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  1. AU="Veronica Davalos"
  2. AU="Koba, Wade R"
  3. AU="Cui, Hongyan"
  4. AU="Ross, Nina E"
  5. AU="Atwa, Hanaa A"
  6. AU="Reid, Carly"

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  1. Article ; Online: Insights from the genetic and transcriptional characterization of a cancer of unknown primary (CUP)

    Veronica Davalos / Manel Esteller

    EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)

    2020  

    Abstract: Cancer of unknown primary (CUP) defines a heterogeneous group of metastatic tumors that lack an identifiable primary tumor, despite a standardized diagnostic work‐up (Fizazi et al, 2015). CUPs are characterized by an aggressive clinical course, unusual ... ...

    Abstract Cancer of unknown primary (CUP) defines a heterogeneous group of metastatic tumors that lack an identifiable primary tumor, despite a standardized diagnostic work‐up (Fizazi et al, 2015). CUPs are characterized by an aggressive clinical course, unusual metastatic pattern, and poor prognosis. Research in this field has been encouraged to unravel the complexity of this enigmatic entity and improve clinical management and survival of CUP patients. In this issue of EMBO Molecular Medicine, Benvenuti et al (2020) describe the molecular characterization of multiple synchronous and spatially distinct metastases from a CUP patient, shedding light on the evolutionary dynamic and distinctive features of CUP.
    Keywords Medicine (General) ; R5-920 ; Genetics ; QH426-470
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Accelerated biological aging in COVID-19 patients

    Xue Cao / Wenjuan Li / Ting Wang / Dongzhi Ran / Veronica Davalos / Laura Planas-Serra / Aurora Pujol / Manel Esteller / Xiaolin Wang / Huichuan Yu

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 7

    Abstract: Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations ... ...

    Abstract Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established epigenetic clocks and telomere length estimators, and describing correlations between epigenetic aging and the risk of SARS-CoV-2 infection and severe disease.
    Keywords Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma

    Veronica Davalos / Claudia D. Lovell / Richard Von Itter / Igor Dolgalev / Praveen Agrawal / Gillian Baptiste / David J. Kahler / Elena Sokolova / Sebastian Moran / Laia Piqué / Eleazar Vega-Saenz de Miera / Barbara Fontanals-Cirera / Alcida Karz / Aristotelis Tsirigos / Chi Yun / Farbod Darvishian / Heather C. Etchevers / Iman Osman / Manel Esteller /
    Markus Schober / Eva Hernando

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 16

    Abstract: Melanocytes can de-differentiate into neural crest cell (NCC)- like states during metastatic melanoma progression. Here the authors compare DNA methylation profiles of NCCs and melanocytes, as well as primary and metastatic patient tissues and identify ... ...

    Abstract Melanocytes can de-differentiate into neural crest cell (NCC)- like states during metastatic melanoma progression. Here the authors compare DNA methylation profiles of NCCs and melanocytes, as well as primary and metastatic patient tissues and identify that DNA methylation changes of NR2F2 isoform 2 influence cell state transitions and melanoma metastatic spread.
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C)

    Veronica Davalos / Carlos A. García-Prieto / Gerardo Ferrer / Sergio Aguilera-Albesa / Juan Valencia-Ramos / Agustí Rodríguez-Palmero / Montserrat Ruiz / Laura Planas-Serra / Iolanda Jordan / Iosune Alegría / Patricia Flores-Pérez / Verónica Cantarín / Victoria Fumadó / Maria Teresa Viadero / Carlos Rodrigo / Maria Méndez-Hernández / Eduardo López-Granados / Roger Colobran / Jacques G. Rivière /
    Pere Soler-Palacín / Aurora Pujol / Manel Esteller

    EClinicalMedicine, Vol 50, Iss , Pp 101515- (2022)

    A multicenter, retrospective study

    2022  

    Abstract: Summary: Background: Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. ...

    Abstract Summary: Background: Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention. However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C. Methods: Peripheral blood samples were recruited from 43 confirmed MIS-C patients. 69 non-COVID-19 pediatric samples and 15 COVID-19 pediatric samples without MIS-C were used as controls. The cases in the two groups were mixed and divided into discovery (MIS-C = 29 and non-MIS-C = 56) and validation (MIS-C = 14 and non-MIS-C = 28) cohorts, and balanced for age, gender and ethnic background. We interrogated 850,000 CpG sites of the human genome for DNA methylation variants. Findings: The DNA methylation content of 33 CpG loci was linked with the presence of MIS-C. Of these sites, 18 (54.5%) were located in described genes. The top candidate gene was the immune T-cell mediator ZEB2; and others highly ranked candidates included the regulator of natural killer cell functional competence SH2D1B; VWA8, which contains a domain of the Von Willebrand factor A involved in the pediatric hemostasis disease; and human leukocyte antigen complex member HLA-DRB1; in addition to pro-inflammatory genes such as CUL2 and AIM2. The identified loci were used to construct a DNA methylation profile (EPIMISC) that was associated with MIS-C in both cohorts. The EPIMISC signature was also overrepresented in Kawasaki disease patients, a childhood pathology with a possible viral trigger, that shares many of the clinical features of MIS-C. Interpretation: We have characterized DNA methylation loci that are associated ...
    Keywords Multisystem inflammatory syndrome in children ; COVID-19 ; Kawasaki disease ; Epigenetics ; DNA methylation ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Epigenome-wide association study of COVID-19 severity with respiratory failure

