.1021/acs.macromol.3c00967
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition.

Timmers, Matt / Peeters, Wouter / Hauwert, Niels J / Rijcken, Cristianne J F / Vermonden, Tina / Dijkgraaf, Ingrid / Liskamp, Rob M J

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 76, Page(s) 11397–11400

Abstract: The site specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins is described. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide ... ...

Abstract	The site specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins is described. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide containing proteins
MeSH term(s)	Azides ; Cycloaddition Reaction ; Peptides ; Antibodies ; Alkynes
Chemical Substances	Azides ; Peptides ; Antibodies ; Alkynes
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc03397j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Covalent Grafting of Functionalized MEW Fibers to Silk Fibroin Hydrogels to Obtain Reinforced Tissue Engineered Constructs.

Viola, Martina / Ainsworth, Madison J / Mihajlovic, Marko / Cedillo-Servin, Gerardo / van Steenbergen, Mies J / van Rijen, Mattie / de Ruijter, Mylène / Castilho, Miguel / Malda, Jos / Vermonden, Tina

Biomacromolecules

2024 Volume 25, Issue 3, Page(s) 1563–1577

Abstract: Hydrogels are ideal materials to encapsulate cells, making them suitable for applications in tissue engineering and regenerative medicine. However, they generally do not possess adequate mechanical strength to functionally replace human tissues, and ... ...

Abstract	Hydrogels are ideal materials to encapsulate cells, making them suitable for applications in tissue engineering and regenerative medicine. However, they generally do not possess adequate mechanical strength to functionally replace human tissues, and therefore they often need to be combined with reinforcing structures. While the interaction at the interface between the hydrogel and reinforcing structure is imperative for mechanical function and subsequent biological performance, this interaction is often overlooked. Melt electrowriting enables the production of reinforcing microscale fibers that can be effectively integrated with hydrogels. Yet, studies on the interaction between these micrometer scale fibers and hydrogels are limited. Here, we explored the influence of covalent interfacial interactions between reinforcing structures and silk fibroin methacryloyl hydrogels (silkMA) on the mechanical properties of the construct and cartilage-specific matrix production
MeSH term(s)	Humans ; Tissue Engineering/methods ; Fibroins/chemistry ; Hydrogels/chemistry ; Cartilage, Articular ; Polymers ; Tissue Scaffolds/chemistry ; Polyesters/chemistry
Chemical Substances	Fibroins (9007-76-5) ; Hydrogels ; Polymers ; Polyesters
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c01147
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Intravitreal hydrogels for sustained release of therapeutic proteins.

Ilochonwu, Blessing C / Urtti, Arto / Hennink, Wim E / Vermonden, Tina

Journal of controlled release : official journal of the Controlled Release Society

2020 Volume 326, Page(s) 419–441

Abstract: This review highlights how hydrogel formulations can improve intravitreal protein delivery to the posterior segment of the eye in order to increase therapeutic outcome and patient compliance. Several therapeutic proteins have shown excellent clinical ... ...

Abstract	This review highlights how hydrogel formulations can improve intravitreal protein delivery to the posterior segment of the eye in order to increase therapeutic outcome and patient compliance. Several therapeutic proteins have shown excellent clinical successes for the treatment of various intraocular diseases. However, drug delivery to the posterior segment of the eye faces significant challenges due to multiple physiological barriers preventing drugs from reaching the retina, among which intravitreal protein instability and rapid clearance from the site of injection. Hence, frequent injections are required to maintain therapeutic levels. Moreover, because the world population ages, the number of patients suffering from ocular diseases, such as age-related macular degeneration (AMD) and diabetic retinopathy (DR) is increasing and causing increased health care costs. Therefore, there is a growing need for suitable delivery systems able to tackle the current limitations in retinal protein delivery, which also may reduce costs. Hydrogels have shown to be promising delivery systems capable of sustaining release of therapeutic proteins and thus extending their local presence. Here, an extensive overview of preclinically developed intravitreal hydrogels is provided with attention to the rational design of clinically useful intravitreal systems. The currently used polymers, crosslinking mechanisms, in vitro/in vivo models and advancements are discussed together with the limitations and future perspective of these biomaterials.
MeSH term(s)	Delayed-Action Preparations/therapeutic use ; Drug Delivery Systems ; Humans ; Hydrogels/therapeutic use ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Polymers/therapeutic use ; Retina
Chemical Substances	Delayed-Action Preparations ; Hydrogels ; Polymers
Language	English
Publishing date	2020-07-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2020.07.031
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