    Manuel Castro de Moura / Veronica Davalos / Laura Planas-Serra / Damiana Alvarez-Errico / Carles Arribas / Montserrat Ruiz / Sergio Aguilera-Albesa / Jesús Troya / Juan Valencia-Ramos / Valentina Vélez-Santamaria / Agustí Rodríguez-Palmero / Judit Villar-Garcia / Juan P. Horcajada / Sergiu Albu / Carlos Casasnovas / Anna Rull / Laia Reverte / Beatriz Dietl / David Dalmau /
    Maria J. Arranz / Laia Llucià-Carol / Anna M. Planas / Jordi Pérez-Tur / Israel Fernandez-Cadenas / Paula Villares / Jair Tenorio / Roger Colobran / Andrea Martin-Nalda / Pere Soler-Palacin / Francesc Vidal / Aurora Pujol / Manel Esteller

    EBioMedicine, Vol 66, Iss , Pp 103339- (2021)

    2021  

    Abstract: Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the ... ...

    Abstract Background: Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide spectrum of disease behaviour. Since DNA methylation has been implicated in the regulation of viral infections and the immune system, we performed an epigenome-wide association study (EWAS) to identify candidate loci regulated by this epigenetic mark that could be involved in the onset of COVID-19 in patients without comorbidities. Methods: Peripheral blood samples were obtained from 407 confirmed COVID-19 patients ≤ 61 years of age and without comorbidities, 194 (47.7%) of whom had mild symptomatology that did not involve hospitalization and 213 (52.3%) had a severe clinical course that required respiratory support. The set of cases was divided into discovery (n = 207) and validation (n = 200) cohorts, balanced for age and sex of individuals. We analysed the DNA methylation status of 850,000 CpG sites in these patients. Findings: The DNA methylation status of 44 CpG sites was associated with the clinical severity of COVID-19. Of these loci, 23 (52.3%) were located in 20 annotated coding genes. These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. Interpretation: We identified DNA methylation sites as epigenetic susceptibility loci for respiratory failure in COVID-19 patients. These candidate biomarkers, combined with other clinical, cellular and genetic factors, could be useful in the clinical stratification and management of patients infected with the SARS-CoV-2. Funding: The Unstoppable campaign of the Josep Carreras Leukaemia Foundation, the Cellex Foundation and the CERCA Programme/Generalitat de Catalunya.
    Keywords Coronavirus ; SARS-CoV-2 ; COVID-19 ; Epigenetics ; DNA methylation ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31

    Viré, Emmanuelle / Alberto Villanueva / Anna Git / August Vidal / Carlos Caldas / Christina Curtis / Isaia Barbieri / Manel Esteller / Samuel Aparicio / Samuel Robson / Tony Kouzarides / Veronica Davalos

    Molecular cell. 2014 Mar. 06, v. 53

    2014  

    Abstract: Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing ... ...

    Abstract Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing the transformation of cells in vitro and potentiating tumor formation and metastatic features in vivo. We identify an inverse correlation between EMSY amplification and miR-31 expression, an antimetastatic microRNA, in the METABRIC cohort of human breast samples. Re-expression of miR-31 profoundly reduced cell migration, invasion, and colony-formation abilities of cells overexpressing EMSY or haboring EMSY amplification. We show that EMSY is recruited to the miR-31 promoter by the DNA binding factor ETS-1, and it represses miR-31 transcription by delivering the H3K4me3 demethylase JARID1b/PLU-1/KDM5B. Altogether, these results suggest a pathway underlying the role of EMSY in breast cancer and uncover potential diagnostic and therapeutic targets in sporadic breast cancer.
    Keywords animal ovaries ; breast neoplasms ; cell movement ; DNA ; humans ; mechanism of action ; metastasis ; microRNA ; oncogenes ; ovarian neoplasms ; transcription (genetics)
    Language English
    Dates of publication 2014-0306
    Size p. 806-818.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2014.01.029
    Database NAL-Catalogue (AGRICOLA)

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